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APTAARALVRSGLLNPPSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATE SLARRLTRDGVAPGRAVGVMCRNGRGFVTAVFAVTLLGADVVPISTEFRSDALAAALRAHHISTVVADNE FAERIAAADDAVAVIDPATAGAEESGGRPAVAAPGRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVTILDR TRLRTGSRISVAMPMFHGLGLGMLMLTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILEL PPRVRARNPLPQLRVVMSSGDRLDPTLGQRFMDTYGDILYNGYGSTEVGIGALATPADLRDAPETVGKPV AGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKAVVDGMTSTGDMGYLDNAGRLFIVGREDDM IISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDAAQLRDYLKDRVSRFEQ PRDINIVASIPRNPTGKVLRKELPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5220 | - | - | 100% (516) | acyl-CoA synthetase |
| M. avium 104 | MAV_3349 | - | 7e-95 | 41.72% (441) | acyl-CoA synthetase |
| M. avium 104 | MAV_4891 | - | 4e-88 | 34.47% (528) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 1e-105 | 41.51% (518) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2427 | - | 1e-101 | 41.14% (525) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 1e-105 | 41.51% (518) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 8e-89 | 35.47% (530) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2539c | - | 1e-100 | 40.15% (528) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0296 | fadD12_2 | 0.0 | 71.40% (514) | long-chain-fatty-acid--CoA ligase FadD12_2 |
| M. smegmatis MC2 155 | MSMEG_0304 | - | 1e-100 | 39.66% (527) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4130 | - | 1e-105 | 42.01% (538) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 0.0 | 70.82% (514) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4225 | - | 1e-102 | 41.90% (525) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0296|M.marinum_M -----MMAAG--VVTTAARALLGSGLLSPSSPAAALRLVRELYRGGTNLY
MUL_4827|M.ulcerans_Agy99 -----MMAAG--VVTTAARALLGSGLLSPSSPAAALRLVRELYRGGTNLY
MAV_5220|M.avium_104 ------MAP------TAARALVRSGLLNPPSPRAVLRLLREASRGGTNPY
Mb1462c|M.bovis_AF2122/97 ----MRIR----QAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFT
Rv1427c|M.tuberculosis_H37Rv ----MRIR----QAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFT
MSMEG_0304|M.smegmatis_MC2_155 MGLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAAMARENMSVT
Mflv_2427|M.gilvum_PYR-GCK ---MSSAA----DQFGLLATLWRARLIAPMRPDRYLRMGLAMRRAGLTAT
Mvan_4225|M.vanbaalenii_PYR-1 ------MA----DPLGLLATLWRARLIAPMRPDRYLRMGLAMRRAGLTAT
TH_4130|M.thermoresistible__bu ------MA----KTIDTLRTLTRAGLIAPLRPDKYLRMTAAVRRTGVSVT
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWG-DLA
MAB_2539c|M.abscessus_ATCC_199 --MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPA
: : : * : : .
MMAR_0296|M.marinum_M TPLAIAAARWPERTAIVDDDGALSYREIQTMTESVAGELTLAGIG-----
MUL_4827|M.ulcerans_Agy99 TPLAIAAARWPERTAIVDDDGALSYREIQTMTESVAGELTLAGIG-----
MAV_5220|M.avium_104 TLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARRLTRDGVA-----
Mb1462c|M.bovis_AF2122/97 AGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAG-----
Rv1427c|M.tuberculosis_H37Rv AGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAG-----
MSMEG_0304|M.smegmatis_MC2_155 SGFASAAQRCPDRPGLVDELGTLTWREIDQQADALAAGLQALSGG-----
Mflv_2427|M.gilvum_PYR-GCK VGFAAAAQRCPDRPGIIDELGTLTWKQLDDRCDALGVALQKE--------
Mvan_4225|M.vanbaalenii_PYR-1 VGFAAAAQRCPDLPGIIDELGTLTWKQLDDRCDALAAALQKH--------
TH_4130|M.thermoresistible__bu VGFAVAAQRCGDRIGLVDEIGELTWRELDDECNALAAALQDRAAGQGKDG
MLBr_02546|M.leprae_Br4923 MLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVR-----
MAB_2539c|M.abscessus_ATCC_199 MLLAASAIRFPDRAALIDDSGQLTYRDLQRRAEAVAAAVYARTPS-----
* .* * .::*: * *:::::: .::. :
MMAR_0296|M.marinum_M --PGQAVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRATALAAALEAH
MUL_4827|M.ulcerans_Agy99 --PGQAVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRATALAAALEAH
MAV_5220|M.avium_104 --PGRAVGVMCRNGRGFVTAVFAVTLLGADVVPISTEFRSDALAAALRAH
Mb1462c|M.bovis_AF2122/97 --PPRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTRE
Rv1427c|M.tuberculosis_H37Rv --PPRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTRE
MSMEG_0304|M.smegmatis_MC2_155 --APRVLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGPALAEVVSRE
Mflv_2427|M.gilvum_PYR-GCK --KPKTVAVMCRNHRGFVEALVAANRIGADVLLLNTSFAGPAMAEVVERE
Mvan_4225|M.vanbaalenii_PYR-1 --TPRTVAVMCRNHRGFVEALVGANRIGADVLLLNTSFAGPAMAEVIERE
TH_4130|M.thermoresistible__bu GKGRGAIGIMCRNHRGFIEALVAADRIGATVLLLNTSFAGPALAEVVDRE
MLBr_02546|M.leprae_Br4923 --GGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSERE
MAB_2539c|M.abscessus_ATCC_199 --APRSVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRH
:.::.** * * : . :** :: :.:.: : .
MMAR_0296|M.marinum_M QMRVMLCDDEFVDQVAGTGESVLVI--------------------DPSTV
MUL_4827|M.ulcerans_Agy99 QMRVMLCDDEFVDQVAGTGESVLVI--------------------DPSTV
MAV_5220|M.avium_104 HISTVVADNEFAERIAAADDAVAVI--------------------DPATA
Mb1462c|M.bovis_AF2122/97 GVDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD---EDHDL---TVEKL
Rv1427c|M.tuberculosis_H37Rv GVDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD---EDHDL---TVEKL
MSMEG_0304|M.smegmatis_MC2_155 KVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDT--AAHDV---TVAAL
Mflv_2427|M.gilvum_PYR-GCK GADIVIYDQEFTETVDRALADTCGA-RRIVAWVDDPAQAGTA---TVEAL
Mvan_4225|M.vanbaalenii_PYR-1 GADIVIYDQEFTATVDRALRDVPGT-TRILAWTD--ADDGST---TLEAL
TH_4130|M.thermoresistible__bu GVDTIVYDEEFTDIVDRALADRPTA-TRILAWVDEPASGPALPHPTVADL
MLBr_02546|M.leprae_Br4923 GAKVIIYDDEYTKVVSKAEPALGKL--RALGVNPDEEEPPGSTDETLAEL
MAB_2539c|M.abscessus_ATCC_199 EPDVLVYDDEYSQAVEESQYQGLRV----LAWRE----NPQENRLTLDSL
:: *:*: : :
MMAR_0296|M.marinum_M TARDCA-RPKVA----PSGRIVLLTSGTTGVPKGVPRKPKVSSGIGVSVT
MUL_4827|M.ulcerans_Agy99 TARDCA-RPKVA----PSGRIVLLTSGTTGVPKGVPRKPKVSSGIGVSAT
MAV_5220|M.avium_104 GAEESGGRPAVA----APGRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVT
Mb1462c|M.bovis_AF2122/97 VAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHSGG---GIGTLKA
Rv1427c|M.tuberculosis_H37Rv VAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHSGG---GIGTLKA
MSMEG_0304|M.smegmatis_MC2_155 TEKFAGRQPQR---GGQKSKVILLTSGTTGTPKGAKHSGG---GPEILKA
Mflv_2427|M.gilvum_PYR-GCK IDAHLGQRPQP---ATRKSDVILLTSGTTGSPKGAKRSAGS-GGSGDLKA
Mvan_4225|M.vanbaalenii_PYR-1 IDAHLGQRPEP---ATRKSDIILLTSGTTGTPKGAKRSAGS-GGASDLKA
TH_4130|M.thermoresistible__bu VAEHRGRRPAKPAAGDEGSRIILLTSGTTGTPKGARAASS--GGAGELAA
MLBr_02546|M.leprae_Br4923 IARSSSAPAPK---VRKRASIIILTSGTTGTPKGANRNTP--ASLAPLGG
MAB_2539c|M.abscessus_ATCC_199 ADQHHPKPPPVR----RPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVT
. : :******* .**.
MMAR_0296|M.marinum_M LLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTVLTRRHFDAEATL
MUL_4827|M.ulcerans_Agy99 LLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTVLTRRHFDAEATL
MAV_5220|M.avium_104 ILDRTRLRTGSRISVAMPMFHGLGLGMLMLTIALGGTVLTHRHFDAEAAL
Mb1462c|M.bovis_AF2122/97 ILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATL
Rv1427c|M.tuberculosis_H37Rv ILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATL
MSMEG_0304|M.smegmatis_MC2_155 ILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTIITRRKFDPEATL
Mflv_2427|M.gilvum_PYR-GCK VLDRTPWRAEEPIVIAAPMFHAWGFSQLLFAALLACPIVTRRKFDPAATL
Mvan_4225|M.vanbaalenii_PYR-1 VLDRTPWRAGEPIVIAAPMFHAWGFSQLLFAALLACPIVTRRKFDPEATL
TH_4130|M.thermoresistible__bu ILGRVPWRAEQTTVIAAPMFHAWGYSQLLFSALLACTIVTRRRFDPEATL
MLBr_02546|M.leprae_Br4923 ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVL
MAB_2539c|M.abscessus_ATCC_199 AMATVRLRSRDRVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAM
: . * . : *:**. * . :. .:: :*:*.. .:
MMAR_0296|M.marinum_M AQTSLHRADGLSVVPIMLARILDLPDQVRARNPLPCLRVVISSGDRLDPS
MUL_4827|M.ulcerans_Agy99 AQTSLHRADGLSVVPIMLARILDLPDQVRARNPLPCLRAVISSGDRLDPS
MAV_5220|M.avium_104 AQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLRVVMSSGDRLDPT
Mb1462c|M.bovis_AF2122/97 DLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPD
Rv1427c|M.tuberculosis_H37Rv DLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPD
MSMEG_0304|M.smegmatis_MC2_155 ELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLRFAAASGSRMRPD
Mflv_2427|M.gilvum_PYR-GCK ALVDKYRATGLAVVPVMFDRIMDLPDEVRNRYSGRSLRFATASGSRMRPD
Mvan_4225|M.vanbaalenii_PYR-1 ALIDRHRATGLAVVPVMFDRIMELPAEVRNRYSGRSLRFATASGSRMRPD
TH_4130|M.thermoresistible__bu QLVDRYRATGLVVVPVMLDRIMELPADVRDRYSGRSLRFVTASGSRMRPD
MLBr_02546|M.leprae_Br4923 EDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAE
MAB_2539c|M.abscessus_ATCC_199 TDIRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSS
:. : .**::: **: ** .. : .
MMAR_0296|M.marinum_M LARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPETVGRPVAGCPVR
MUL_4827|M.ulcerans_Agy99 LARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPETVGRPVAGCPVR
MAV_5220|M.avium_104 LGQRFMDTYGDILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVR
Mb1462c|M.bovis_AF2122/97 VVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGRPAEGTEIR
Rv1427c|M.tuberculosis_H37Rv VVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGRPAEGTEIR
MSMEG_0304|M.smegmatis_MC2_155 VVIAFMDRFGDVIYNNYNATEAGMIATATPADLRAAPDTAGRPAEGTEIR
Mflv_2427|M.gilvum_PYR-GCK VVTAFMDQFGDVIYNNYNATEAGMIATATPEDLRAAPDTAGKAADGTELR
Mvan_4225|M.vanbaalenii_PYR-1 VVTAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPDTAGRAADGTELR
TH_4130|M.thermoresistible__bu VVLDFMDRFGDVIYNNYNATEAGMIATATPADLRAAPSTAGKPADGTEIR
MLBr_02546|M.leprae_Br4923 LATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKGVKVK
MAB_2539c|M.abscessus_ATCC_199 TVSGVLEAFGPILVNGYGSTEAGVVAIASPKDLVASPNTIGRTALGVSVR
:: * :: * *.:** .. : * * :* . * * . * ::
MMAR_0296|M.marinum_M IFDRNGRPVGPRVTGRIFVGGELNSDGYS-----GGGGKAVIDGMASTGD
MUL_4827|M.ulcerans_Agy99 IFDRNGRPVGARVTGRIFVGGELNSDGYS-----GGGGKAVIDGMASTGD
MAV_5220|M.avium_104 ILDRNNRPVGPRVTGRIFVGGELAGTRYT-----DGGGKAVVDGMTSTGD
Mb1462c|M.bovis_AF2122/97 ILDQQFTEVPTGEVGTIYVRNDSQFDGYT-----SGAAKDFHAGFMSSGD
Rv1427c|M.tuberculosis_H37Rv ILDQQFTEVPTGEVGTIYVRNDSQFDGYT-----SGAAKDFHAGFMSSGD
MSMEG_0304|M.smegmatis_MC2_155 ILDGDLRDLPTGEVGTIYVRNSTQFDGYT-----SGTTKDFHEGFMCSGD
Mflv_2427|M.gilvum_PYR-GCK ILDAEHRELPTGEVGQIFVRSGTLFDGYT-----SGSTKDFHDGFMASGD
Mvan_4225|M.vanbaalenii_PYR-1 ILDAEHRDVPTGEVGQIFVRSSTLFDGYT-----SGTTKAFHDGFMASGD
TH_4130|M.thermoresistible__bu ILDDALRPVPTGEVGQIFVRSNTLFDGYT-----SGTTKDFHEGFMASGD
MLBr_02546|M.leprae_Br4923 ILDDSGKEVPRGQVGRIFVGNAFPFEGYT-----GGGGKQIIDGLLSSGD
MAB_2539c|M.abscessus_ATCC_199 ILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHVNTGD
*: .* *:* . *: * . * :**
MMAR_0296|M.marinum_M MGYLDESGRLYIVGREDDMIVSGGENVYPRSLENALASHPDVAENAVIGV
MUL_4827|M.ulcerans_Agy99 MGYLDESGRLYIVGREDDMIVSGGENVYPRSLENALASHPDVAENAVIGV
MAV_5220|M.avium_104 MGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGV
Mb1462c|M.bovis_AF2122/97 VGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGV
Rv1427c|M.tuberculosis_H37Rv VGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGV
MSMEG_0304|M.smegmatis_MC2_155 VGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVAEAAVIGV
Mflv_2427|M.gilvum_PYR-GCK LGYLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKTLMSHPEVAEATVLGV
Mvan_4225|M.vanbaalenii_PYR-1 MGYLDGAGRLFVVGRDDEMIVSGGENVYPIEVEKTLTTHAAVAEAAVLGV
TH_4130|M.thermoresistible__bu LGRLDEDGRLFVVGRDDEMIVSGGENVYPIEVEQVLARHPDVAEATVIGV
MLBr_02546|M.leprae_Br4923 VGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGV
MAB_2539c|M.abscessus_ATCC_199 MGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGV
:* :* . *:: **.*:**:*****::* :*. : :. :.: ..:**
MMAR_0296|M.marinum_M ADEQFGQRLAAFVVARPGC-DIDADAIRDYLKGRVSRFEQPRDIHLVSSI
MUL_4827|M.ulcerans_Agy99 ADEQFGQRLAAFVVARPGC-DIDADAIRDYLKGRVSRFEQPRDIYLVSSI
MAV_5220|M.avium_104 PDERFGHRLAAFVVLHPGS-GVDAAQLRDYLKDRVSRFEQPRDINIVASI
Mb1462c|M.bovis_AF2122/97 DDQQYGQRLAAFVVLKPGV-SATPETLKQHVRDNLANYKVPRDIAVLDEL
Rv1427c|M.tuberculosis_H37Rv DDQQYGQRLAAFVVLKPGV-SATPETLKQHVRDNLANYKVPRDIAVLDEL
MSMEG_0304|M.smegmatis_MC2_155 DDEQFGQRLAAFVVLSG---DATVDDLKSHVRDNLANYKVPRDITILDEL
Mflv_2427|M.gilvum_PYR-GCK EDSEYGQRLAAFVVLTDGS-GLTPEDLKQHVRANLANYKVPRDITILPEL
Mvan_4225|M.vanbaalenii_PYR-1 DDEQYGQRLAAFVVPAAGA-SVTVEELKQHVRENLANYKVPRDITIMAEL
TH_4130|M.thermoresistible__bu DDEQFGQRLAAFVVLRDGA-GATPDGLKQHVRDNLANYKVPRSISVLDEL
MLBr_02546|M.leprae_Br4923 DDKEWGARLRAFVVKKQDA-TIDEDAIKAYVRDHLARYKVPREVIFLEEL
MAB_2539c|M.abscessus_ATCC_199 PDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEI
*. :* * **** :: ::: : .:: *: . .: .:
MMAR_0296|M.marinum_M PRNPAGKVLRKQLASYAEPEAQS
MUL_4827|M.ulcerans_Agy99 PRNPAGKVLRKQLASYAEPEAQS
MAV_5220|M.avium_104 PRNPTGKVLRKELPG--------
Mb1462c|M.bovis_AF2122/97 PRGITGKILRTELQSRVGS----
Rv1427c|M.tuberculosis_H37Rv PRGITGKILRTELQSRVGS----
MSMEG_0304|M.smegmatis_MC2_155 PRNSTGKIARRELQEKVNG----
Mflv_2427|M.gilvum_PYR-GCK PRGSTGKILRNELRGS-------
Mvan_4225|M.vanbaalenii_PYR-1 PRGSTGKILRNELRGR-------
TH_4130|M.thermoresistible__bu PRGSTGKILRTELQARAQSG---
MLBr_02546|M.leprae_Br4923 PRNPTGKVLKRELRDFEVH----
MAB_2539c|M.abscessus_ATCC_199 PRNASGKVLRAKLNSPGAC----
**. :**: : :*