For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PPLDTAATARLTREDRGYHKSLKNRQLQMIALGGAIGTGLFLGAGGRLASAGPGLFLVYGICGFFVFLIL RALGELVLHRPSSGSFVSYAREFFGEKVAFVAGWMYFLNWAMTGVVDTTAIAHYCHYWKALQFVPQWTLA LVALVSVLLMNLISVKLFGELEFWAALIKVIALVIFLIIGSIFLAGRYHVDGQETGLGLWRSHGGFLPTG LVPLVLVTSGVVFAYAAIELVGTAAGEAAEPEKIMPRAINSVVFRIGLFYIGSTVLLALLLPYTAYREHV SPFVTFFSKVGIEGAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPKFTAPMSKNGVPYGGILL TAGIGTLGIVLNAVKPSQAFEIVLHIAATGVIAAWATIVACQLRFHRLTISGVLQRPSFRMPWSPYSGWI TLAFLASVLILMLFDEVYGRWMLAAILVGVPALIGGWYLVRNRVQVAARDTVASE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0627 | ansP1_1 | - | 100% (476) | L-asparagine permease AnsP1_1 |
| M. marinum M | MMAR_4815 | ansP1 | 0.0 | 70.15% (459) | L-asparagine permease AnsP1 |
| M. marinum M | MMAR_1093 | cycA | 6e-82 | 37.47% (467) | D-serine/D-alanine/glycine transporter, CycA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0354c | ansP2 | 0.0 | 83.51% (473) | L-asparagine ABC transporter permease |
| M. gilvum PYR-GCK | Mflv_1998 | - | 1e-72 | 35.28% (428) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv0346c | ansP2 | 0.0 | 83.51% (473) | L-asparagine ABC transporter permease |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 0.0 | 69.51% (469) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_1132c | - | 1e-177 | 65.58% (462) | L-asparagine ABC transporter permease |
| M. avium 104 | MAV_4626 | - | 7e-78 | 36.67% (450) | gaba permease |
| M. smegmatis MC2 155 | MSMEG_6196 | - | 1e-75 | 35.82% (455) | gaba permease |
| M. thermoresistible (build 8) | TH_0471 | - | 3e-20 | 23.54% (446) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_0383 | ansP1 | 0.0 | 69.28% (459) | L-asparagine permease AnsP1 |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 3e-20 | 23.54% (446) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1998|M.gilvum_PYR-GCK ---------------------MSAAPTLKKALNQ----RQLTMIAIGGVI
MAV_4626|M.avium_104 ---------------------MAGTSQLRQGLSQ----RQLSMIALGGVI
MSMEG_6196|M.smegmatis_MC2_155 --------------MLESRSDLSSSDEPRSGLARSLKTRHMTMIAIGGAI
Mb0354c|M.bovis_AF2122/97 -------------MPPLDITD-ERLTREDTGYHKGLHSRQLQMIALGGAI
Rv0346c|M.tuberculosis_H37Rv -------------MPPLDITD-ERLTREDTGYHKGLHSRQLQMIALGGAI
MMAR_0627|M.marinum_M -------------MPPLDTAATARLTREDRGYHKSLKNRQLQMIALGGAI
MLBr_01305|M.leprae_Br4923 ------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAI
MUL_0383|M.ulcerans_Agy99 ------MRTPSSPTHPDDIALAS----EDAGYHKSLKPRQLQMIAIGGAI
MAB_1132c|M.abscessus_ATCC_199 -------------MASPANYDVSALTREDEGYHKGLKNRQVQMIGIGGAI
TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVI
Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDEPSTRLRKELNWWDLTVFGVSVVI
: .: ::.:. .*
Mflv_1998|M.gilvum_PYR-GCK GAGLFVGSG-VVIADTGPGAFLTYGMAGVLIIMVMRMLAEMAVANPSTGS
MAV_4626|M.avium_104 GAGLFVGSG-VVIKDTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGS
MSMEG_6196|M.smegmatis_MC2_155 GAGLFVGSG-AVIKTAGPAAIVSYVVAGALVLCTLRMLGEMVVAKPRTGA
Mb0354c|M.bovis_AF2122/97 GTGLFLGAG-GRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGS
Rv0346c|M.tuberculosis_H37Rv GTGLFLGAG-GRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGS
MMAR_0627|M.marinum_M GTGLFLGAG-GRLASAGPGLFLVYGICGFFVFLILRALGELVLHRPSSGS
MLBr_01305|M.leprae_Br4923 GTGLFLGAG-GRLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGS
MUL_0383|M.ulcerans_Agy99 GTGLFLGAG-GRLASAGPALFLVYAVCGVFAFLILRALSELVLHRPSSGS
MAB_1132c|M.abscessus_ATCC_199 GTGLFMGAG-GRLHSAGPGLFVVYAICGLFVFFMLRALGELVLHRPSSGS
TH_0471|M.thermoresistible__bu GAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGS
Mvan_1740|M.vanbaalenii_PYR-1 GAGIFTITASTAANITGPAISLSFIIAAIACGLAALCYAEFASTVPVAGS
*:*:* :. :**. : : :.. .*:. * :*:
Mflv_1998|M.gilvum_PYR-GCK FADYSRNALGHWAGFSVGWLYWYFWVIVVGFEAIAGAKIVQYW---MDVP
MAV_4626|M.avium_104 FADYAAAALGRWAGFSVAWLYWYFWVIVVGFEAVAGGKVLNYW---FHAP
MSMEG_6196|M.smegmatis_MC2_155 FADYARIGIGPWAGFTLGWLYWYYYVIIIAVEAVAGAQILAVW---VGLP
Mb0354c|M.bovis_AF2122/97 FVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIP
Rv0346c|M.tuberculosis_H37Rv FVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIP
MMAR_0627|M.marinum_M FVSYAREFFGEKVAFVAGWMYFLNWAMTGVVDTTAIAHYCHYWKALQFVP
MLBr_01305|M.leprae_Br4923 FVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFTALP
MUL_0383|M.ulcerans_Agy99 FVSYAREFFGEKAAYVAGWMYFLNWAMTSIVDSTAIATYFHFWRVFEGIP
MAB_1132c|M.abscessus_ATCC_199 FVSYAREFLGEKAAYVAGWMCFVNWASTSIVDVTAVALYMHYWGAFKAVP
TH_0471|M.thermoresistible__bu AYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLGEVFEFAGAT
Mvan_1740|M.vanbaalenii_PYR-1 AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLGTVFGFAGGT
:: * ..: .* : . . . .
Mflv_1998|M.gilvum_PYR-GCK LWLS-------ALIFMVLMTATNLFSVASYGEFEFWFAGIKVAAIIAFIA
MAV_4626|M.avium_104 LWVL-------SLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLV
MSMEG_6196|M.smegmatis_MC2_155 LWLM-------AMLLMAALTLTNLISVRWFGEFEFWFSGIKVAAIVSFIV
Mb0354c|M.bovis_AF2122/97 QWTL-------ALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLI
Rv0346c|M.tuberculosis_H37Rv QWTL-------ALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLI
MMAR_0627|M.marinum_M QWTL-------ALVALVSVLLMNLISVKLFGELEFWAALIKVIALVIFLI
MLBr_01305|M.leprae_Br4923 QWTL-------ALLALAVVLVMNLISVEWFGELEFWAALIKVCALMAFLV
MUL_0383|M.ulcerans_Agy99 QWAL-------ALFALGIALSMNLISETLFGEIEFWAALIKVVSLLTFRV
MAB_1132c|M.abscessus_ATCC_199 QWVI-------ALIALIIVLTMNMISVKLFGEMEFWAALIKVVALVAFLI
TH_0471|M.thermoresistible__bu TRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVI
Mvan_1740|M.vanbaalenii_PYR-1 TEVAGFQLDWGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVI
:: : . . ..: : :** :: .
Mflv_1998|M.gilvum_PYR-GCK VGAAFVLG---------------LWPGKGADFSNLTSHGGFMPLGFGAIT
MAV_4626|M.avium_104 VGAAYVIG---------------LVPGHHDGLTNLVSHGGFFPRGVGAVF
MSMEG_6196|M.smegmatis_MC2_155 VGLLWVFG---------------VWPGDTNGLTNLVAHGGFAPNGFGSIF
Mb0354c|M.bovis_AF2122/97 VGTVFLAGR-------------YKIDGQETGVSLWSSHGGIVPTGLLPIV
Rv0346c|M.tuberculosis_H37Rv VGTVFLAGR-------------YKIDGQETGVSLWSSHGGIVPTGLLPIV
MMAR_0627|M.marinum_M IGSIFLAGR-------------YHVDGQETGLGLWRSHGGFLPTGLVPLV
MLBr_01305|M.leprae_Br4923 VGTIFLGGR-------------YPVDGHNTGLSLWTSHGGLFPTGVAPLI
MUL_0383|M.ulcerans_Agy99 VGTIFLAGR-------------YPVDGHSTGLGLLAHGGGLFPYGLLPLV
MAB_1132c|M.abscessus_ATCC_199 FGIVFLAGR-------------FTVDGSTTGLSVIADNGGLFPNGLLAMV
TH_0471|M.thermoresistible__bu VGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLL
Mvan_1740|M.vanbaalenii_PYR-1 VGAFYIKAENFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVL
.* :: . . .. . * :
Mflv_1998|M.gilvum_PYR-GCK VGIVTVIFSMVGAEIATIAAAESQDPERAVAKAANSVILRILIFYVGAVL
MAV_4626|M.avium_104 AAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVF
MSMEG_6196|M.smegmatis_MC2_155 GAVVVVIFAFGGAEIVTIAAAESAEPAKSVARATTGVIWRIILFYVGSIF
Mb0354c|M.bovis_AF2122/97 LVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTV
Rv0346c|M.tuberculosis_H37Rv LVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTV
MMAR_0627|M.marinum_M LVTSGVVFAYAAIELVGTAAGEAAEPEKIMPRAINSVVFRIGLFYIGSTV
MLBr_01305|M.leprae_Br4923 VVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVI
MUL_0383|M.ulcerans_Agy99 VVTSGVVFAYAAVELVGTAAGETAEPEKVMPRAINSVIARIALFYVGSLF
MAB_1132c|M.abscessus_ATCC_199 LITSGVVFAYASVELVGTAAGETENPEKVMPKAINAVVFRIAIFYVGSLV
TH_0471|M.thermoresistible__bu AGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSL
Mvan_1740|M.vanbaalenii_PYR-1 AGASIVFFAFIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAV
*.*: . :: :* *: :* : : :. . : : :::. .
Mflv_1998|M.gilvum_PYR-GCK LLVLIVPWNDESVS--ASPFVAAFNAMGIPYADHVMNAVVLTAVLSCLNS
MAV_4626|M.avium_104 LLVAILPWDSVELG--ASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNS
MSMEG_6196|M.smegmatis_MC2_155 LVVCILPWNDASVL--SSPYVAALEKLQIPGAGLIMNIVILTAVLSVLNS
Mb0354c|M.bovis_AF2122/97 LLALLLPYTAYKEH--VSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNA
Rv0346c|M.tuberculosis_H37Rv LLALLLPYTAYKEH--VSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNA
MMAR_0627|M.marinum_M LLALLLPYTAYREH--VSPFVTFFSKVGIEGAGSVMNLVVLTAALSSLNA
MLBr_01305|M.leprae_Br4923 LLALLLPYSAFKAS--ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNA
MUL_0383|M.ulcerans_Agy99 LLGLLLPYTDYKAG--ESPFVTFFDKIGVTGAGSIMNVVVMTAAFSSLNA
MAB_1132c|M.abscessus_ATCC_199 LLALLLPYTTYKAG--ESPFVTFFARVGVPHAGDVMNFVVLTAALSSLNA
TH_0471|M.thermoresistible__bu VLTGMVHYTELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIV
Mvan_1740|M.vanbaalenii_PYR-1 VLTGMVSYTELRDA-ETQNLATAFSLNGVDWAAKVISIGALAGLTTVVIV
:: :: : .: : . * ::. ::. : :
Mflv_1998|M.gilvum_PYR-GCK GMYTASRMLFVLAARREAPAALVKVTNRGVPANAILASSVVGFLCVIAAA
MAV_4626|M.avium_104 GLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAILCSSAVGFLCVVMAR
MSMEG_6196|M.smegmatis_MC2_155 SIYTSSRMLRVLASHGDAPQWLVRTNTRGVPTRAILASTVVGWVSVVLAY
Mb0354c|M.bovis_AF2122/97 GLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNA
Rv0346c|M.tuberculosis_H37Rv GLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNA
MMAR_0627|M.marinum_M GLYSTGRILRSMAINGSGPKFTAPMSKNGVPYGGILLTAGIGTLGIVLNA
MLBr_01305|M.leprae_Br4923 GLYATGRVMHSIAINGSGPKFTARMSKNGVPYGGILLAAVICLCGVALNA
MUL_0383|M.ulcerans_Agy99 GLYSTGRILRSMAMNGSAPSFTARMSQRGVPYGGICLTAAIGLIGVLLNG
MAB_1132c|M.abscessus_ATCC_199 GLYSTGRILRSMSMNGSAPSFLSRMSSGGVPYPGILLTGSFTVLGVFMNM
TH_0471|M.thermoresistible__bu LVLGQTRVLFAMSRDGLLPRPLSKTGPRGTPVR---ITVLVGALVAIAAS
Mvan_1740|M.vanbaalenii_PYR-1 LVLGQTRVLFAMSRDGLLPRQLAKTGEHGTPVR---ITLIVGAVVAVTAT
: *:: :: * *.* : .
Mflv_1998|M.gilvum_PYR-GCK VSPDTIFAFLLNSSGAIILFVYLLIAISQIVLR---YRTPDSKLRVKMWL
MAV_4626|M.avium_104 VAPNTVFLFLLNSSGAIILFVYWLIALSQIVLR---RRTPAERLSVKMWF
MSMEG_6196|M.smegmatis_MC2_155 IAPDSLFLFLVNSCGVVAIFMYVMIGVSELRVRRAIEREDPAKLTLKMWF
Mb0354c|M.bovis_AF2122/97 IKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMANAGQLQRPKFRMPL
Rv0346c|M.tuberculosis_H37Rv IKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMANAGQLQRPKFRMPL
MMAR_0627|M.marinum_M VKPSQAFEIVLHIAATGVIAAWATIVACQLRFHRLTISGVLQRPSFRMPW
MLBr_01305|M.leprae_Br4923 FNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAGIMRRPRFRMPL
MUL_0383|M.ulcerans_Agy99 VVPEMAFEIVLNIAALGILASWATIVCCQIQLFRWSKQGIVYRPSFRMWG
MAB_1132c|M.abscessus_ATCC_199 VIPARAFETALDVAALGILASWATIVICQLRLYQWSRHGILKRGKFQMPG
TH_0471|M.thermoresistible__bu VFPVGNLEEMVN---IGTLFAFALVSAGVIVLR---RTRPDLKRGFRVPF
Mvan_1740|M.vanbaalenii_PYR-1 VFPIGKLEEMVN---IGTLFAFVLVSAGVLVLR---RTRPDLKRGFRTPW
. * : : : : : : . : .:
Mflv_1998|M.gilvum_PYR-GCK FPVLSGLTALGILAILVQMFIDTALRSQLVLSLLSWAVVIALFAANKWFV
MAV_4626|M.avium_104 FPVLSVLTLAGITAVLVQMAFDATARSQLWLSLLSWAVVVALY-----FV
MSMEG_6196|M.smegmatis_MC2_155 FPYLPIAVIACFVLVLVAMLFDADQRVQLLASVVSLAVVLLAYALRKRHG
Mb0354c|M.bovis_AF2122/97 SPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLVRNR
Rv0346c|M.tuberculosis_H37Rv SPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLVRNR
MMAR_0627|M.marinum_M SPYSGWITLAFLASVLILMLFDEVYGRWMLAAILVGVPALIGGWYLVRNR
MLBr_01305|M.leprae_Br4923 APYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIVPALIAGWYSIRKR
MUL_0383|M.ulcerans_Agy99 APYTGYLTLVFLFAVLVLMGFSYPIDTWTVATLGLIIPMLIGGWFLVRDR
MAB_1132c|M.abscessus_ATCC_199 APYTGYATVVFLIAVLLLMCYEN---YWNLVAIGIFTPLLIIGWYLQRDR
TH_0471|M.thermoresistible__bu VPWLPLAAIAACLWLMLNLTGLTWVRFLGWMALGLVLYFFYGRHHSMLGR
Mvan_1740|M.vanbaalenii_PYR-1 VPLLPILAIAACVWLMLNLTGLTWIRFLIWMAIGVVVYFLYGRRHSLVGR
* . ::: : : .
Mflv_1998|M.gilvum_PYR-GCK KKRPAEGDSGAPTGPPHRVLVLANRTVDSDELLAELSRIGADQTAEYLVV
MAV_4626|M.avium_104 AR--SRGRVAAR--------------------------------------
MSMEG_6196|M.smegmatis_MC2_155 QVPATDTKQAARTDE-----------------------------------
Mb0354c|M.bovis_AF2122/97 VTAVAHHAIDHTKSVAVVHSA--DPI------------------------
Rv0346c|M.tuberculosis_H37Rv VTAVAHHAIDHTKSVAVVHSA--DPI------------------------
MMAR_0627|M.marinum_M VQVAARDTVASE--------------------------------------
MLBr_01305|M.leprae_Br4923 VMTIARERMGYTGPFPAIANPPVQPSERSHSQNP----------------
MUL_0383|M.ulcerans_Agy99 VLEIARRRIGYIGEFPVVANP--GPMDKK---------------------
MAB_1132c|M.abscessus_ATCC_199 VMRLAQERVGYTGAYPVIAETPMMDDPPNLGDK-----------------
TH_0471|M.thermoresistible__bu GMTDISARRTG---------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 RMG-----------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK VPASAVDTGAAATHGPRDVTEATQEAATARLESTLAALRGKNLTVQGELG
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_6196|M.smegmatis_MC2_155 --------------------------------------------------
Mb0354c|M.bovis_AF2122/97 --------------------------------------------------
Rv0346c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0627|M.marinum_M --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
MUL_0383|M.ulcerans_Agy99 --------------------------------------------------
MAB_1132c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK DYRPLRALDHAVAEFGPDQIVIATLPPEFSMWHRFDVVDRARAQFTVPVT
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_6196|M.smegmatis_MC2_155 --------------------------------------------------
Mb0354c|M.bovis_AF2122/97 --------------------------------------------------
Rv0346c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0627|M.marinum_M --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
MUL_0383|M.ulcerans_Agy99 --------------------------------------------------
MAB_1132c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK HVVATSAVGNQVPR
MAV_4626|M.avium_104 --------------
MSMEG_6196|M.smegmatis_MC2_155 --------------
Mb0354c|M.bovis_AF2122/97 --------------
Rv0346c|M.tuberculosis_H37Rv --------------
MMAR_0627|M.marinum_M --------------
MLBr_01305|M.leprae_Br4923 --------------
MUL_0383|M.ulcerans_Agy99 --------------
MAB_1132c|M.abscessus_ATCC_199 --------------
TH_0471|M.thermoresistible__bu --------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------