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GLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAAMARENMSVTSGFASAAQRCPDRPGLVDELG TLTWREIDQQADALAAGLQALSGGAPRVLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGPALAEVVS REKVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDTAAHDVTVAALTEKFAGRQPQRGGQKSKVILLTS GTTGTPKGAKHSGGGPEILKAILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTIITRRKFDPEAT LELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLRFAAASGSRMRPDVVIAFMDRFGDVIYNNYNA TEAGMIATATPADLRAAPDTAGRPAEGTEIRILDGDLRDLPTGEVGTIYVRNSTQFDGYTSGTTKDFHEG FMCSGDVGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVAEAAVIGVDDEQFGQRLAAFVV LSGDATVDDLKSHVRDNLANYKVPRDITILDELPRNSTGKIARRELQEKVNG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0304 | - | - | 100% (543) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0599 | - | e-107 | 41.86% (516) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0257 | - | 9e-50 | 29.74% (491) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 0.0 | 77.46% (528) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0435 | - | 0.0 | 77.08% (541) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 0.0 | 77.46% (528) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-110 | 42.48% (492) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 1e-106 | 42.71% (494) | acyl-CoA synthetase |
| M. marinum M | MMAR_2233 | fadD12 | 0.0 | 76.24% (543) | long-chain-fatty-acid--CoA ligase FadD12 |
| M. avium 104 | MAV_3349 | - | 0.0 | 78.62% (449) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4130 | - | 0.0 | 70.83% (545) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 1e-105 | 39.92% (531) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0232 | - | 0.0 | 77.63% (541) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0435|M.gilvum_PYR-GCK ---------MG----ITDPVTNALGLISTMMRAGVIAPMRPDKYMRIVGA
Mvan_0232|M.vanbaalenii_PYR-1 ---------MG----ITDPVTKTLGLLSTMVRAGVIAPMRPDKYLRIAGA
MSMEG_0304|M.smegmatis_MC2_155 ---------MGLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAA
Mb1462c|M.bovis_AF2122/97 -----------------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
Rv1427c|M.tuberculosis_H37Rv -----------------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
MMAR_2233|M.marinum_M ---------------MAPRIDQILGLITTLARSGLIAPMRPDRYLKIAAA
MAV_3349|M.avium_104 --------------------------------------------------
TH_4130|M.thermoresistible__bu -------------------MAKTIDTLRTLTRAGLIAPLRPDKYLRMTAA
MUL_4827|M.ulcerans_Agy99 ----------------MMAAGVVTTAARALLGSGLLSPSSPAAALRLVRE
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MAB_4340c|M.abscessus_ATCC_199 MSITAERPLFSKLQTLAKRGGAELHYLRKVIEAGMLKLDPPNVLAGLVRD
Mflv_0435|M.gilvum_PYR-GCK MQRENMAITSGFAAAAQRCPDRAGLVDELGILTWRQIDQRADALAAALQA
Mvan_0232|M.vanbaalenii_PYR-1 MQRENMAITSGFAAAAQRCPDRAGLIDELGILTWRQIDQRADAFAAALQA
MSMEG_0304|M.smegmatis_MC2_155 MARENMSVTSGFASAAQRCPDRPGLVDELGTLTWREIDQQADALAAGLQA
Mb1462c|M.bovis_AF2122/97 MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
Rv1427c|M.tuberculosis_H37Rv MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
MMAR_2233|M.marinum_M MRREGMGFTAGFAAAAQRCPDRPGLVDELGTLTWRQLDERSNALAAALQA
MAV_3349|M.avium_104 --------------------------------------------------
TH_4130|M.thermoresistible__bu VRRTGVSVTVGFAVAAQRCGDRIGLVDEIGELTWRELDDECNALAAALQD
MUL_4827|M.ulcerans_Agy99 LYRGGTNLYTPLAIAAARWPERTAIVDDDGALSYREIQTMTESVAGELTL
MLBr_02546|M.leprae_Br4923 MRKWG-DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIA
MAB_4340c|M.abscessus_ATCC_199 FYRFG-EIGAVPAFGAHRSPSRTAIIDDEGSITYAELNDAVNALAHGLNR
Mflv_0435|M.gilvum_PYR-GCK LPEGQPE-------VIGLMARNHRGFVDSLIAANRIGADVLLLNTSFAGP
Mvan_0232|M.vanbaalenii_PYR-1 LPGGQPE-------VIALMARNHRGFVDALIAANRIGADVLLLNTSFAGP
MSMEG_0304|M.smegmatis_MC2_155 LSGGAPR-------VLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGP
Mb1462c|M.bovis_AF2122/97 LPAGPPR-------VVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
Rv1427c|M.tuberculosis_H37Rv LPAGPPR-------VVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
MMAR_2233|M.marinum_M LPAGSPK-------VVGIMCRNHRGFVEALVAANRIGADILLLNTAFAGP
MAV_3349|M.avium_104 --------------MIGIMCRNHRGFVEAPVAADRIGADIVLLNTSFAGP
TH_4130|M.thermoresistible__bu RAAGQGKDGGKGRGAIGIMCRNHRGFIEALVAADRIGATVLLLNTSFAGP
MUL_4827|M.ulcerans_Agy99 AGIGPGQ-------AVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRAT
MLBr_02546|M.leprae_Br4923 KGVRGGD-------GIAILARNHRWFVIANYGCARVGARIILLNSEFSGP
MAB_4340c|M.abscessus_ATCC_199 LGIKGGD-------GVAILARNHRWFIIANYAAHRAGARVILLNTDFSGP
:.::.** * *: : . ** ::*:*: * ..
Mflv_0435|M.gilvum_PYR-GCK ALAEVLQREGEGRAVAVIYDEEFTETVDRAVADRPET-TRILAWTDSDT-
Mvan_0232|M.vanbaalenii_PYR-1 ALAEVMEREGEGRSVAVVYDEEFTDTVDRALAGRPDT-TRIVAWTDTPG-
MSMEG_0304|M.smegmatis_MC2_155 ALAEVVSRE---KVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDTAA-
Mb1462c|M.bovis_AF2122/97 ALAEVVTREG---VDTVVYDEEFSATVDRALAEKPQA-TRIVAWTDED--
Rv1427c|M.tuberculosis_H37Rv ALAEVVTREG---VDTVVYDEEFSATVDRALAEKPQA-TRIVAWTDED--
MMAR_2233|M.marinum_M ALADVVAREG---VDTVIYDEEFTATVDRAFDGRPQA-TRIVAWSDGQ--
MAV_3349|M.avium_104 ALADVITREG---VDAVIYDEEFTATVDRALAGRPDA-IRIVAWTDTE--
TH_4130|M.thermoresistible__bu ALAEVVDREG---VDTIVYDEEFTDIVDRALADRPTA-TRILAWVDEPAS
MUL_4827|M.ulcerans_Agy99 ALAAALEAHQ---MRVMLCDDEFVDQV----AGTGES----VLVIDPS--
MLBr_02546|M.leprae_Br4923 QIKEVSEREG---AKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEP-
MAB_4340c|M.abscessus_ATCC_199 QTKEVAEREG---ARVLIYDAEYAEFLDGYSPELGRIMALPTNPDNPDQ-
. . .:: * *: : :
Mflv_0435|M.gilvum_PYR-GCK ----DALTVEGLIAEHGGQEPVR---SVEKARVILLTSGTTGTPKGAKHS
Mvan_0232|M.vanbaalenii_PYR-1 ----DRLTVEGMIAEHGGQEPVR---APEKSRVILLTSGTTGTPKGASHS
MSMEG_0304|M.smegmatis_MC2_155 ----HDVTVAALTEKFAGRQPQR---GGQKSKVILLTSGTTGTPKGAKHS
Mb1462c|M.bovis_AF2122/97 ----HDLTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHS
Rv1427c|M.tuberculosis_H37Rv ----HDLTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHS
MMAR_2233|M.marinum_M ----HDLTVEQLVNAHLGDQPER---TGRTGRLILLTSGTTGTPKGAKHS
MAV_3349|M.avium_104 ----HQHTVDKLIASKAGAQPIR---TGRKGKMILLTSGTTGTPKGAKQS
TH_4130|M.thermoresistible__bu GPALPHPTVADLVAEHRGRRPAKPAAGDEGSRIILLTSGTTGTPKGARAA
MUL_4827|M.ulcerans_Agy99 -------TVTARDCARPKVAPSG--------RIVLLTSGTTGVPKGVPRK
MLBr_02546|M.leprae_Br4923 -PGSTDETLAELIARSSSAPAPK---VRKRASIIILTSGTTGTPKGANRN
MAB_4340c|M.abscessus_ATCC_199 -PASTDETIASVIKRNSTSPAPR---PSKYSSLVILTSGTTGTPKGAPRK
*: . :::*******.***.
Mflv_0435|M.gilvum_PYR-GCK GG---DPGVLKSILDRTPWRAEQPVVIVAPMFHAWGFSQLAFAASMSCTI
Mvan_0232|M.vanbaalenii_PYR-1 GG---DPSVLKAILDRTPWRAEQPVVIVAPMFHAWGFSQLAFAASMSCTI
MSMEG_0304|M.smegmatis_MC2_155 GG---GPEILKAILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTI
Mb1462c|M.bovis_AF2122/97 GG---GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTI
Rv1427c|M.tuberculosis_H37Rv GG---GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTI
MMAR_2233|M.marinum_M GGS-GGIGTLKAILDRTPWRAEQPIVIVAPMFHAWGFSQLVLAASLACTI
MAV_3349|M.avium_104 GGN-AGIGTLKAILDRTPWRAEEPVVIVAPMFHAWGFSQLLLAASFACPV
TH_4130|M.thermoresistible__bu SS--GGAGELAAILGRVPWRAEQTTVIAAPMFHAWGYSQLLFSALLACTI
MUL_4827|M.ulcerans_Agy99 PKVSSGIGVSATLLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTV
MLBr_02546|M.leprae_Br4923 TP--ASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTL
MAB_4340c|M.abscessus_ATCC_199 LA--LTLAPVGGMFSHVPFRSGEVTSVPAPMFHALGYLHQSLALTLGCTL
:: :. * . : :****. *: :: :. .:
Mflv_0435|M.gilvum_PYR-GCK ITRRKFDPEATLELVDKFRATGLCVVPVMFDRIMELPEEVLDKYSGRSLR
Mvan_0232|M.vanbaalenii_PYR-1 VTRRRFDPEATLELVDKYRATGLCVVPVMFDRIMDLPDEVLDKYSGRSLR
MSMEG_0304|M.smegmatis_MC2_155 ITRRKFDPEATLELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLR
Mb1462c|M.bovis_AF2122/97 VTRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLR
Rv1427c|M.tuberculosis_H37Rv VTRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLR
MMAR_2233|M.marinum_M VTRRKFDPEATLDLIDRHRATGLVVVPVMFDRIMELPTKVLNRYSGRTLR
MAV_3349|M.avium_104 ITRRKFDPEATLDLIDRHRATGLVVVPVMFDRIMDLPAEVRRRYECRSLR
TH_4130|M.thermoresistible__bu VTRRRFDPEATLQLVDRYRATGLVVVPVMLDRIMELPADVRDRYSGRSLR
MUL_4827|M.ulcerans_Agy99 LTRRHFDAEATLAQTSLHRADGLSVVPIMLARILDLPDQVRARNPLPCLR
MLBr_02546|M.leprae_Br4923 VLRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLR
MAB_4340c|M.abscessus_ATCC_199 ILRRKFKPENVLADVEKFKVTAIVVVPVMLNRLLNALDELSVKPDLSSLR
: **:*.. .* . .:. .: ***:*: *::: .: : **
Mflv_0435|M.gilvum_PYR-GCK FAAASGSRMRPDIVIKFMDRFGDVIYNNYNATEAGMIATATPRDLRAAPD
Mvan_0232|M.vanbaalenii_PYR-1 FAAASGSRMRPDVVIKFMDRFGDVIYNNYNATEAGMIATATPRDLRAAPD
MSMEG_0304|M.smegmatis_MC2_155 FAAASGSRMRPDVVIAFMDRFGDVIYNNYNATEAGMIATATPADLRAAPD
Mb1462c|M.bovis_AF2122/97 FAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPD
Rv1427c|M.tuberculosis_H37Rv FAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPD
MMAR_2233|M.marinum_M FAAASGSRMRPDVVVAFMNRFGDVIYNNYNATEAGMIATATPADLRAAPD
MAV_3349|M.avium_104 FAAASGSRMRPDVVVAFMDEFGDVIYNNYNATEAGMIATATPADLRAAPD
TH_4130|M.thermoresistible__bu FVTASGSRMRPDVVLDFMDRFGDVIYNNYNATEAGMIATATPADLRAAPS
MUL_4827|M.ulcerans_Agy99 AVISSGDRLDPSLARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPE
MLBr_02546|M.leprae_Br4923 VVFVSGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSA
MAB_4340c|M.abscessus_ATCC_199 IVFVSGSQLGGELASRAMDTLGPVIYNLYGSTEVAFATIARPQDLAINPS
. **.:: .:. :: * *:** *.:** .: : * * :* .
Mflv_0435|M.gilvum_PYR-GCK TAGRPAEGTEIKILDSEFNEVPTGETGGIWVRNSTQFDGYTSGSTKDFHD
Mvan_0232|M.vanbaalenii_PYR-1 TAGRPAEGTEIRILDADFNEVPTGEVGGIYVRNSTQFDGYTTGKTKDFHE
MSMEG_0304|M.smegmatis_MC2_155 TAGRPAEGTEIRILDGDLRDLPTGEVGTIYVRNSTQFDGYTSGTTKDFHE
Mb1462c|M.bovis_AF2122/97 TAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHA
Rv1427c|M.tuberculosis_H37Rv TAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHA
MMAR_2233|M.marinum_M TAGRPAEGTEIRILDQEFNEVPEGEVGSIFVCNDSQFDGYTSGTTKDFHA
MAV_3349|M.avium_104 TAGRPAGGTEIRILDPEFNELPAGEVGTIYVRNNTQFDGYTSGSSKDFHE
TH_4130|M.thermoresistible__bu TAGKPADGTEIRILDDALRPVPTGEVGQIFVRSNTLFDGYTSGTTKDFHE
MUL_4827|M.ulcerans_Agy99 TVGRPVAGCPVRIFDRNGRPVGARVTGRIFVGGELNSDGYSGGGGKAVID
MLBr_02546|M.leprae_Br4923 TVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIID
MAB_4340c|M.abscessus_ATCC_199 TVGPVVKGATVKILDDEGKPVSQGTVGRIFVSNAIPFDGYTGGGHKQIID
*.* . * ::*:* : .* *:* . :**: * * .
Mflv_0435|M.gilvum_PYR-GCK GFMSSGDVGYLDEEGRLFVVGRDDEMIVSGGENVYPIEVEKTLTSHPDVA
Mvan_0232|M.vanbaalenii_PYR-1 GFMSSGDVGYFDEAGRLFVVGRDDEMIVSGGENVYPIEVEKTLAAHPDVA
MSMEG_0304|M.smegmatis_MC2_155 GFMCSGDVGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVA
Mb1462c|M.bovis_AF2122/97 GFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVA
Rv1427c|M.tuberculosis_H37Rv GFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVA
MMAR_2233|M.marinum_M GFMSSGDVGYLDRNGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPEVA
MAV_3349|M.avium_104 GFMSSGDLGYLDSAGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVA
TH_4130|M.thermoresistible__bu GFMASGDLGRLDEDGRLFVVGRDDEMIVSGGENVYPIEVEQVLARHPDVA
MUL_4827|M.ulcerans_Agy99 GMASTGDMGYLDESGRLYIVGREDDMIVSGGENVYPRSLENALASHPDVA
MLBr_02546|M.leprae_Br4923 GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
MAB_4340c|M.abscessus_ATCC_199 GLMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPEVI
*: .:**:* :* . *:: **:*:********::* .:*. :: ** *
Mflv_0435|M.gilvum_PYR-GCK EATVLGVDDEKFGQRLAAFVVLNPG----AAATPEALKQHVRDNLANYKV
Mvan_0232|M.vanbaalenii_PYR-1 EATVLGVDDEKFGQRLEAFVVLTAD----AAATPETLKQHVRDNLANYKV
MSMEG_0304|M.smegmatis_MC2_155 EAAVIGVDDEQFGQRLAAFVVLSG------DATVDDLKSHVRDNLANYKV
Mb1462c|M.bovis_AF2122/97 EAAVIGVDDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKV
Rv1427c|M.tuberculosis_H37Rv EAAVIGVDDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKV
MMAR_2233|M.marinum_M EAAVIGVDDEQYGQRLAAFVVLEPDADLDENAAPETLKQHVRDNLANYKV
MAV_3349|M.avium_104 EAAVIGVDDEQYGQRLAAFVVLAP----EARATPEALKQHVRDNLANYKV
TH_4130|M.thermoresistible__bu EATVIGVDDEQFGQRLAAFVVLRDG----AGATPDGLKQHVRDNLANYKV
MUL_4827|M.ulcerans_Agy99 ENAVIGVADEQFGQRLAAFVVARPG----CDIDADAIRDYLKGRVSRFEQ
MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQD----ATIDEDAIKAYVRDHLARYKV
MAB_4340c|M.abscessus_ATCC_199 EATALGVDDPEWGARLRAFVVRHPD----STVDADGIRAYVRDNLARYKV
* :.:** * ::* ** **** : :: :::..::.::
Mflv_0435|M.gilvum_PYR-GCK PREITVLDELPRSITGKISRKDLKDRLDNA---
Mvan_0232|M.vanbaalenii_PYR-1 PREITILDELPRGVTGKISRKDLQDRLDNA---
MSMEG_0304|M.smegmatis_MC2_155 PRDITILDELPRNSTGKIARRELQEKVNG----
Mb1462c|M.bovis_AF2122/97 PRDIAVLDELPRGITGKILRTELQSRVGS----
Rv1427c|M.tuberculosis_H37Rv PRDIAVLDELPRGITGKILRTELQSRVGS----
MMAR_2233|M.marinum_M PREIAVLDELPRGSTGKILRAELQAKVCGT---
MAV_3349|M.avium_104 PREISVLDELPRSSTGKILRADLRARVGG----
TH_4130|M.thermoresistible__bu PRSISVLDELPRGSTGKILRTELQARAQSG---
MUL_4827|M.ulcerans_Agy99 PRDIYLVSSIPRNPAGKVLRKQLASYAEPEAQS
MLBr_02546|M.leprae_Br4923 PREVIFLEELPRNPTGKVLKRELRDFEVH----
MAB_4340c|M.abscessus_ATCC_199 PRDVVFLDVLPRNPSGKILKRELRELEV-----
**.: .:. :**. :**: : :*