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ARAAETASETPLIRDQFAEPLVSTPELAAVREQVAAWWAQTDDDDDPDFTVDSQQMTDYLAVRTHFFDSY FIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTMVYEIDLPKVLDYKEHTLARHGAAPVAALRAVPVDLRH DWPQALRDAGFQTSLPTAWLAEGLLPFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQ RWARQRAKRQARGQDTSFDPFDLWFDDEGQPDPADWFAAHGWTTDSVQVGAEALRLGRTATSQEGPFVNR FVTAGKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4761 | - | - | 100% (288) | O-methyltransferase |
| M. ulcerans Agy99 | MUL_4762 | - | 1e-60 | 47.64% (275) | O-methyltransferase |
| M. ulcerans Agy99 | MUL_4763 | - | 9e-57 | 48.15% (270) | hypothetical protein MUL_4763 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0151 | - | 3e-61 | 48.36% (275) | hypothetical protein Mb0151 |
| M. gilvum PYR-GCK | Mflv_0743 | - | 3e-59 | 45.89% (292) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0146 | - | 3e-61 | 48.36% (275) | hypothetical protein Rv0146 |
| M. leprae Br4923 | MLBr_02640 | - | 2e-60 | 49.09% (275) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4607c | - | 5e-62 | 50.37% (268) | hypothetical protein MAB_4607c |
| M. marinum M | MMAR_0358 | - | 1e-166 | 98.96% (288) | O-methyltransferase |
| M. avium 104 | MAV_5150 | - | 2e-68 | 53.70% (270) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0095 | - | 3e-65 | 48.96% (288) | methyltransferase |
| M. thermoresistible (build 8) | TH_2759 | - | 2e-64 | 51.30% (269) | PUTATIVE methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 1e-59 | 46.55% (275) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5150|M.avium_104 -MTDLDSSLPPSVRTAGDSWTITELVGATALGVAAARAAETAGPDPLIRD
TH_2759|M.thermoresistible__bu MVMMFDVTEAASARSEGDSWDITESVGATALGVAAERALETSQPDPLIRD
MAB_4607c|M.abscessus_ATCC_199 ------------MRVDGDTWDITSSVGATALGVAAARATETLRADALIRD
Mb0151|M.bovis_AF2122/97 ------------MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRD
Rv0146|M.tuberculosis_H37Rv ------------MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRD
MLBr_02640|M.leprae_Br4923 ------------MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRD
Mflv_0743|M.gilvum_PYR-GCK ---------MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALIND
Mvan_0104|M.vanbaalenii_PYR-1 ---------MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDD
MSMEG_0095|M.smegmatis_MC2_155 ---------MSSLRTDDDTWDIATSVGSTAVMVAAARAGETERDDALIRD
MUL_4761|M.ulcerans_Agy99 ----------------------------------MARAAETASETPLIRD
MMAR_0358|M.marinum_M -----------MPRTADDSWDIATSVGATAVMVALARAAETASETPLIRD
** ** .** *
MAV_5150|M.avium_104 EFAGLLVSSAGPA--WARLADPEQSWLDD--DPHGKRAHRVGIDYQAVRT
TH_2759|M.thermoresistible__bu EYAFLLVSAAGPP--WTQLASSDLSWLGD--DETARRMHLMSRDYQAVRT
MAB_4607c|M.abscessus_ATCC_199 PFAQILVDATGKATGWERLVAGDIDWP----DPEAGRIYDRMVDYQATRT
Mb0151|M.bovis_AF2122/97 PYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRT
Rv0146|M.tuberculosis_H37Rv PYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRT
MLBr_02640|M.leprae_Br4923 PYAKLLVTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRT
Mflv_0743|M.gilvum_PYR-GCK PYAKVLVEGAGAG-AWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRT
Mvan_0104|M.vanbaalenii_PYR-1 PYAKILVAGAGNG-AWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRT
MSMEG_0095|M.smegmatis_MC2_155 PYAKILVAGAGTG-VWETVLDSEFAAKIENLDPEAAAIFAHMGNYQAVRT
MUL_4761|M.ulcerans_Agy99 QFAEPLVSTPELAAVREQVAA-WWAQTDDDDDPDFTVDSQQMTDYLAVRT
MMAR_0358|M.marinum_M QFAEPLVSTPELAAVREQVAA-WWAQTDDDDDPDFTVDSQQMTDYLAVRT
:* ** . : * .* *.**
MAV_5150|M.avium_104 HYFDEYFDGALRAGIRQVVILAAGLDSRAYRLNWPAGTTVYEIDQPKVLE
TH_2759|M.thermoresistible__bu HYFDRYFAAAARAGIRQIVLLAAGLDSRAYRLDWPAGTVVYELDQPRVLD
MAB_4607c|M.abscessus_ATCC_199 HFFDEYFLAAAAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLK
Mb0151|M.bovis_AF2122/97 NFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLS
Rv0146|M.tuberculosis_H37Rv NFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLS
MLBr_02640|M.leprae_Br4923 NFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLA
Mflv_0743|M.gilvum_PYR-GCK HFFDAFFSAAVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLD
Mvan_0104|M.vanbaalenii_PYR-1 HFFDAFFAAAVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLA
MSMEG_0095|M.smegmatis_MC2_155 HFFDAYYREAADAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPKVLE
MUL_4761|M.ulcerans_Agy99 HFFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTMVYEIDLPKVLD
MMAR_0358|M.marinum_M HFFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTTVYEIDLPKVLD
::** :: * *:**.*:**:******:** ** ** *:*:* * **
MAV_5150|M.avium_104 YKTETLQRHGATPAAVRRPVPVDLRDDWPAALTAAGFQAARPTAWLAEGL
TH_2759|M.thermoresistible__bu FKNRTLQAHGAVAKADRRTVAVDLRDDWPAALRHAGFDSAAPTAWLAEGL
MAB_4607c|M.abscessus_ATCC_199 FKDSALAAH--QPTAQRRGVAIDLREDWPAALRAAGFDSAQPTAWLAEGL
Mb0151|M.bovis_AF2122/97 YKSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGL
Rv0146|M.tuberculosis_H37Rv YKSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGL
MLBr_02640|M.leprae_Br4923 YKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGL
Mflv_0743|M.gilvum_PYR-GCK YKSSTLAAHGVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGL
Mvan_0104|M.vanbaalenii_PYR-1 YKSSTLASHGVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGL
MSMEG_0095|M.smegmatis_MC2_155 YKSATLREHGIEPVAQRREVPVDLRFDWPTALHDAGFDASLPTAWLAEGL
MUL_4761|M.ulcerans_Agy99 YKEHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGL
MMAR_0358|M.marinum_M YKEHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGL
:* :* : . * * *. *** *** ** :**:. ********
MAV_5150|M.avium_104 LPYLPSDAQDRLFEMVTALSAAGSQVAVEVFGMNSRSN-AQR----W---
TH_2759|M.thermoresistible__bu LCYLPADAQDRLFERITALSAPGSWLAVEAFHHDPQRA-TERRRAEWRDR
MAB_4607c|M.abscessus_ATCC_199 LPYLPADAQDNLFRDIGVLSAAGSRVAVEGYEGKLVLDESEEEAVRREQV
Mb0151|M.bovis_AF2122/97 LMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEER---RAEMRARFK
Rv0146|M.tuberculosis_H37Rv LMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEER---RAEMRARFK
MLBr_02640|M.leprae_Br4923 LMYLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEW---REQMQLRFR
Mflv_0743|M.gilvum_PYR-GCK LMYLPADAQDRLFAQITELSAPGSQVAAESMGVHAPDR---RERMRERFA
Mvan_0104|M.vanbaalenii_PYR-1 LMYLPADAQDRLFAQITELSAPGSRVAAESMGIHAQDR---RERMRERFA
MSMEG_0095|M.smegmatis_MC2_155 LMYLPAEAQDRLFELVTELSAPGSRIAVETAGVAATDR---REAMRERFK
MUL_4761|M.ulcerans_Agy99 LPFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQRWAR
MMAR_0358|M.marinum_M LPFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQRWAR
* :**: **. ** : *. ** :*.* .
MAV_5150|M.avium_104 -LRMRER--LGLDVNVAALTYHEPDRSDAAAWLTGHGWRVHSVDNRDEMA
TH_2759|M.thermoresistible__bu TARMKAA--LDLNLDFEALTYDDPDRADAGEWLAAHGWHPDSVPGTEEMA
MAB_4607c|M.abscessus_ATCC_199 RAAFKTA--IDVDVTIENLIYEDENRADPAEWLDAHGWSVTKTDAHDEMA
Mb0151|M.bovis_AF2122/97 KVADVLG--IEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMR
Rv0146|M.tuberculosis_H37Rv KVADVLG--IEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMR
MLBr_02640|M.leprae_Br4923 RVSDALG--FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMR
Mflv_0743|M.gilvum_PYR-GCK SIASQID--IEP-MDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMR
Mvan_0104|M.vanbaalenii_PYR-1 SITAQFD--VEP-MDITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMR
MSMEG_0095|M.smegmatis_MC2_155 KFADQLN--LSSALDIQELVYDDPDRADVAEWLDAHGWRARGVHALDEMR
MUL_4761|M.ulcerans_Agy99 QRAKRQARGQDTSFDPFDLWFDDEGQPDPADWFAAHGWTTDSVQVGAEAL
MMAR_0358|M.marinum_M QRAKRQARGQDTSFDPFDLWFDDEGQPDPADWFAAHGWTTDSVQAGAEAL
. * :.: .:. . *: ***
MAV_5150|M.avium_104 RLGRPVP--EDLSDEAVRSTLLRAHLGGSTG
TH_2759|M.thermoresistible__bu RMGRPVP--ADLLDVAVPSTLLRAHLNGASR
MAB_4607c|M.abscessus_ATCC_199 RLGRPVA--EDVERGTFRGQLIQGELR----
Mb0151|M.bovis_AF2122/97 RVGRWVEGVPMADDPTAFAEFVTAERL----
Rv0146|M.tuberculosis_H37Rv RVGRWVEGVPMADDPTAFAEFVTAERL----
MLBr_02640|M.leprae_Br4923 RVGRWGDGVPMADDKDAFAEFVTAHRL----
Mflv_0743|M.gilvum_PYR-GCK RLDRYVE-VADS-DGQSFSTFTTGTKL----
Mvan_0104|M.vanbaalenii_PYR-1 RLHRLVE-IADG-DDQSFSTFTTAVKR----
MSMEG_0095|M.smegmatis_MC2_155 RLDRLVE-LPDDPDRAAFSTFVTAQRL----
MUL_4761|M.ulcerans_Agy99 RLGRTAT----SQEGPFVNRFVTAGKP----
MMAR_0358|M.marinum_M RLGRTAH----SQEGPFVNRFVTAGKP----
*: * : .