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MSSAADQFGLLATLWRARLIAPMRPDRYLRMGLAMRRAGLTATVGFAAAAQRCPDRPGIIDELGTLTWKQ LDDRCDALGVALQKEKPKTVAVMCRNHRGFVEALVAANRIGADVLLLNTSFAGPAMAEVVEREGADIVIY DQEFTETVDRALADTCGARRIVAWVDDPAQAGTATVEALIDAHLGQRPQPATRKSDVILLTSGTTGSPKG AKRSAGSGGSGDLKAVLDRTPWRAEEPIVIAAPMFHAWGFSQLLFAALLACPIVTRRKFDPAATLALVDK YRATGLAVVPVMFDRIMDLPDEVRNRYSGRSLRFATASGSRMRPDVVTAFMDQFGDVIYNNYNATEAGMI ATATPEDLRAAPDTAGKAADGTELRILDAEHRELPTGEVGQIFVRSGTLFDGYTSGSTKDFHDGFMASGD LGYLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKTLMSHPEVAEATVLGVEDSEYGQRLAAFVVLTDGSG LTPEDLKQHVRANLANYKVPRDITILPELPRGSTGKILRNELRGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2427 | - | - | 100% (535) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0435 | - | 0.0 | 71.00% (531) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0341 | - | e-111 | 43.90% (492) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 0.0 | 72.02% (529) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 0.0 | 72.02% (529) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-112 | 42.72% (515) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 1e-107 | 43.90% (492) | acyl-CoA synthetase |
| M. marinum M | MMAR_2233 | fadD12 | 0.0 | 72.46% (541) | long-chain-fatty-acid--CoA ligase FadD12 |
| M. avium 104 | MAV_3349 | - | 0.0 | 74.77% (444) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0304 | - | 0.0 | 70.86% (532) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4130 | - | 0.0 | 71.99% (539) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 1e-104 | 42.86% (490) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4225 | - | 0.0 | 87.74% (530) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2427|M.gilvum_PYR-GCK ----------------MSSAADQFGLLATLWRARLIAPMRPDRYLRMGLA
Mvan_4225|M.vanbaalenii_PYR-1 -------------------MADPLGLLATLWRARLIAPMRPDRYLRMGLA
Mb1462c|M.bovis_AF2122/97 -----------------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
Rv1427c|M.tuberculosis_H37Rv -----------------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
MMAR_2233|M.marinum_M ---------------MAPRIDQILGLITTLARSGLIAPMRPDRYLKIAAA
MAV_3349|M.avium_104 --------------------------------------------------
MSMEG_0304|M.smegmatis_MC2_155 ---------MGLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAA
TH_4130|M.thermoresistible__bu -------------------MAKTIDTLRTLTRAGLIAPLRPDKYLRMTAA
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
MAB_4340c|M.abscessus_ATCC_199 MSITAERPLFSKLQTLAKRGGAELHYLRKVIEAGMLKLDPPNVLAGLVRD
Mflv_2427|M.gilvum_PYR-GCK MRRAGLTATVGFAAAAQRCPDRPGIIDELGTLTWKQLDDRCDALGVALQK
Mvan_4225|M.vanbaalenii_PYR-1 MRRAGLTATVGFAAAAQRCPDLPGIIDELGTLTWKQLDDRCDALAAALQK
Mb1462c|M.bovis_AF2122/97 MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
Rv1427c|M.tuberculosis_H37Rv MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
MMAR_2233|M.marinum_M MRREGMGFTAGFAAAAQRCPDRPGLVDELGTLTWRQLDERSNALAAALQA
MAV_3349|M.avium_104 --------------------------------------------------
MSMEG_0304|M.smegmatis_MC2_155 MARENMSVTSGFASAAQRCPDRPGLVDELGTLTWREIDQQADALAAGLQA
TH_4130|M.thermoresistible__bu VRRTGVSVTVGFAVAAQRCGDRIGLVDEIGELTWRELDDECNALAAALQD
MLBr_02546|M.leprae_Br4923 MRKWG-DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIA
MUL_1191|M.ulcerans_Agy99 IAKWG-EFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAGHAVANALLA
MAB_4340c|M.abscessus_ATCC_199 FYRFG-EIGAVPAFGAHRSPSRTAIIDDEGSITYAELNDAVNALAHGLNR
Mflv_2427|M.gilvum_PYR-GCK E----------KPKTVAVMCRNHRGFVEALVAANRIGADVLLLNTSFAGP
Mvan_4225|M.vanbaalenii_PYR-1 H----------TPRTVAVMCRNHRGFVEALVGANRIGADVLLLNTSFAGP
Mb1462c|M.bovis_AF2122/97 LPAG-------PPRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
Rv1427c|M.tuberculosis_H37Rv LPAG-------PPRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
MMAR_2233|M.marinum_M LPAG-------SPKVVGIMCRNHRGFVEALVAANRIGADILLLNTAFAGP
MAV_3349|M.avium_104 --------------MIGIMCRNHRGFVEAPVAADRIGADIVLLNTSFAGP
MSMEG_0304|M.smegmatis_MC2_155 LSGG-------APRVLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGP
TH_4130|M.thermoresistible__bu RAAGQGKDGGKGRGAIGIMCRNHRGFIEALVAADRIGATVLLLNTSFAGP
MLBr_02546|M.leprae_Br4923 KGVR-------GGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGP
MUL_1191|M.ulcerans_Agy99 KGVS-------AGDGVAILARNHRWFLIANYGAARAGARIILLNSEFSGP
MAB_4340c|M.abscessus_ATCC_199 LGIK-------GGDGVAILARNHRWFIIANYAAHRAGARVILLNTDFSGP
:.::.**** *: : . * ** ::***: *:**
Mflv_2427|M.gilvum_PYR-GCK AMAEVVEREGADIVIYDQEFTETVDRALADTCGA-RRIVAWVDDPA---Q
Mvan_4225|M.vanbaalenii_PYR-1 AMAEVIEREGADIVIYDQEFTATVDRALRDVPGT-TRILAWTD--A---D
Mb1462c|M.bovis_AF2122/97 ALAEVVTREGVDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD------E
Rv1427c|M.tuberculosis_H37Rv ALAEVVTREGVDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD------E
MMAR_2233|M.marinum_M ALADVVAREGVDTVIYDEEFTATVDRAFDGRPQA-TRIVAWSD------G
MAV_3349|M.avium_104 ALADVITREGVDAVIYDEEFTATVDRALAGRPDA-IRIVAWTD------T
MSMEG_0304|M.smegmatis_MC2_155 ALAEVVSREKVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDT-----A
TH_4130|M.thermoresistible__bu ALAEVVDREGVDTIVYDEEFTDIVDRALADRPTA-TRILAWVDEPASGPA
MLBr_02546|M.leprae_Br4923 QIKEVSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEP--PG
MUL_1191|M.ulcerans_Agy99 QIKEVSEREGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEED--SG
MAB_4340c|M.abscessus_ATCC_199 QTKEVAEREGARVLIYDAEYAEFLDGYSPELGRIMALPTNPDNPDQ--PA
:* ** . ::** *:: :. .
Mflv_2427|M.gilvum_PYR-GCK AGTATVEALIDAHLGQRPQP---ATRKSDVILLTSGTTGSPKGAKRSAGS
Mvan_4225|M.vanbaalenii_PYR-1 DGSTTLEALIDAHLGQRPEP---ATRKSDIILLTSGTTGTPKGAKRSAGS
Mb1462c|M.bovis_AF2122/97 DHDLTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHSGG-
Rv1427c|M.tuberculosis_H37Rv DHDLTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHSGG-
MMAR_2233|M.marinum_M QHDLTVEQLVNAHLGDQPER---TGRTGRLILLTSGTTGTPKGAKHSGGS
MAV_3349|M.avium_104 EHQHTVDKLIASKAGAQPIR---TGRKGKMILLTSGTTGTPKGAKQSGGN
MSMEG_0304|M.smegmatis_MC2_155 AHDVTVAALTEKFAGRQPQR---GGQKSKVILLTSGTTGTPKGAKHSGG-
TH_4130|M.thermoresistible__bu LPHPTVADLVAEHRGRRPAKPAAGDEGSRIILLTSGTTGTPKGAR-AASS
MLBr_02546|M.leprae_Br4923 STDETLAELIARSSSAPAPK---VRKRASIIILTSGTTGTPKGANRNTP-
MUL_1191|M.ulcerans_Agy99 STDETLAELIARSSTAPAPK---AGKHASIIILTSGTTGTPKGANRSTP-
MAB_4340c|M.abscessus_ATCC_199 STDETIASVIKRNSTSPAPR---PSKYSSLVILTSGTTGTPKGAPRKLA-
*: : . . :::*******:****
Mflv_2427|M.gilvum_PYR-GCK GGSGDLKAVLDRTPWRAEEPIVIAAPMFHAWGFSQLLFAALLACPIVTRR
Mvan_4225|M.vanbaalenii_PYR-1 GGASDLKAVLDRTPWRAGEPIVIAAPMFHAWGFSQLLFAALLACPIVTRR
Mb1462c|M.bovis_AF2122/97 -GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRR
Rv1427c|M.tuberculosis_H37Rv -GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRR
MMAR_2233|M.marinum_M GGIGTLKAILDRTPWRAEQPIVIVAPMFHAWGFSQLVLAASLACTIVTRR
MAV_3349|M.avium_104 AGIGTLKAILDRTPWRAEEPVVIVAPMFHAWGFSQLLLAASFACPVITRR
MSMEG_0304|M.smegmatis_MC2_155 -GPEILKAILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTIITRR
TH_4130|M.thermoresistible__bu GGAGELAAILGRVPWRAEQTTVIAAPMFHAWGYSQLLFSALLACTIVTRR
MLBr_02546|M.leprae_Br4923 ASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRR
MUL_1191|M.ulcerans_Agy99 PTLAPVGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLRR
MAB_4340c|M.abscessus_ATCC_199 LTLAPVGGMFSHVPFRSGEVTSVPAPMFHALGYLHQSLALTLGCTLILRR
: .::.:.*::: : : ****** *: : :: :...:: **
Mflv_2427|M.gilvum_PYR-GCK KFDPAATLALVDKYRATGLAVVPVMFDRIMDLPDEVRNRYSGRSLRFATA
Mvan_4225|M.vanbaalenii_PYR-1 KFDPEATLALIDRHRATGLAVVPVMFDRIMELPAEVRNRYSGRSLRFATA
Mb1462c|M.bovis_AF2122/97 RFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAA
Rv1427c|M.tuberculosis_H37Rv RFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAA
MMAR_2233|M.marinum_M KFDPEATLDLIDRHRATGLVVVPVMFDRIMELPTKVLNRYSGRTLRFAAA
MAV_3349|M.avium_104 KFDPEATLDLIDRHRATGLVVVPVMFDRIMDLPAEVRRRYECRSLRFAAA
MSMEG_0304|M.smegmatis_MC2_155 KFDPEATLELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLRFAAA
TH_4130|M.thermoresistible__bu RFDPEATLQLVDRYRATGLVVVPVMLDRIMELPADVRDRYSGRSLRFVTA
MLBr_02546|M.leprae_Br4923 RFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFV
MUL_1191|M.ulcerans_Agy99 KFKPQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFV
MAB_4340c|M.abscessus_ATCC_199 KFKPENVLADVEKFKVTAIVVVPVMLNRLLNALDELSVKPDLSSLRIVFV
:*.* .* :::.:.*.: *****:.*::: .: : . :*:.. .
Mflv_2427|M.gilvum_PYR-GCK SGSRMRPDVVTAFMDQFGDVIYNNYNATEAGMIATATPEDLRAAPDTAGK
Mvan_4225|M.vanbaalenii_PYR-1 SGSRMRPDVVTAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPDTAGR
Mb1462c|M.bovis_AF2122/97 SGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGR
Rv1427c|M.tuberculosis_H37Rv SGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGR
MMAR_2233|M.marinum_M SGSRMRPDVVVAFMNRFGDVIYNNYNATEAGMIATATPADLRAAPDTAGR
MAV_3349|M.avium_104 SGSRMRPDVVVAFMDEFGDVIYNNYNATEAGMIATATPADLRAAPDTAGR
MSMEG_0304|M.smegmatis_MC2_155 SGSRMRPDVVIAFMDRFGDVIYNNYNATEAGMIATATPADLRAAPDTAGR
TH_4130|M.thermoresistible__bu SGSRMRPDVVLDFMDRFGDVIYNNYNATEAGMIATATPADLRAAPSTAGK
MLBr_02546|M.leprae_Br4923 SGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGP
MUL_1191|M.ulcerans_Agy99 SGSQLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVGP
MAB_4340c|M.abscessus_ATCC_199 SGSQLGGELASRAMDTLGPVIYNLYGSTEVAFATIARPQDLAINPSTVGP
***:: ::. :. :* **** *.:** .: : * * ** . *.*
Mflv_2427|M.gilvum_PYR-GCK AADGTELRILDAEHRELPTGEVGQIFVRSGTLFDGYTSGSTKDFHDGFMA
Mvan_4225|M.vanbaalenii_PYR-1 AADGTELRILDAEHRDVPTGEVGQIFVRSSTLFDGYTSGTTKAFHDGFMA
Mb1462c|M.bovis_AF2122/97 PAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHAGFMS
Rv1427c|M.tuberculosis_H37Rv PAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHAGFMS
MMAR_2233|M.marinum_M PAEGTEIRILDQEFNEVPEGEVGSIFVCNDSQFDGYTSGTTKDFHAGFMS
MAV_3349|M.avium_104 PAGGTEIRILDPEFNELPAGEVGTIYVRNNTQFDGYTSGSSKDFHEGFMS
MSMEG_0304|M.smegmatis_MC2_155 PAEGTEIRILDGDLRDLPTGEVGTIYVRNSTQFDGYTSGTTKDFHEGFMC
TH_4130|M.thermoresistible__bu PADGTEIRILDDALRPVPTGEVGQIFVRSNTLFDGYTSGTTKDFHEGFMA
MLBr_02546|M.leprae_Br4923 VVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDGLLS
MUL_1191|M.ulcerans_Agy99 VVKGVKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGGGHKQIIDGLMS
MAB_4340c|M.abscessus_ATCC_199 VVKGATVKILDDEGKPVSQGTVGRIFVSNAIPFDGYTGGGHKQIIDGLMS
. *. ::*** :. * ** *:* . *:***.* * : *::.
Mflv_2427|M.gilvum_PYR-GCK SGDLGYLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKTLMSHPEVAEATV
Mvan_4225|M.vanbaalenii_PYR-1 SGDMGYLDGAGRLFVVGRDDEMIVSGGENVYPIEVEKTLTTHAAVAEAAV
Mb1462c|M.bovis_AF2122/97 SGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAV
Rv1427c|M.tuberculosis_H37Rv SGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAV
MMAR_2233|M.marinum_M SGDVGYLDRNGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPEVAEAAV
MAV_3349|M.avium_104 SGDLGYLDSAGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAV
MSMEG_0304|M.smegmatis_MC2_155 SGDVGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVAEAAV
TH_4130|M.thermoresistible__bu SGDLGRLDEDGRLFVVGRDDEMIVSGGENVYPIEVEQVLARHPDVAEATV
MLBr_02546|M.leprae_Br4923 SGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATA
MUL_1191|M.ulcerans_Agy99 SGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHPDVVEATA
MAB_4340c|M.abscessus_ATCC_199 SGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPEVIEATA
***:* :* . *:: *************::* *** : *. * **:.
Mflv_2427|M.gilvum_PYR-GCK LGVEDSEYGQRLAAFVVLTD----GSGLTPEDLKQHVRANLANYKVPRDI
Mvan_4225|M.vanbaalenii_PYR-1 LGVDDEQYGQRLAAFVVPAA----GASVTVEELKQHVRENLANYKVPRDI
Mb1462c|M.bovis_AF2122/97 IGVDDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKVPRDI
Rv1427c|M.tuberculosis_H37Rv IGVDDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKVPRDI
MMAR_2233|M.marinum_M IGVDDEQYGQRLAAFVVLEPDADLDENAAPETLKQHVRDNLANYKVPREI
MAV_3349|M.avium_104 IGVDDEQYGQRLAAFVVLAP----EARATPEALKQHVRDNLANYKVPREI
MSMEG_0304|M.smegmatis_MC2_155 IGVDDEQFGQRLAAFVVLSG------DATVDDLKSHVRDNLANYKVPRDI
TH_4130|M.thermoresistible__bu IGVDDEQFGQRLAAFVVLRD----GAGATPDGLKQHVRDNLANYKVPRSI
MLBr_02546|M.leprae_Br4923 IGVDDKEWGARLRAFVVKKQ----DATIDEDAIKAYVRDHLARYKVPREV
MUL_1191|M.ulcerans_Agy99 LGVDDKEWGARLRAFVVKKP----DTDLDEETVKHYVRDHLARYKVPREV
MAB_4340c|M.abscessus_ATCC_199 LGVDDPEWGARLRAFVVRHP----DSTVDADGIRAYVRDNLARYKVPRDV
:**:* ::* ** **** : :: :** :**.*****.:
Mflv_2427|M.gilvum_PYR-GCK TILPELPRGSTGKILRNELRGS----
Mvan_4225|M.vanbaalenii_PYR-1 TIMAELPRGSTGKILRNELRGR----
Mb1462c|M.bovis_AF2122/97 AVLDELPRGITGKILRTELQSRVGS-
Rv1427c|M.tuberculosis_H37Rv AVLDELPRGITGKILRTELQSRVGS-
MMAR_2233|M.marinum_M AVLDELPRGSTGKILRAELQAKVCGT
MAV_3349|M.avium_104 SVLDELPRSSTGKILRADLRARVGG-
MSMEG_0304|M.smegmatis_MC2_155 TILDELPRNSTGKIARRELQEKVNG-
TH_4130|M.thermoresistible__bu SVLDELPRGSTGKILRTELQARAQSG
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH-
MUL_1191|M.ulcerans_Agy99 IFLEELPRNPTGKILKRELREMEIE-
MAB_4340c|M.abscessus_ATCC_199 VFLDVLPRNPSGKILKRELRELEV--
.: ***. :**: : :*: