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MRNVAIVGAGMTPFAEHFELGIKDLVPMAYAEAVAAVDKGIDKSEIQAAWFGELSTTDGFPSGILADTLD LTDIPVTRVENACATGNDAIRNGAMAIASGICDVVLVVGADKVRETSSNTTFWDWAAMTRDNAWDYPLGL VAPANFALHVIRYLHESPATKEHMAMVAVKNHFHALKNPKAQLRYEITVEQALAAPIVVEPFGLYDCTPQ SDGAAAVILAAEDVVDRYTDRPVWVRGVGLGMDRVMHQHKSDMTTFPPTVRAAKTAMAMAGVTPRDIDVA EVHDCFTGVELISYEDLGFANRFEAYKLVEGREHYVGGSIPVNPSGGLKAKGHPPGATGVAQCYELFNQL RGQAENQVDGARIGLAHNIGGPTAVSAVTILSNEKN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1817 | - | - | 100% (386) | thiolase family protein |
| M. avium 104 | MAV_2557 | - | 0.0 | 94.56% (386) | thiolase family protein |
| M. avium 104 | MAV_5079 | - | 2e-58 | 35.61% (396) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2813c | ltp1 | 1e-53 | 35.38% (390) | lipid-transfer protein |
| M. gilvum PYR-GCK | Mflv_2505 | - | 1e-167 | 72.70% (381) | thiolase |
| M. tuberculosis H37Rv | Rv2790c | ltp1 | 1e-53 | 35.38% (390) | lipid-transfer protein |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 1e-05 | 23.18% (302) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0378 | - | 7e-52 | 36.18% (387) | lipid-transfer protein |
| M. marinum M | MMAR_1918 | ltp1 | 1e-52 | 34.95% (392) | lipid-transfer protein Ltp1 |
| M. smegmatis MC2 155 | MSMEG_4778 | - | 1e-47 | 36.64% (393) | putative thiolase |
| M. thermoresistible (build 8) | TH_2654 | - | 0.0 | 93.62% (376) | PUTATIVE Thiolase |
| M. ulcerans Agy99 | MUL_2143 | ltp1 | 7e-53 | 34.95% (392) | lipid-transfer protein |
| M. vanbaalenii PYR-1 | Mvan_4153 | - | 1e-166 | 72.97% (381) | thiolase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1817|M.avium_104 ---------MRNVAIVGAGMTPFAEHFELGIKDLVPMA-YAEAVAAVDKG
TH_2654|M.thermoresistible__bu -------------------MTPFGEHFELGIKDLVPMA-YAEAVANVDKG
Mflv_2505|M.gilvum_PYR-GCK ---------MRRAAIVGAGMTPFAEHFALGIKDLIPMA-FSACASSVDKG
Mvan_4153|M.vanbaalenii_PYR-1 ---------MRRVAIVGAGMTPFGEHFALGMKDLLPMA-FSECARTVDKG
MSMEG_4778|M.smegmatis_MC2_155 --------MTNDVAIIGVGLHPFGR---FDKPAVQMGA-EAIRLALKDAG
MMAR_1918|M.marinum_M MPNNGS----NRVFVIGVGMTKFEKPGRREGWDYPDMARESGTNALNDAG
MUL_2143|M.ulcerans_Agy99 MPNNGS----NRVFVIGVGMTKFEKPGRREGWDYPDMARESGTNALNDAG
Mb2813c|M.bovis_AF2122/97 MPNQGSS---NKVYVIGVGMTKFEKPGRREGWDYPDMARESGTKALRDAG
Rv2790c|M.tuberculosis_H37Rv MPNQGSS---NKVYVIGVGMTKFEKPGRREGWDYPDMARESGTKALRDAG
MAB_0378|M.abscessus_ATCC_1997 MPPKGSSKVLEKVYVIGVGMTKFEKPGRREGWDYPAMAKESGTNALTDAG
MLBr_01158|M.leprae_Br4923 --------MTTSVIVTGARTPIGKLMGSLKDFSASDLGAITIAAALKKAN
. : . .
MAV_1817|M.avium_104 IDKSEIQAAWFGELSTTDG--FPSGILADTLDL-TDIPVTRVENACATGN
TH_2654|M.thermoresistible__bu ISKSEIEAAWFGELSTTDG--FPSGILADTLDL-TDIPVTRVENACATGN
Mflv_2505|M.gilvum_PYR-GCK LAKDDLQAAWIGAMGTADG--FPSGILADTLGL-PNLPVTRVENSCATGH
Mvan_4153|M.vanbaalenii_PYR-1 LSKADLQAAWFGAMGTADG--FPSGILADTLGL-PELPVTRVENSCATGH
MSMEG_4778|M.smegmatis_MC2_155 VEWKDIQFGFGGSYEVSN-----PDSVTRLVGL-TGITFTNVFNACATSA
MMAR_1918|M.marinum_M IEYREVEHAYVG-YVYGES--TSGQRAVYELGM-TGIPVVNVNNNCSTGS
MUL_2143|M.ulcerans_Agy99 IEYREVEHAYVG-YVYGES--TSGQRAVYELGM-TGIPVVNVNNNCSTGS
Mb2813c|M.bovis_AF2122/97 IDYREVEQGYVG-YVYGES--TSGQRALYELGM-TGIPIVNVNNNCSTGS
Rv2790c|M.tuberculosis_H37Rv IDYREVEQGYVG-YVYGES--TSGQRALYELGM-TGIPIVNVNNNCSTGS
MAB_0378|M.abscessus_ATCC_1997 IDYGKVEAAYVG-YCAGES--TSGQRAVYELGM-TGIPVTNVNNNCSTGS
MLBr_01158|M.leprae_Br4923 VAPSIVQYVIIGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGL
: :: * .: :. : : * :.
MAV_1817|M.avium_104 DAIRNGAMAIASGICDVVLVVGADKVRETSSNTTFWDWAAMTRDNAWDYP
TH_2654|M.thermoresistible__bu DAVRNGVMAIASGMYDVVLVVGADKVRETSSNTTFWEWAAMTRDNAWDYP
Mflv_2505|M.gilvum_PYR-GCK DAIRNALFGVSSGAFDVALVIGADKLRDTTSAGMLWEWEAMARDMAWDYP
Mvan_4153|M.vanbaalenii_PYR-1 DAIRNALFGIASGAFDVALVMGADKLRDTTSAEMLWEWEAMARDMAWDYP
MSMEG_4778|M.smegmatis_MC2_155 SAIQQTADTIRLGKYDIGVAVGLDKHPRG---AFTDDPAKLALPQWYAQN
MMAR_1918|M.marinum_M TALFLAAQAIRGGLADCTVALGFEKMKPGSLSSSYDDRTQPMDKHVKALA
MUL_2143|M.ulcerans_Agy99 TALFLAAQAIRGGLADCTVALGFEKMKPGSLSSSYDDRTQPMDKHVKALA
Mb2813c|M.bovis_AF2122/97 TALYLGAQAIRGGLADCVLALGFEKMQPGALGGGADDRESPLGRHVKALA
Rv2790c|M.tuberculosis_H37Rv TALYLGAQAIRGGLADCVLALGFEKMQPGALGGGADDRESPLGRHVKALA
MAB_0378|M.abscessus_ATCC_1997 TALYNAAQAIRGGLADVTLALGFEKMQPGSLGATFTDREQPMQRHIEALA
MLBr_01158|M.leprae_Br4923 DAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRSGYKYGDVTIVDH
*: : * * :. * :.
MAV_1817|M.avium_104 -----LGLVAPANFALHVIRYLHESPATKEHMAMVAVKNHFHALKNPKAQ
TH_2654|M.thermoresistible__bu -----LGLVAPANFALHVTRYLHESPATKEHLAMVAVKNHFHALKNPKAQ
Mflv_2505|M.gilvum_PYR-GCK -----LGLVAPAGFALHVRRYLHESPATEEHLAMVAVKNHRHGVNNPKAR
Mvan_4153|M.vanbaalenii_PYR-1 -----LGLVAPAGFALHVRRYLHESPATEEHLAMVAVKNHRHGVNNTKAR
MSMEG_4778|M.smegmatis_MC2_155 -----GQFVTTKFFGMKANKYLHDHNISQDTLARVANKNFRNGALNPNAF
MMAR_1918|M.marinum_M QIAEFAFPVAPWMFGAAGREHMQQYGSTAEHFAKIGFKNHKHSVNNPFAQ
MUL_2143|M.ulcerans_Agy99 QIAEFAFPVAPWMFGAAGREHMQQYGSTAEHFAKIGFKNHKHSVNNPFAQ
Mb2813c|M.bovis_AF2122/97 EIDEFGFPVAPWMFGAAGREHMKKYGTTAEHFAKIGYKNHKHSVNNPYAQ
Rv2790c|M.tuberculosis_H37Rv EIDEFGFPVAPWMFGAAGREHMKKYGTTAEHFAKIGYKNHKHSVNNPYAQ
MAB_0378|M.abscessus_ATCC_1997 GVFDFAFPPAPWMFGAAGREHMQKYGTTAEHFAKIGYKNHKHSVNNPYAQ
MLBr_01158|M.leprae_Br4923 ----LAYDGLHDVFTNQPMGALTEQRNDVEKFTRQEQDEFAARSHQKAAA
* : . : :: .:. : *
MAV_1817|M.avium_104 LRYEITVEQALAAPIVVEPFGLYDCTPQSDGAAAVILAAEDVVDR--YTD
TH_2654|M.thermoresistible__bu LRYEITVEQALAAPIVVEPFGLYDCTPQSDGAAAVILAAEDVVDR--YTD
Mflv_2505|M.gilvum_PYR-GCK LRFEITMEQALNAPTVVTPFRLYDCAPQSDGAAALVIASEDVVDK--FTD
Mvan_4153|M.vanbaalenii_PYR-1 LRFEITMEQALNAPTVVTPFRLYDCAPQSDGAAALVIAADDVVDR--FTD
MSMEG_4778|M.smegmatis_MC2_155 RRKEISVEEILASPTLNHPLTQYMFCAPDEGAAAVIMCRADIAHK--FTD
MMAR_1918|M.marinum_M FQEAYTLDDILASRMIYEPLTKLQCSPTSDGSGAAILASESFVDSHGLAG
MUL_2143|M.ulcerans_Agy99 FQEAYTLDDILASRMIYEPLTKLRCSPTSDGSGAAILASESFVDSHGLAG
Mb2813c|M.bovis_AF2122/97 FQDEYTLDDILASKMISDPLTKLQCSPTSDGSAAVVLASEDYLANHNLAG
Rv2790c|M.tuberculosis_H37Rv FQDEYTLDDILASKMISDPLTKLQCSPTSDGSAAVVLASEDYLANHNLAG
MAB_0378|M.abscessus_ATCC_1997 FQEEYTLQDILDAKEIYAPLTKLQCSPTSDGSGAAILASERFVEQNGLGD
MLBr_01158|M.leprae_Br4923 AWKDGVFADEVVPVSIPQSKGDSLQFTEDEGIRANTSAESLAGLKPAFRC
. : : . : . . .:* * .
MAV_1817|M.avium_104 RPVWVRG-----VGLGMDRVMHQHKSDMTTFPPTVRAAKTAMAMAGVTPR
TH_2654|M.thermoresistible__bu RPVWVRG-----VGIGMDRVMHQHKQDMTTFPPTVRAAKAAMKMAGVTPK
Mflv_2505|M.gilvum_PYR-GCK RPVWIRG-----VGLGLDSVMHQHKPDLTTFPATTRAAKQAFAMAGMTPS
Mvan_4153|M.vanbaalenii_PYR-1 RPVWITG-----VGLGLDSVMHQHKPDLTTFPATTRAAKQAFAMAGRSPS
MSMEG_4778|M.smegmatis_MC2_155 KPVYVRASEIRTRTFGAYEVHATSAPPESDAAPTVYAARAAYEAAGIGPE
MMAR_1918|M.marinum_M RAVEIVG--QAMTTDFASTFDG-SAKNLIGYDMNVQAAQRVYQQSGLGPE
MUL_2143|M.ulcerans_Agy99 RAVEIVG--QAMTTDFASTFDG-SAKNLIGYDMNVQAARRVYQQSGLGPE
Mb2813c|M.bovis_AF2122/97 RAVEIVG--QAMTTDFASTFDG-SARNIIGYDMTVQAAQRVYQQSGLGPK
Rv2790c|M.tuberculosis_H37Rv RAVEIVG--QAMTTDFASTFDG-SARNIIGYDMTVQAAQRVYQQSGLGPK
MAB_0378|M.abscessus_ATCC_1997 RAVEIVG--QAMTTDIPGTLESKSAITLVGFDMAKLAAQKVYEQAQISAD
MLBr_01158|M.leprae_Br4923 GGTITPG-SASQISDGAATVVVMNKEKAQQLGLTWLVEIGAHGVVAGPDS
. . . . .
MAV_1817|M.avium_104 DIDVAEVHDCFTGV--ELISYEDLGFANRFEAYKLVEGREHYVG--GSIP
TH_2654|M.thermoresistible__bu DIDVAEVHDCFTGV--ELISYEDLGFADRFEAYKIVEGRENYVG--GSIP
Mflv_2505|M.gilvum_PYR-GCK DVDVAEVHDFLTGI--ELMSYEDLGFAEKLGGYKLLEAEVTSVG--GALP
Mvan_4153|M.vanbaalenii_PYR-1 DVDVAEVHDFLTGI--ELMSYEDLGFAERLGGYKLLEAEVTSLG--GALP
MSMEG_4778|M.smegmatis_MC2_155 DVDIAQLQDTDAGA--EVIHMAETGLCADGDQEKLIAEGATEID--GSIP
MMAR_1918|M.marinum_M DFQVIELHDCFSAN--ELLLYEALGLCGQGEAPKLIDNGDTTYG--GRWV
MUL_2143|M.ulcerans_Agy99 DFQVIELHDCFSAN--ELLLYEALGLCGQGEAPKLIDNGDTTYG--GRWV
Mb2813c|M.bovis_AF2122/97 DFGVIELHDCFSAN--ELLLYEALGLCGPGEAPELIDDNQTTYG--GRWV
Rv2790c|M.tuberculosis_H37Rv DFGVIELHDCFSAN--ELLLYEALGLCGPGEAPELIDDNQTTYG--GRWV
MAB_0378|M.abscessus_ATCC_1997 DVDVIELHDCFSAN--ELITYEALGLCAEGEGGKLVDNGDTTYG--GRWV
MLBr_01158|M.leprae_Br4923 TLQSQPANAIKKAVDREGISVEQLDVVEINEAFAAVALASARELGIAPEL
. : . * : .. : .
MAV_1817|M.avium_104 VNPSGGLKAKGHPPGATGVAQCYELFNQLRGQAEN-QVDG-AR---IGLA
TH_2654|M.thermoresistible__bu VNPSGGLKAKGHPPGATGVAQCYELFNQLRGEAEN-QVDG-AR---VALA
Mflv_2505|M.gilvum_PYR-GCK VNPSGGLKAKGHPPGATGVAQCVELFAQLRGEAVN-QVDG-AR---IGLA
Mvan_4153|M.vanbaalenii_PYR-1 VNPSGGLKAKGHPPGATGVAQCVELFAQLRGEAVN-QVDG-AR---IGLA
MSMEG_4778|M.smegmatis_MC2_155 VNTDGGLIANGEPIGASGLRQMHELVRQLRGEAGDRQVPGNPR---VGLA
MMAR_1918|M.marinum_M VNPSGGLISKGHPLGATGLAQCCELTWQLRGTADRRQVDDVT----AALQ
MUL_2143|M.ulcerans_Agy99 VNPSGGLISKGHPLGATGLAQCCELTWQLRGTADRRQVDNVT----AALQ
Mb2813c|M.bovis_AF2122/97 VNPSGGLISKGHPLGATGLAQCAELTWQLRGTAEARQVDNVT----AALQ
Rv2790c|M.tuberculosis_H37Rv VNPSGGLISKGHPLGATGLAQCAELTWQLRGTAEARQVDNVT----AALQ
MAB_0378|M.abscessus_ATCC_1997 VNPSGGLISKGHPLGATGLAQCAELTWQLRGDADKRQVASASQKTGVALQ
MLBr_01158|M.leprae_Br4923 VNVNGGAIAVGHPLGMSGARITLHVALELARRGSG-----------YGVA
** .** : *.* * :* .: :* . .:
MAV_1817|M.avium_104 HNIGGPTAVSAVTILSNEKN-
TH_2654|M.thermoresistible__bu HNIGGPTAVSAVTILSSEKD-
Mflv_2505|M.gilvum_PYR-GCK HNIGGPTAVAAVTILEGPDGG
Mvan_4153|M.vanbaalenii_PYR-1 HNIGGPTAVSAVTILEGPSGN
MSMEG_4778|M.smegmatis_MC2_155 QVYGAPGTASATILSL-----
MMAR_1918|M.marinum_M HNIGLGGAAVVTAYQRAER--
MUL_2143|M.ulcerans_Agy99 HNIGLGGAAVVTAYQRAER--
Mb2813c|M.bovis_AF2122/97 HNIGLGGAAVVTAYQRAER--
Rv2790c|M.tuberculosis_H37Rv HNIGLGGAAVVTAYQRAER--
MAB_0378|M.abscessus_ATCC_1997 HNLGLGGACVVTAYKPANR--
MLBr_01158|M.leprae_Br4923 ALCGAGGQGDALILRAV----
* .