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VALGNINEWQPPHGPVTMWMAAPAALEAARAARRSDLPPSYQQNQHLWAAYHGKVLDRQLPRLMVVAWDI PGACDIGAMTATINAHLHRQDTYHSWFEHDNGVFVRRVIDRPEDIDYVAVPLGQMNADQVRTHVLTSTPQ TLEWGCFTYGIIQHAEYFTFYASVDHLHIDGLSAALIFLDIHLTYQELAHTGRLPAALPEIRSYRDYAVR QREKAAALTLSSPEIKDWIEFARDTDGDWPSFPLPLGDTWASSKGDLLTVELMDAADTASFDAACLAAGA RFIGGVLACTALAEHELTGKTTYHGFTARDTRTPGVDTMTLGWFASLIPVTVPTAGETFAQAARTAQKSF DDAQRLADVPVERVLELATPDELGIKLPTQLPMMLSFLDFRKIPLNGLWAETKFGTYGDSLSHGGVNMWI NRQAANTTVTMSFPDNAIARDSVLRYIATLIRVFTRVARPAADEPVIVVPQPDSHEPGTSAPTADDTEAA *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4883 | - | - | 100% (491) | condensation domain-containing protein |
| M. avium 104 | MAV_2723 | - | e-111 | 49.41% (427) | PapA2 protein |
| M. avium 104 | MAV_1762 | - | e-103 | 41.51% (465) | condensation domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1214 | papA3 | 1e-111 | 43.95% (471) | polyketide synthase associated protein PapA3 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 2e-94 | 41.08% (465) | condensation domain-containing protein |
| M. tuberculosis H37Rv | Rv1182 | papA3 | 1e-111 | 43.95% (471) | polyketide synthase associated protein PapA3 |
| M. leprae Br4923 | MLBr_01230 | papA3 | 1e-104 | 41.90% (463) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0852 | - | 1e-122 | 48.37% (461) | polyketide synthase associated protein PapA2 |
| M. marinum M | MMAR_2343 | - | 1e-101 | 44.02% (468) | hypothetical protein MMAR_2343 |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 2e-98 | 41.29% (482) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-110 | 44.84% (475) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 3e-98 | 41.20% (466) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 4e-94 | 40.00% (465) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2343|M.marinum_M MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQAPVSAVPPSHI
TH_2204|M.thermoresistible__bu --MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQAPVSSVPVSYM
MUL_1531|M.ulcerans_Agy99 --MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYM
MSMEG_4728|M.smegmatis_MC2_155 -------MFELTDIQNWDDAPGKHVSWGPSPSTVAKVAEAPVSDVPASYQ
Mb1214|M.bovis_AF2122/97 --MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYM
Rv1182|M.tuberculosis_H37Rv --MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYM
MLBr_01230|M.leprae_Br4923 ---MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVAYM
Mflv_0404|M.gilvum_PYR-GCK ---MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQAPVSSVPVSYM
Mvan_0270|M.vanbaalenii_PYR-1 ---MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRAQVSSVPVSYM
MAV_4883|M.avium_104 -------MVALGNINEWQPPHGPVTMWMAAPAALEAARAARRSDLPPSYQ
MAB_0852|M.abscessus_ATCC_1997 -------MVALGTIHDWRPTPGTVISWSASPRAREVAAQAPASTIPPSYQ
. : :* * * .: : . * * :* ::
MMAR_2343|M.marinum_M QARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYVINSHLRRHDT
TH_2204|M.thermoresistible__bu QAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYVINAHMRRHDT
MUL_1531|M.ulcerans_Agy99 QAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDT
MSMEG_4728|M.smegmatis_MC2_155 QAQHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHVINAYLRRHDT
Mb1214|M.bovis_AF2122/97 QAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDT
Rv1182|M.tuberculosis_H37Rv QAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDT
MLBr_01230|M.leprae_Br4923 QAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDT
Mflv_0404|M.gilvum_PYR-GCK QGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHAVNAYLRRHDT
Mvan_0270|M.vanbaalenii_PYR-1 QGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHAVNAYLRRHDT
MAV_4883|M.avium_104 QNQHLWAAYHGKVLDRQLPRLMVVAWDIPGACDIGAMTATINAHLHRQDT
MAB_0852|M.abscessus_ATCC_1997 QAQHLRSYRDLARQDREMARLGIGSWDVPGVCDIDAMTAAINAHLRRHDT
* :*: . .* : : . **: : :*::::*:**
MMAR_2343|M.marinum_M YRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QWQDYILA-TPG
TH_2204|M.thermoresistible__bu YRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QWQQHLLS-TPD
MUL_1531|M.ulcerans_Agy99 FRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRERLLA-TPS
MSMEG_4728|M.smegmatis_MC2_155 YHSRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQTCD-QWREHILD-TPG
Mb1214|M.bovis_AF2122/97 YRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLP-QIREIVQN-TPD
Rv1182|M.tuberculosis_H37Rv YRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLP-QIREIVQN-TPD
MLBr_01230|M.leprae_Br4923 YRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLA-QIRELAVS-TPD
Mflv_0404|M.gilvum_PYR-GCK FRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVD-EIHAHVVA-IPS
Mvan_0270|M.vanbaalenii_PYR-1 FRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVD-EIFAHVVD-IPS
MAV_4883|M.avium_104 YHSWFEHD-NGVFVRRVIDRPEDIDYVAVPLGQMNAD-QVRTHVLTSTPQ
MAB_0852|M.abscessus_ATCC_1997 YHSWFEFDPVDKIVRHVIDDPASIDFVPQDHGLQGPD-EIRAHLLRTSGT
::* *: : *: : * .: .. * :
MMAR_2343|M.marinum_M PLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEIEAMYNTLAD
TH_2204|M.thermoresistible__bu PLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEIHMQYAALVG
MUL_1531|M.ulcerans_Agy99 PLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVS
MSMEG_4728|M.smegmatis_MC2_155 PLQWDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEIHLMYAALVS
Mb1214|M.bovis_AF2122/97 PLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVG
Rv1182|M.tuberculosis_H37Rv PLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVG
MLBr_01230|M.leprae_Br4923 PLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEFHMMYSALVS
Mflv_0404|M.gilvum_PYR-GCK PLEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEANGMYSALSS
Mvan_0270|M.vanbaalenii_PYR-1 PLEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEANGMYSALSG
MAV_4883|M.avium_104 TLEWGCFTYGIIQHAEYFTFYASVDHLHIDGLSAALIFLDIHLTYQELAH
MAB_0852|M.abscessus_ATCC_1997 PLSWDCFTFGVIQRADHFTVYISVDHLHTDGMSTGILYIEIQLMYASLVH
.*.*.*. :.::* :*: .:**:: *. . : . * *
MMAR_2343|M.marinum_M GGAP-ISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFFESNDGALP
TH_2204|M.thermoresistible__bu GGAP-IPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFAGQMGGTLP
MUL_1531|M.ulcerans_Agy99 GGAP-LRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLP
MSMEG_4728|M.smegmatis_MC2_155 GGAP-ITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFLEGNNGTMP
Mb1214|M.bovis_AF2122/97 GHAP-LELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFP
Rv1182|M.tuberculosis_H37Rv GHAP-LELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFP
MLBr_01230|M.leprae_Br4923 GAGP-LELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFAEPNEGSFP
Mflv_0404|M.gilvum_PYR-GCK GGAA-LALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFAENNSDGFP
Mvan_0270|M.vanbaalenii_PYR-1 GGAA-LTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFAENSGGGFP
MAV_4883|M.avium_104 TGRLPAALPEIRSYRDYAVRQREKAAALTLSSPEIKDWIEFARDTDGDWP
MAB_0852|M.abscessus_ATCC_1997 GSAL--QLPPPAGYLDFSARELAHNQAMTLDSFEVQTWLRYARDNGGTLP
* .: ::. *: :* .* : * : . *
MMAR_2343|M.marinum_M SFPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARFSGGVFACA
TH_2204|M.thermoresistible__bu NFPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARFVGGVFACA
MUL_1531|M.ulcerans_Agy99 KFPLPLGDTS--AQCEMMGVRLMDERQTLALEAACMSAGARFCGGVFAIS
MSMEG_4728|M.smegmatis_MC2_155 KFPLPLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRFIGGVFAAA
Mb1214|M.bovis_AF2122/97 DFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACC
Rv1182|M.tuberculosis_H37Rv DFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACC
MLBr_01230|M.leprae_Br4923 DFPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARFVGGVLACC
Mflv_0404|M.gilvum_PYR-GCK EFPLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARFVGGLFACL
Mvan_0270|M.vanbaalenii_PYR-1 EFPLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARFVGGLFACL
MAV_4883|M.avium_104 SFPLPLGDTWASSKGDLLTVELMDAADTASFDAACLAAGARFIGGVLACT
MAB_0852|M.abscessus_ATCC_1997 DFALPLGDRTAPNVGAMVAIPLLDAHGTVAFEKACEQAGVRFSGGVFACT
.*.****: : ::* * :: .. ** ** **::*
MMAR_2343|M.marinum_M ALAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTVAVA-SSFD
TH_2204|M.thermoresistible__bu ALTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITVPAAGVSFG
MUL_1531|M.ulcerans_Agy99 AVVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFG
MSMEG_4728|M.smegmatis_MC2_155 ALAQYQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITVPVG-SSFA
Mb1214|M.bovis_AF2122/97 GLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFG
Rv1182|M.tuberculosis_H37Rv GLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFG
MLBr_01230|M.leprae_Br4923 GLAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAGSSFG
Mflv_0404|M.gilvum_PYR-GCK AQVEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITVPIGAASFG
Mvan_0270|M.vanbaalenii_PYR-1 AQVEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITVPIGATSFA
MAV_4883|M.avium_104 ALAEHELTGKTTYHGFTARDTRTPGVDTMTLGWFASLIPVTVPTAGETFA
MAB_0852|M.abscessus_ATCC_1997 ALIDRELTGAGTFYGITPYDTRGTAEEQMSVGWYASFIPFIVDMSDDSFA
. : :*:. :: ... * : :: **:.. :*. * :*
MMAR_2343|M.marinum_M ETVRGAQANFDASAHLANVPFERVLELA-PWLK-KPPPRGGFPMVSFLDG
TH_2204|M.thermoresistible__bu EAARAAQQSFDSGIGLGHVPYDRVLELV-PSLR-RAETCS--PMMSFLDA
MUL_1531|M.ulcerans_Agy99 EIVKAAQGSFDSGRDLAEVPLDCVMELV-LWLR-EGQWGA--PLLFYLDA
MSMEG_4728|M.smegmatis_MC2_155 ETARTAQRSFDSGLYLAHVPFDRVLELG-ATERGLRAPDPGVPMVSYLDA
Mb1214|M.bovis_AF2122/97 DAARAAQTSFDSGVKLAEVPYDRVVELS-STLT---MPRPNFPVVNFLDA
Rv1182|M.tuberculosis_H37Rv DAARAAQTSFDSGVKLAEVPYDRVVELS-STLT---MPRPNFPVVNFLDA
MLBr_01230|M.leprae_Br4923 DAARAAQNCFDTDVHLAEVPYDRVVELA-PTVH---KPRPNFPVINFLDA
Mflv_0404|M.gilvum_PYR-GCK EAAWAAQSSFDSGLNMAKVPYYRVLELA-PWLG---WPRPNFPVSNFFHG
Mvan_0270|M.vanbaalenii_PYR-1 DAAWAAQASFDSNLFMAKVPYYRVLELA-PWLS---WPRPNFPVSNFFHG
MAV_4883|M.avium_104 QAARTAQKSFDDAQRLADVPVERVLELATPDELGIKLPTQLPMMLSFLDF
MAB_0852|M.abscessus_ATCC_1997 TVARSAQKSFDECQPLAKVPFERALELAGPDS-GLTAPEYVVPMVSFLDA
. ** ** :..** .:** : ::.
MMAR_2343|M.marinum_M GVPPLSGVVAMQLDRI--NARAFSDGRVAARVCIWVNKFQEETTVTASFP
TH_2204|M.thermoresistible__bu GVPPLSALVASQLDGL--NARVYGDGKVPAQLCMWVNRMDNETSVTVFFP
MUL_1531|M.ulcerans_Agy99 GIPPLSAMANSHVEGL--RARLCHDGGMMGQIDIRVNRLEKETQLTVLFP
MSMEG_4728|M.smegmatis_MC2_155 TAAPLSPAVVAEWNRI--NGRIFSEMGAANQVGMWVNQFGSGTWITVAFP
Mb1214|M.bovis_AF2122/97 GAAPLSVLLTAELTGT--NIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFP
Rv1182|M.tuberculosis_H37Rv GAAPLSVLLTAELTGT--NIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFP
MLBr_01230|M.leprae_Br4923 GTAPLSVLLTAGLDGL--NIGVYSDGRYSYQMSIYVIRVEQETAVAVMFP
Mflv_0404|M.gilvum_PYR-GCK GAAPLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTEMAIMHP
Mvan_0270|M.vanbaalenii_PYR-1 GAAPLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTVMAIMHP
MAV_4883|M.avium_104 RKIPLNGLWAETKFGT------YGDSLSHGGVNMWINRQAANTTVTMSFP
MAB_0852|M.abscessus_ATCC_1997 RKIPVSAEWDRINGGI------YGDSRSSDQVCMWVNRFENETNLTISFP
*:. : : : : : * :: .*
MMAR_2343|M.marinum_M NNPIAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL--------
TH_2204|M.thermoresistible__bu DNPVARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQPA------
MUL_1531|M.ulcerans_Agy99 NNPVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYE
MSMEG_4728|M.smegmatis_MC2_155 NNPVARASVQEYVDAFRSVCVAVAEGRHDDVPTPRVNELDLRSA------
Mb1214|M.bovis_AF2122/97 DNPIARESVARYLATLKSVFQRVAESGQQQNVA-----------------
Rv1182|M.tuberculosis_H37Rv DNPIARESVARYLATLKSVFQRVAESGQQQNVA-----------------
MLBr_01230|M.leprae_Br4923 DNPEAQESVARYLETLKSVFECVAESGHWRNVA-----------------
Mflv_0404|M.gilvum_PYR-GCK DNPVAKRSVERYMQTMSSVASLVADTGHWGRVA-----------------
Mvan_0270|M.vanbaalenii_PYR-1 DNPVAKKSVTRYMKVMKSVAGLVADSGTWGLVA-----------------
MAV_4883|M.avium_104 DNAIARDSVLRYIATLIRVFTRVARPAADEPVIVVPQPDSHEPGTSAPTA
MAB_0852|M.abscessus_ATCC_1997 DNAVARESVSRYFEVARVVYQRVAQSQFVS--------------------
:*. * ** .*. . :*
MMAR_2343|M.marinum_M --------------
TH_2204|M.thermoresistible__bu --------------
MUL_1531|M.ulcerans_Agy99 PPATVSPLTSWRTG
MSMEG_4728|M.smegmatis_MC2_155 --------------
Mb1214|M.bovis_AF2122/97 --------------
Rv1182|M.tuberculosis_H37Rv --------------
MLBr_01230|M.leprae_Br4923 --------------
Mflv_0404|M.gilvum_PYR-GCK --------------
Mvan_0270|M.vanbaalenii_PYR-1 --------------
MAV_4883|M.avium_104 DDTEAA--------
MAB_0852|M.abscessus_ATCC_1997 --------------