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VNSKVSRSWLLMNPSREASLEAAIASTNADEVILDLEDAVAPNEKEPARGRVLEYLNSGGNAWVRVNDAS SDFWSADCRALADARGLKGVVLAKTEGGNHMWDTSNRLGGETPVIALIETARGLSRVHDIAAARPCFRIA FGVNDYTLDIGVDQDPLALAYSRSQLVVASRAAHIPGPIDGPTRDPAELPEAVSLTRRMGMTGKLALRSS DADTINTGLSPSDEDVSWAQDFVDRFNSQGGKPKDGSDLPRLNRARIILERARMLGLITP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4737 | - | - | 100% (270) | putative citrate lyase/aldolase |
| M. abscessus ATCC 19977 | MAB_1369 | - | 3e-15 | 31.09% (238) | citrate lyase beta chain |
| M. abscessus ATCC 19977 | MAB_4378c | - | 4e-10 | 27.34% (278) | putative citrate lyase beta subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3102c | - | 3e-59 | 42.75% (269) | hypothetical protein Mb3102c |
| M. gilvum PYR-GCK | Mflv_4009 | - | 8e-62 | 44.98% (269) | HpcH/HpaI aldolase |
| M. tuberculosis H37Rv | Rv3075c | - | 3e-59 | 42.75% (269) | hypothetical protein Rv3075c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1583 | citE_2 | 9e-58 | 42.01% (269) | citrate lyase beta subunit, CitE_2 |
| M. avium 104 | MAV_3981 | - | 9e-61 | 43.12% (269) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2667 | - | 2e-61 | 43.38% (272) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. thermoresistible (build 8) | TH_3034 | - | 6e-13 | 29.28% (263) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_3451 | citE_2 | 2e-57 | 41.64% (269) | citrate lyase beta subunit, CitE_2 |
| M. vanbaalenii PYR-1 | Mvan_2378 | - | 3e-61 | 43.49% (269) | HpcH/HpaI aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3102c|M.bovis_AF2122/97 ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
Rv3075c|M.tuberculosis_H37Rv ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
MMAR_1583|M.marinum_M MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MUL_3451|M.ulcerans_Agy99 MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MAV_3981|M.avium_104 ------MYEQVNSSAAEPDDIGSRIDPVLARSWLLVNGTHPDRFQSAVDS
Mflv_4009|M.gilvum_PYR-GCK ------MYDQSFGEAAFGE-QGQRIDPVLARSWLLVNGAHYERFQAAAHS
Mvan_2378|M.vanbaalenii_PYR-1 ------MYEQNFSESAFGE-QGQRIDPVLARSWLLVNGSHYDRFQAAAHS
MSMEG_2667|M.smegmatis_MC2_155 ------MYDQPIHDPDPSASPGFRIDPVLARSWLLVNGAQYERFAPASRS
MAB_4737|M.abscessus_ATCC_1997 ------------------------MNSKVSRSWLLMNPSREASLEAAIAS
TH_3034|M.thermoresistible__bu -----------------------------------VPGSSAKMIAKAKTL
: : : *
Mb3102c|M.bovis_AF2122/97 R-ADIVVLDIEDAVAPKDKHAARDNAVRWFGDG----NADWVRINGFGTP
Rv3075c|M.tuberculosis_H37Rv R-ADIVVLDIEDAVAPKDKHAARDNAVRWFGDG----NADWVRINGFGTP
MMAR_1583|M.marinum_M R-ADIVVLDIEDAVAPKDKGSARDNVVHWLGDG----NADWVRINGFGTP
MUL_3451|M.ulcerans_Agy99 R-ADIVVVDIEDAVAPKDKGSARDNVVHWLGDG----NADWVRINGFGTP
MAV_3981|M.avium_104 R-ADIVVFDIEDAVAPKDKNAARDNVVSWLRAG----NVDWVRINGFGTP
Mflv_4009|M.gilvum_PYR-GCK R-ADIVVLDIEDAVAPKDKAAARANVVRWLGEG----HADWVRVNGFGTE
Mvan_2378|M.vanbaalenii_PYR-1 R-ADIVVLDIEDAVAPKDKAAARANVTRWFGEG----HDDWVRINGFGTE
MSMEG_2667|M.smegmatis_MC2_155 R-ADIVILDIEDAVAPKDKAAARDNVVRWLSEG----NTDWVRVNGFGTP
MAB_4737|M.abscessus_ATCC_1997 TNADEVILDLEDAVAPNEKEPARGRVLEYLNSG----GNAWVRVNDASSD
TH_3034|M.thermoresistible__bu P-ADQVFLDLEDAVAPDAKAEARTRVAAALAEDGWGDQMRGVRVNDWSTP
** *..*:******. * ** .. : . **:*. .:
Mb3102c|M.bovis_AF2122/97 WWADDLAMLADSP---VGGVMLAMVESVDHVT---------ETAKRLP--
Rv3075c|M.tuberculosis_H37Rv WWADDLAMLADSP---VGGVMLAMVESVDHVT---------ETAKRLP--
MMAR_1583|M.marinum_M WWADDIAILAGSS---VGGVMLAMVESVDHVT---------ETARRLP--
MUL_3451|M.ulcerans_Agy99 WWADDIAILAGSS---VGGVMLAMVESVDHVT---------ETARRLP--
MAV_3981|M.avium_104 WWADDLTALAGTP---VGGVMLAMVESVDHVT---------ETAKRLP--
Mflv_4009|M.gilvum_PYR-GCK WWAGDLEMLAGTS---VGGVMLAMVESVDHVT---------ETAKRLP--
Mvan_2378|M.vanbaalenii_PYR-1 WWAGDLEMLAGTS---VGGVMLAMVESVDHVT---------ETVKRLP--
MSMEG_2667|M.smegmatis_MC2_155 WWADDLDTLKGTS---VGGIMLAMVESVDHVT---------ETANRLP--
MAB_4737|M.abscessus_ATCC_1997 FWSADCRALADARG--LKGVVLAKTEGGNHMW---------DTSNRLGG-
TH_3034|M.thermoresistible__bu WTHSDVIEVVSAAGAHLDIIVLPKVTDVSHIHALDLLLSQLEVQHGLPVG
: * : .: : ::*. . . .*: :. . *
Mb3102c|M.bovis_AF2122/97 NVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFR-----RDTGFGED
Rv3075c|M.tuberculosis_H37Rv NVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFR-----RDTGFGED
MMAR_1583|M.marinum_M NVPIVALVETARGLERITEIASAKGTFRLAFGIGDFR-----RDTGFGED
MUL_3451|M.ulcerans_Agy99 NVPIVALVETARGLERITEIASAKGTFRLAFGIGDFR-----RDTGFGKD
MAV_3981|M.avium_104 DVPIVALVETARGLERITEIAATKGTFRLAFGIGDFR-----RDTGFGED
Mflv_4009|M.gilvum_PYR-GCK GVPIVALVETARGLERITEIAAAKGTFRLAFGIGDFR-----RDTGFGGD
Mvan_2378|M.vanbaalenii_PYR-1 GVPIVALVETARGLERINEIASAKGTFRLAFGIGDFR-----RDTGFGDN
MSMEG_2667|M.smegmatis_MC2_155 DVPIVALVETARGLERITEIAATKGTFRLAFGIGDFR-----RDTGFGEN
MAB_4737|M.abscessus_ATCC_1997 ETPVIALIETARGLSRVHDIAAARPCFRIAFGVNDYT-----LDIGVDQD
TH_3034|M.thermoresistible__bu RIGIEAQIENAQGLTNIDAIAAAPRVQALVLGPADLMASLNMRTLVVGEQ
: * :*.*:** .: **:: :.:* * .. :
Mb3102c|M.bovis_AF2122/97 P------ATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVS-
Rv3075c|M.tuberculosis_H37Rv P------ATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVS-
MMAR_1583|M.marinum_M A------TTLAYARSRFTIAAKAAGLPSAIDGPTIGSNPLKLIEASAVS-
MUL_3451|M.ulcerans_Agy99 A------TTLAYARSRFTIAAKAAGLPSAIDGPTIGSNPLKLIEASAVS-
MAV_3981|M.avium_104 P------ATLAYTRSRFTIASKAADLPSAIDGPTIGSNPLKLIEATAVS-
Mflv_4009|M.gilvum_PYR-GCK A------LTLAYTRSRFTIAAKAAHLPSAIDGPTVGSSALKLSEATAVS-
Mvan_2378|M.vanbaalenii_PYR-1 P------MTLAYARSRFTIAAKAAHLPSAIDGPTVGSSALRLSEATAVS-
MSMEG_2667|M.smegmatis_MC2_155 P------ATLAYARSRFTIAAKAAHLPSAIDGPTVGSSPLKLAEATAVS-
MAB_4737|M.abscessus_ATCC_1997 P------LALAYSRSQLVVASRAAHIPGPIDGPTR--DPAELPEAVSLT-
TH_3034|M.thermoresistible__bu PEGYDVGDAYHHVLMRILIAARTHGIA-AIDGPFLQIRDVEAFRRVAARS
. : : :: :*::: :. .**** . . :
Mb3102c|M.bovis_AF2122/97 AEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNG
Rv3075c|M.tuberculosis_H37Rv AEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNG
MMAR_1583|M.marinum_M VEFGMTGKICLSPEQCAVVNEGLSPSQDEIGWAKEFFAEFERDGGEIRNG
MUL_3451|M.ulcerans_Agy99 VEFGMTGKICLSPEQCAVVNEGLSPSQDEIGWAKEFFAEFERDGGEIRNG
MAV_3981|M.avium_104 TQFGMTGKICLTPDQCSVVNEGLSPSQDEIAWAKEFFAEFERDGGEIRNG
Mflv_4009|M.gilvum_PYR-GCK AEFGMTGKICLTPEQCLTVNEGLSPSAEEIAWAKEFFVEFERDGGEIRNG
Mvan_2378|M.vanbaalenii_PYR-1 AEFGMTGKICLTPEQCPTVNEGLSPSAEEITWAKEFFVEFERDGGEIRNG
MSMEG_2667|M.smegmatis_MC2_155 AEFGMTGKICLTPDQCPTVNEGLSPSQDEISWAKEFFAEFQRDGGEIRNG
MAB_4737|M.abscessus_ATCC_1997 RRMGMTGKLALRSSDADTINTGLSPSDEDVSWAQDFVDRFNSQGGKPKDG
TH_3034|M.thermoresistible__bu AALGYDGKWVLHPDQIAAGNEVFSPRQEDYNHAELILEAYEWYTSQAG-G
:* ** * ..: . * :** :: *: :. : .: *
Mb3102c|M.bovis_AF2122/97 SDLPRIARATKILDLARAYGIEVSDFE--DEP-VHMPAPTDTYHY--
Rv3075c|M.tuberculosis_H37Rv SDLPRIARATKILDLARAYGIEVSDFE--DEP-VHMPAPTDTYHY--
MMAR_1583|M.marinum_M SDLPRIARATKILDLARAYGIEASDFE--DEP-VHSPAPTDTYHY--
MUL_3451|M.ulcerans_Agy99 SDLPRIARATKILDLARAYGIEASDFE--DEP-VHSPAPTDTYHY--
MAV_3981|M.avium_104 SDLPRIARATKILELARAYGIEALDID--EEERDHSPAPSDTYHY--
Mflv_4009|M.gilvum_PYR-GCK SDLPRIARANKILELARAYGIEPSEFDDVDEP-THIPAPSDTYHY--
Mvan_2378|M.vanbaalenii_PYR-1 SDLPRIARATKILDLARAYGIEPSDFDDVDEP-AHIPAPSDTYHY--
MSMEG_2667|M.smegmatis_MC2_155 SDLPRIARANKILDLARAYGIHEPEYSN-DDP-DHVPAPSDTYHY--
MAB_4737|M.abscessus_ATCC_1997 SDLPRLNRARIILERARMLGLITP-----------------------
TH_3034|M.thermoresistible__bu ARGAAMLGDEMIDEASRKMALVIAAKG----RAAGMTRTGGRFQPPS
: . : * : :* .: