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TNFAMLPPEVNSLRMFTGAGSAPMLDAATAWDSMASELGVAASSFSSVTSGLAGDAWQGAASAAMTAAAS SYAKLLGAASTRAAAAATQAKAVAGVFEDARAAMVHPLAVAANRSAFLKLVQSNWLGLNAPAIMATEGHY EQMWAQDVATMAGYHAGVSSAAAALPGGLQQLLKTLPNLGIGNIGNANIGNGNIGTANIGTGNSGVGNTP ITPGIAGNYNIGGGNNGNNNLGAGNYGNFNFGFGNKGDGNIGFGNGGPANLSRLNPFALQPAPGNNNVGM GNTGNNNFGLGNLGDGNIGGGNYGNNNIGLGLLGSNLVGVGGAYYDTAAGQFHFDGLNTGSGNIGIGNSG NNNIGFFNSGDGNIGAFSSGTNSVLPGHLNSFGVGNSGIGNFGVGNAGAGNFGAGNSGLLNTGVGNAGSI DTGAFNGNNLNTGFLNSGKTNTGFGNSGHENTGFWNSGDVNTGVGATTDSGLATSGFGNTGEVGISGFGN TATGGFRSGDMSGFFNTAAGGSSYTGVSSGFFNTGLTDPIGPFASGVLSGFNSGIFNTGIAVSGLFSLSQ LAR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1130 | - | - | 100% (564) | PPE family protein |
M. marinum M | MMAR_1129 | - | 0.0 | 73.29% (569) | PPE family protein |
M. marinum M | MMAR_5047 | - | 0.0 | 59.22% (564) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3588 | PPE64 | 0.0 | 59.58% (574) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 3e-23 | 34.62% (182) | PPE protein |
M. tuberculosis H37Rv | Rv3558 | PPE64 | 0.0 | 59.58% (574) | PPE family protein |
M. leprae Br4923 | MLBr_01182 | - | 4e-27 | 37.77% (188) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_4284c | - | 6e-22 | 33.41% (416) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4704 | - | 6e-45 | 51.61% (186) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-23 | 34.43% (183) | PPE family protein |
M. thermoresistible (build 8) | TH_3113 | - | 1e-22 | 37.27% (161) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_0890 | - | 0.0 | 72.58% (569) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-25 | 36.81% (182) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1130|M.marinum_M -----------MTN--FAMLPPEVNSLRMFTGAGSAPMLDAATAWDSMAS MUL_0890|M.ulcerans_Agy99 -----------MTN--FAMLPPEINSSLMFSGAGSAPMLDAAAAWEGLAS Mb3588|M.bovis_AF2122/97 -----------MAH--FSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAA Rv3558|M.tuberculosis_H37Rv -----------MAH--FSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAA MAV_4704|M.avium_104 -----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAE MLBr_01182|M.leprae_Br4923 -----------MFD--FAALSPETNSTRMYLGPGSSPILTAAAAWVVLAK Mflv_0325|M.gilvum_PYR-GCK -MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSA Mvan_0415|M.vanbaalenii_PYR-1 -----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSA MSMEG_0619|M.smegmatis_MC2_155 -----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSA TH_3113|M.thermoresistible__bu -----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSD MAB_4284c|M.abscessus_ATCC_199 MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAE .: .: * .. . .. . :: MMAR_1130|M.marinum_M ELGV-------------AASSFSSVTSGLAGDAWQGA---ASAAMTAAAS MUL_0890|M.ulcerans_Agy99 ELGT-------------AASSSSSVTSGLVSDAWQGA---ASAAMNAVAT Mb3588|M.bovis_AF2122/97 ELGT-------------AASSFSSVTTGLTGQAWQGP---ASAAMAAAAA Rv3558|M.tuberculosis_H37Rv ELGT-------------AASSFSSVTTGLTGQAWQGP---ASAAMAAAAA MAV_4704|M.avium_104 ELAS-------------SAQSFSSVTSDLASGSWQGA---SSAAMMTVAN MLBr_01182|M.leprae_Br4923 ELTA-------------AAQGLQSAVEALLT-TFEGE---SAAALAERVT Mflv_0325|M.gilvum_PYR-GCK EYAS-------------AAAELTSILAGVQSGAWEGP---SSQQYVAAHT Mvan_0415|M.vanbaalenii_PYR-1 EYAA-------------AAAELSSILADVQAGAWEGP---SSEQYVAAHT MSMEG_0619|M.smegmatis_MC2_155 EYAA-------------AAAELTSVLSAVQAGSWEGP---SSEQYVAAHA TH_3113|M.thermoresistible__bu EYRA-------------AAVELAAVVSQTCATAWEGV---GADAYAAAHG MAB_4284c|M.abscessus_ATCC_199 SVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDN . . . :* .. MMAR_1130|M.marinum_M SYAKLLGAASTRAAAAATQAKAVAG------------------------- MUL_0890|M.ulcerans_Agy99 PYAQFLSAASTQAAGAASQAKAVAG------------------------- Mb3588|M.bovis_AF2122/97 PYAGFLTTASAQAQLAAGQAKAVAS------------------------- Rv3558|M.tuberculosis_H37Rv PYAGFLTTASAQAQLAAGQAKAVAS------------------------- MAV_4704|M.avium_104 QYVSWLSAAAAQAEEVSHQASAIAT------------------------- MLBr_01182|M.leprae_Br4923 PYEKWLTQNAASAELTATQLTVAAN------------------------- Mflv_0325|M.gilvum_PYR-GCK PYLAWLAQQSAVSAATAVQHDTAAA------------------------- Mvan_0415|M.vanbaalenii_PYR-1 PYLAWLAQQSAAGAAAAAQHEAAAA------------------------- MSMEG_0619|M.smegmatis_MC2_155 PYLQWLAQQSANSAAAAVQHETAAA------------------------- TH_3113|M.thermoresistible__bu PYLFWLTDTAAAAAAAGAQLEAAAA------------------------- MAB_4284c|M.abscessus_ATCC_199 DFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNR : : . . : MMAR_1130|M.marinum_M --------VFEDARAAMVHPLAVAANRSAFLKLVQSNWLGLNA------- MUL_0890|M.ulcerans_Agy99 --------AFEVARAAMIHPLEVLANRNVFVQLIRTNLFGLNA------- Mb3588|M.bovis_AF2122/97 --------VFEAAKAAIVPPAAVAANREAFLALIRSNWLGLNA------- Rv3558|M.tuberculosis_H37Rv --------VFEAAKAAIVPPAAVAANREAFLALIRSNWLGLNA------- MAV_4704|M.avium_104 --------AFEVALAATVQPAVVAANRALVQALAATNWLGQNT------- MLBr_01182|M.leprae_Br4923 --------AYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNS------- Mflv_0325|M.gilvum_PYR-GCK --------AYTTALATMPTLPELALNHTTHAVLVGTNFLGINT------- Mvan_0415|M.vanbaalenii_PYR-1 --------AYSTALATMPTLPELALNHTTHAVLVATNFLGINT------- MSMEG_0619|M.smegmatis_MC2_155 --------AYSTALATMPTMAELALNHTMHGVLVATNFFGINT------- TH_3113|M.thermoresistible__bu --------AHASALAAMPTMAELTANRTTHAALVATNFFGVNT------- MAB_4284c|M.abscessus_ATCC_199 DTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSNIINADHGSNVGVD . . : . : :* :. : MMAR_1130|M.marinum_M PAIMATEGHYEQMWAQDVATMAGYHAGVSSAAAALPG--GLQQLLKTLPN MUL_0890|M.ulcerans_Agy99 PAIMAAEGQYEQMWAQDVAAMVSYHGGASSAAASLPS--GLQQILQSLPN Mb3588|M.bovis_AF2122/97 PWIAAVESLYEEYWAADVAAMTGYHAGASQAAAQLPLPAGLQQFLNTLPN Rv3558|M.tuberculosis_H37Rv PWIAAVESLYEEYWAADVAAMTGYHAGASQAAAQLPLPAGLQQFLNTLPN MAV_4704|M.avium_104 PAIADIEAAYEQMWASDVAAMFGYHADASAAVAKLPP------WNEVLQN MLBr_01182|M.leprae_Br4923 TAIAEKEAEYTEMWIQDAAAMTSYQASVLEAVGATKA--------FTAPP Mflv_0325|M.gilvum_PYR-GCK IPIALNEADYVRMWIQAATTMATYQSVSGAALAATPT----SAPAPSVLL Mvan_0415|M.vanbaalenii_PYR-1 IPIAMTEADYVRMWIQAATTMATYQAVSGAALAATPT----ATPAPFVLA MSMEG_0619|M.smegmatis_MC2_155 IPIALNEADYVRMWIQAATTMSTYQAVSGAAVAAAPV----SAPAPFLLK TH_3113|M.thermoresistible__bu IPIAVNEADYARMWIQAATTMATYEAVASAAVSATPR----TVAPPPILG MAB_4284c|M.abscessus_ATCC_199 QSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTN . * . : : MMAR_1130|M.marinum_M LGIGNIGNANIGNGNIGTANIGTGNSGVGNTPITPGIAGNYNIGGGNNGN MUL_0890|M.ulcerans_Agy99 LGLGNKGNANLGSGNTGIGNIGVGNSGEGNSALVPPQSGNYNIGGGNNGN Mb3588|M.bovis_AF2122/97 LGIGNQGNANLGGGNTGSGNIGNGNKG------------SSNLGGGNIGN Rv3558|M.tuberculosis_H37Rv LGIGNQGNANLGGGNTGSGNIGNGNKG------------SSNLGGGNIGN MAV_4704|M.avium_104 LGFSNASTAVTRP--AGSGAVARGYTS--------------RIAG----- MLBr_01182|M.leprae_Br4923 LGVNEVGLAQEVVEEVVEEVVEEVVEA----------------------- Mflv_0325|M.gilvum_PYR-GCK PGVGEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLF Mvan_0415|M.vanbaalenii_PYR-1 PGVGEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLF MSMEG_0619|M.smegmatis_MC2_155 PGVGEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG- TH_3113|M.thermoresistible__bu AGTGESATAAITGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPP MAB_4284c|M.abscessus_ATCC_199 IGSGNTTNTEIGSHNQANIGTSTSAGGSAAVGGNAGLAGNAGLAGNAGLA * .: : MMAR_1130|M.marinum_M NNLGAGNYGNFNFGFGNKGDGNIGFGNGGPANLSRLNPFALQPA------ MUL_0890|M.ulcerans_Agy99 NNLGAGNIGNFNFGFGNNGTGNFGFGNAGPADLSNPNLFTFHVT------ Mb3588|M.bovis_AF2122/97 NNIGSGNRGSDNFGAGNVGTGNIGFGNQGPIDVNLLATPGQNNVG----- Rv3558|M.tuberculosis_H37Rv NNIGSGNRGSDNFGAGNVGTGNIGFGNQGPIDVNLLATPGQNNVG----- MAV_4704|M.avium_104 ----------------------------------FLAPRAPQ-------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK EPIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA------- Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA------- MSMEG_0619|M.smegmatis_MC2_155 QAILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVF------ TH_3113|M.thermoresistible__bu GFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNP------- MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGN MMAR_1130|M.marinum_M -------------------------PGNNNVGMGNTGNNNFGLGNLGDGN MUL_0890|M.ulcerans_Agy99 -------------------------PGENNIGIGNTGNGNFGLGNTGDGN Mb3588|M.bovis_AF2122/97 ----------------------LGNIGNNNMGFGNTGDANTGGGNTGNGN Rv3558|M.tuberculosis_H37Rv ----------------------LGNIGNNNMGFGNTGDANTGGGNTGNGN MAV_4704|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 ----------------------------------EQAISQAALDQAVNEG Mflv_0325|M.gilvum_PYR-GCK ---------------------------VSWVGASILYPSLFLLPLLATT- Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------VSWVGASILYPSLLLLPLVATT- MSMEG_0619|M.smegmatis_MC2_155 ------------------------FNLVGWPTWGMIFASPFLIPALAALG TH_3113|M.thermoresistible__bu ---------------------------------AYLFPVLVYLLFTGVVH MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG MMAR_1130|M.marinum_M IGGGNYGNNNIGLGLLGSNLVGVGGAYYDTAAGQFHFDGLNTGSGNIGIG MUL_0890|M.ulcerans_Agy99 IGGGNTGIGNIGFGLNGNNLVGVGGAYYDTAAGQFHFDGLNTGSGNIGIG Mb3588|M.bovis_AF2122/97 IGGGNTGNNNFGFGNTGNNNIGIG-LTGNNQMGINLAGLLNSGSGNIGIG Rv3558|M.tuberculosis_H37Rv IGGGNTGNNNFGFGNTGNNNIGIG-LTGNNQMGINLAGLLNSGSGNIGIG MAV_4704|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 MEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTL Mflv_0325|M.gilvum_PYR-GCK -LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAP Mvan_0415|M.vanbaalenii_PYR-1 -LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAP MSMEG_0619|M.smegmatis_MC2_155 ITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP-LAVGISPA TH_3113|M.thermoresistible__bu TTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVP MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAAVAGNAAVAGNAAVAGNAAVGGVLNTGVSGAIGGSSHVG MMAR_1130|M.marinum_M NSGNNNIGFFNSGDGNIGAFSSGTNSVLPGHLNSFGVGNSGIGNFGVGNA MUL_0890|M.ulcerans_Agy99 NSGSNNIGFFNSGDGNIGAFSSGTNSVFPGQLNSFGVGNSGTGNLGFGNA Mb3588|M.bovis_AF2122/97 NSGTNNIGLFNSGSGNIGVFNTGANTLVPGDLNNLGVGNSGNANIGFGNA Rv3558|M.tuberculosis_H37Rv NSGTNNIGLFNSGSGNIGVFNTGANTLVPGDLNNLGVGNSGNANIGFGNA MAV_4704|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 SMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMG-SAVQST Mflv_0325|M.gilvum_PYR-GCK PPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVR Mvan_0415|M.vanbaalenii_PYR-1 PPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVR MSMEG_0619|M.smegmatis_MC2_155 GVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLG TH_3113|M.thermoresistible__bu AADGGASAAPVPAGGPSLPS-GSSAPPAPTGSAAPTTGTAPGGAGSPPPA MAB_4284c|M.abscessus_ATCC_199 GAINESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVGGGISESLG MMAR_1130|M.marinum_M GAGNFGAGNSGLLNTGVGNAGSIDTGAFNGNNLNTGFLNSGKTNTGFGNS MUL_0890|M.ulcerans_Agy99 GSGNAGFGNSGLLNTGFGNAGSTNTGGFNGNNLNTGFLNSGEVNTGIGNS Mb3588|M.bovis_AF2122/97 GVLNTGFGNASILNTGLGNAGELNTGFGNAGFVNTGFDNSGNVNTGNGNS Rv3558|M.tuberculosis_H37Rv GVLNTGFGNASILNTGLGNAGELNTGFGNAGFVNTGFDNSGNVNTGNGNS MAV_4704|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 GRGLLGSSSGGHVTAQLGRAASIGS------------LRVPQTWTTASQP Mflv_0325|M.gilvum_PYR-GCK DSTGAKAPAGTIPAAASG----IAASAAERRKRRRRQKEEIKGRGYADAY Mvan_0415|M.vanbaalenii_PYR-1 DSTSAKAPASGIPAAASG----VAASAAERRKRRRRQKDEIAGRAYADAY MSMEG_0619|M.smegmatis_MC2_155 NKSQVAAPASGVPAAASG----VAASLASRRKRRRKKGAQIEERGYADAY TH_3113|M.thermoresistible__bu GHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGS MAB_4284c|M.abscessus_ATCC_199 GSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGS MMAR_1130|M.marinum_M GHENTGFWNSGD--VNTGVGATTDSGLA------TSGFGNTGEVGISGFG MUL_0890|M.ulcerans_Agy99 GHINTGFLNAGN--VNTGIGNATDAGEVGLTATDSSGFFNTG-YGVSGFG Mb3588|M.bovis_AF2122/97 GNINTGSWNAGN--VNTGFGIITDSGLT------NSGFGNTG-TDVSGFF Rv3558|M.tuberculosis_H37Rv GNINTGSWNAGN--VNTGFGIITDSGLT------NSGFGNTG-TDVSGFF MAV_4704|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 VTAATRALSPAR--VAVAT------------------------------- Mflv_0325|M.gilvum_PYR-GCK ADYEELPDDGPP--EQPAPRVTASTRGA-------------------GPM Mvan_0415|M.vanbaalenii_PYR-1 ADYEPEPDDEPP--VRQEPRIAATERGA-------------------GPM MSMEG_0619|M.smegmatis_MC2_155 MDYEE-PDEDPA--PQPEPRVRASERGS-------------------DAM TH_3113|M.thermoresistible__bu AAAAAAARESAP--IRRRRGQKDGLHGHR-----------------HEHQ MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTGVGGGVNTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAH MMAR_1130|M.marinum_M NTATGGFRSGDMSGFFNTAAGGSSYTGVSSGFFNTGLTDPIGPFASGVLS MUL_0890|M.ulcerans_Agy99 NAADESSYGHGVSAFGNTAVGTAFEVGVSSGFFNTGYSEAIGPFALGQVS Mb3588|M.bovis_AF2122/97 NTPTG-PLAVDVSGFFNTASGGTVINGQTSGIGNIGVP---GTLFGSVRS Rv3558|M.tuberculosis_H37Rv NTPTG-PLAVDVSGFFNTASGGTVINGQTSGIGNIGVP---GTLFGSVRS MAV_4704|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 ESESAPLLGGGLPMAPMVPGGGSGTGGVNTALR----------------- Mflv_0325|M.gilvum_PYR-GCK GFAGTVSRGDEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGR Mvan_0415|M.vanbaalenii_PYR-1 GFAGTVSRDAAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ MSMEG_0619|M.smegmatis_MC2_155 GFTGTVTRHDVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP----- TH_3113|M.thermoresistible__bu QPASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEP----- MAB_4284c|M.abscessus_ATCC_199 TSAINDALGGSGSVGGSTAVGGGAHTSAINESMNSSINASHSSSMNESFG MMAR_1130|M.marinum_M GFNSGIFNTGIAVSGLFSLSQLAR------------- MUL_0890|M.ulcerans_Agy99 GFNSGFFNWGTANSGLFSLSKLAIKS----------- Mb3588|M.bovis_AF2122/97 GLNTGLFNMGTAISGLFNLRQLLG------------- Rv3558|M.tuberculosis_H37Rv GLNTGLFNMGTAISGLFNLRQLLG------------- MAV_4704|M.avium_104 ------------------------------------- MLBr_01182|M.leprae_Br4923 -LQPRAFVMPRNPAAG--------------------- Mflv_0325|M.gilvum_PYR-GCK DGHDGHDGKEKP------------------------- Mvan_0415|M.vanbaalenii_PYR-1 ERHNHHDGKDSQ------------------------- MSMEG_0619|M.smegmatis_MC2_155 -SPDDPEGGPRR------------------------- TH_3113|M.thermoresistible__bu SSPTDRAHRPAEPN----------------------- MAB_4284c|M.abscessus_ATCC_199 SSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH