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QPLKILRNPMFWGVNALAIIVVLALTAAAVYVSPPGEKSVVFFTDDAASVRPGEDVRIAGITVGRVKDLS IEPNQVKVRASVDSSAFVGDQSQIQVRMLTVVGGYYVNLVSLGNKPLGNRAIPLERVTMPYNLMRALTDA TKITEGVDPKPIRQSLDRIQAGLNGTNVDTLSAVIDAGNALTSTIDRQRGQITTILNLSDEYIDQLSNYR ERLQELVSKLSILEQTLVLYGKGFAGALSGMGDIGDAFLEPFGKFWVNHREEFIEKVREWQDRFRRWAND NSRIIPRLRRIRDKIERVLDAQNARPELLATDLCIPMPGSPC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5050 | - | - | 100% (323) | putative Mce family protein |
| M. avium 104 | MAV_0104 | - | 5e-19 | 26.48% (253) | virulence factor Mce family protein |
| M. avium 104 | MAV_2386 | - | 9e-18 | 27.08% (240) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 6e-18 | 26.54% (260) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_4536 | - | 3e-20 | 27.62% (239) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 6e-18 | 26.54% (260) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-12 | 27.17% (173) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4032 | - | 1e-23 | 30.95% (210) | putative Mce family protein |
| M. marinum M | MMAR_0179 | mce6C | 2e-16 | 25.32% (237) | MCE-family protein Mce6C |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 3e-18 | 26.25% (240) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3264 | - | 2e-18 | 28.02% (207) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4917 | mce6C | 8e-17 | 25.32% (237) | MCE-family protein Mce6C |
| M. vanbaalenii PYR-1 | Mvan_0924 | - | 5e-17 | 27.27% (220) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3264|M.thermoresistible__bu --------------------VTVGAVGVLIVAMLVVGALQYDKLMFWT-D
Mvan_0924|M.vanbaalenii_PYR-1 -----------MKPMTERNPLAVGAVGAVTVGAVLLGALNFDDLPFADGA
Mb3527c|M.bovis_AF2122/97 ------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQG
Rv3497c|M.tuberculosis_H37Rv ------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQG
Mflv_4536|M.gilvum_PYR-GCK -----------MQKYRGASLVRAGFLGAVLIALVIVVGLQPQQLWAMATS
MMAR_0179|M.marinum_M MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVLIGALLLVK--QAGIGY
MUL_4917|M.ulcerans_Agy99 MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVMIGALLLVK--QGGIGY
MSMEG_1145|M.smegmatis_MC2_155 MAEARKARRR--KPLESYNRLWLGVVAVAVVSVLIGAMLLVR--VADIGY
MLBr_02591|M.leprae_Br4923 -----------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFAR
MAV_5050|M.avium_104 -----------MQPLKILR--NPMFWGVNALAIIVVLALTAAAVYVSPPG
MAB_4032|M.abscessus_ATCC_1997 -----MFARNRPILDEHEAAKRNRRNGLIGVLVIAAVLAATGVAFVNTSG
. :
TH_3264|M.thermoresistible__bu KSYTAYFTQAGG-LRAGAMVQVSGLRSGRVTSVALEGSQVRVKFDVNRKV
Mvan_0924|M.vanbaalenii_PYR-1 ADYSAYFADAAG-LQPDAPVQVAGLRVGQVTDISLDGPRVLVEFDVDKGV
Mb3527c|M.bovis_AF2122/97 KTYDAYFTDAGG-ITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSI
Rv3497c|M.tuberculosis_H37Rv KTYDAYFTDAGG-ITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSI
Mflv_4536|M.gilvum_PYR-GCK VRYQAVFAEAGG-LAAGNEVKVSGVTVGSVSDVALDRGSALVTFSVDSAV
MMAR_0179|M.marinum_M RRYTAEFLQAAS-LQPDNVVSVAGVPVGNVISVRLAGDHVEARLRVKDNI
MUL_4917|M.ulcerans_Agy99 RRYTAEFLQAAS-LQPDNVVSVAGVPVGNVISVRLAGNHVEARLRVKDNI
MSMEG_1145|M.smegmatis_MC2_155 TQYTARFLQAAA-LKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVRNDV
MLBr_02591|M.leprae_Br4923 PSYYGQFTDTGG-LNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TN
MAV_5050|M.avium_104 EKSVVFFTDDAASVRPGEDVRIAGITVGRVKDLSIEPNQVKVRASVDSSA
MAB_4032|M.abscessus_ATCC_1997 MKTYALHLRASGGLRAGDDVRIAGISVGKVSTVRIDKSLVEATFTVDHAV
. .. : . * ::*: * * : : . :
TH_3264|M.thermoresistible__bu RLGDRSEAAIKTKSLLGAKYLEITTRGDGVLGGP--IPADRTTPPYELPD
Mvan_0924|M.vanbaalenii_PYR-1 RLGDRTEAAIKTKTVLGAKYVEVIPRGAGGQSGP--IPLERTTSPYQLTD
Mb3527c|M.bovis_AF2122/97 VVGDQSLAAIRTDTILGERSIAVSPAGSG-KSTT--IPLSRTTTPYTLNG
Rv3497c|M.tuberculosis_H37Rv VVGDQSLAAIRTDTILGERSIAVSPAGSG-KSTT--IPLSRTTTPYTLNG
Mflv_4536|M.gilvum_PYR-GCK RVGDATTATVGISTVLGERVLVLKPDGSRSLGSMGVIPLTRTGSPYSLTD
MMAR_0179|M.marinum_M ALGRDTRAAIKITTIFGSRYIDLHPTGAGVPPGQ-TIDLAHTEVPYDLQA
MUL_4917|M.ulcerans_Agy99 ALGRDTRAAIKITTIFGSRYIDLHPTGAGVPPGQ-TIDLAHTEVPYDLQA
MSMEG_1145|M.smegmatis_MC2_155 GLGKDSRAKIMVTTILGSRYLSLEPAGDGTLPDR-TFDLSHTDVPYDLQE
MLBr_02591|M.leprae_Br4923 RIGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYD
MAV_5050|M.avium_104 FVGDQSQIQVRMLTVVGGYYVNLVSLGNKPLGNR-AIPLERVTMPYNLMR
MAB_4032|M.abscessus_ATCC_1997 PVGSESRADIRMLTPLGGHYLALYPEGSTPLGKT-PIPPERTSIPFEINE
:* : : : .* : : . * : : *:
TH_3264|M.thermoresistible__bu ALGDLATTISGLDTIGVSDSLATLAETFSGT-APDVQQAVQGLSAFSETI
Mvan_0924|M.vanbaalenii_PYR-1 VLGDLASTINGLDTAELSTSLDTLADTFSDT-PPELRIAVQGVSRFADTI
Mb3527c|M.bovis_AF2122/97 VLQDLGRNANDLNRPQFEQALNVFTQALHDA-TPQVRGAVDGLTSLSRAL
Rv3497c|M.tuberculosis_H37Rv VLQDLGRNANDLNRPQFEQALNVFTQALHDA-TPQVRGAVDGLTSLSRAL
Mflv_4536|M.gilvum_PYR-GCK AVGEFTTNTEGTDTAAINQSLDTLSETIERV-APQLGPTFDGVSRLSKSL
MMAR_0179|M.marinum_M ALADSTRTFEQVDGDRIASSLTVLGQALNGL-PDVFPQALENVRALSSVI
MUL_4917|M.ulcerans_Agy99 ALADSTRTFEQVDGDRIASSLTVLGQALNGL-PDVFPQALENVRALSSVI
MSMEG_1145|M.smegmatis_MC2_155 ALTDVTTTFEKVDSDKFAETLQILGSQLETL-PPVIPQALENTHTLSTII
MLBr_02591|M.leprae_Br4923 AFFDATKVASGWNIDTIKQSLKVVSETIDQT-YPHLSAALDGVAKFSDTI
MAV_5050|M.avium_104 ALTDATKITEGVDPKPIRQSLDRIQAGLNGTNVDTLSAVIDAGNALTSTI
MAB_4032|M.abscessus_ATCC_1997 LFQKFTPVVKKVDAKVIHDSLMEVANAVDKY-PNGLRDFFQSSQSLIKAL
. . . : . :* . . . .: : :
TH_3264|M.thermoresistible__bu DRRNRHLRELLADARKVSDVLGERSEQIVKLVRHSNALLIALQQQSVALD
Mvan_0924|M.vanbaalenii_PYR-1 NQRDEQLRSLLSNVSKVSGVLAERSDQIVRLVADTNALLSQLRQQSSSLD
Mb3527c|M.bovis_AF2122/97 NRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALS
Rv3497c|M.tuberculosis_H37Rv NRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALS
Mflv_4536|M.gilvum_PYR-GCK NSRNESLGALLDAAADVTGVLSERSAQVNTLLLNANDLLAVLQDRRYAIV
MMAR_0179|M.marinum_M SQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFH
MUL_4917|M.ulcerans_Agy99 SQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFH
MSMEG_1145|M.smegmatis_MC2_155 AQRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRATFH
MLBr_02591|M.leprae_Br4923 GARDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVD
MAV_5050|M.avium_104 DRQRGQITTILNLSDEYIDQLSNYRERLQELVSKLSILEQTLVLYGKGFA
MAB_4032|M.abscessus_ATCC_1997 EPTTEDFHATLNYANEYLRAFKTGKEQLASIVTMMSKLGAKYSKSTTDLI
: : : : :: . * .
TH_3264|M.thermoresistible__bu QISHHISLFARQTSE----LVAENRAELRPALDKLNGVLTIVDNRRDRLQ
Mvan_0924|M.vanbaalenii_PYR-1 QISGNISAVSRQIKG----FITENRPQFKPALDKLNGVLTIVERRKEKLQ
Mb3527c|M.bovis_AF2122/97 ALISGIDDVAAQISG----FVADNRKEFGPALSKLNLVLANLNERRDYIT
Rv3497c|M.tuberculosis_H37Rv ALISGIDDVAAQISG----FVADNRKEFGPALSKLNLVLANLNERRDYIT
Mflv_4536|M.gilvum_PYR-GCK NLLASTTAVAQELSG----MVEDNEQELAPTLEKLNTVSEMLERNRDNIS
MMAR_0179|M.marinum_M AMMQALTQVVGSLRT----IVVDDRAALEDVVQTMEQLSAKLAEQDALFR
MUL_4917|M.ulcerans_Agy99 AMMQALTQVVGSLRT----IVVDDRAALEDVVQTMEQLSAKLAEQDALFR
MSMEG_1145|M.smegmatis_MC2_155 AMMDALTNLVQTLSG----IVIDDRPELEKLVEDLRQLSSLLSKNDGMLR
MLBr_02591|M.leprae_Br4923 ALLGNVAAFAAQVQR----LINDN-PNLNHVLEQLHQLSGILVQHKDDLA
MAV_5050|M.avium_104 GALSGMGDIGDAFLEPFGKFWVNHREEFIEKVREWQDRFRRWANDNSRII
MAB_4032|M.abscessus_ATCC_1997 EVFVLLRDLARIFDR----FFKAYARDYEPMLNGLDDIVDTLTKYPEKLG
. : : . :
TH_3264|M.thermoresistible__bu ETLPLLNKYVMQLGESVASGPFFKAYIVNLLPGQFLQPFIDAAFSDLGLD
Mvan_0924|M.vanbaalenii_PYR-1 ESITRLNGYSMSLGEAISSGPFFKGLIANLPPGQFIQPFVEAAFSDLGLD
Mb3527c|M.bovis_AF2122/97 EALKRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG---
Rv3497c|M.tuberculosis_H37Rv EALKRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG---
Mflv_4536|M.gilvum_PYR-GCK ASLKGLAKYQVTQGEAVNNGFFYNGFASNLLPGPAIQPFLDYALGFR---
MMAR_0179|M.marinum_M NLLEIAPVPVRELANASGYG---NALELNAAAGPLVDSWMCAISGRA---
MUL_4917|M.ulcerans_Agy99 NLLEIAPVPVRELANASGYG---NALEINAAAGPLVDSWMCAISGRA---
MSMEG_1145|M.smegmatis_MC2_155 SILQTAPIALRNIANMTGTG---NAIDFNSSSGLLVDSWMCAISGRA---
MLBr_02591|M.leprae_Br4923 NTLIQVAAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGID
MAV_5050|M.avium_104 PRLRRIRDKIERVLDAQNARP-------ELLATDLCIPMPGSPC------
MAB_4032|M.abscessus_ATCC_1997 KAAEQWGQLVGIVLPMLSGNGITINENDRVIPGQDVCLPHFFRFC-----
.
TH_3264|M.thermoresistible__bu PN-----------VLSPSERTDPLTGQAA---------------------
Mvan_0924|M.vanbaalenii_PYR-1 PN-----------VLLPSQLTDPPVGQPA---------------------
Mb3527c|M.bovis_AF2122/97 --------------KLPDSLADYLRGFIQ---------------------
Rv3497c|M.tuberculosis_H37Rv --------------KLPDSLADYLRGFIQ---------------------
Mflv_4536|M.gilvum_PYR-GCK ---------------RGVNAGQPPDNAGP---------------------
MMAR_0179|M.marinum_M ---------------KQFGLIQYFKDCA----------------------
MUL_4917|M.ulcerans_Agy99 ---------------KQFGLIQYFKDCA----------------------
MSMEG_1145|M.smegmatis_MC2_155 ---------------KQFGMIQYFQDCK----------------------
MLBr_02591|M.leprae_Br4923 PENFWRSAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGS
MAV_5050|M.avium_104 --------------------------------------------------
MAB_4032|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3264|M.thermoresistible__bu ----------------------TPALPVPYPRTGQGGEPHLTLPDAITGK
Mvan_0924|M.vanbaalenii_PYR-1 ----------------------TPALPVPYPRTGQGGEPRLTLPDAITGN
Mb3527c|M.bovis_AF2122/97 ----------------------ERWIIRPKSP------------------
Rv3497c|M.tuberculosis_H37Rv ----------------------ERWIIRPKSP------------------
Mflv_4536|M.gilvum_PYR-GCK ----------------------RAEFPWPYNGIPGGSR------------
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PCSYTPAHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQ
MAV_5050|M.avium_104 --------------------------------------------------
MAB_4032|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3264|M.thermoresistible__bu PGDPRYPYREPLPAPPPGGPPPGPPAEAPPNEASDQPSPQPTLVLAPGEP
Mvan_0924|M.vanbaalenii_PYR-1 PGDPRYPYREPLPAPPPGGPPPGPPDPVLP-----APTHGPVVTSDPTEP
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4536|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 TSPPNPDGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAP
MAV_5050|M.avium_104 --------------------------------------------------
MAB_4032|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3264|M.thermoresistible__bu GAPAPSVPPPPPEAVP----------------------
Mvan_0924|M.vanbaalenii_PYR-1 STASSTGGSRPEEAPQ----------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------
Mflv_4536|M.gilvum_PYR-GCK --------------------------------------
MMAR_0179|M.marinum_M --------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------
MLBr_02591|M.leprae_Br4923 AAPAQDSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN
MAV_5050|M.avium_104 --------------------------------------
MAB_4032|M.abscessus_ATCC_1997 --------------------------------------