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VSVDNAAAATLVRAPRGWQRVGALSSRVGAFAIVEIQKLQHDRTELVTRMVQPALWLLIFGTTFSHLHMI DTGPVSYLAFLAPGIIAQSALFISIFYGIQIIWDRDAGVLAKLMVTPAPASALVTGKAFAAGVRSVAQVV GVLALAYLMRIGLTVNPLRILAAMGIVMLGAAFFACLSMTLAGLVRNRDRLMGIGQAITMPLFFASNALY PVELMPTWLHVLSKINPLSYEVNALRALLIGTPFNPVDIAVLAAAAVTGILTASTLLRRLVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5182 | - | - | 100% (272) | ABC-type drug export system, membrane protein |
| M. avium 104 | MAV_3251 | - | 1e-13 | 27.23% (202) | ABC transporter efflux protein, DrrB family protein |
| M. avium 104 | MAV_2004 | - | 2e-13 | 25.58% (258) | ABC-2 type transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2963 | drrC | 2e-09 | 24.45% (229) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. gilvum PYR-GCK | Mflv_1937 | - | 7e-16 | 28.57% (189) | ABC-2 type transporter |
| M. tuberculosis H37Rv | Rv2938 | drrC | 2e-09 | 24.45% (229) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02350 | - | 3e-10 | 21.40% (215) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | MAB_2753 | - | 3e-06 | 25.67% (261) | ABC transporter permease |
| M. marinum M | MMAR_3262 | - | 7e-10 | 26.52% (230) | integral membrane protein ABC transporter |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 1e-118 | 82.82% (262) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | TH_0090 | - | 4e-08 | 25.56% (180) | membrane protein |
| M. ulcerans Agy99 | MUL_2012 | drrC | 8e-10 | 24.88% (209) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. vanbaalenii PYR-1 | Mvan_4795 | - | 1e-15 | 26.70% (191) | ABC-2 type transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5182|M.avium_104 --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
TH_0090|M.thermoresistible__bu VLNVVNARVGQQSVETVLTGLTDAGEGLTQAADGADRLHTGLVAADDGAH
MAB_2753|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5182|M.avium_104 --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
TH_0090|M.thermoresistible__bu DLSVGADALAAGLVTARDGAAQLAAGTGQLAAAVDTAIDPLLHTLDRVGA
MAB_2753|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5182|M.avium_104 -------------------------------------MSVDNAAAATLVR
MSMEG_6510|M.smegmatis_MC2_155 -------------------------------------MSVE------LVR
Mb2963|M.bovis_AF2122/97 -----------------------------------MITTTSQEIELAPTR
Rv2938|M.tuberculosis_H37Rv -----------------------------------MITTTSQEIELAPTR
MLBr_02350|M.leprae_Br4923 -----------------------------------MITMISQTVGLVPAS
MUL_2012|M.ulcerans_Agy99 -----------------------------------MIGMTSQEIAFAPAQ
Mflv_1937|M.gilvum_PYR-GCK -------------------------------------MTAVDSQTHTPVQ
Mvan_4795|M.vanbaalenii_PYR-1 -------------------------------------MTALDTEAHAAVR
MMAR_3262|M.marinum_M --------------------------------------------------
TH_0090|M.thermoresistible__bu LGLDPDEVGAVATRLSGAVRSTTERIAALHIDQHHAAAVLDQAVTFLRTN
MAB_2753|M.abscessus_ATCC_1997 --------------------------------------MTDTTTPRFDPG
MAV_5182|M.avium_104 APRGWQRVGALSSRVGAFAIVE---------IQKLQHDRTELVTRMVQPA
MSMEG_6510|M.smegmatis_MC2_155 APRGLRRVRAVAMRMGAFALVE---------LQKLRHDRTELFTRMVQPA
Mb2963|M.bovis_AF2122/97 LPGSQNAARLFVAQTLLQTNRL---------LTRWARDYITVIGAIVLPI
Rv2938|M.tuberculosis_H37Rv LPGSQNAARLFVAQTLLQTNRL---------LTRWARDYITVIGAIVLPI
MLBr_02350|M.leprae_Br4923 LQYPNNSVRALVSQTLLQTKRL---------LTRWARDYVTIIGALVLPI
MUL_2012|M.ulcerans_Agy99 SQHTDHSARLLIWQTLVQTQRI---------LTRWSRDFVTLIEALVFPI
Mflv_1937|M.gilvum_PYR-GCK PRPVPIRPTNLAQQSWIMVKRN---------MIHTKRMPEMLSDVTAQPI
Mvan_4795|M.vanbaalenii_PYR-1 PQPVPIRPTNLAQQSWIMVKRN---------MIHTKRMPEMLSDVTAQPI
MMAR_3262|M.marinum_M -----------------MLKRN---------LIRVRRRPETLMQLLLQPI
TH_0090|M.thermoresistible__bu PDPAAHHLGEALAGVQRMLRAQGIDPATDEGLIRLRDSAAQLESELADPN
MAB_2753|M.abscessus_ATCC_1997 TFTPDPRPSAVHTMLFAQFWLE---------LKLLLRNGEQLLLTMFIPI
: : *
MAV_5182|M.avium_104 LWLLIFGTTFSH--------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 LWLLIFGQTFSR--------------------------------------
Mb2963|M.bovis_AF2122/97 LFMVVLNIVLG---------------------------------------
Rv2938|M.tuberculosis_H37Rv LFMVVLNIVLG---------------------------------------
MLBr_02350|M.leprae_Br4923 LFLVVLNIVLG---------------------------------------
MUL_2012|M.ulcerans_Agy99 LFMLVLKIVLG---------------------------------------
Mflv_1937|M.gilvum_PYR-GCK MFVLLFAFVFG---------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 MFVLLFAFVFG---------------------------------------
MMAR_3262|M.marinum_M AFMLFFTFIVG---------------------------------------
TH_0090|M.thermoresistible__bu SRLRTFLTAALDGGLRGEVVRLRDGVNRLDTGARQLSAGLVRLADGGQQL
MAB_2753|M.abscessus_ATCC_1997 TLLIGLTLLPLG--------------------------------------
: :
MAV_5182|M.avium_104 --------------------LHMIDTGPVSYLAFLAPGIIAQSALFISIF
MSMEG_6510|M.smegmatis_MC2_155 --------------------LHVVDTGGVPYLAFLAPGIIAQSALFISIF
Mb2963|M.bovis_AF2122/97 --------------------NLAYVVTHDSGLYSIVPLIALGAAITGSTF
Rv2938|M.tuberculosis_H37Rv --------------------NLAYVVTHDSGLYSIVPLIALGAAITGSTF
MLBr_02350|M.leprae_Br4923 --------------------NLAYVVTYDSGLYSFVPLITLGAAITGSTF
MUL_2012|M.ulcerans_Agy99 --------------------NLIYAVTHHDAMYSIVPLIALGAAITGSAF
Mflv_1937|M.gilvum_PYR-GCK --------------------ASITNTGGASYREFLLPGIQAQTIVFSAFV
Mvan_4795|M.vanbaalenii_PYR-1 --------------------ASITNTGGASYREFLLPGIQAQTIVFSAFV
MMAR_3262|M.marinum_M --------------------RSISENAAPHYREYLLPGIQAQAIVATIIL
TH_0090|M.thermoresistible__bu ATGAGRLADGTGQLRAGSRELADALRDGSTQVPSWTPEQRSDVAAAMAAP
MAB_2753|M.abscessus_ATCC_1997 -------------------------QFPGSRTDIFVPAIMALAVISTAFT
*
MAV_5182|M.avium_104 -YGIQIIWDRDAG------------------------VLAKLMVTPAPAS
MSMEG_6510|M.smegmatis_MC2_155 -YGIQIIWDRDAG------------------------ILAKLMVTPAPAS
Mb2963|M.bovis_AF2122/97 -VAIDLMRERSFG------------------------LLARLWVLPVHRA
Rv2938|M.tuberculosis_H37Rv -VAIDLMRERSFG------------------------LLARLWVLPVHRA
MLBr_02350|M.leprae_Br4923 -VAIDLVRERSIG------------------------LLSRLWVLPIHRA
MUL_2012|M.ulcerans_Agy99 -VAIDLMRERTSG------------------------LLSRLWVLPVHRM
Mflv_1937|M.gilvum_PYR-GCK -VASGITADVEKG------------------------IIDRFRSLPISRS
Mvan_4795|M.vanbaalenii_PYR-1 -VASGITADVEKG------------------------IIDRFRSLPISRS
MMAR_3262|M.marinum_M -VGAAISADVEND------------------------VFIRFRSLPISNS
TH_0090|M.thermoresistible__bu -VELDLVTHNPAATFGTGFAPFFLPLALFIGALIVWMLLTPLQSRPIVNG
MAB_2753|M.abscessus_ATCC_1997 GQAIAVGFDRRYG------------------------ALKRLGATALPVW
: . : : .
MAV_5182|M.avium_104 ALVTGKAFAAGVR-SVAQVVGVLALAYLMRIGLTVNPLRILAAMGIVMLG
MSMEG_6510|M.smegmatis_MC2_155 ALVAGKAFAAGVR-SVVQVIGVVALAYLMGIALTLNPLRILAAMGVVVLG
Mb2963|M.bovis_AF2122/97 SGLISRILANAIR-TLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVIL
Rv2938|M.tuberculosis_H37Rv SGLISRILANAIR-TLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVIL
MLBr_02350|M.leprae_Br4923 SGLLARILANTIR-TFVTTLVMLVTGVILGFRFRQGVIASLMWVSVPVIF
MUL_2012|M.ulcerans_Agy99 SGLMARILADAVR-ILFTTLVMLGVGILMGFEFRQGLIASLMWLCVPVTL
Mflv_1937|M.gilvum_PYR-GCK SVLIGRSIASVIH-SSLGALVMALTGLAIGWRIRNGVGEAVLAFALLMLF
Mvan_4795|M.vanbaalenii_PYR-1 SVLIGRSIASVIH-SSLGVLVMALTGLAIGWRIRNGVAEAVLAFALLLLF
MMAR_3262|M.marinum_M APLIARGLVSLLY-AAIVYILIGISGMLIGWRMHGSLADAVLAFVLVLVF
TH_0090|M.thermoresistible__bu LGALRVVLASFWPGLLIVVAQVVVMYAVVHFGVGLKAEHPLATVAFLILI
MAB_2753|M.abscessus_ATCC_1997 GIIAGKALAVVTV-VVLQAAVIGAIGGALGWRP--HPVGLLVGAVVIAIG
:. : : : .
MAV_5182|M.avium_104 AAFFACLSMTLAGLVRNRDRLMGIGQAITMPLFFASNALYPVELMPTWLH
MSMEG_6510|M.smegmatis_MC2_155 AAFFACLSMTLAGLVRKRDRLMGIGQAITMPLFFASNALYPVDIMPTWLR
Mb2963|M.bovis_AF2122/97 GIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTG-LVPLNSYPGWIQ
Rv2938|M.tuberculosis_H37Rv GIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTG-LVPLNSYPGWIQ
MLBr_02350|M.leprae_Br4923 GIAIAVMVTTVALYTEQTFVVEAVELVQAIAVFLSTG-LVPLNQYPGWIQ
MUL_2012|M.ulcerans_Agy99 GIAFAVMVTTVALYSSQAVIVEGVELTQAIAIFFSTG-LIPLDQYPHWIQ
Mflv_1937|M.gilvum_PYR-GCK GFGMIWFGILIGSLMRSVEAVNGVMFTALFPVTFLANTFVPTEPMPHWLR
Mvan_4795|M.vanbaalenii_PYR-1 GFGMIWFGILIGSLLRTVEAVNGVMFTALFPVTFLANTFVPTEPMPRWLR
MMAR_3262|M.marinum_M GVGFMWLGMVVGLMVRTVEVVGAAVFLITLPIISISNCFVPTQPMPHALR
TH_0090|M.thermoresistible__bu GATFLALIQAFNAVFG-VAVGRVVTLAFLMLQLVSAGGIYPVETTAKPFQ
MAB_2753|M.abscessus_ATCC_1997 TAAFVAMGLLLGGTLRAEIVLALANLLWFIFAGLGALTLEDGRTTDAIPR
: : . : : : :
MAV_5182|M.avium_104 VLSKINPLSYEVNALRALLIGT---------PFN-PVDIAVLAAAAVTGI
MSMEG_6510|M.smegmatis_MC2_155 WLSAVNPLSYEVNALRGLLIGT---------PTNWVLDITVLVAAAVLGV
Mb2963|M.bovis_AF2122/97 PFVAHQPVSYAIAAMRGFAMGG---------PVLSPMIGMLVWTAGICVV
Rv2938|M.tuberculosis_H37Rv PFVAHQPVSYAIAAMRGFAMGG---------PVLSPMIGMLVWTAGICVV
MLBr_02350|M.leprae_Br4923 PLVAHQPVSYAIAAMRGLSMGG---------PVLASMVAMLVWTAGICAS
MUL_2012|M.ulcerans_Agy99 PVVAHQPVSYAVSAMRGLSMGG---------PVLLPMIGVLLWTAGICAV
Mflv_1937|M.gilvum_PYR-GCK VIAEWNPVSSLAQAMRELWGNGGPAPASAQLPLHYPVASTILWSLALTAV
Mvan_4795|M.vanbaalenii_PYR-1 VIAEWNPVSSLAQAMRELWGNGGPAPAGAQLPLHHPVLATVLWSLALTAV
MMAR_3262|M.marinum_M VIAEWNPLSSLALALRKLTIDEPMAPPSAQLPLHHPALSTLIYSIVLTAL
TH_0090|M.thermoresistible__bu IIHPFDPMTYAVNGLRQLIVGG----VDQRLWIAIAVLAGLLAASTAASA
MAB_2753|M.abscessus_ATCC_1997 AVVLLARLS-PSGALSEALAAA----------MTLSVDWFAIAVLAVWGA
. :: .: :
MAV_5182|M.avium_104 LTASTLLRRLVA--------
MSMEG_6510|M.smegmatis_MC2_155 VAASALLRRLVR--------
Mb2963|M.bovis_AF2122/97 CAVPLAIGYRRASTH-----
Rv2938|M.tuberculosis_H37Rv CAVPLAIGYRRASTH-----
MLBr_02350|M.leprae_Br4923 CAVPLGVGYRRACTH-----
MUL_2012|M.ulcerans_Agy99 CAVPLAVGWRRASTH-----
Mflv_1937|M.gilvum_PYR-GCK FAPFALYAYKRRTGG-----
Mvan_4795|M.vanbaalenii_PYR-1 FAPFALYAYKRRTGG-----
MMAR_3262|M.marinum_M LAPIAIRAYIRRTSL-----
TH_0090|M.thermoresistible__bu WAARRNRQYTMQRLHPPIEV
MAB_2753|M.abscessus_ATCC_1997 LAGYGALRWFKFT-------
: