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MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGAGGRLASAGPGLFLVYGICGIFVFLIL RALGELVLHRPSSGSFVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLA LIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTG LLPIVLVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAYKEHV SPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILL TAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMANAGQLQRPKFRMPLSPFSGYL TLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0354c | ansP2 | - | 100% (487) | L-asparagine ABC transporter permease |
M. bovis AF2122 / 97 | Mb2151 | ansP1 | 0.0 | 72.94% (462) | L-asparagine permease ansP1 |
M. bovis AF2122 / 97 | Mb1730c | cycA | 9e-82 | 39.91% (431) | D-serine/alanine/glycine transporter protein CycA |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1998 | - | 6e-75 | 36.30% (416) | amino acid permease-associated region |
M. tuberculosis H37Rv | Rv0346c | ansP2 | 0.0 | 100.00% (487) | L-asparagine ABC transporter permease |
M. leprae Br4923 | MLBr_01305 | ansP2 | 0.0 | 71.00% (462) | putative L-asparagine permease |
M. abscessus ATCC 19977 | MAB_2914 | - | 1e-179 | 64.32% (468) | L-asparagine permease 1 (L-asparagine transport) |
M. marinum M | MMAR_0627 | ansP1_1 | 0.0 | 83.51% (473) | L-asparagine permease AnsP1_1 |
M. avium 104 | MAV_4626 | - | 6e-74 | 36.54% (416) | gaba permease |
M. smegmatis MC2 155 | MSMEG_5473 | - | 4e-73 | 35.02% (414) | transporter |
M. thermoresistible (build 8) | TH_0471 | - | 1e-18 | 24.72% (441) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
M. ulcerans Agy99 | MUL_0383 | ansP1 | 0.0 | 67.01% (485) | L-asparagine permease AnsP1 |
M. vanbaalenii PYR-1 | Mvan_1740 | - | 4e-18 | 24.37% (439) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1998|M.gilvum_PYR-GCK -------------------------MSAAPTLKKALNQRQLTMIAIGGVI MSMEG_5473|M.smegmatis_MC2_155 -------------------------MGDTPALKRALSQRQLRMIAIGGVI MAV_4626|M.avium_104 -------------------------MAGTSQLRQGLSQRQLSMIALGGVI Mb0354c|M.bovis_AF2122/97 ------MPPLDITD--------ERLTREDTGYHKGLHSRQLQMIALGGAI Rv0346c|M.tuberculosis_H37Rv ------MPPLDITD--------ERLTREDTGYHKGLHSRQLQMIALGGAI MMAR_0627|M.marinum_M ------MPPLDTAAT-------ARLTREDRGYHKSLKNRQLQMIALGGAI MLBr_01305|M.leprae_Br4923 ------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAI MUL_0383|M.ulcerans_Agy99 ------MRTPSSPTHP----DDIALASEDAGYHKSLKPRQLQMIAIGGAI MAB_2914|M.abscessus_ATCC_1997 ------MTSPATYDT-------SAPAPEEQGYHKGLNNRQVQMIGIGGAI TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVI Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDEPSTRLRKELNWWDLTVFGVSVVI :: * :: ::.:. .* Mflv_1998|M.gilvum_PYR-GCK GAGLFVGSGVVIA-DTGPGAFLTYGMAGVLIIMVMRMLAEMAVANPSTGS MSMEG_5473|M.smegmatis_MC2_155 GAGLFVGSGVVIG-DTGPGTFITYGLAGVLIIMVMRMLAEMAVANPSTGS MAV_4626|M.avium_104 GAGLFVGSGVVIK-DTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGS Mb0354c|M.bovis_AF2122/97 GTGLFLGAGGRLA-SAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGS Rv0346c|M.tuberculosis_H37Rv GTGLFLGAGGRLA-SAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGS MMAR_0627|M.marinum_M GTGLFLGAGGRLA-SAGPGLFLVYGICGFFVFLILRALGELVLHRPSSGS MLBr_01305|M.leprae_Br4923 GTGLFLGAGGRLA-KAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGS MUL_0383|M.ulcerans_Agy99 GTGLFLGAGGRLA-SAGPALFLVYAVCGVFAFLILRALSELVLHRPSSGS MAB_2914|M.abscessus_ATCC_1997 GTGLFMGAGGRLH-SAGPGLFLVYAVCGVFVFFILRALGELILHRPSSGS TH_0471|M.thermoresistible__bu GAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGS Mvan_1740|M.vanbaalenii_PYR-1 GAGIFTITASTAANITGPAISLSFIIAAIACGLAALCYAEFASTVPVAGS *:*:* :. :**. : : :... : .*: * :** Mflv_1998|M.gilvum_PYR-GCK FADYSRNALGHWAGFSVGWLYWYFWVIVVGFEAIAGAKIVQYW---MDVP MSMEG_5473|M.smegmatis_MC2_155 FADYSRNALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQFW---IDVP MAV_4626|M.avium_104 FADYAAAALGRWAGFSVAWLYWYFWVIVVGFEAVAGGKVLNYW---FHAP Mb0354c|M.bovis_AF2122/97 FVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIP Rv0346c|M.tuberculosis_H37Rv FVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIP MMAR_0627|M.marinum_M FVSYAREFFGEKVAFVAGWMYFLNWAMTGVVDTTAIAHYCHYWKALQFVP MLBr_01305|M.leprae_Br4923 FVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFTALP MUL_0383|M.ulcerans_Agy99 FVSYAREFFGEKAAYVAGWMYFLNWAMTSIVDSTAIATYFHFWRVFEGIP MAB_2914|M.abscessus_ATCC_1997 FVSYAREFLGEKAAYVAGWMYFFNWAATAIVDVTAIALYMHYWSAFKAIP TH_0471|M.thermoresistible__bu AYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLGEVFEFAGAT Mvan_1740|M.vanbaalenii_PYR-1 AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLGTVFGFAGGT :: *. ..: .* : . . . . . Mflv_1998|M.gilvum_PYR-GCK LWLS-------ALIFMVLMTATNLFSVASYGEFEFWFAGIKVAAIIAFIA MSMEG_5473|M.smegmatis_MC2_155 LWLT-------ALILLIAMTATNLFSVSSFGEFEYWFAGVKVAAILAFIG MAV_4626|M.avium_104 LWVL-------SLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLV Mb0354c|M.bovis_AF2122/97 QWTL-------ALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLI Rv0346c|M.tuberculosis_H37Rv QWTL-------ALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLI MMAR_0627|M.marinum_M QWTL-------ALVALVSVLLMNLISVKLFGELEFWAALIKVIALVIFLI MLBr_01305|M.leprae_Br4923 QWTL-------ALLALAVVLVMNLISVEWFGELEFWAALIKVCALMAFLV MUL_0383|M.ulcerans_Agy99 QWAL-------ALFALGIALSMNLISETLFGEIEFWAALIKVVSLLTFRV MAB_2914|M.abscessus_ATCC_1997 QWSI-------ALIALVIVLTMNTISVKLFGEMEFWAALIKVVAIMGFLV TH_0471|M.thermoresistible__bu TRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVI Mvan_1740|M.vanbaalenii_PYR-1 TEVAGFQLDWGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVI :* : . . .. : :** :: . Mflv_1998|M.gilvum_PYR-GCK VGAAFVLG---------LWPGKGADFSNLTSHGGFMP------LGFGAIT MSMEG_5473|M.smegmatis_MC2_155 LGAFYVLG---------VWPDKDLDFSNLTAHGGFFP------LGATAVT MAV_4626|M.avium_104 VGAAYVIG---------LVPGHHDGLTNLVSHGGFFP------RGVGAVF Mb0354c|M.bovis_AF2122/97 VGTVFLAGR-------YKIDGQETGVSLWSSHGGIVP------TGLLPIV Rv0346c|M.tuberculosis_H37Rv VGTVFLAGR-------YKIDGQETGVSLWSSHGGIVP------TGLLPIV MMAR_0627|M.marinum_M IGSIFLAGR-------YHVDGQETGLGLWRSHGGFLP------TGLVPLV MLBr_01305|M.leprae_Br4923 VGTIFLGGR-------YPVDGHNTGLSLWTSHGGLFP------TGVAPLI MUL_0383|M.ulcerans_Agy99 VGTIFLAGR-------YPVDGHSTGLGLLAHGGGLFP------YGLLPLV MAB_2914|M.abscessus_ATCC_1997 IGTVFLAGR-------FTVEGASTGPSVIADNGGLLP------TGLMALV TH_0471|M.thermoresistible__bu VGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLL Mvan_1740|M.vanbaalenii_PYR-1 VGAFYIKAENFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVL :*: :: . . . .:.. * : Mflv_1998|M.gilvum_PYR-GCK VGIVTVIFSMVGAEIATIAAAESQDPERAVAKAANSVILRILIFYVGAVL MSMEG_5473|M.smegmatis_MC2_155 VGVVTVIFSMVGAEIATIAAAESSDPERAVAKAANSVILRIALFFVGSAF MAV_4626|M.avium_104 AAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVF Mb0354c|M.bovis_AF2122/97 LVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTV Rv0346c|M.tuberculosis_H37Rv LVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTV MMAR_0627|M.marinum_M LVTSGVVFAYAAIELVGTAAGEAAEPEKIMPRAINSVVFRIGLFYIGSTV MLBr_01305|M.leprae_Br4923 VVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVI MUL_0383|M.ulcerans_Agy99 VVTSGVVFAYAAVELVGTAAGETAEPEKVMPRAINSVIARIALFYVGSLF MAB_2914|M.abscessus_ATCC_1997 IVTSGVVFAYSAVELVGIAAGETENPDKVMPRAINSVVFRVAVFYVGSLI TH_0471|M.thermoresistible__bu AGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSL Mvan_1740|M.vanbaalenii_PYR-1 AGASIVFFAFIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAV *.*: . :: :* *: :* : : :. : : : :::. . Mflv_1998|M.gilvum_PYR-GCK LLVLIVPWNDESVS--ASPFVAAFNAMGIPYADHVMNAVVLTAVLSCLNS MSMEG_5473|M.smegmatis_MC2_155 LLVTILPWNSDQTV--ASPFVAAFTEMGIPYADHIMNAVVLTAVLSCLNS MAV_4626|M.avium_104 LLVAILPWDSVELG--ASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNS Mb0354c|M.bovis_AF2122/97 LLALLLPYTAYKEH--VSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNA Rv0346c|M.tuberculosis_H37Rv LLALLLPYTAYKEH--VSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNA MMAR_0627|M.marinum_M LLALLLPYTAYREH--VSPFVTFFSKVGIEGAGSVMNLVVLTAALSSLNA MLBr_01305|M.leprae_Br4923 LLALLLPYSAFKAS--ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNA MUL_0383|M.ulcerans_Agy99 LLGLLLPYTDYKAG--ESPFVTFFDKIGVTGAGSIMNVVVMTAAFSSLNA MAB_2914|M.abscessus_ATCC_1997 LLALLLPYGTYKAG--ESPFVTFFSRIGVPYAGDVMNFVVLTAALSSLNA TH_0471|M.thermoresistible__bu VLTGMVHYTELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIV Mvan_1740|M.vanbaalenii_PYR-1 VLTGMVSYTELRDA-ETQNLATAFSLNGVDWAAKVISIGALAGLTTVVIV :* :: : .: : *. * ::. .::. : : Mflv_1998|M.gilvum_PYR-GCK GMYTASRMLFVLAARREAPAALVKVTNRGVPANAILASSVVGFLCVIAAA MSMEG_5473|M.smegmatis_MC2_155 GMYTASRMLFVLAARREAPPQLVAVTRRGVPATAILTSSVIGLICVIAAA MAV_4626|M.avium_104 GLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAILCSSAVGFLCVVMAR Mb0354c|M.bovis_AF2122/97 GLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNA Rv0346c|M.tuberculosis_H37Rv GLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNA MMAR_0627|M.marinum_M GLYSTGRILRSMAINGSGPKFTAPMSKNGVPYGGILLTAGIGTLGIVLNA MLBr_01305|M.leprae_Br4923 GLYATGRVMHSIAINGSGPKFTARMSKNGVPYGGILLAAVICLCGVALNA MUL_0383|M.ulcerans_Agy99 GLYSTGRILRSMAMNGSAPSFTARMSQRGVPYGGICLTAAIGLIGVLLNG MAB_2914|M.abscessus_ATCC_1997 GLYSTGRILRSLAMNGSAPKVLSRMTSGGVPFMGIAVTGALTLVGIFMNL TH_0471|M.thermoresistible__bu LVLGQTRVLFAMSRDGLLPRPLSKTGPRGTPVR---ITVLVGALVAIAAS Mvan_1740|M.vanbaalenii_PYR-1 LVLGQTRVLFAMSRDGLLPRQLAKTGEHGTPVR---ITLIVGAVVAVTAT : *:: :: * *.* : : Mflv_1998|M.gilvum_PYR-GCK VSPDTIFAFLLNSSGAIILFVYLLIAISQIVLRYRT---PDSKLR---VK MSMEG_5473|M.smegmatis_MC2_155 FFPDTIFQFLLNSSGAVILFVYLLIAISQIVLRRRT---DDSMLK---VK MAV_4626|M.avium_104 VAPNTVFLFLLNSSGAIILFVYWLIALSQIVLRRRT---PAERLS---VK Mb0354c|M.bovis_AF2122/97 IKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMA---NAGQLQRPKFR Rv0346c|M.tuberculosis_H37Rv IKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMA---NAGQLQRPKFR MMAR_0627|M.marinum_M VKPSQAFEIVLHIAATGVIAAWATIVACQLRFHRLT---ISGVLQRPSFR MLBr_01305|M.leprae_Br4923 FNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMA---KAGIMRRPRFR MUL_0383|M.ulcerans_Agy99 VVPEMAFEIVLNIAALGILASWATIVCCQIQLFRWS---KQGIVYRPSFR MAB_2914|M.abscessus_ATCC_1997 VIPAEAFETALDLAALGIISSWATIVICQIQLYRWS---QRGILQRGSFR TH_0471|M.thermoresistible__bu VFPVGNLEEMVN---IGTLFAFALVSAGVIVLRRTRPDLKRG-------- Mvan_1740|M.vanbaalenii_PYR-1 VFPIGKLEEMVN---IGTLFAFVLVSAGVLVLRRTRPDLKRG-------- . * : : : : : : : Mflv_1998|M.gilvum_PYR-GCK MWLFPVLSGLTALGILAILVQMFIDT-ALRSQLVLSLLSWAVVIALFAAN MSMEG_5473|M.smegmatis_MC2_155 MWLFPVLSILTAAAIFAILVQMFVQGGDNRSALVLSLASWAVVIVLFWLN MAV_4626|M.avium_104 MWFFPVLSVLTLAGITAVLVQMAFDA-TARSQLWLSLLSWAVVVALY--- Mb0354c|M.bovis_AF2122/97 MPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLV Rv0346c|M.tuberculosis_H37Rv MPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLV MMAR_0627|M.marinum_M MPWSPYSGWITLAFLASVLILMLFDEVYGRWMLAAILVGVPALIGGWYLV MLBr_01305|M.leprae_Br4923 MPLAPYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIVPALIAGWYSI MUL_0383|M.ulcerans_Agy99 MWGAPYTGYLTLVFLFAVLVLMGFSYPIDTWTVATLGLIIPMLIGGWFLV MAB_2914|M.abscessus_ATCC_1997 MPGAPYTGYLTLAFLAAVVVLMCYEN---AWNLIAIAVLVPVLTAGWYLC TH_0471|M.thermoresistible__bu -FRVPFVPWLPLAAIAACLWLMLNLT---GLTWVRFLGWMALGLVLYFFY Mvan_1740|M.vanbaalenii_PYR-1 -FRTPWVPLLPILAIAACVWLMLNLT---GLTWIRFLIWMAIGVVVYFLY * :. : . : * . : Mflv_1998|M.gilvum_PYR-GCK KWFVKKRPAEGDSGAPTGPPHRVLVLANRTVDSDELLAELSRIGADQTAE MSMEG_5473|M.smegmatis_MC2_155 RMFVSRRPQTPDVAPTSEHPHRVLVLANQTVESDELLDELRRIGADRDTT MAV_4626|M.avium_104 --FVARSRG--------------------------------RVAAR---- Mb0354c|M.bovis_AF2122/97 RNRVTAVAH-------------------------------HAIDHTKSVA Rv0346c|M.tuberculosis_H37Rv RNRVTAVAH-------------------------------HAIDHTKSVA MMAR_0627|M.marinum_M RNRVQVAAR-------------------------------DTVASE---- MLBr_01305|M.leprae_Br4923 RKRVMTIAR-------------------------------ERMGYTGPFP MUL_0383|M.ulcerans_Agy99 RDRVLEIAR-------------------------------RRIGYIGEFP MAB_2914|M.abscessus_ATCC_1997 RGRVLQLAR-------------------------------ERIGYTGAYP TH_0471|M.thermoresistible__bu GRHHSMLGR--------------------------------GMTDISARR Mvan_1740|M.vanbaalenii_PYR-1 GRRHSLVGR--------------------------------RMG------ : Mflv_1998|M.gilvum_PYR-GCK YLVVVPASAVDTGAAATHGPRDVTEATQEAATARLESTLAALRGKNLTVQ MSMEG_5473|M.smegmatis_MC2_155 YYVVVPASPIDTGVANTHGPLDISEATQQAAQERLDSTLATLRSGDFEAT MAV_4626|M.avium_104 -------------------------------------------------- Mb0354c|M.bovis_AF2122/97 VVHSADPI------------------------------------------ Rv0346c|M.tuberculosis_H37Rv VVHSADPI------------------------------------------ MMAR_0627|M.marinum_M -------------------------------------------------- MLBr_01305|M.leprae_Br4923 AIANPPVQPSERSHSQNP-------------------------------- MUL_0383|M.ulcerans_Agy99 VVANPGPMDKK--------------------------------------- MAB_2914|M.abscessus_ATCC_1997 VIAHTPMLDDPPGESHR--------------------------------- TH_0471|M.thermoresistible__bu TG------------------------------------------------ Mvan_1740|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1998|M.gilvum_PYR-GCK GELGDYRPLRALDHAVAEFGPDQIVIATLPPEFSMWHRFDVVDRARAQFT MSMEG_5473|M.smegmatis_MC2_155 GTLGEYRPLRALAKAVETFRPDQIVISTLPPEESVWQRFDVVDRARAEHH MAV_4626|M.avium_104 -------------------------------------------------- Mb0354c|M.bovis_AF2122/97 -------------------------------------------------- Rv0346c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0627|M.marinum_M -------------------------------------------------- MLBr_01305|M.leprae_Br4923 -------------------------------------------------- MUL_0383|M.ulcerans_Agy99 -------------------------------------------------- MAB_2914|M.abscessus_ATCC_1997 -------------------------------------------------- TH_0471|M.thermoresistible__bu -------------------------------------------------- Mvan_1740|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1998|M.gilvum_PYR-GCK VPVTHVVATSAVGNQVPR MSMEG_5473|M.smegmatis_MC2_155 LPVTHVVSRVRATEPAP- MAV_4626|M.avium_104 ------------------ Mb0354c|M.bovis_AF2122/97 ------------------ Rv0346c|M.tuberculosis_H37Rv ------------------ MMAR_0627|M.marinum_M ------------------ MLBr_01305|M.leprae_Br4923 ------------------ MUL_0383|M.ulcerans_Agy99 ------------------ MAB_2914|M.abscessus_ATCC_1997 ------------------ TH_0471|M.thermoresistible__bu ------------------ Mvan_1740|M.vanbaalenii_PYR-1 ------------------