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MMAAGVVTTAARALLGSGLLSPSSPAAALRLVRELYRGGTNLYTPLAIAAARWPERTAIVDDDGALSYRE IQTMTESVAGELTLAGIGPGQAVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRATALAAALEAHQMRV MLCDDEFVDQVAGTGESVLVIDPSTVTARDCARPKVAPSGRIVLLTSGTTGVPKGVPRKPKVSSGIGVSV TLLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTVLTRRHFDAEATLAQTSLHRADGLSVVPIMLA RILDLPDQVRARNPLPCLRVVISSGDRLDPSLARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPET VGRPVAGCPVRIFDRNGRPVGPRVTGRIFVGGELNSDGYSGGGGKAVIDGMASTGDMGYLDESGRLYIVG REDDMIVSGGENVYPRSLENALASHPDVAENAVIGVADEQFGQRLAAFVVARPGCDIDADAIRDYLKGRV SRFEQPRDIHLVSSIPRNPAGKVLRKQLASYAEPEAQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0296 | fadD12_2 | - | 100% (528) | long-chain-fatty-acid--CoA ligase FadD12_2 |
| M. marinum M | MMAR_2233 | fadD12 | e-110 | 41.28% (533) | long-chain-fatty-acid--CoA ligase FadD12 |
| M. marinum M | MMAR_0528 | fadD2 | 5e-95 | 35.04% (528) | fatty-acid-CoA ligase FadD2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 1e-112 | 42.03% (533) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0435 | - | 1e-104 | 40.11% (536) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 1e-112 | 42.03% (533) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-98 | 36.98% (530) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 1e-103 | 39.10% (532) | acyl-CoA synthetase |
| M. avium 104 | MAV_5220 | - | 0.0 | 71.40% (514) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0304 | - | 1e-104 | 39.92% (531) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4130 | - | 1e-107 | 40.88% (543) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 0.0 | 99.24% (528) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4225 | - | 1e-102 | 40.94% (530) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0296|M.marinum_M ----------------MMAAGVVTTAARALLGSGLLSPSSPAAALRLVRE
MUL_4827|M.ulcerans_Agy99 ----------------MMAAGVVTTAARALLGSGLLSPSSPAAALRLVRE
MAV_5220|M.avium_104 -----------------MAP----TAARALVRSGLLNPPSPRAVLRLLRE
Mb1462c|M.bovis_AF2122/97 ---------MR--------IRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
Rv1427c|M.tuberculosis_H37Rv ---------MR--------IRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
Mflv_0435|M.gilvum_PYR-GCK ---------MG----ITDPVTNALGLISTMMRAGVIAPMRPDKYMRIVGA
MSMEG_0304|M.smegmatis_MC2_155 ---------MGLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAA
Mvan_4225|M.vanbaalenii_PYR-1 -------------------MADPLGLLATLWRARLIAPMRPDRYLRMGLA
TH_4130|M.thermoresistible__bu -------------------MAKTIDTLRTLTRAGLIAPLRPDKYLRMTAA
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MAB_4340c|M.abscessus_ATCC_199 MSITAERPLFSKLQTLAKRGGAELHYLRKVIEAGMLKLDPPNVLAGLVRD
: : : * :
MMAR_0296|M.marinum_M LYRGGTNLYTPLAIAAARWPERTAIVDDDGALSYREIQTMTESVAGELTL
MUL_4827|M.ulcerans_Agy99 LYRGGTNLYTPLAIAAARWPERTAIVDDDGALSYREIQTMTESVAGELTL
MAV_5220|M.avium_104 ASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARRLTR
Mb1462c|M.bovis_AF2122/97 MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
Rv1427c|M.tuberculosis_H37Rv MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
Mflv_0435|M.gilvum_PYR-GCK MQRENMAITSGFAAAAQRCPDRAGLVDELGILTWRQIDQRADALAAALQA
MSMEG_0304|M.smegmatis_MC2_155 MARENMSVTSGFASAAQRCPDRPGLVDELGTLTWREIDQQADALAAGLQA
Mvan_4225|M.vanbaalenii_PYR-1 MRRAGLTATVGFAAAAQRCPDLPGIIDELGTLTWKQLDDRCDALAAALQK
TH_4130|M.thermoresistible__bu VRRTGVSVTVGFAVAAQRCGDRIGLVDEIGELTWRELDDECNALAAALQD
MLBr_02546|M.leprae_Br4923 MRKWG-DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIA
MAB_4340c|M.abscessus_ATCC_199 FYRFG-EIGAVPAFGAHRSPSRTAIIDDEGSITYAELNDAVNALAHGLNR
: . * * * .::*: * ::: ::: .::* *
MMAR_0296|M.marinum_M AGIGP-------GQAVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRAT
MUL_4827|M.ulcerans_Agy99 AGIGP-------GQAVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRAT
MAV_5220|M.avium_104 DGVAP-------GRAVGVMCRNGRGFVTAVFAVTLLGADVVPISTEFRSD
Mb1462c|M.bovis_AF2122/97 LPAGP-------PRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
Rv1427c|M.tuberculosis_H37Rv LPAGP-------PRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
Mflv_0435|M.gilvum_PYR-GCK LPEGQ-------PEVIGLMARNHRGFVDSLIAANRIGADVLLLNTSFAGP
MSMEG_0304|M.smegmatis_MC2_155 LSGGA-------PRVLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGP
Mvan_4225|M.vanbaalenii_PYR-1 HT----------PRTVAVMCRNHRGFVEALVGANRIGADVLLLNTSFAGP
TH_4130|M.thermoresistible__bu RAAGQGKDGGKGRGAIGIMCRNHRGFIEALVAADRIGATVLLLNTSFAGP
MLBr_02546|M.leprae_Br4923 KGVRG-------GDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGP
MAB_4340c|M.abscessus_ATCC_199 LGIKG-------GDGVAILARNHRWFIIANYAAHRAGARVILLNTDFSGP
:.::.** * *: : . ** :: :.:.* .
MMAR_0296|M.marinum_M ALAAALEAHQ---MRVMLCDDEFVDQVAGTGES--------VLVIDPSTV
MUL_4827|M.ulcerans_Agy99 ALAAALEAHQ---MRVMLCDDEFVDQVAGTGES--------VLVIDPSTV
MAV_5220|M.avium_104 ALAAALRAHH---ISTVVADNEFAERIAAADDA--------VAVIDPATA
Mb1462c|M.bovis_AF2122/97 ALAEVVTREG---VDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD-EDH
Rv1427c|M.tuberculosis_H37Rv ALAEVVTREG---VDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD-EDH
Mflv_0435|M.gilvum_PYR-GCK ALAEVLQREGEGRAVAVIYDEEFTETVDRAVADRPET-TRILAWTDSDTD
MSMEG_0304|M.smegmatis_MC2_155 ALAEVVSRE---KVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDTAAH
Mvan_4225|M.vanbaalenii_PYR-1 AMAEVIEREG---ADIVIYDQEFTATVDRALRDVPGT-TRILAWTDADDG
TH_4130|M.thermoresistible__bu ALAEVVDREG---VDTIVYDEEFTDIVDRALADRPTA-TRILAWVDEPAS
MLBr_02546|M.leprae_Br4923 QIKEVSEREG---AKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPP
MAB_4340c|M.abscessus_ATCC_199 QTKEVAEREG---ARVLIYDAEYAEFLDGYSPELGRIMALPTNPDNPDQP
. . :: * *: : :
MMAR_0296|M.marinum_M T------------ARDCA-RPKVA----PSGRIVLLTSGTTGVPKGVPRK
MUL_4827|M.ulcerans_Agy99 T------------ARDCA-RPKVA----PSGRIVLLTSGTTGVPKGVPRK
MAV_5220|M.avium_104 G------------AEESGGRPAVA----APGRIVLLTSGTTGKPKGVPRA
Mb1462c|M.bovis_AF2122/97 D-----LTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHS
Rv1427c|M.tuberculosis_H37Rv D-----LTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHS
Mflv_0435|M.gilvum_PYR-GCK A-----LTVEGLIAEHGGQEPVR---SVEKARVILLTSGTTGTPKGAKHS
MSMEG_0304|M.smegmatis_MC2_155 D-----VTVAALTEKFAGRQPQR---GGQKSKVILLTSGTTGTPKGAKHS
Mvan_4225|M.vanbaalenii_PYR-1 S-----TTLEALIDAHLGQRPEP---ATRKSDIILLTSGTTGTPKGAKRS
TH_4130|M.thermoresistible__bu GPALPHPTVADLVAEHRGRRPAKPAAGDEGSRIILLTSGTTGTPKGARAA
MLBr_02546|M.leprae_Br4923 GS--TDETLAELIARSSSAPAPKV---RKRASIIILTSGTTGTPKGANRN
MAB_4340c|M.abscessus_ATCC_199 AS--TDETIASVIKRNSTSPAPRP---SKYSSLVILTSGTTGTPKGAPRK
. . :::******* ***.
MMAR_0296|M.marinum_M PKVSSGIGVSVTLLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTV
MUL_4827|M.ulcerans_Agy99 PKVSSGIGVSATLLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTV
MAV_5220|M.avium_104 PQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGMLMLTIALGGTV
Mb1462c|M.bovis_AF2122/97 GG---GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTI
Rv1427c|M.tuberculosis_H37Rv GG---GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTI
Mflv_0435|M.gilvum_PYR-GCK GG---DPGVLKSILDRTPWRAEQPVVIVAPMFHAWGFSQLAFAASMSCTI
MSMEG_0304|M.smegmatis_MC2_155 GG---GPEILKAILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTI
Mvan_4225|M.vanbaalenii_PYR-1 AGS-GGASDLKAVLDRTPWRAGEPIVIAAPMFHAWGFSQLLFAALLACPI
TH_4130|M.thermoresistible__bu SS--GGAGELAAILGRVPWRAEQTTVIAAPMFHAWGYSQLLFSALLACTI
MLBr_02546|M.leprae_Br4923 TP--ASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTL
MAB_4340c|M.abscessus_ATCC_199 LA--LTLAPVGGMFSHVPFRSGEVTSVPAPMFHALGYLHQSLALTLGCTL
:: :. * . : ****. * :: :. .:
MMAR_0296|M.marinum_M LTRRHFDAEATLAQTSLHRADGLSVVPIMLARILDLPDQVRARNPLPCLR
MUL_4827|M.ulcerans_Agy99 LTRRHFDAEATLAQTSLHRADGLSVVPIMLARILDLPDQVRARNPLPCLR
MAV_5220|M.avium_104 LTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLR
Mb1462c|M.bovis_AF2122/97 VTRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLR
Rv1427c|M.tuberculosis_H37Rv VTRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLR
Mflv_0435|M.gilvum_PYR-GCK ITRRKFDPEATLELVDKFRATGLCVVPVMFDRIMELPEEVLDKYSGRSLR
MSMEG_0304|M.smegmatis_MC2_155 ITRRKFDPEATLELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLR
Mvan_4225|M.vanbaalenii_PYR-1 VTRRKFDPEATLALIDRHRATGLAVVPVMFDRIMELPAEVRNRYSGRSLR
TH_4130|M.thermoresistible__bu VTRRRFDPEATLQLVDRYRATGLVVVPVMLDRIMELPADVRDRYSGRSLR
MLBr_02546|M.leprae_Br4923 VLRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLR
MAB_4340c|M.abscessus_ATCC_199 ILRRKFKPENVLADVEKFKVTAIVVVPVMLNRLLNALDELSVKPDLSSLR
: :*:*.. .* . .:. .: .**::: *::: : : **
MMAR_0296|M.marinum_M VVISSGDRLDPSLARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPE
MUL_4827|M.ulcerans_Agy99 AVISSGDRLDPSLARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPE
MAV_5220|M.avium_104 VVMSSGDRLDPTLGQRFMDTYGDILYNGYGSTEVGIGALATPADLRDAPE
Mb1462c|M.bovis_AF2122/97 FAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPD
Rv1427c|M.tuberculosis_H37Rv FAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPD
Mflv_0435|M.gilvum_PYR-GCK FAAASGSRMRPDIVIKFMDRFGDVIYNNYNATEAGMIATATPRDLRAAPD
MSMEG_0304|M.smegmatis_MC2_155 FAAASGSRMRPDVVIAFMDRFGDVIYNNYNATEAGMIATATPADLRAAPD
Mvan_4225|M.vanbaalenii_PYR-1 FATASGSRMRPDVVTAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPD
TH_4130|M.thermoresistible__bu FVTASGSRMRPDVVLDFMDRFGDVIYNNYNATEAGMIATATPADLRAAPS
MLBr_02546|M.leprae_Br4923 VVFVSGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSA
MAB_4340c|M.abscessus_ATCC_199 IVFVSGSQLGGELASRAMDTLGPVIYNLYGSTEVAFATIARPQDLAINPS
. **.:: : :: * ::** *.:** .: : * * :* .
MMAR_0296|M.marinum_M TVGRPVAGCPVRIFDRNGRPVGPRVTGRIFVGGELNSDGYSGGGGKAVID
MUL_4827|M.ulcerans_Agy99 TVGRPVAGCPVRIFDRNGRPVGARVTGRIFVGGELNSDGYSGGGGKAVID
MAV_5220|M.avium_104 TVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKAVVD
Mb1462c|M.bovis_AF2122/97 TAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHA
Rv1427c|M.tuberculosis_H37Rv TAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHA
Mflv_0435|M.gilvum_PYR-GCK TAGRPAEGTEIKILDSEFNEVPTGETGGIWVRNSTQFDGYTSGSTKDFHD
MSMEG_0304|M.smegmatis_MC2_155 TAGRPAEGTEIRILDGDLRDLPTGEVGTIYVRNSTQFDGYTSGTTKDFHE
Mvan_4225|M.vanbaalenii_PYR-1 TAGRAADGTELRILDAEHRDVPTGEVGQIFVRSSTLFDGYTSGTTKAFHD
TH_4130|M.thermoresistible__bu TAGKPADGTEIRILDDALRPVPTGEVGQIFVRSNTLFDGYTSGTTKDFHE
MLBr_02546|M.leprae_Br4923 TVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIID
MAB_4340c|M.abscessus_ATCC_199 TVGPVVKGATVKILDDEGKPVSQGTVGRIFVSNAIPFDGYTGGGHKQIID
*.* . * ::*:* : .* *:* . *:.* * .
MMAR_0296|M.marinum_M GMASTGDMGYLDESGRLYIVGREDDMIVSGGENVYPRSLENALASHPDVA
MUL_4827|M.ulcerans_Agy99 GMASTGDMGYLDESGRLYIVGREDDMIVSGGENVYPRSLENALASHPDVA
MAV_5220|M.avium_104 GMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVA
Mb1462c|M.bovis_AF2122/97 GFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVA
Rv1427c|M.tuberculosis_H37Rv GFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVA
Mflv_0435|M.gilvum_PYR-GCK GFMSSGDVGYLDEEGRLFVVGRDDEMIVSGGENVYPIEVEKTLTSHPDVA
MSMEG_0304|M.smegmatis_MC2_155 GFMCSGDVGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVA
Mvan_4225|M.vanbaalenii_PYR-1 GFMASGDMGYLDGAGRLFVVGRDDEMIVSGGENVYPIEVEKTLTTHAAVA
TH_4130|M.thermoresistible__bu GFMASGDLGRLDEDGRLFVVGRDDEMIVSGGENVYPIEVEQVLARHPDVA
MLBr_02546|M.leprae_Br4923 GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
MAB_4340c|M.abscessus_ATCC_199 GLMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPEVI
*: .:**:* :* . *:: **:*:**:*****::* :*. :: *. *
MMAR_0296|M.marinum_M ENAVIGVADEQFGQRLAAFVVARPGCDIDADAIRDYLKGRVSRFEQPRDI
MUL_4827|M.ulcerans_Agy99 ENAVIGVADEQFGQRLAAFVVARPGCDIDADAIRDYLKGRVSRFEQPRDI
MAV_5220|M.avium_104 DNAVIGVPDERFGHRLAAFVVLHPGSGVDAAQLRDYLKDRVSRFEQPRDI
Mb1462c|M.bovis_AF2122/97 EAAVIGVDDQQYGQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDI
Rv1427c|M.tuberculosis_H37Rv EAAVIGVDDQQYGQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDI
Mflv_0435|M.gilvum_PYR-GCK EATVLGVDDEKFGQRLAAFVVLNPGAAATPEALKQHVRDNLANYKVPREI
MSMEG_0304|M.smegmatis_MC2_155 EAAVIGVDDEQFGQRLAAFVVLSG--DATVDDLKSHVRDNLANYKVPRDI
Mvan_4225|M.vanbaalenii_PYR-1 EAAVLGVDDEQYGQRLAAFVVPAAGASVTVEELKQHVRENLANYKVPRDI
TH_4130|M.thermoresistible__bu EATVIGVDDEQFGQRLAAFVVLRDGAGATPDGLKQHVRDNLANYKVPRSI
MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV
MAB_4340c|M.abscessus_ATCC_199 EATALGVDDPEWGARLRAFVVRHPDSTVDADGIRAYVRDNLARYKVPRDV
: :.:** * .:* ** **** :: ::: .::.:: **.:
MMAR_0296|M.marinum_M HLVSSIPRNPAGKVLRKQLASYAEPEAQS
MUL_4827|M.ulcerans_Agy99 YLVSSIPRNPAGKVLRKQLASYAEPEAQS
MAV_5220|M.avium_104 NIVASIPRNPTGKVLRKELPG--------
Mb1462c|M.bovis_AF2122/97 AVLDELPRGITGKILRTELQSRVGS----
Rv1427c|M.tuberculosis_H37Rv AVLDELPRGITGKILRTELQSRVGS----
Mflv_0435|M.gilvum_PYR-GCK TVLDELPRSITGKISRKDLKDRLDNA---
MSMEG_0304|M.smegmatis_MC2_155 TILDELPRNSTGKIARRELQEKVNG----
Mvan_4225|M.vanbaalenii_PYR-1 TIMAELPRGSTGKILRNELRGR-------
TH_4130|M.thermoresistible__bu SVLDELPRGSTGKILRTELQARAQSG---
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH----
MAB_4340c|M.abscessus_ATCC_199 VFLDVLPRNPSGKILKRELRELEV-----
.: :**. :**: : :*