For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LESRSDLSSSDEPRSGLARSLKTRHMTMIAIGGAIGAGLFVGSGAVIKTAGPAAIVSYVVAGALVLCTLR MLGEMVVAKPRTGAFADYARIGIGPWAGFTLGWLYWYYYVIIIAVEAVAGAQILAVWVGLPLWLMAMLLM AALTLTNLISVRWFGEFEFWFSGIKVAAIVSFIVVGLLWVFGVWPGDTNGLTNLVAHGGFAPNGFGSIFG AVVVVIFAFGGAEIVTIAAAESAEPAKSVARATTGVIWRIILFYVGSIFLVVCILPWNDASVLSSPYVAA LEKLQIPGAGLIMNIVILTAVLSVLNSSIYTSSRMLRVLASHGDAPQWLVRTNTRGVPTRAILASTVVGW VSVVLAYIAPDSLFLFLVNSCGVVAIFMYVMIGVSELRVRRAIEREDPAKLTLKMWFFPYLPIAVIACFV LVLVAMLFDADQRVQLLASVVSLAVVLLAYALRKRHGQVPATDTKQAARTDE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6196 | - | - | 100% (473) | gaba permease |
| M. smegmatis MC2 155 | MSMEG_5473 | - | e-127 | 51.71% (439) | transporter |
| M. smegmatis MC2 155 | MSMEG_3587 | - | 3e-73 | 37.19% (449) | D-serine/D-alanine/glycine transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0535 | gabP | 1e-130 | 52.96% (423) | GABA permease GabP |
| M. gilvum PYR-GCK | Mflv_1998 | - | 1e-132 | 52.28% (438) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv0522 | gabP | 1e-130 | 52.96% (423) | GABA permease GabP |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 8e-80 | 36.32% (468) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4909 | - | 1e-136 | 53.65% (438) | GABA permease GabP |
| M. marinum M | MMAR_4201 | gabP_1 | 1e-132 | 50.33% (459) | GabA permease GabP_1 |
| M. avium 104 | MAV_4626 | - | 1e-136 | 53.69% (447) | gaba permease |
| M. thermoresistible (build 8) | TH_0471 | - | 9e-21 | 23.21% (448) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_4508 | gabP_1 | 1e-132 | 50.33% (459) | GabA permease GabP_1 |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 7e-22 | 22.37% (447) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1998|M.gilvum_PYR-GCK ----------------------MSAAPT---LKKALNQRQLTMIAIGGVI
MAB_4909|M.abscessus_ATCC_1997 --------------------MATTAAPSEGGLQHSLQKRHLTMIAIGGVI
Mb0535|M.bovis_AF2122/97 ------------------------------------------MIAIGGVI
Rv0522|M.tuberculosis_H37Rv ------------------------------------------MIAIGGVI
MAV_4626|M.avium_104 -----------------------MAGTS--QLRQGLSQRQLSMIALGGVI
MSMEG_6196|M.smegmatis_MC2_155 --------------MLESRSDLSSSDEPRSGLARSLKTRHMTMIAIGGAI
MMAR_4201|M.marinum_M --------------------MAGADTEHEIALGKGLRQRHLSLIALGGVI
MUL_4508|M.ulcerans_Agy99 --------------------MAGADTEHEIALGKGLRQRHLSLIALGGVI
MLBr_01305|M.leprae_Br4923 ------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAI
TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVI
Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDEPSTRLRKELNWWDLTVFGVSVVI
::.:. .*
Mflv_1998|M.gilvum_PYR-GCK GAGLFVGSG-VVIADTGPGAFLTYGMAGVLIIMVMRMLAEMAVANPSTGS
MAB_4909|M.abscessus_ATCC_1997 GAGLFVGSG-ATIQAAGPAAFLTYAITGVLIVLVMRMLGEMAVANPSTGS
Mb0535|M.bovis_AF2122/97 GAGLFVGSG-VVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGA
Rv0522|M.tuberculosis_H37Rv GAGLFVGSG-VVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGA
MAV_4626|M.avium_104 GAGLFVGSG-VVIKDTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGS
MSMEG_6196|M.smegmatis_MC2_155 GAGLFVGSG-AVIKTAGPAAIVSYVVAGALVLCTLRMLGEMVVAKPRTGA
MMAR_4201|M.marinum_M GAGLFVGSG-VVIAGTGPAAVISFLIAGLITMLIMRMLAEMAASQPVVGS
MUL_4508|M.ulcerans_Agy99 GAGLFVGSG-VVIAGTGPAAVISFLIAGLITMLIMRMLAEMAASQPVVGS
MLBr_01305|M.leprae_Br4923 GTGLFLGAG-GRLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGS
TH_0471|M.thermoresistible__bu GAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGS
Mvan_1740|M.vanbaalenii_PYR-1 GAGIFTITASTAANITGPAISLSFIIAAIACGLAALCYAEFASTVPVAGS
*:*:* :. :**. : : : . .*:. * *:
Mflv_1998|M.gilvum_PYR-GCK FADYSRNALGHWAGFSVGWLYWYFWVIVVGFEAIAGAKIVQYWM------
MAB_4909|M.abscessus_ATCC_1997 FADYSRRALGDWAGFSVGWLYWYFWVIVVGFEAVAGGKLIQDWLP-----
Mb0535|M.bovis_AF2122/97 FADYAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWI------
Rv0522|M.tuberculosis_H37Rv FADYAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWI------
MAV_4626|M.avium_104 FADYAAAALGRWAGFSVAWLYWYFWVIVVGFEAVAGGKVLNYWF------
MSMEG_6196|M.smegmatis_MC2_155 FADYARIGIGPWAGFTLGWLYWYYYVIIIAVEAVAGAQILAVWV------
MMAR_4201|M.marinum_M FYVYARQALGPRGGFVTGWMYWYFFVVVVAVETVAGGRILQLWVP-----
MUL_4508|M.ulcerans_Agy99 FYVYARQALGPRGGFVTGWMYWYFFVVVVAVETVAGGRILQLWVP-----
MLBr_01305|M.leprae_Br4923 FVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFT---
TH_0471|M.thermoresistible__bu AYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLGEVFEFAGAT
Mvan_1740|M.vanbaalenii_PYR-1 AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLGTVFGFAGGT
:: :* .: .* : : . : . . :
Mflv_1998|M.gilvum_PYR-GCK ----DVPLWLSALIFMVLMTATNLFSVASYGEFEFWFAGIKVAAIIAFIA
MAB_4909|M.abscessus_ATCC_1997 ----HAPLWLIALLLMLAMTATNLFSVRSYGEFEYWFASVKVAAIVAFLV
Mb0535|M.bovis_AF2122/97 ----DAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLV
Rv0522|M.tuberculosis_H37Rv ----DAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLV
MAV_4626|M.avium_104 ----HAPLWVLSLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLV
MSMEG_6196|M.smegmatis_MC2_155 ----GLPLWLMAMLLMAALTLTNLISVRWFGEFEFWFSGIKVAAIVSFIV
MMAR_4201|M.marinum_M ----QIPLWVLSLGLLLALTATNLVSARSFGEFEYWFSSIKVIAVVVFLG
MUL_4508|M.ulcerans_Agy99 ----QIPLWVLSLGLLLALTATNLVSARSFGEFEYWFSSIKVIAVVVFLG
MLBr_01305|M.leprae_Br4923 ----ALPQWTLALLALAVVLVMNLISVEWFGELEFWAALIKVCALMAFLV
TH_0471|M.thermoresistible__bu TRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVI
Mvan_1740|M.vanbaalenii_PYR-1 TEVAGFQLDWGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVI
:: : : .. . .. : :** .:: .:
Mflv_1998|M.gilvum_PYR-GCK VGAAFVLGLWPGK---------------GADFSNLTSHGGFMPLGFGAIT
MAB_4909|M.abscessus_ATCC_1997 AGTCYVLGLWPGK---------------KLDFSNLTVHEGFMPHGPGAIF
Mb0535|M.bovis_AF2122/97 LGTAFAFGLLPGH---------------GMDFSNLSAHGGFFPDGVGAVF
Rv0522|M.tuberculosis_H37Rv LGTAFAFGLLPGH---------------GMDFSNLSAHGGFFPDGVGAVF
MAV_4626|M.avium_104 VGAAYVIGLVPGH---------------HDGLTNLVSHGGFFPRGVGAVF
MSMEG_6196|M.smegmatis_MC2_155 VGLLWVFGVWPGD---------------TNGLTNLVAHGGFAPNGFGSIF
MMAR_4201|M.marinum_M LGLLWTMGLWPSA---------------TPGLGKLVDFGGFAPLGWGAVL
MUL_4508|M.ulcerans_Agy99 LGLLWTMGLWPSA---------------TPGLGKLVDFGGFAPLGWGAVL
MLBr_01305|M.leprae_Br4923 VGTIFLGGRYPVDGH-------------NTGLSLWTSHGGLFPTGVAPLI
TH_0471|M.thermoresistible__bu VGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLL
Mvan_1740|M.vanbaalenii_PYR-1 VGAFYIKAENFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVL
* : . .: * :
Mflv_1998|M.gilvum_PYR-GCK VGIVTVIFSMVGAEIATIAAAESQDPERAVAKAANSVILRILIFYVGAVL
MAB_4909|M.abscessus_ATCC_1997 SSIVIVIFSMVGAEIATIAAAESKDPAKAISQATNSVIYRVAIFFVGSIF
Mb0535|M.bovis_AF2122/97 AAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVF
Rv0522|M.tuberculosis_H37Rv AAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVF
MAV_4626|M.avium_104 AAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVF
MSMEG_6196|M.smegmatis_MC2_155 GAVVVVIFAFGGAEIVTIAAAESAEPAKSVARATTGVIWRIILFYVGSIF
MMAR_4201|M.marinum_M AAVVPCVAFYTGAEIVTVAAAESAEPERAVSRAMKSIVARIIAFYVGSIL
MUL_4508|M.ulcerans_Agy99 AAVVPCVAFYTGAEIVTVAAAESAEPEGSVSRAMKSIVARIIAFYVGSIL
MLBr_01305|M.leprae_Br4923 VVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVI
TH_0471|M.thermoresistible__bu AGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSL
Mvan_1740|M.vanbaalenii_PYR-1 AGASIVFFAFIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAV
. . :: :* *: :* : :. : : ::*. .
Mflv_1998|M.gilvum_PYR-GCK LLVLIVPWNDESVS--ASPFVAAFNAMGIPYADHVMNAVVLTAVLSCLNS
MAB_4909|M.abscessus_ATCC_1997 LIAVIVPWNSPELG--TSPYVTAFKTMGIPAADHIMRVVVLTAVLSCLNS
Mb0535|M.bovis_AF2122/97 LLTVILPWNSLELG--ASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNS
Rv0522|M.tuberculosis_H37Rv LLTVILPWNSLELG--ASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNS
MAV_4626|M.avium_104 LLVAILPWDSVELG--ASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNS
MSMEG_6196|M.smegmatis_MC2_155 LVVCILPWNDASVL--SSPYVAALEKLQIPGAGLIMNIVILTAVLSVLNS
MMAR_4201|M.marinum_M VVVAVVPWNTKSVG--VSPYASALAVIGIPGVTTVMNAIVLTAVLSCLNS
MUL_4508|M.ulcerans_Agy99 VVVAVVPWNTKSVG--VSPYASALAVIGIPGVTTVMNAIVLTAVLSCLNS
MLBr_01305|M.leprae_Br4923 LLALLLPYSAFKAS--ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNA
TH_0471|M.thermoresistible__bu VLTGMVHYTELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIV
Mvan_1740|M.vanbaalenii_PYR-1 VLTGMVSYTELRDA-ETQNLATAFSLNGVDWAAKVISIGALAGLTTVVIV
::. :: : .: : . . :: *:. : :
Mflv_1998|M.gilvum_PYR-GCK GMYTASRMLFVLAARREAPAALVKVTNRGVPANAILASSVVGFLCVIAAA
MAB_4909|M.abscessus_ATCC_1997 AMYTASRMLFVLAGRGEAPRSWLKVNARGVPVQAILASSFIGFVCVILAY
Mb0535|M.bovis_AF2122/97 GLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSVVGFLCVIMAW
Rv0522|M.tuberculosis_H37Rv GLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSVVGFLCVIMAW
MAV_4626|M.avium_104 GLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAILCSSAVGFLCVVMAR
MSMEG_6196|M.smegmatis_MC2_155 SIYTSSRMLRVLASHGDAPQWLVRTNTRGVPTRAILASTVVGWVSVVLAY
MMAR_4201|M.marinum_M ALYTTSRMAFALTIHGDGPRFFTKLSRSGVPRRAIILGTTVGYASVVATY
MUL_4508|M.ulcerans_Agy99 ALYTTSRMAFALTIHGDGPRFFTKLSRSGVPRRAIILGTTVGYASVVATY
MLBr_01305|M.leprae_Br4923 GLYATGRVMHSIAINGSGPKFTARMSKNGVPYGGILLAAVICLCGVALNA
TH_0471|M.thermoresistible__bu LVLGQTRVLFAMSRDGLLPRPLSKTGPRGTP---VRITVLVGALVAIAAS
Mvan_1740|M.vanbaalenii_PYR-1 LVLGQTRVLFAMSRDGLLPRQLAKTGEHGTP---VRITLIVGAVVAVTAT
: *: :: * : *.* : : .
Mflv_1998|M.gilvum_PYR-GCK VSPDTIFAFLLNSSGAIILFVYLLIAISQIVLRYRTPDS---KLRVKMWL
MAB_4909|M.abscessus_ATCC_1997 FFEHTVFLFLLNSSGAVILFVYLMIAISQYVLRRRTPEE---KLLVKMWG
Mb0535|M.bovis_AF2122/97 VSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQ---NLGVRMWL
Rv0522|M.tuberculosis_H37Rv VSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQ---NLGVRMWL
MAV_4626|M.avium_104 VAPNTVFLFLLNSSGAIILFVYWLIALSQIVLRRRTPAE---RLSVKMWF
MSMEG_6196|M.smegmatis_MC2_155 IAPDSLFLFLVNSCGVVAIFMYVMIGVSELRVRRAIEREDPAKLTLKMWF
MMAR_4201|M.marinum_M VWGDVVFEFLVNSYGAVALFVYLIIAISQVILRRRAEREDPGGLRLKMWL
MUL_4508|M.ulcerans_Agy99 VWGDVVFEFLVNSYGAVALFVYLIIAISQVILRRRAEREDPGGLRLKMWL
MLBr_01305|M.leprae_Br4923 FNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAGIMRRPRFRMPL
TH_0471|M.thermoresistible__bu VFPVGNLEEMVN---IGTLFAFALVSAGVIVLRRTRPDL---KRGFRVPF
Mvan_1740|M.vanbaalenii_PYR-1 VFPIGKLEEMVN---IGTLFAFVLVSAGVLVLRRTRPDL---KRGFRTPW
. : ::. : : : :: .:
Mflv_1998|M.gilvum_PYR-GCK FPVLSGLTALGILAILVQMFIDTALRSQLVLSLLSWAVVIALFAANKWFV
MAB_4909|M.abscessus_ATCC_1997 YPALTILTAIGIVAILVAMGFQDATRTQLWTSLLSWGVILLLFAILRLTR
Mb0535|M.bovis_AF2122/97 FPGLSIVTVTGIVAVLARMAFDYAARSQLWLSLLSWAVVVGCYLVTTLVR
Rv0522|M.tuberculosis_H37Rv FPGLSIVTVTGIVAVLARMAFDYAARSQLWLSLLSWAVVVGCYLVTTLVR
MAV_4626|M.avium_104 FPVLSVLTLAGITAVLVQMAFDATARSQLWLSLLSWAVVVALYFVARSRG
MSMEG_6196|M.smegmatis_MC2_155 FPYLPIAVIACFVLVLVAMLFDADQRVQLLASVVSLAVVLLAYALRKRHG
MMAR_4201|M.marinum_M FPWLSYATIALMASVILAMAALSATRSQFLMSGVTLVLILATYEVRRRRR
MUL_4508|M.ulcerans_Agy99 FPWLSYATIALMASVILAMAALSATRSRFLMSGVTLVLILATYEVRRRRR
MLBr_01305|M.leprae_Br4923 APYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIVPALIAGWYSIRKR
TH_0471|M.thermoresistible__bu VPWLPLAAIAACLWLMLNLTGLTWVRFLGWMALGLVLYFFYGRHHSMLGR
Mvan_1740|M.vanbaalenii_PYR-1 VPLLPILAIAACVWLMLNLTGLTWIRFLIWMAIGVVVYFLYGRRHSLVGR
* . :: : : .
Mflv_1998|M.gilvum_PYR-GCK KKRPAEGDSGAPTGPPHRVLVLANRTVDSDELLAELSRIGADQTAEYLVV
MAB_4909|M.abscessus_ATCC_1997 RRTPEPGE----------------RTTR----------------------
Mb0535|M.bovis_AF2122/97 RPLNRPW-------------------------------------------
Rv0522|M.tuberculosis_H37Rv RPLNRPW-------------------------------------------
MAV_4626|M.avium_104 RVAAR---------------------------------------------
MSMEG_6196|M.smegmatis_MC2_155 QVPATDTKQAARTDE-----------------------------------
MMAR_4201|M.marinum_M VAVARNATVAARAFQPGVPMPACAQRCG----------------------
MUL_4508|M.ulcerans_Agy99 VAVARNATVAARAFQPGVPMPACAQRCG----------------------
MLBr_01305|M.leprae_Br4923 VMTIARERMGYTGPFPAIANPPVQPSERSHSQNP----------------
TH_0471|M.thermoresistible__bu GMTDISARRTG---------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 RMG-----------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK VPASAVDTGAAATHGPRDVTEATQEAATARLESTLAALRGKNLTVQGELG
MAB_4909|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0535|M.bovis_AF2122/97 --------------------------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_6196|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4201|M.marinum_M --------------------------------------------------
MUL_4508|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK DYRPLRALDHAVAEFGPDQIVIATLPPEFSMWHRFDVVDRARAQFTVPVT
MAB_4909|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0535|M.bovis_AF2122/97 --------------------------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_6196|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4201|M.marinum_M --------------------------------------------------
MUL_4508|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK HVVATSAVGNQVPR
MAB_4909|M.abscessus_ATCC_1997 --------------
Mb0535|M.bovis_AF2122/97 --------------
Rv0522|M.tuberculosis_H37Rv --------------
MAV_4626|M.avium_104 --------------
MSMEG_6196|M.smegmatis_MC2_155 --------------
MMAR_4201|M.marinum_M --------------
MUL_4508|M.ulcerans_Agy99 --------------
MLBr_01305|M.leprae_Br4923 --------------
TH_0471|M.thermoresistible__bu --------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------