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MKLGQVFDPRRNALNALRLVLAAEVMLFHSWPITGHMPPKSILQLFFSVGVDGFFAISGFLITRSWLSDP RLRDYLTARALRILPGFYICLIVTAFVFAPLSVVIQGGSPAKLLGSAAPLEYVLKNSAIVYLQPSIDGTL HGVPGGNAWNGSMWSLIWELLCYLVVAAIGVVGLGNRRWISPLILVLATLGALVVPPLTFPGVWTIPQLA VRSAIMFSAGAVMYQWRDVIPARWSLVAVALAIVAAAGFLPDYRVVGALPLAYAVIVTGSLLKSERLVLR TDLSYGVYIYAFPTQQLLAVCGLATRLHPALFFLASVAATLPLAAASWFLIEKPSMALKRRLKRKWTGPR AAESDPRVSQAEPAPADVLADRPAPEAPGHF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4409 | - | - | 100% (381) | putative acyltransferase |
| M. avium 104 | MAV_4410 | - | e-148 | 73.09% (353) | AtfA_1 |
| M. avium 104 | MAV_4408 | - | e-137 | 68.73% (355) | putative acyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0530 | - | 2e-10 | 25.77% (326) | membrane acyltransferase |
| M. gilvum PYR-GCK | Mflv_1859 | - | 6e-11 | 24.27% (342) | acyltransferase 3 |
| M. tuberculosis H37Rv | Rv0517 | - | 2e-10 | 25.77% (326) | membrane acyltransferase |
| M. leprae Br4923 | MLBr_02670 | - | 5e-11 | 25.95% (393) | hypothetical protein MLBr_02670 |
| M. abscessus ATCC 19977 | MAB_4110c | - | 1e-133 | 64.12% (379) | acetyltransferase AtfA |
| M. marinum M | MMAR_0854 | - | 1e-08 | 24.83% (286) | membrane acyltransferase |
| M. smegmatis MC2 155 | MSMEG_0390 | - | 1e-114 | 57.82% (358) | putative acyltransferase |
| M. thermoresistible (build 8) | TH_4330 | - | 3e-07 | 22.68% (388) | PUTATIVE acyltransferase 3 |
| M. ulcerans Agy99 | MUL_0606 | - | 3e-09 | 24.21% (409) | membrane acyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1670 | - | 8e-13 | 26.11% (360) | acyltransferase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0530|M.bovis_AF2122/97 -------MAGGMDQPPGQPRRRTRQQSS----DGKNGVRAAEITGEIRAL
Rv0517|M.tuberculosis_H37Rv -------MAGGMDQPPGQPRRRTRQQSS----DGKNGVRAAEITGEIRAL
MMAR_0854|M.marinum_M --------MRWLDPRVSRTSRRTRQRISRWRERGKTIVRSPMLRGEIKAL
MUL_0606|M.ulcerans_Agy99 --MPVGGLVRWLDPRVSRTSRRTRQRISRWRERGKTIVRSPMLQGEIKAL
Mflv_1859|M.gilvum_PYR-GCK --------MTAVSAAPIRVGPRRYVGPG----------------QSIPAL
MLBr_02670|M.leprae_Br4923 --------MRRVGLLRIWNQPERRNG--------------------IPAL
MAV_4409|M.avium_104 -----------MKLGQVFDPRR-------------------------NAL
MAB_4110c|M.abscessus_ATCC_199 -----------MKLGSVFDSRN-------------------------NAL
MSMEG_0390|M.smegmatis_MC2_155 -------------MGKVFDPRN-------------------------NAL
Mvan_1670|M.vanbaalenii_PYR-1 MLPGGDRMVTRVDRWREASGRRRRRAER---------------ANYRLDI
TH_4330|M.thermoresistible__bu --MPGTLVAMAVTAEQVAGNPGDSSGAS----PRDLSHEVSGTRSFLPAV
:
Mb0530|M.bovis_AF2122/97 TGLRIVAAVWVVLFHFRPMLGDASPGFRDALAPVLDCGAQGVDLFFILSG
Rv0517|M.tuberculosis_H37Rv TGLRIVAAVWVVLFHFRPMLGDASPGFRDALAPVLDCGAQGVDLFFILSG
MMAR_0854|M.marinum_M TGLRIVAAVWVVLFHFRPMLADASPDFRENLAPVLNCGAQGVDLFFILSG
MUL_0606|M.ulcerans_Agy99 TGLRIVAAAWVVLFHFRPMLADASPDFRENLAPVLNCGAQGVDLFFILSG
Mflv_1859|M.gilvum_PYR-GCK DGVRAIAVALVLADHGG--------------VPGLSGGFLGVDVFFVLSG
MLBr_02670|M.leprae_Br4923 DGLRAIAVALVLTQHGG--------------IPGLSGGFIGVDLFFVLSG
MAV_4409|M.avium_104 NALRLVLAAEVMLFHSWPITG-HMPPK----SILQLFFSVGVDGFFAISG
MAB_4110c|M.abscessus_ATCC_199 NACRLALATEVILFHSFPLTGRVVESK----AILQLLFSVGVDGFFALSG
MSMEG_0390|M.smegmatis_MC2_155 NALRLLLAVGVILWHSWPLSGHGVTYK----PLEQLLEQVWVDGFFAISG
Mvan_1670|M.vanbaalenii_PYR-1 QGLRAVAVLAVVAHHLWG---------------IPPGGFVGIDVFFVITG
TH_4330|M.thermoresistible__bu EGLRACAALGVIVTHVAFQTGHTSGAVG----RLLGRFDLAVAVFFALSG
. * . *: * : ** ::*
Mb0530|M.bovis_AF2122/97 FVLTWNYLDRMGRSWSVRANLHFLWLRLARVWPVY-LVTLHLAAVWVIFT
Rv0517|M.tuberculosis_H37Rv FVLTWNYLDRMGRSWSVRANLHFLWLRLARVWPVY-LVTLHLAAVWVIFT
MMAR_0854|M.marinum_M FVLTWNYLDRMGHSWSTRATLHFLWLRLARVWPVY-LVTMHLAALLVIMT
MUL_0606|M.ulcerans_Agy99 FVLTWNYLDRMGHSWSTRATLHFLWLRLARVWPVY-LVTMHLAALLVIMT
Mflv_1859|M.gilvum_PYR-GCK FLITSLLLDEIGRTG--RVGLKGFWIRRARRLLPA-LVVMVLAVVAVRGL
MLBr_02670|M.leprae_Br4923 FLITSLLLDELRHTG--RIDAINFWIRRACRLLPA-LVLMVLTVGIAREL
MAV_4409|M.avium_104 FLITRSWLSDP--------RLRDYLTARALRILPG-FYICLIVTAFVFAP
MAB_4110c|M.abscessus_ATCC_199 FLITASWLRNP--------DVREYFVARALRILPG-YYIVLAITAFVVAP
MSMEG_0390|M.smegmatis_MC2_155 FLITSSWLRNP--------RLRDYATARVLRIFPG-LWVCLLIIAFVMAP
Mvan_1670|M.vanbaalenii_PYR-1 YFVTENLLKASAEHG--DPSLRRFYSDRLRRIVPAATVVLVLTVVASVYL
TH_4330|M.thermoresistible__bu FLLWRGHAAAVRGLR-PTPATGRYLRSRVVRIMPG----YLVAVVVILLL
:.:
Mb0530|M.bovis_AF2122/97 LHVGHVPSPEAGQLTAISYVRQILLVQLWFQPYFDGS--SWDGPAWSISA
Rv0517|M.tuberculosis_H37Rv LHVGHVPSPEAGQLTAISYVRQILLVQLWFQPYFDGS--SWDGPAWSISA
MMAR_0854|M.marinum_M LHVGHVPLPEVGQLTAVSYIRQVLMVQLWFQPFFDDS--SWDGPAWSISA
MUL_0606|M.ulcerans_Agy99 LHVGHVPLPEVGQLTAVSYIRQVLMVQLWFQPFFDDS--SWDGPAWSISA
Mflv_1859|M.gilvum_PYR-GCK FSDESVANLRDDAVATFFWMSNWIFVAQDTDYFSQGAPPSPLQHTWSLAV
MLBr_02670|M.leprae_Br4923 FPYQALTNLRNDAIATFLWVANWRFVVHKADYFTQGTPPSPLQHAWSLGV
MAV_4409|M.avium_104 LSVVIQGGSPAKLLGSAAPLEYVLKNSAIVYLQPSIDGTLHGVPGGNAWN
MAB_4110c|M.abscessus_ATCC_199 LSVAIQGGSAARLLFSSAPVEYVLKNSALVQLQLDVGGTPHDIPYPGIWN
MSMEG_0390|M.smegmatis_MC2_155 IGVLLQGGSVSGLMSSYAPIEYVLNNAVLNVYYAGINGTPQGIPWPGVWN
Mvan_1670|M.vanbaalenii_PYR-1 LPQPAVRDITFDALFAFFFVANWHFAAAGTDIPATIDSVSPLLHYWPLSI
TH_4330|M.thermoresistible__bu LP------------GATADLTVWLANLTLTQIYVPLTLTSGLTQMWSLSV
: : :
Mb0530|M.bovis_AF2122/97 EWLAYLLFGLLILVIFRMKHATRARGLMWLAFAASLPPVVLLLASGQFYT
Rv0517|M.tuberculosis_H37Rv EWLAYLLFGLLILVIFRMKHATRARGLMWLAFAASLPPVVLLLASGQFYT
MMAR_0854|M.marinum_M EWLAYLLFGALVLVIFRMTHATRARNLMWLAFAASLPPVILLLASGQFYT
MUL_0606|M.ulcerans_Agy99 EWLAYLLFGALVLVIFRMTHATRARNLMWLAFAASLPPVILLLASGQFYT
Mflv_1859|M.gilvum_PYR-GCK EEQYYVLWPLLIAAVIAGLTALAYRRGMTLSQRAVRTAVFLLATAGIVAS
MLBr_02670|M.leprae_Br4923 EEQYYLVWPLLLIAVTLLLAARARRRCRYATLGAVRLAVFVLASLGALAS
MAV_4409|M.avium_104 GSMWSLIWELLCYLVVAAIGVVGLGNRRWISPLILVLATLGALVVPPLTF
MAB_4110c|M.abscessus_ATCC_199 ASLWSLVFEVMCYIAVAGLGLLGLASRRWTAPVILILATIAAIMLPPLTF
MSMEG_0390|M.smegmatis_MC2_155 GSLWTLVFEMICYIAVAVLGIVGLLKRRWVIPAIFVLTLCATAYFSYPVF
Mvan_1670|M.vanbaalenii_PYR-1 EEQFLLVWPVLIVAITLIAVRGAWSHARWLTTTAVVMGVVVAASFGGALY
TH_4330|M.thermoresistible__bu EMTFYLVLPLLALLARQVPVRARIP---VLLATAVLSLFWVRIPFGPDSG
:: :
Mb0530|M.bovis_AF2122/97 P----------------WSWLPRIVTQFAAGALACAAVRRLRPTDR----
Rv0517|M.tuberculosis_H37Rv P----------------WSWLPRIVTQFAAGALACAAVRRLRPTDR----
MMAR_0854|M.marinum_M P----------------WSWLPRIVTQFVAGALAAAAVRRLRLTDR----
MUL_0606|M.ulcerans_Agy99 P----------------WRWLPRIVTQFVAGALAAAAVRRLRLTDR----
Mflv_1859|M.gilvum_PYR-GCK ATATALMSSDGNLNRVYFGTDTRVQALLVGAAAAALLVRDWRGLTAGLEI
MLBr_02670|M.leprae_Br4923 ATVAIARVCDVTRDRIYFGTDTRAQALLVGAAASALLVRDWPSLNRGWCL
MAV_4409|M.avium_104 PG---------------VWTIPQLAVRSAIMFSAGAVMYQWRDVIPARWS
MAB_4110c|M.abscessus_ATCC_199 PG---------------LWTIPQLAVRSAIMFSAGALLYQWRDRIPARWS
MSMEG_0390|M.smegmatis_MC2_155 A----------------MQTIPQMVARFAVMFAAGALIHQYRDVIPARWS
Mvan_1670|M.vanbaalenii_PYR-1 QT----------------STSPDWAYLSTATRAWELGIGALLATAAGTFA
TH_4330|M.thermoresistible__bu LN--------------PWNWPPAFFSWFAAGMILAELTVTRVGWFHRLAR
. .
Mb0530|M.bovis_AF2122/97 -ARRIAGYLSVLVGVAIVGILYLLHAHPLAGVEDS--GGVVDVLFVPLVI
Rv0517|M.tuberculosis_H37Rv -ARRIAGYLSVLVGVAIVGILYLLHAHPLAGVEDS--GGVVDVLFVPLVI
MMAR_0854|M.marinum_M -ARRASGYLSVLLIAAIVGILYLVDAHPISGVVDS--GGVVDVLFVPLIV
MUL_0606|M.ulcerans_Agy99 -ARRASGYLSVLLIAAIVGILYLVDAHPISGVVDS--GGVVDVLFVPLIV
Mflv_1859|M.gilvum_PYR-GCK FRSRWARWVAWSLPVVGLVVLFLAARIATGSVEEFRSGLLIVVALAAVLV
MLBr_02670|M.leprae_Br4923 IRTRWGQLIARFLPVLGLAGLAAATHYATGGAGDFRHGLLIGVAIAAVIV
MAV_4409|M.avium_104 -----------------LVAVALAIVAAAGFLPDYRVVGALPLAYAVIVT
MAB_4110c|M.abscessus_ATCC_199 -----------------LVAVSVVIVLFSGMLPDYRVLGALPLAYAVVVS
MSMEG_0390|M.smegmatis_MC2_155 -----------------LVGIAVVLVLASGFLSNYRVIGALPLAYAVIVA
Mvan_1670|M.vanbaalenii_PYR-1 ---RIPELLRPVLSWAGVALVVAAVFLIDGSAGFPAPWALLPVAGAALVV
TH_4330|M.thermoresistible__bu -RRVLMGMFALAAFLVAASPLVGLEGLAPGSIVQVTLKTVMGALLAAALL
: . : . :
Mb0530|M.bovis_AF2122/97 SLAIGVG---SLPALLSTRLMVFGGQISFCLYMVHELVHTAWG-------
Rv0517|M.tuberculosis_H37Rv SLAIGVG---SLPALLSTRLMVFGGQISFCLYMVHELVHTAWG-------
MMAR_0854|M.marinum_M TLAVGVG---SLPRLLSTRVMVYGGEISFCLYMVHELVHTAWG-------
MUL_0606|M.ulcerans_Agy99 TLAVGVG---SLPRLLSTRVMVYGGEISFCLYMVHEPVHTAWG-------
Mflv_1859|M.gilvum_PYR-GCK IAPVALAQDGPVARLLSVWPLVGLGAISYGVYLWHWPIFLILNGERTGAS
MLBr_02670|M.leprae_Br4923 IAPVALEQRGTVARLLALRPLVWLGTISYGIYLWHWPIFLALNGERTGWS
MAV_4409|M.avium_104 ------------GSLLKSERLVLRTDLSYGVYIYAFPTQQLLA-------
MAB_4110c|M.abscessus_ATCC_199 ------------GVLIKNKRMNIHTDLSYGVYIYASPTQQLLA-------
MSMEG_0390|M.smegmatis_MC2_155 ------------GALLRNRRLNLRNDLSYGVYIYAFPVQQLLA-------
Mvan_1670|M.vanbaalenii_PYR-1 AAGIGREP--GFQGLLRNRASTYLGDLSYALYLVHWPVIVLLA-------
TH_4330|M.thermoresistible__bu APLVLDRPD-TPHRFLASAPMVTLGRWSYGIFVWHLAALAMVFP------
:: *: :::
Mb0530|M.bovis_AF2122/97 ---------------WAVQQYELALQDQPWKWNVVGLLAIALG-------
Rv0517|M.tuberculosis_H37Rv ---------------WAVQQYELALQDQPWKWNVVGLLAIALG-------
MMAR_0854|M.marinum_M ---------------WAVLQFELTPQDNPWKWNVIGLLVIAVA-------
MUL_0606|M.ulcerans_Agy99 ---------------WAVLQFELTPQDNPWKWNVIGLLVIAVA-------
Mflv_1859|M.gilvum_PYR-GCK GWQLFALRCAATIAVAAVSWWLIEQPVREWRPAFVPMLPLAGATAATAAV
MLBr_02670|M.leprae_Br4923 GVPLFASRCSATVAVAAVSWWLIEQPIRHWRPVRVPLLPLAAATVASAAA
MAV_4409|M.avium_104 ----------------VCGLATRLHPALFFLASVAATLPLAAAS------
MAB_4110c|M.abscessus_ATCC_199 ----------------VAGLYA-LNPFVFFGVSAVATLIPAAFS------
MSMEG_0390|M.smegmatis_MC2_155 ----------------ILGFAN-SQPFLFFVIATAATVPLAALS------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------VVMAPNVYFYASVLTLTLGLAVAC------
TH_4330|M.thermoresistible__bu ---------------MIGEFPFNGNMPVVLVLTVLFTIAIAAVS------
: *
Mb0530|M.bovis_AF2122/97 --------------------------------------------------
Rv0517|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0854|M.marinum_M --------------------------------------------------
MUL_0606|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1859|M.gilvum_PYR-GCK LTMTVLPVRVVP--PTPEPGPLVDIAALVGPEVP-VEVTRAPTPRAPGDL
MLBr_02670|M.leprae_Br4923 ATMWVIPVGTETGLRDIALPPEVSTVAAVSPSPPRGKLSSTRDPNQP--F
MAV_4409|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4330|M.thermoresistible__bu --------------------------------------------------
Mb0530|M.bovis_AF2122/97 ---------AAILLYHFVEEP-----------------------------
Rv0517|M.tuberculosis_H37Rv ---------AAILLYHFVEEP-----------------------------
MMAR_0854|M.marinum_M ---------ASVLLYHFIEEP-----------------------------
MUL_0606|M.ulcerans_Agy99 ---------ASVLLYHFIEEP-----------------------------
Mflv_1859|M.gilvum_PYR-GCK RVAVFGDSIAWTMMRYLPDTPGVDFADFTTIGCGIARGGPYEYVGQELQQ
MLBr_02670|M.leprae_Br4923 TVAVFGDSIGWTWMHYLPPTPGFAFIDHTVIGCSLVRGTPYQYIGQTLEQ
MAV_4409|M.avium_104 --------------WFLIEKP-----------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------WFLIEKR-----------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------WFLVEKR-----------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------HHFVENP-----------------------------
TH_4330|M.thermoresistible__bu --------------YGLVEQP-----------------------------
:
Mb0530|M.bovis_AF2122/97 -------DRRWMRRM-----------------VDVKAASARSEPGEP---
Rv0517|M.tuberculosis_H37Rv -------GRRWMRRM-----------------VDVKAASARSEPGEP---
MMAR_0854|M.marinum_M -------ARRWMRRM-----------------VDVRAVTARIEPSEP---
MUL_0606|M.ulcerans_Agy99 -------ARRWMRRM-----------------VDVRAVTARIEPSEP---
Mflv_1859|M.gilvum_PYR-GCK KPECDEWPARWAQRIGHQKPDVVLLMVGRWEVVDRMSEGRWTHIGEPGYD
MLBr_02670|M.leprae_Br4923 RPECDNWPIRWSTQINKDHPNVALLIIGRWETVNRVNEGQWTHIGDPTFD
MAV_4409|M.avium_104 -------SMALKRRL------------------KRKWTGPRAAESDPRVS
MAB_4110c|M.abscessus_ATCC_199 -------ALALKSRL------------------KRK----RATSAG--TL
MSMEG_0390|M.smegmatis_MC2_155 -------AIALKSRL------------------KRR--------------
Mvan_1670|M.vanbaalenii_PYR-1 --------LRYASLD----------------ALRQAREDMRHNLFHVELS
TH_4330|M.thermoresistible__bu --------CRAAYRR---------------------WEMRRARPDAP---
Mb0530|M.bovis_AF2122/97 --VGSTRYQIDDALEGVSARAV----------------------------
Rv0517|M.tuberculosis_H37Rv --VGSTRYQIDDALEGVSARAV----------------------------
MMAR_0854|M.marinum_M --VNGKRNQADGALEGFSARAV----------------------------
MUL_0606|M.ulcerans_Agy99 --VNGKRNQADGALEGFSARAV----------------------------
Mflv_1859|M.gilvum_PYR-GCK AYLRSELNRALDILGSTGARLVVATEPYNRRAEKADGSLYPEDQPDRVER
MLBr_02670|M.leprae_Br4923 SYLNAELQQALNILGSSGVRVVVATVPYSRGGEKPDGQLYPEDQPDRVNQ
MAV_4409|M.avium_104 QAEPAPADVLADRPAPEAPGHF----------------------------
MAB_4110c|M.abscessus_ATCC_199 GVEPAVADSVALRERALSPHEDS---------------------------
MSMEG_0390|M.smegmatis_MC2_155 -----RTDTVADTTQKVSDRGAG---------------------------
Mvan_1670|M.vanbaalenii_PYR-1 TKIAGVAALVLITLSVISFAMGPDALHHTDPAQTDTTNVSP---------
TH_4330|M.thermoresistible__bu ---APPLDSAVTSVATPISR------------------------------
Mb0530|M.bovis_AF2122/97 --------------------------------------------------
Rv0517|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0854|M.marinum_M --------------------------------------------------
MUL_0606|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1859|M.gilvum_PYR-GCK WNTMLREVVDERPNATVLDLNEKLSPNGYYQMRVNGLKVRSDGVHPTPEA
MLBr_02670|M.leprae_Br4923 WNTMLRNTVSQHSNVQILDLNKKLCPDGVYTAKVDGIKVRSDGVHLTPEG
MAV_4409|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4330|M.thermoresistible__bu --------------------------------------------------
Mb0530|M.bovis_AF2122/97 ---------------
Rv0517|M.tuberculosis_H37Rv ---------------
MMAR_0854|M.marinum_M ---------------
MUL_0606|M.ulcerans_Agy99 ---------------
Mflv_1859|M.gilvum_PYR-GCK VEWMTPWLVEAIRTP
MLBr_02670|M.leprae_Br4923 VKWLTPWLEESLK--
MAV_4409|M.avium_104 ---------------
MAB_4110c|M.abscessus_ATCC_199 ---------------
MSMEG_0390|M.smegmatis_MC2_155 ---------------
Mvan_1670|M.vanbaalenii_PYR-1 ---------------
TH_4330|M.thermoresistible__bu ---------------