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MPRTADDSWDIATSVGATAVMVALARAAETASETPLIRDQFAEPLVSTPELAAVREQVAAWWAQTDDDDD PDFTVDSQQMTDYLAVRTHFFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTTVYEIDLPKVLDYK EHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGLLPFLPAAAQHALFTAIDANSAT GSRVAVEMFGVDEDARRAAEERAQRWARQRAKRQARGQDTSFDPFDLWFDDEGQPDPADWFAAHGWTTDS VQAGAEALRLGRTAHSQEGPFVNRFVTAGKP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0358 | - | - | 100% (311) | O-methyltransferase |
| M. marinum M | MMAR_0357 | - | 2e-71 | 50.84% (297) | O-methyltransferase |
| M. marinum M | MMAR_0955 | - | 7e-65 | 45.28% (318) | hypothetical protein MMAR_0955 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0151 | - | 8e-72 | 51.18% (297) | hypothetical protein Mb0151 |
| M. gilvum PYR-GCK | Mflv_0743 | - | 1e-69 | 48.41% (314) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0146 | - | 9e-72 | 51.18% (297) | hypothetical protein Rv0146 |
| M. leprae Br4923 | MLBr_02640 | - | 2e-71 | 51.85% (297) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4606c | - | 2e-72 | 50.33% (306) | hypothetical protein MAB_4606c |
| M. avium 104 | MAV_5150 | - | 2e-76 | 54.79% (292) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0095 | - | 5e-77 | 51.94% (310) | methyltransferase |
| M. thermoresistible (build 8) | TH_4502 | - | 2e-72 | 48.78% (328) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_4761 | - | 1e-167 | 98.96% (288) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 1e-70 | 49.16% (297) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0095|M.smegmatis_MC2_155 --------MSSLRTDDDTWDIATSVGSTAVMVAAARAGETERDDALIRDP
TH_4502|M.thermoresistible__bu --------MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDP
Mflv_0743|M.gilvum_PYR-GCK --------MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALINDP
Mvan_0104|M.vanbaalenii_PYR-1 --------MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDDP
Mb0151|M.bovis_AF2122/97 -----------MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDP
Rv0146|M.tuberculosis_H37Rv -----------MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDP
MLBr_02640|M.leprae_Br4923 -----------MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDP
MAB_4606c|M.abscessus_ATCC_199 -----MTGTTTARSDDDSWDIASSVGATAVMVAAARAAETRSASPLIQDP
MMAR_0358|M.marinum_M ----------MPRTADDSWDIATSVGATAVMVALARAAETASETPLIRDQ
MUL_4761|M.ulcerans_Agy99 ---------------------------------MARAAETASETPLIRDQ
MAV_5150|M.avium_104 MTDLDSSLPPSVRTAGDSWTITELVGATALGVAAARAAETAGPDPLIRDE
:** ** .** *
MSMEG_0095|M.smegmatis_MC2_155 YAKILVAGAGTG-VWETVLDSEFAAKIENLDPEAAAIFAHMGNYQAVRTH
TH_4502|M.thermoresistible__bu YAKVLVAGAGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTH
Mflv_0743|M.gilvum_PYR-GCK YAKVLVEGAGAG-AWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTH
Mvan_0104|M.vanbaalenii_PYR-1 YAKILVAGAGNG-AWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTH
Mb0151|M.bovis_AF2122/97 YARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTN
Rv0146|M.tuberculosis_H37Rv YARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTN
MLBr_02640|M.leprae_Br4923 YAKLLVTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTN
MAB_4606c|M.abscessus_ATCC_199 FAQLLVERAGSG-AWSVLASDGLRQQLAELDPDADRVMQYAVDYQAVRTR
MMAR_0358|M.marinum_M FAEPLVSTPELAAVREQVAAWWAQTDDDD-DPDFTVDSQQMTDYLAVRTH
MUL_4761|M.ulcerans_Agy99 FAEPLVSTPELAAVREQVAAWWAQTDDDD-DPDFTVDSQQMTDYLAVRTH
MAV_5150|M.avium_104 FAGLLVSSAGPAWARLADP---EQSWLDD-DPHGKRAHRVGIDYQAVRTH
:* ** . . *.. .* ****.
MSMEG_0095|M.smegmatis_MC2_155 FFDAYYREAADAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPKVLEY
TH_4502|M.thermoresistible__bu FFDTYFARAAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEY
Mflv_0743|M.gilvum_PYR-GCK FFDAFFSAAVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDY
Mvan_0104|M.vanbaalenii_PYR-1 FFDAFFAAAVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAY
Mb0151|M.bovis_AF2122/97 FFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSY
Rv0146|M.tuberculosis_H37Rv FFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSY
MLBr_02640|M.leprae_Br4923 FFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAY
MAB_4606c|M.abscessus_ATCC_199 FFDGFFERAAHAGITQVVILAAGLDSRAYRLDWPAGTTVYEIDQPLVLQY
MMAR_0358|M.marinum_M FFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTTVYEIDLPKVLDY
MUL_4761|M.ulcerans_Agy99 FFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTMVYEIDLPKVLDY
MAV_5150|M.avium_104 YFDEYFDGALRAGIRQVVILAAGLDSRAYRLNWPAGTTVYEIDQPKVLEY
:** :: * *: *.****:******:** ** ** *:*** * ** *
MSMEG_0095|M.smegmatis_MC2_155 KSATLREHGIEPVAQRREVPVDLRFDWPTALHDAGFDASLPTAWLAEGLL
TH_4502|M.thermoresistible__bu KSATLAAHGVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLL
Mflv_0743|M.gilvum_PYR-GCK KSSTLAAHGVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLL
Mvan_0104|M.vanbaalenii_PYR-1 KSSTLASHGVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLL
Mb0151|M.bovis_AF2122/97 KSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLL
Rv0146|M.tuberculosis_H37Rv KSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLL
MLBr_02640|M.leprae_Br4923 KSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLL
MAB_4606c|M.abscessus_ATCC_199 KRHTLDAHDVRSACLRREVPVDLRQDWPAALQREGFDVAEPTAWLAEGLL
MMAR_0358|M.marinum_M KEHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGLL
MUL_4761|M.ulcerans_Agy99 KEHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGLL
MAV_5150|M.avium_104 KTETLQRHGATPAAVRRPVPVDLRDDWPAALTAAGFQAARPTAWLAEGLL
* ** :. . . * *. *** *** ** **: *********
MSMEG_0095|M.smegmatis_MC2_155 MYLPAEAQDRLFELVTELSAPGSRIAVETAGVAATDR-----REAMRERF
TH_4502|M.thermoresistible__bu MYLPADAQDRLFENITALSAPGSRLAVETAAEEPVDR-----REQMRARM
Mflv_0743|M.gilvum_PYR-GCK MYLPADAQDRLFAQITELSAPGSQVAAESMGVHAPDR-----RERMRERF
Mvan_0104|M.vanbaalenii_PYR-1 MYLPADAQDRLFAQITELSAPGSRVAAESMGIHAQDR-----RERMRERF
Mb0151|M.bovis_AF2122/97 MYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEER-----RAEMRARF
Rv0146|M.tuberculosis_H37Rv MYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEER-----RAEMRARF
MLBr_02640|M.leprae_Br4923 MYLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEW-----REQMQLRF
MAB_4606c|M.abscessus_ATCC_199 MYLPTEAQDRLFELIVDQSAPGSRIAVEAVGPDNDKRQ--EFRSKMRAHF
MMAR_0358|M.marinum_M PFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQRWARQ
MUL_4761|M.ulcerans_Agy99 PFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQRWARQ
MAV_5150|M.avium_104 PYLPSDAQDRLFEMVTALSAAGSQVAVEVFGMNSRSN------AQRWLRM
:**: **. ** : *. **::*.* :
MSMEG_0095|M.smegmatis_MC2_155 KKFADQLNLSSA-LDIQELVYDDPDRADVAEWLDAHGWRARGVHALDEMR
TH_4502|M.thermoresistible__bu ERIASQFGLEKA-LDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMR
Mflv_0743|M.gilvum_PYR-GCK ASIASQIDIEP--MDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMR
Mvan_0104|M.vanbaalenii_PYR-1 ASITAQFDVEP--MDITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMR
Mb0151|M.bovis_AF2122/97 KKVADVLGIEQT-IDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMR
Rv0146|M.tuberculosis_H37Rv KKVADVLGIEQT-IDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMR
MLBr_02640|M.leprae_Br4923 RRVSDALGFEQA-VDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMR
MAB_4606c|M.abscessus_ATCC_199 DRARKLAGMDGESLDVGSLMYHDENRTDVPQWLAGRGWTVRAIPAEVEMA
MMAR_0358|M.marinum_M RAKRQARGQDTS-FDPFDLWFDDEGQPDPADWFAAHGWTTDSVQAGAEAL
MUL_4761|M.ulcerans_Agy99 RAKRQARGQDTS-FDPFDLWFDDEGQPDPADWFAAHGWTTDSVQVGAEAL
MAV_5150|M.avium_104 RER---LGLDVN-VA--ALTYHEPDRSDAAAWLTGHGWRVHSVDNRDEMA
. . . * :.: .:. . *: :** .
MSMEG_0095|M.smegmatis_MC2_155 RLDR--LVE-LPDDP---------DRAAFSTFVTAQRL-
TH_4502|M.thermoresistible__bu RLDR--FVA-AAMPPGDDADAADLDDTAFSKFVTAERPS
Mflv_0743|M.gilvum_PYR-GCK RLDR--YVE-VADSD----------GQSFSTFTTGTKL-
Mvan_0104|M.vanbaalenii_PYR-1 RLHR--LVE-IADGD----------DQSFSTFTTAVKR-
Mb0151|M.bovis_AF2122/97 RVGR--WVEGVPMAD---------DPTAFAEFVTAERL-
Rv0146|M.tuberculosis_H37Rv RVGR--WVEGVPMAD---------DPTAFAEFVTAERL-
MLBr_02640|M.leprae_Br4923 RVGR--WGDGVPMAD---------DKDAFAEFVTAHRL-
MAB_4606c|M.abscessus_ATCC_199 EAGRPGYIEEDLRGN---------------TLIEAELKG
MMAR_0358|M.marinum_M RLGR------TAHSQ---------EGPFVNRFVTAGKP-
MUL_4761|M.ulcerans_Agy99 RLGR------TATSQ---------EGPFVNRFVTAGKP-
MAV_5150|M.avium_104 RLGRPVPEDLSDEAV---------RSTLLRAHLGGSTG-
. * .