For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSYVVAIPDMLASAAADVAGIGSSVGAANAAAVGATTGVMAAADDEVSVAIAALFSGHGQAYRAISAQAA AFHDQFLRALTGAGGAYAAAEAANASPLQAAQQQALAVINAPTNALLGRPLIGNGTDGLAGTGAAGGAGG LLWGNGGNGGSGAAGQAGGAGGAAGLIGTGGAGGMGGAGGGAGGMGGSGGWLLGNGGAGGAGGVGGAGVS GGVGGTGGNAVMFGNGGAGGMGGAGADGAVGAAGTAGTSTSAGGVGGVGGDGGNAGNGGAGGNGGLFVGV GGAGGQGGAGGAGGTGGAGGAGWDATAAGVLAATGGDGGDSGGGGAGGNGGAGGAGGHGSALFGAAGANG NGGAGGAGGNPGAPGNGGIGGVGPDAATSGGMGGTGGDPGAVGGGGNGGAAGGAGAVAGASGAAGTIIAG NGGNGGAGGAGYAADGPAGPAIGNGGDGGRGGAGGFYGNGGAGGAGGNSAPGGGNGGNGGTGGDSGAMGS SGGRGGDGGVGTNGGAGGGGGNATSYGTANATGGAGGDGGAGSRGTGGTGGAGGGGGAAQILNGASAATA TGGAGGAGGDGNDGGNAGVGGAASTRGTGNVTGGTGGDGGTGSTGIGGSGGDGGNVEVNNDASTVSFVGG AGGHGGDGATDGGAGGDGGRTTIDGAGSRATATGGTGGDGGNGGTGHGGGGGSGGTAINYGAGDAFGGAA GKGGTGVVGGNGGSGGAAYNYGTGNATGADGAAGTDGTTGAGGSGGSGGAASVLNSASIATATSGSGGAG GDGTDGGNGGSGGFAFTFGTGNIIAGVGGDGGTGSTGVGGIGGSGGGADINNGASTVVPQGGAGGHGGDG ATDGGAGGAGGFTEIDSSASVLAATGGAGGDGGSGGTGRGGTGGVGGVGINNGSGEAIGGAPGAGGTGAV GGDGGQGGAAYSYGTGDATGSAGAAGTAGTTGVGGTGGAGGAAYTLNGASTATATGGIGGNGGDGGTANG SNGGNGGAGGYASTTGTGTASAGNGGRGGDGTATVATGGTGGVGGNAHAPAGSPVPGVGGKGGNPGPGGK PGPNGADGIVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0609 | - | - | 100% (1061) | PE-PGRS family protein |
| M. marinum M | MMAR_5294 | - | 0.0 | 47.23% (1228) | PE-PGRS family protein |
| M. marinum M | MMAR_0943 | - | 0.0 | 49.00% (1145) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0593c | PE_PGRS7 | 0.0 | 48.85% (1175) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-171 | 47.30% (814) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv3345c | PE_PGRS50 | 0.0 | 45.41% (1330) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 4e-13 | 37.50% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 4e-52 | 37.67% (438) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 5e-24 | 43.45% (168) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-173 | 40.31% (1099) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 6e-42 | 39.87% (301) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0572 | - | 0.0 | 63.25% (947) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-163 | 46.24% (811) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0609|M.marinum_M --MSYVVAIPDMLASAAADVAGIGSSVGAANAAAVGATTGVMAAADDEVS
MUL_0572|M.ulcerans_Agy99 --MSYVVAIPDMLASAAADVAGIGSSVGAANTAAVGATTGVMAAADDEVS
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRS-PLRKPKFPAALAPE
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0593c|M.bovis_AF2122/97 --MSFVIATPEMLTTAATDLAKIGSTITAANTAAA-AVAKVLPASADEVS
Rv3345c|M.tuberculosis_H37Rv -MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDEVS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M VAIAALFSGHGQAYRAISAQAAAFHDQFLRALTGAGGAYAAAEAANASPL
MUL_0572|M.ulcerans_Agy99 VAIAALFSGHGQAYQAISAQAAAFHDQFLRALTGAGGAYAAAEAANASPL
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 SPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTN-----
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0593c|M.bovis_AF2122/97 VAVAALFGTHAQEYQTVSAQVATFHDRFVQTLSAAASSYVAAEAV-----
Rv3345c|M.tuberculosis_H37Rv AAIAALFGTHAQEYQALSARVATFHEQFVRSLTAAGSAYATAEAANASPL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M QAAQQQALAVINAPTNALLGRPLIGNGTDGLAGTGAAGGAGGLLWGNGGN
MUL_0572|M.ulcerans_Agy99 QAAEQEVLAVINAPTNALLGRPLIGNGTDGLAGTGAAGGAGGLLWGNGGN
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 -TTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLS-VVTL
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0593c|M.bovis_AF2122/97 -NVEQSLLAAVNAPTQALFGRPLIGNGADGSPGTGQAGGPGGILYGNGGN
Rv3345c|M.tuberculosis_H37Rv QALEQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGGLLWGNGGN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLS
MAV_4827|M.avium_104 ---------------------MNIVLGVSMAPSSIQMVVLEGEYADGATV
MMAR_0609|M.marinum_M GGSGAAGQAGGAGGAAGLIGTGGAGGMGGAG--GGAGGMG----------
MUL_0572|M.ulcerans_Agy99 GGSGAAGQAGGAGGAAGLIGTGGAGGMGGAG--GGAGGMG----------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTV----------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------MMFLAPPGGPG----------
Mb0593c|M.bovis_AF2122/97 GGSGAPGQRGGAGGAAGLIGNGGNGGAGGVGTTGGAGGHG----------
Rv3345c|M.tuberculosis_H37Rv GGSGAAGQVGGPGGAAGLFGNGGSGGSGGAGAAGGVGGSGGWLNGNGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSG----------
MAV_4827|M.avium_104 EEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQLS---------
MMAR_0609|M.marinum_M -----------GSGGWLLGNGGAGGAGGVGGAGVSG----GVGGTGGNAV
MUL_0572|M.ulcerans_Agy99 -----------GSGGWLLGNGGAGGAGGVGCAGVSG----GVGGTGGNAM
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 -----------NPQAQLPVPTVASAVLDPTQIVNWL----IYQPLH----
Mflv_5091|M.gilvum_PYR-GCK -------------------------------MVTFG----GGATPT----
Mvan_1264|M.vanbaalenii_PYR-1 -----------PISAAIQLTSTGSEATEPWYVVSFG----GSGAPT----
Mb0593c|M.bovis_AF2122/97 -----------GAGGWLYGNGGAGGFGGAGAVGGNG----GAGGTAGLFG
Rv3345c|M.tuberculosis_H37Rv GAGGTGANGGAGGNAWLFGAGGSGGAGTNGGVGGSGGFVYGNGGAGGIGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------NLQNYYAAQPDGPSILSPSLLSPRDN---DFLSHNDTDF
MAV_4827|M.avium_104 -----------SIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAAL
MMAR_0609|M.marinum_M MFGNGGAGGMGGAGADGAVGAAGTAGTSTSAGGVGGVGGDGGNAGNGGAG
MUL_0572|M.ulcerans_Agy99 LFGNGGAGGMGGAGADGAVGAAGTAGTSTSAGGVG---------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 AAGQQFWVVSPIGSTLGGVINTISGQYLIGNGING--------TADNPNG
Mflv_5091|M.gilvum_PYR-GCK PTSLGAAAVDLSGTSCG----------LICNGQDG--------TGQN---
Mvan_1264|M.vanbaalenii_PYR-1 PNNLAASLVDLSGTSCG----------LICNGQDG--------TGQN---
Mb0593c|M.bovis_AF2122/97 VGGAGGAGGNGIAGVTGTSASTPGGSGTAGGAGGI--------GGNGGAG
Rv3345c|M.tuberculosis_H37Rv IGGIGGNGGDAGLFGNGGAGGAGAAGLPGAAGLNGGDGSDGGNGGTGGNG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ASHNPIASGNQVMSPSGNVDSFNRGPLLDLS-------------------
MAV_4827|M.avium_104 AQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIP--------------
MMAR_0609|M.marinum_M GNGGLFVGVGGAGGQGGAGGAGGTGGAGGAGWDATA-AGVLAATGGDGGD
MUL_0572|M.ulcerans_Agy99 ----------------------------GAGWDATA-AGVLAATGGDGGD
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GTGGLLFGDGGHGYDG--------SAAGLAGGNGGN-AGLFG-NGGNGGV
Mflv_5091|M.gilvum_PYR-GCK --GGILFGNGGSGWNS--------DVVGMDGGNGGN-GGLFGGNGGNGGN
Mvan_1264|M.vanbaalenii_PYR-1 --GGILFGNGGSGWNS--------EIAGVSGGNGGN-AGLFGGNGGNGGN
Mb0593c|M.bovis_AF2122/97 GAGGVLMGNGGNGGAGGEGGPGGAGGAGASGAHATN-LGADGQAGGNGGN
Rv3345c|M.tuberculosis_H37Rv GRGGLLVGNGGAGGAGGVGGDGGKGGAGDPSFAVNNGAGGNGGHGGNPGV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -FGDLQFGNRDTTAIG-------DGAVAVGGSNSGPIASGQGSTAVNGDV
MAV_4827|M.avium_104 ---DVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAP
MMAR_0609|M.marinum_M SGGGGAG-----------------GNGGAGGAGGHGSALFGAAGANGNGG
MUL_0572|M.ulcerans_Agy99 SGGGGAG-----------------GNGGAGGAGGHGSALFGADGANGNGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GWAGLDG-----------------GNGGSGGL----LMGIG--GAGGAGG
Mflv_5091|M.gilvum_PYR-GCK GLGGGNG-----------------GNGGNAGA----FALFGNGGNGGNGG
Mvan_1264|M.vanbaalenii_PYR-1 GLGSGDG-----------------GNGGDAGL----FSLFGRGGNGGNGG
Mb0593c|M.bovis_AF2122/97 GGAGGTG-----------------GVGGPGGG----HGLLGLGGSHGAGG
Rv3345c|M.tuberculosis_H37Rv GGAGGAGGLLAGAHGAAGATPTSGGNGGDGGIGATANSPLQAGGAGGNGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 RDSNIIN----------------ADHGSNVGVDQSQTRVGGDYTNVSGHG
MAV_4827|M.avium_104 LKQVLQT-----------------TTFLDVSVAEEPETALARGAALAAAN
MMAR_0609|M.marinum_M AGGAGGNPGAPGN---------------GGIGGVG---------------
MUL_0572|M.ulcerans_Agy99 AGGAGGNPGAPGN---------------GGTGGVG---------------
TH_3810|M.thermoresistible__bu ---------VDG------------------DGGSGGRTG-----------
MSMEG_0868|M.smegmatis_MC2_155 VGADGTSAHVDGGTG--------------GTGGTGGGTGGTGGIGGTGGG
Mflv_5091|M.gilvum_PYR-GCK VGVVGATGAVGAP----------------GVAGATGATG-----------
Mvan_1264|M.vanbaalenii_PYR-1 VGIAGATGAVGAP----------------GVAGATGATG-----------
Mb0593c|M.bovis_AF2122/97 AGGSGGDGGAPGDGGNGATGTWGHNLGAGGTGGNGGNPGAGG-AGGAGGA
Rv3345c|M.tuberculosis_H37Rv HGGLVGNGGTGGAGG-------------AGHAGSTGATG--TALQPTGGN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SADIDKSVTVVDD------------------HSQRNTTN-----------
MAV_4827|M.avium_104 APLFASSTAALAYAQD------------PGTGAVDQYSLP--------DY
MMAR_0609|M.marinum_M PDAATSGGMGGTGGDPGAVGGGGNGGAAGGAGAVAGAS-----------G
MUL_0572|M.ulcerans_Agy99 PDAATSGGMGGTGGDPGAVGGRGNSGAAGGAGAVAGAS-----------G
TH_3810|M.thermoresistible__bu LFSKLSR------------GGDGGDGGLG---------------------
MSMEG_0868|M.smegmatis_MC2_155 LFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNV-----------T
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAGAVG-----------S
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAGAVG-----------S
Mb0593c|M.bovis_AF2122/97 SVGGSAHGANGAPGTTSTSGGNGGDGGKGADAISSGQ------------T
Rv3345c|M.tuberculosis_H37Rv GTNGGAGGHGGNGGNGGAQHGDGGVGGKGGAGGSGGAGGNGFDAATLGSP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 INDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTSTSAG------------
MAV_4827|M.avium_104 LYVPVDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPE------------
MMAR_0609|M.marinum_M AAGTIIAGNGGNGGAGG--------AGYAADGPAGPAIGNGGDG-----G
MUL_0572|M.ulcerans_Agy99 AAGTIIAGNGGNGGAGG--------AGYAADGPAGPAIGNGGDG-----G
TH_3810|M.thermoresistible__bu --------------------------GNGGHGGGTGIISLLS--------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANG-----G
Mflv_5091|M.gilvum_PYR-GCK AGAAGEAGETGTWGNAG-------LPGKAGDAGGAGAVGAAGAA-----G
Mvan_1264|M.vanbaalenii_PYR-1 AGTAGSAGAPGVWGNAG-------LPGAAGAAGGAGAIGTAGVA-----G
Mb0593c|M.bovis_AF2122/97 GANGGRGGDGGQVGNGG--------AGGAGGRGGAGGLGFGSEAPGRPGG
Rv3345c|M.tuberculosis_H37Rv GADGGMGGNGGKGGDGG-------KAGDGGAGAAGDVTLAVNQGAGGDGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -GSAAVGGNAGLAGNAG-------LAGNAGLAGNAGLAGNAGLAG-----
MAV_4827|M.avium_104 --DSEPRRRPVLLVGSG--------LAVVGISAVLALEIALAIG------
MMAR_0609|M.marinum_M RGGAGGFYGNG------------GAGGAGGNSAPGGGNGGNGGTG----G
MUL_0572|M.ulcerans_Agy99 HGGAGGFYGNG------------GAGGAGGNSAPGGGTGGNGGTG----G
TH_3810|M.thermoresistible__bu ------LAGNG------------GNGGNGY-RTTDNN-------------
MSMEG_0868|M.smegmatis_MC2_155 TVDGHAIGGNG------------GNGGNGS-TTAAGGNGGTGGTGRVIAE
Mflv_5091|M.gilvum_PYR-GCK TVGTAGATGGT------------GTGANGG-AGGVGGVGGTGAAG--AAG
Mvan_1264|M.vanbaalenii_PYR-1 AAGTAGATGGT------------GVGGNGG-AGQAGGIGGTGAAG--AAG
Mb0593c|M.bovis_AF2122/97 AGGTGGAGGNGGT--------QAGDGGTGG-AGGAGGDGGSGGAG-SIGF
Rv3345c|M.tuberculosis_H37Rv NGGEVGVGGKGGAGGVSANPALNGSAGANGTAPTSGGNGGNGGAG-ATPT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---NAGLAGNA------------GLAGNAGLAGNAGLAGNAGLAG-----
MAV_4827|M.avium_104 ----------------------IRTTGTVALQPTPNQHLIVPTEQAPAPP
MMAR_0609|M.marinum_M DSGAMGSSGGRGGDGGVGTNGGAGGGGGNAT------------SYGTANA
MUL_0572|M.ulcerans_Agy99 DSGAMGSSGGRGGDGGVGTNGGAGGGGGNAT------------SYGTANA
TH_3810|M.thermoresistible__bu --------ALDGGHGGN------GGNVGFF-------------SLFNLG-
MSMEG_0868|M.smegmatis_MC2_155 GTGSTAEGTATGGDGGHSTGTGIGGNGGIG-------------SVYAYGN
Mflv_5091|M.gilvum_PYR-GCK GAGGLGETGTTGGAGGVGGQGTAGGTGGVG-------------GIGGAGS
Mvan_1264|M.vanbaalenii_PYR-1 QAGTAGETGVTGGVGGIGGQGTEGGTGGVG-------------GVGGVGA
Mb0593c|M.bovis_AF2122/97 NASAPGAAGSPGGNGGNGGPGGAGGEGGAGGL-----------ALAASGQ
Rv3345c|M.tuberculosis_H37Rv VAGENGGAGGNGGHGGSVGNGGAGGAGGNGVAGTGLALNGGNGGNGGIGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------NAGLAGNAGLAGNAGLAGNAGLAG-------------------
MAV_4827|M.avium_104 PVQASAPQPKISVPEPVAAPKPLSPPVAAPLP------------------
MMAR_0609|M.marinum_M TG-------GAGGDGGAGSR-------------GTGGTGGAGGGGGAAQI
MUL_0572|M.ulcerans_Agy99 TG-------GAGGDGGTGST-------------GNGGSG-----------
TH_3810|M.thermoresistible__bu ---------GAGGWGGSG---------------VDG--------------
MSMEG_0868|M.smegmatis_MC2_155 NGAVSG--TATGGRGGDG---------------IDGGTGGAGGMGEIYSG
Mflv_5091|M.gilvum_PYR-GCK TG-------AVGGVGGKG---------------IQGGQGLQGGKG-----
Mvan_1264|M.vanbaalenii_PYR-1 TG-------GAGGVGGKG---------------IQGGQGLQGGQG-----
Mb0593c|M.bovis_AF2122/97 NGSQGA--GGDGGAGGNGGTPGNGGHGAAGALGVNGGVGGAGGHGG----
Rv3345c|M.tuberculosis_H37Rv NGGSAAGTGGDGGKGGNGGAGANGQDFSASANGANGGQGGNGGNGGIGGK
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------NAGLAGNAG---------------LAGNAG-----------
MAV_4827|M.avium_104 ---------AAPPPAAPP--------------------------------
MMAR_0609|M.marinum_M LNGASAATATGGAGGAGGDGNDGGNAG-----------------VGGAAS
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu -------------------VDVVGGN------------------------
MSMEG_0868|M.smegmatis_MC2_155 ADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKA
Mflv_5091|M.gilvum_PYR-GCK --------GDGGAGGKGGDADSMGSAG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------GDGGTGGTGGDATSMGEAG-----------------------
Mb0593c|M.bovis_AF2122/97 ------DPGVGGAGGQGGSGSTPGANG-----------------------
Rv3345c|M.tuberculosis_H37Rv GGDAFATFAKAGNGGAGGNGGNVGVAG-----QGGAGGKGAIPAMKGATG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M TRGTGNVTGGTGGDGGTGSTGI------------------------GGSG
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu ------PDGGTPG-------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GHGGKASDGGKGGNGGDALVMA-AGATGVATGNTAIGGNGGAASANGAVG
Mflv_5091|M.gilvum_PYR-GCK ------ATGGKGGNG-----------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------ATGGKGGNG-----------------------------------
Mb0593c|M.bovis_AF2122/97 APGNTPTSGGNGGNGGRGADATGFGQTGASGGRGGDGGLVGNGGAGGAGG
Rv3345c|M.tuberculosis_H37Rv ADGTAPTSGGDGGNGGNGASPT-----------------------VAGGN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M GDGGNVEVNNDASTVSFVGGAGGHGGDGATDG---------GAGGDGGRT
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu ----------------------AHG----------------ESHTP----
MSMEG_0868|M.smegmatis_MC2_155 GNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPA
Mflv_5091|M.gilvum_PYR-GCK ----------------------GNGGRG-------------GLFGKGGNA
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------GNGGRG-------------SLFGRGGNA
Mb0593c|M.bovis_AF2122/97 NGSKGLPGLGRLGNPGLDGGTGGNGGAGGSGGAWAGNGGTGGAGGTGGVG
Rv3345c|M.tuberculosis_H37Rv GGDGGKGGSGGNVGNGGNGGAGGNGAAGQAGTPGPTSGDSGTSGTDGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M TIDGAGSRATATGGTGGDGGNGGTG----HGGGGGSGG------TAINYG
MUL_0572|M.ulcerans_Agy99 ----------------GDGGNGGTG----HGGGGGPGG------TAINYG
TH_3810|M.thermoresistible__bu GVYTDRQ---------GEDGEDGTG--TGIGGRGGNGG-----SSSGTHP
MSMEG_0868|M.smegmatis_MC2_155 GTTIDKGK--AAGGNGGDGGFNGTG--GATGGRGGDGAGASVWKANGQHS
Mflv_5091|M.gilvum_PYR-GCK GNGADGG----TGGAGGAGGTGGTGGAGGTGGTGGTGGIGGAGSTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GNGGNGG----TGGNGGNGGTGGTGGNGGTGGTGGTGGIGGAGSTGGTGG
Mb0593c|M.bovis_AF2122/97 GTGGSGSDGVNGSSAGADGHPGGTGGVGGTGGKGGDGGDGGAAPNGVAGS
Rv3345c|M.tuberculosis_H37Rv GNGGAGGAGGTLAGHGGNGGKGGNGGQGGIGGAGERGADGAGPNANGANG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------LAGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAA
MAV_4827|M.avium_104 --------------LPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDP
MMAR_0609|M.marinum_M AGD-----------------------------------------AFGGAA
MUL_0572|M.ulcerans_Agy99 AGD-----------------------------------------AFGGAA
TH_3810|M.thermoresistible__bu MAE-------------------------------------------DGEH
MSMEG_0868|M.smegmatis_MC2_155 TGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDG
Mflv_5091|M.gilvum_PYR-GCK TGG------------------------------------------TGGTG
Mvan_1264|M.vanbaalenii_PYR-1 TGG------------------------------------------TGGTG
Mb0593c|M.bovis_AF2122/97 QGPGGAGGDGGTGGVGGNGGRGIDGADGATAGARGQDGGAGGAGGKGGRG
Rv3345c|M.tuberculosis_H37Rv ENG----GSGGNGGDGGAGGNGGAGGKAQAAGYTDGATGTGGDGGNGGDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VAG------------------------------------------NAAVA
MAV_4827|M.avium_104 VSP----------------------------------------PQLLAPP
MMAR_0609|M.marinum_M GKGGTGVVGGNGGSG-------------GAAYNYGTGNATGA--------
MUL_0572|M.ulcerans_Agy99 GKGGTGVVGGNGGSG-------------GAAYNYGTGNAT----------
TH_3810|M.thermoresistible__bu VKALDGRPGLDG----------------GNGSHGGNGGH-----------
MSMEG_0868|M.smegmatis_MC2_155 GRGGDGALGGNGGTGGVGL---------GNGGKGGNGGN-----------
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTGGTG-------------GTGGKGGTGGT-----------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGTG-------------GTGGKGGTGGT-----------
Mb0593c|M.bovis_AF2122/97 GTGGPGGAGPAGTTGSQGAG--------GNGGSGGTGGDPGDGGNGANGS
Rv3345c|M.tuberculosis_H37Rv GKAGDGGAGENGLNSGAMLPGGGTVGNPGTGGNGGNGGNAGVGGTGGKAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAAVGGVLNTGVSG-------------AIGGSSHVGGAIN---------
MAV_4827|M.avium_104 RLSVPQPVQPPVRVP-------------QPPSPPQVGGTVP---------
MMAR_0609|M.marinum_M -------DGAAGTDGTTGAGGSGGSGGAASVLN-------------SASI
MUL_0572|M.ulcerans_Agy99 -----------------GAGGSSGSGGAASVPN-------------SAST
TH_3810|M.thermoresistible__bu -------GGRGG------FLGIGGSGGWG---------------------
MSMEG_0868|M.smegmatis_MC2_155 -------GGNGGTYVDPSHTGAGGNGGNGGAGRIR-----VNNGTATGTA
Mflv_5091|M.gilvum_PYR-GCK -------GGAGGTGGDGGTGGTGGTGGTGG--------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------GGDGGTGGTGGTGGTGGTGGTGG--------------------
Mb0593c|M.bovis_AF2122/97 VFTNNGIGGNGGNGGNAGPSGAGGSGGAGSTFG-------ATGSSSSIHV
Rv3345c|M.tuberculosis_H37Rv TGSLTGLDGTDGITPNGGNGGNGGNGGKGGTAGNGSGAAGGNGGNGGSGL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------ESLGGSGSVGGSTAVGG-----------------
MAV_4827|M.avium_104 ----------------QSPPQHQTPPGEGTPPK-----------------
MMAR_0609|M.marinum_M ATATSGSGGAGG----------DGTDGGNGGSGGFAFTFG----------
MUL_0572|M.ulcerans_Agy99 ATATSGSGGAGG----------DGTDGGNGGSGGFAFTFG----------
TH_3810|M.thermoresistible__bu --GHGGNGGDTD---------ADGGNGGDGGNGG----------------
MSMEG_0868|M.smegmatis_MC2_155 TGGNGGNGGNGD---------ADGHRGGKGGDGGEALIRATVIGSN----
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGAGD---------GTGGTGGTGGTGGQG--------------
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGAGD---------GLGGTGGTGGTGGFG--------------
Mb0593c|M.bovis_AF2122/97 NGGNGGNGGNGDHALSGN--GAAGGNGGNGGNGSLRGSGGAGGHGG----
Rv3345c|M.tuberculosis_H37Rv NGGDAGNGGNGGGALNQAGFFGTGGKGGNGGNGGAGMINGGLGGFGGAGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -GAHTGVGGGVS----------TGVGVGSHVGGGIS--------------
MAV_4827|M.avium_104 PDGPGNYGGGHVP---------TPGAGGSGGSGG----------------
MMAR_0609|M.marinum_M -----TGNIIAGVGGDGGTGSTG---------------------------
MUL_0572|M.ulcerans_Agy99 -----TGNIIAGVGGGGGTGSTG---------------------------
TH_3810|M.thermoresistible__bu ---------SAGRGGTGGLRGVF---------------------------
MSMEG_0868|M.smegmatis_MC2_155 ----ASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATD
Mflv_5091|M.gilvum_PYR-GCK --------GQGGQGGTGGTGGQG------------------------GLG
Mvan_1264|M.vanbaalenii_PYR-1 --------GQGGQGGTGGTGGQG------------------------GLG
Mb0593c|M.bovis_AF2122/97 ----NGGNASRGMGGDGGTGGAGGNAGQIGNGGAGGNGGDGGTGSDGNPG
Rv3345c|M.tuberculosis_H37Rv GGAVDVAATTGGAGGNGGAGGFASTGLGGPGGAGGPGGAGDFASGVGGVG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------ESLGGSGSVGGSTAVG---------------------------
MAV_4827|M.avium_104 -----------GHVPTPGAGGSG---------------------------
MMAR_0609|M.marinum_M ----VGGIGGSGGGADIN----------------NGASTVVPQGGAGGHG
MUL_0572|M.ulcerans_Agy99 ----VGGIGGSGGGADIN----------------NGAFTVVPQGGAGGHG
TH_3810|M.thermoresistible__bu -----GINGGNGR------------------------------AGLGGRG
MSMEG_0868|M.smegmatis_MC2_155 GHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNG
Mflv_5091|M.gilvum_PYR-GCK GGGGTGGQGGTGGTGGQG--------------GTGGTGGTGGTGGTGGAG
Mvan_1264|M.vanbaalenii_PYR-1 GVGGTGGTGGTGGTGGQG--------------GTGGTGGTGGTGGTGGAG
Mb0593c|M.bovis_AF2122/97 AITGSGGRGGDGGVGGQGG-------------SVAGDGADGGRGGAGGTG
Rv3345c|M.tuberculosis_H37Rv GAGGDGGAGGVGGFGGQG--------------GIGGEGRTGGNGGSGGDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----GGAHTGVGGGVSTG-------------------------VGVGSHV
MAV_4827|M.avium_104 -----GSGGGHVPTPGTG--------------------------GPGGTG
MMAR_0609|M.marinum_M GDG--------------------ATDGGAGGAGGFTEIDSSASVLAATGG
MUL_0572|M.ulcerans_Agy99 GDG--------------------ATDGGAGGAGGFTEIDSSASVIAATGG
TH_3810|M.thermoresistible__bu XX-------------------------XXGGGVGAAVRSGNG----VFSG
MSMEG_0868|M.smegmatis_MC2_155 GDGVVNTT---ANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSG
Mflv_5091|M.gilvum_PYR-GCK GDG------------------GLGGLGGFGGSGGTGGQGGLGGPGGSTGG
Mvan_1264|M.vanbaalenii_PYR-1 GDG------------------GLGGLGGFGGVGGTGGQGGQGGPGGSTGG
Mb0593c|M.bovis_AF2122/97 GTGLRGTTG--ATGATGTFDAGADGHGGNGGTGGVGGTGGAGGGGGNGGA
Rv3345c|M.tuberculosis_H37Rv GGGISLGGNGGLGGNGGVSETGFGGAGGNGGYGGPGGPEGNGGLGGNGGA
MLBr_01183|M.leprae_Br4923 -----------------------------------MPLFLNAEPQALTAA
MAB_4284c|M.abscessus_ATCC_199 GGG---------------------ISESLGGSGSVGGSTAVGGGAHTGVG
MAV_4827|M.avium_104 GSG-----------------------GGHVPTPGAGTPGGSGGGHLPFPG
. .
MMAR_0609|M.marinum_M AG--------GDGGSGGTGRGGTGG----------VGGVGINNGSGEAIG
MUL_0572|M.ulcerans_Agy99 AG--------GDGGSGGTGRGGTGGGGTGGGGTGGGGGVGINNGSGEAIG
TH_3810|M.thermoresistible__bu GG---------GTPSAGFGVPTT---IQFPAGSCTSRAVSREGIMPSSRA
MSMEG_0868|M.smegmatis_MC2_155 YGS-TLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTA
Mflv_5091|M.gilvum_PYR-GCK AG-----GAGGQAGTAGKGGLFGGSGSAGKAGATGAAGASGGKGAQGATG
Mvan_1264|M.vanbaalenii_PYR-1 AG-----GAGGQAGVAGKGGLFGGSGSAGTAGVTGASGASGGKGAQGATG
Mb0593c|M.bovis_AF2122/97 GG--KALSPTGNNGSQGAGGDGGAGGTGGTGGTGGDGGRGAHGTLFSSLA
Rv3345c|M.tuberculosis_H37Rv GGNGGVSTTGGDGGAGGKGGNGGDGGNVGLGGDAGSGGAGGNGGIGTDAG
MLBr_01183|M.leprae_Br4923 AN-----------TLEGLSAATVASNAAAAQLTTEIAPPAADDVSILLAH
MAB_4284c|M.abscessus_ATCC_199 GG---------VNTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTSA
MAV_4827|M.avium_104 AG--------------STPGGSGGGHLPTPGAGTPGGGLGGFGGGHAPAP
. .
MMAR_0609|M.marinum_M GAPGAGGTGAVGGDG----------------------GQGGAAYSYGTGD
MUL_0572|M.ulcerans_Agy99 GAPGAGGTGAVGGDG----------------------GQGGAAYSYGTGD
TH_3810|M.thermoresistible__bu ASARAGAACASSTSR----------------------SRRSFCCSRA---
MSMEG_0868|M.smegmatis_MC2_155 TGGDGGAATTAGATG----------------------GAGGFSNIAAIHG
Mflv_5091|M.gilvum_PYR-GCK AQGATGAQGATGATG----------------------AAGKAGATGAAGA
Mvan_1264|M.vanbaalenii_PYR-1 AQGATGAQGATGATG----------------------ASGAQGSAGSAGS
Mb0593c|M.bovis_AF2122/97 GTGGTGGNGGTGGTG----------------------GTGGAGGAGGTGS
Rv3345c|M.tuberculosis_H37Rv GAGGAGGAGGNGGSSKSTTTGNAGSGGAGGNGGTGLNGAGGAGGAGGNAG
MLBr_01183|M.leprae_Br4923 FFSGHGRQYQAHASQ------------------------GATNHQDLIQS
MAB_4284c|M.abscessus_ATCC_199 INDALGGSGSVGGST----------------------AVGGGAHTSAINE
MAV_4827|M.avium_104 GGGLGGGGGHAPAPG------------------------GGLGGFGGGHS
*
MMAR_0609|M.marinum_M ATGSAGAAGTAGTTGVGGTGGAGGAAYTLN-------GASTATATG----
MUL_0572|M.ulcerans_Agy99 ATGSAGAAGTAGTTGVGGTGGAGGAAYTLN-------GASTATATG----
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 AITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSA----
Mflv_5091|M.gilvum_PYR-GCK AGAAGSAGTTGAQGSAGTNGANGANGSQGAAGKAGATG--TTGATG----
Mvan_1264|M.vanbaalenii_PYR-1 AGVAGSAGTTGAQGSAGTNGANGANGSQGAAGKAGATG--TTGATG----
Mb0593c|M.bovis_AF2122/97 TLGATGATGAAGRAGNGGVGGSGGLGSAFGPGGTGGMGGAGGTSTV----
Rv3345c|M.tuberculosis_H37Rv VAGVSFGNAVGGDGGNGGNGGHGGDGTTGGAGGKGGNGSSGAASGSGVVN
MLBr_01183|M.leprae_Br4923 LLTSSSAYAGTETANHDSL-------------------------------
MAB_4284c|M.abscessus_ATCC_199 SMNSSINASHSSSMNESFGSSMGSHG------------------------
MAV_4827|M.avium_104 GGGLGGLGGGHK--------------------------------------
MMAR_0609|M.marinum_M -GIGGNGGDGGTANG--SNGGNGGAGG-------YASTTGTGTASAGNGG
MUL_0572|M.ulcerans_Agy99 -GIGGNGGDGGTANG--SNGGNGGAGG-------YASTTGTGTASVGNGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 -VAGNGGDGGVNGTGG-ASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGG
Mflv_5091|M.gilvum_PYR-GCK -AAGEDGDAGSGGSG--INGGAGGAGG-----------AGGEGGEGGDGG
Mvan_1264|M.vanbaalenii_PYR-1 -AAGDAGDPGSEAVD--INGGAGGAGG-----------AGGEGGEGGAGG
Mb0593c|M.bovis_AF2122/97 -SAGGDGGRGGFGGDG-LDASSGGNGGD----GGHGGDGFRTAGAGGRGG
Rv3345c|M.tuberculosis_H37Rv VTAGHGGNGGNGGNGGNGSAGAGGQGGAGGSAGNGGHGGGATGGDGGNGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -AAGTGFEAQGHAQG--------------------------HASETAHTT
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M RGGDGTATVA----TGGTGGVGGNAHAPAG-------------SPVPGVG
MUL_0572|M.ulcerans_Agy99 RGGDGTATVA----TGGTGGVGGNAHAPAG-------------SPVPGVG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 NGGDGSEPG-----PGGNGAGGAGGNGGTGGT-------TAGGSGNGGNG
Mflv_5091|M.gilvum_PYR-GCK KGGAGAEGG-----AGGGGGAGGSGAGGAG--------------GAGGSG
Mvan_1264|M.vanbaalenii_PYR-1 AGGDGSEGG-----AGGSGGAGGSGTGGAG--------------GAGGSG
Mb0593c|M.bovis_AF2122/97 DGGKGADPGGLFPIPGAGGKGGTGGTGGTAHLGPLAIIGQSGQPGQFGSP
Rv3345c|M.tuberculosis_H37Rv NGGNSGNSTGVAGLAGGAAGAGGNGGGTSSAAGHGGSGGSGGSGTTGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LPGAEHH-------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M GKGGNPGPGGKPGPNGADGIVV----------------------------
MUL_0572|M.ulcerans_Agy99 GKGGNPGPGGKPGPNGADGIVV----------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGADGTPGTAGTTGANNP---------------------------
Mflv_5091|M.gilvum_PYR-GCK GSGGSGGSGGSGGAAGDSDD------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GSGGSGGAGGSGGAAGDSD-------------------------------
Mb0593c|M.bovis_AF2122/97 GADGRGGAGGAGGGGGAGGSF-----------------------------
Rv3345c|M.tuberculosis_H37Rv AAGGNGGAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQRRRRWCRWQR
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M --------------------------------------------------
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0593c|M.bovis_AF2122/97 --------------------------------------------------
Rv3345c|M.tuberculosis_H37Rv RCRRQRWRWRCRQRRLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQR
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0609|M.marinum_M --------
MUL_0572|M.ulcerans_Agy99 --------
TH_3810|M.thermoresistible__bu --------
MSMEG_0868|M.smegmatis_MC2_155 --------
Mflv_5091|M.gilvum_PYR-GCK --------
Mvan_1264|M.vanbaalenii_PYR-1 --------
Mb0593c|M.bovis_AF2122/97 --------
Rv3345c|M.tuberculosis_H37Rv QRSRWQRR
MLBr_01183|M.leprae_Br4923 --------
MAB_4284c|M.abscessus_ATCC_199 --------
MAV_4827|M.avium_104 --------