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MTLGQVFDPRRNALNAWRLLLAAEVMLWHCWPITNRLPPAATLQLLFSVGVDGFFAISGFLITRSWLDDP RLRDFLAARALRILPGYYVCLIVTAFAVAPLSVAIQGGSVGALLSSGAPLEYLAKNSAVAYFHLNIGATP GGVPHPGVWNGSLWSLVWEVACYLAVAAIGVAGLADRRWMSVAVLALAVVGAALVPPLTYPGQWTVAQLA VRSAIMFAAGAVVYQWKDVIPARWSLVAVCVVVVAAASRLPDYRVVAALPLAYAIIVSGALLRNRRLRLA TDLSYGVYIYAFPVQQLLAVCGLARLPVAVFFLTALAATLPLAAASWWLIEKPSMALKRRLRRKWSAATT AERGHPATTAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4410 | - | - | 100% (362) | AtfA_1 |
| M. avium 104 | MAV_4409 | - | e-149 | 73.09% (353) | putative acyltransferase |
| M. avium 104 | MAV_4408 | - | e-131 | 65.56% (363) | putative acyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0115 | - | 6e-11 | 27.56% (352) | transmembrane acyltransferase |
| M. gilvum PYR-GCK | Mflv_1859 | - | 2e-13 | 28.57% (350) | acyltransferase 3 |
| M. tuberculosis H37Rv | Rv0111 | - | 6e-11 | 27.56% (352) | transmembrane acyltransferase |
| M. leprae Br4923 | MLBr_02670 | - | 8e-10 | 26.59% (346) | hypothetical protein MLBr_02670 |
| M. abscessus ATCC 19977 | MAB_4110c | - | 1e-125 | 63.48% (345) | acetyltransferase AtfA |
| M. marinum M | MMAR_0477 | - | 1e-06 | 23.96% (359) | integral membrane acyltransferase |
| M. smegmatis MC2 155 | MSMEG_0390 | - | 1e-111 | 57.68% (345) | putative acyltransferase |
| M. thermoresistible (build 8) | TH_1720 | - | 3e-08 | 24.63% (337) | PROBABLE ACYLTRANSFERASE |
| M. ulcerans Agy99 | MUL_4492 | - | 9e-07 | 26.99% (226) | integral membrane acyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1670 | - | 3e-16 | 28.90% (353) | acyltransferase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0115|M.bovis_AF2122/97 MPARSVPRPRWVAPVRRVGRLAVWDRPERRSG----IPALDGLRAIAVAL
Rv0111|M.tuberculosis_H37Rv MPARSVPRPRWVAPVRRVGRLAVWDRPERRSG----IPALDGLRAIAVAL
MLBr_02670|M.leprae_Br4923 --------------MRRVGLLRIWNQPERRNG----IPALDGLRAIAVAL
Mflv_1859|M.gilvum_PYR-GCK --------------MTAVSAAPIRVGPRRYVGPGQSIPALDGVRAIAVAL
TH_1720|M.thermoresistible__bu --------------VRPSPETDLDQGGLEQVSTVDRVAALTGVRAVAALS
MUL_4492|M.ulcerans_Agy99 ---------------MTLPEATDAQGGLEQISHVDRVASLTGIRAVAALL
MMAR_0477|M.marinum_M ----------------------MVTDGQQVGGTRSFLPPVEGMRACAAMG
MAV_4410|M.avium_104 -----------------MTLGQVFDPRR---------NALNAWRLLLAAE
MAB_4110c|M.abscessus_ATCC_199 -----------------MKLGSVFDSRN---------NALNACRLALATE
MSMEG_0390|M.smegmatis_MC2_155 -------------------MGKVFDPRN---------NALNALRLLLAVG
Mvan_1670|M.vanbaalenii_PYR-1 -----MLPGGDRMVTRVDRWREASGRRRRRAERANYRLDIQGLRAVAVLA
: . * .
Mb0115|M.bovis_AF2122/97 VLASHG---------GIPGMGGG--FIGVDAFFVLSGFLITS-LLLDELG
Rv0111|M.tuberculosis_H37Rv VLASHG---------GIPGMGGG--FIGVDAFFVLSGFLITS-LLLDELG
MLBr_02670|M.leprae_Br4923 VLTQHG---------GIPGLSGG--FIGVDLFFVLSGFLITS-LLLDELR
Mflv_1859|M.gilvum_PYR-GCK VLADHG---------GVPGLSGG--FLGVDVFFVLSGFLITS-LLLDEIG
TH_1720|M.thermoresistible__bu VMGTHAAYGTGTYNHGYVGLIFARMDIGVAVFFVLSGFLLFRPWVRAAAD
MUL_4492|M.ulcerans_Agy99 VVTTHAAYTTGKYTHGYWGLVSARMEIGVPIFFVLSGFLLFRPWVHSAVT
MMAR_0477|M.marinum_M VVVTHVAFQTG-HSSGVAGRLFGRFDLAVAVFFALSGFLLWRGHAAAARG
MAV_4410|M.avium_104 VMLWHCWPITN-RLPP-AATLQLLFSVGVDGFFAISGFLITRSWLDDP--
MAB_4110c|M.abscessus_ATCC_199 VILFHSFPLTG-RVVESKAILQLLFSVGVDGFFALSGFLITASWLRNP--
MSMEG_0390|M.smegmatis_MC2_155 VILWHSWPLSG-HGVTYKPLEQLLEQVWVDGFFAISGFLITSSWLRNP--
Mvan_1670|M.vanbaalenii_PYR-1 VVAHHLWG------------IPPGGFVGIDVFFVITGYFVTENLLKAS-A
*: * : : **.::*:::
Mb0115|M.bovis_AF2122/97 RTGRIDLSGFWIRRARRLLP---ALVLMVLTVSAARALFPDQALTGLRSD
Rv0111|M.tuberculosis_H37Rv RTGRIDLSGFWIRRARRLLP---ALVLMVLTVSAARALFPDQALTGLRSD
MLBr_02670|M.leprae_Br4923 HTGRIDAINFWIRRACRLLP---ALVLMVLTVGIARELFPYQALTNLRND
Mflv_1859|M.gilvum_PYR-GCK RTGRVGLKGFWIRRARRLLP---ALVVMVLAVVAVRGLFSDESVANLRDD
TH_1720|M.thermoresistible__bu GTAAPSVRRYARNRVRRIMP---AYVVTVLAAYGIYAVRELE-----PNP
MUL_4492|M.ulcerans_Agy99 GAPPPSLRRYTAHRVRRIMP---AYVVVVLIAYVIYHYRIAG-----PNP
MMAR_0477|M.marinum_M GSPRPRTGHYLRSRAVRIMP---AYVVAVVVILSLLPD----------SD
MAV_4410|M.avium_104 -----RLRDFLAARALRILPGYYVCLIVTAFAVAPLSVAIQGGSVGALLS
MAB_4110c|M.abscessus_ATCC_199 -----DVREYFVARALRILPGYYIVLAITAFVVAPLSVAIQGGSAARLLF
MSMEG_0390|M.smegmatis_MC2_155 -----RLRDYATARVLRIFPGLWVCLLIIAFVMAPIGVLLQGGSVSGLMS
Mvan_1670|M.vanbaalenii_PYR-1 EHGDPSLRRFYSDRLRRIVP--AATVVLVLTVVASVYLLPQPAVRDITFD
: * *:.* :
Mb0115|M.bovis_AF2122/97 AIAAFLWTANWRFVAQNTDYFTQGAPPSPLQHTWSLGVEEQYYVVWPLLL
Rv0111|M.tuberculosis_H37Rv AIAAFLWTANWRFVAQNTDYFTQGAPPSPLQHTWSLGVEEQYYVVWPLLL
MLBr_02670|M.leprae_Br4923 AIATFLWVANWRFVVHKADYFTQGTPPSPLQHAWSLGVEEQYYLVWPLLL
Mflv_1859|M.gilvum_PYR-GCK AVATFFWMSNWIFVAQDTDYFSQGAPPSPLQHTWSLAVEEQYYVLWPLLI
TH_1720|M.thermoresistible__bu GHTWVGLLRNLTLTQIYSDDYLTAYAHQGLTQMWSLAVEVAFYAALPVLA
MUL_4492|M.ulcerans_Agy99 GHSWMGLVRNLTLTQIYTDGYLGSYLHQGLTQMWSLAVEASFYVLLPFLA
MMAR_0477|M.marinum_M HASLTVWLANLTLTQIYVPLTLTG----GLTQMWSLSVEVGFYLALPLLA
MAV_4410|M.avium_104 SGAPLEYLAKNSAVAYFHLNIGATPGGVPHPGVWNGSLWSLVWEVACYLA
MAB_4110c|M.abscessus_ATCC_199 SSAPVEYVLKNSALVQLQLDVGGTPHDIPYPGIWNASLWSLVFEVMCYIA
MSMEG_0390|M.smegmatis_MC2_155 SYAPIEYVLNNAVLNVYYAGINGTPQGIPWPGVWNGSLWTLVFEMICYIA
Mvan_1670|M.vanbaalenii_PYR-1 ALFAFFFVANWHFAAAGTDIPATIDSVSPLLHYWPLSIEEQFLLVWPVLI
: * .: :
Mb0115|M.bovis_AF2122/97 IGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMASATAAVAFTSAAT
Rv0111|M.tuberculosis_H37Rv IGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMASATAAVAFTSAAT
MLBr_02670|M.leprae_Br4923 IAVTLLLAARARRRCRYATLGAVRLAVFVLASLGALASATVAIARVCDVT
Mflv_1859|M.gilvum_PYR-GCK AAVIAGLTALAYRRGMTLSQRAVRTAVFLLATAGIVASATATALMSSDGN
TH_1720|M.thermoresistible__bu W---LLLVVLARRRWRPVPLLTGLGVLAVVSPLWVVVLHRTDWLPLGAGF
MUL_4492|M.ulcerans_Agy99 Y---LLLVVISRRRWQPKLVVGALLAMATITPGWLVLIHTVSLFPDGARL
MMAR_0477|M.marinum_M F---LARRVPVGARVP----VIAAAAALSLAWAWLPVAAGSGMNPLN---
MAV_4410|M.avium_104 VAAIGVAGLADRRWMSVAVLALAVVGAALVPPLTYPGQWTVAQLAVR---
MAB_4110c|M.abscessus_ATCC_199 VAGLGLLGLASRRWTAPVILILATIAAIMLPPLTFPGLWTIPQLAVR---
MSMEG_0390|M.smegmatis_MC2_155 VAVLGIVGLLKRRWVIPAIFVLTLCATAYFSYPVFA-MQTIPQMVAR---
Mvan_1670|M.vanbaalenii_PYR-1 VAITLIAVRGAWSHARWLTTTAVVMGVVVAASFGGALYQTSTS-------
.
Mb0115|M.bovis_AF2122/97 RDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARL
Rv0111|M.tuberculosis_H37Rv RDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARL
MLBr_02670|M.leprae_Br4923 RDRIYFGTDTRAQALLVGAAASALLVRDWPSLNRGWCLIRTRWGQLIARF
Mflv_1859|M.gilvum_PYR-GCK LNRVYFGTDTRVQALLVGAAAAALLVRDWRGLTAGLEIFRSRWARWVAWS
TH_1720|M.thermoresistible__bu WLPHYL-------IWFVGGMVLAVLQAQGVRAYAAATVP-------VAVA
MUL_4492|M.ulcerans_Agy99 WLPSYL-------AWFLGGMLLTVLQAMKVQCYALAALP-------LATI
MMAR_0477|M.marinum_M WPPAFF-------SWFAAGMLLAEWVHSPIGLVHRLARHRVLIG-VVAML
MAV_4410|M.avium_104 -----------SAIMFAAGAVVYQWKDVIPARWS------------LVAV
MAB_4110c|M.abscessus_ATCC_199 -----------SAIMFSAGALLYQWRDRIPARWS------------LVAV
MSMEG_0390|M.smegmatis_MC2_155 -----------FAVMFAAGALIHQYRDVIPARWS------------LVGI
Mvan_1670|M.vanbaalenii_PYR-1 ------------PDWAYLSTATRAWELGIGALLATAAGTFARIPELLRPV
. :
Mb0115|M.bovis_AF2122/97 LPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAV
Rv0111|M.tuberculosis_H37Rv LPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAV
MLBr_02670|M.leprae_Br4923 LPVLGLAGLAAATHYATGGAGDFRHGLLIGVAIAAVIVIAPVALEQRGTV
Mflv_1859|M.gilvum_PYR-GCK LPVVGLVVLFLAARIATGSVEEFRSGLLIVVALAAVLVIAPVALAQDGPV
TH_1720|M.thermoresistible__bu AYLIVATPIAGDTGAPVLNLGQDLA-KVMFYAVIATLVVAPPALGNRGWY
MUL_4492|M.ulcerans_Agy99 CYFIVATPIAGAPTTSPSALTEAVV-KACFYTVIATLAVAPLALGDQGWY
MMAR_0477|M.marinum_M AYLVAASPLAGPAGLVQGSATQFAV-KTAMGAVVAFALVAPLVLDRPGTP
MAV_4410|M.avium_104 CVVVVAAASRLPDYRVVAALPLAYAIIVSGALLRNRRLRLATDLSYGVYI
MAB_4110c|M.abscessus_ATCC_199 SVVIVLFSGMLPDYRVLGALPLAYAVVVSGVLIKNKRMNIHTDLSYGVYI
MSMEG_0390|M.smegmatis_MC2_155 AVVLVLASGFLSNYRVIGALPLAYAVIVAGALLRNRRLNLRNDLSYGVYI
Mvan_1670|M.vanbaalenii_PYR-1 LSWAGVALVVAAVFLIDGSAGFPAP--WALLPVAGAALVVAAGIGREPGF
:
Mb0115|M.bovis_AF2122/97 ARILAWRPLVWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAAT
Rv0111|M.tuberculosis_H37Rv ARILAWRPLVWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAAT
MLBr_02670|M.leprae_Br4923 ARLLALRPLVWLGTISYGIYLWHWPIFLALNGERTGWSGVPLFASRCSAT
Mflv_1859|M.gilvum_PYR-GCK ARLLSVWPLVGLGAISYGVYLWHWPIFLILNGERTGASGWQLFALRCAAT
TH_1720|M.thermoresistible__bu TRMLGSRPMVWLGEISYEIFLVHV--------------------IVMEIA
MUL_4492|M.ulcerans_Agy99 SQLLASRPMVWLGEISYEIFLVHL--------------------VTMEFA
MMAR_0477|M.marinum_M HRLLGSTTMVTLGRWSYGLFIWHL--------------------AALDMV
MAV_4410|M.avium_104 YAFPVQQLLAVCGLARLPVAVFFL--------------------TALAAT
MAB_4110c|M.abscessus_ATCC_199 YASPTQQLLAVAGLYALNPFVFFG--------------------VSAVAT
MSMEG_0390|M.smegmatis_MC2_155 YAFPVQQLLAILGFANSQPFLFFV--------------------IATAAT
Mvan_1670|M.vanbaalenii_PYR-1 QGLLRNRASTYLGDLSYALYLVHWPVIVLLAVVMAPN--VYFYASVLTLT
. * : . .
Mb0115|M.bovis_AF2122/97 VVLAGASWWLIEQPIRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGP
Rv0111|M.tuberculosis_H37Rv VVLAGASWWLIEQPIRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGP
MLBr_02670|M.leprae_Br4923 VAVAAVSWWLIEQPIRHWRPVRVPLLPLAAATVASAAAATMWVIPVGTET
Mflv_1859|M.gilvum_PYR-GCK IAVAAVSWWLIEQPVREWRPAFVPMLPLAGATAATAAVLTMTVLPVRVVP
TH_1720|M.thermoresistible__bu MVSVLRWPVYTGSVLGLFATTLALTIPVAWLLHRFTRPPIRPAVPARSAD
MUL_4492|M.ulcerans_Agy99 MVYVVRYWVYTGSMLNLFIATMVITIPLAWVLHRFTR--------VRSE-
MMAR_0477|M.marinum_M FP-VIGTFAFTGRMPTVLVLTLIFGFAIAAVSYALVESPCREALRRWEKR
MAV_4410|M.avium_104 LPLAAASWWLIEKPSMALKRRLRRKWSAATTAERGHPATTAAR-------
MAB_4110c|M.abscessus_ATCC_199 LIPAAFSWFLIEKRALALKSRLKRKRATSAGTLGVEPAVADSVALRERAL
MSMEG_0390|M.smegmatis_MC2_155 VPLAALSWFLVEKRAIALKSRLKRRRTDTVADTTQKVSDRGAG-------
Mvan_1670|M.vanbaalenii_PYR-1 LGLAVACHHFVENPLRYASLDALRQAREDMRHNLFHVELSTKIAGVAALV
. .
Mb0115|M.bovis_AF2122/97 GLREIGLPPGVSAVAAVSPSPPEASQPAPGPRDPNRPFTVSVFGDSIGWT
Rv0111|M.tuberculosis_H37Rv GLREIGLPPGVSAVAAVSPSPPEASQPAPGPRDPNRPFTVSVFGDSIGWT
MLBr_02670|M.leprae_Br4923 GLRDIALPPEVSTVAAVSPSPPRGKLSS--TRDPNQPFTVAVFGDSIGWT
Mflv_1859|M.gilvum_PYR-GCK PTPEPG--PLVDIAALVGPEVPVEVTRAPTPRAPG-DLRVAVFGDSIAWT
TH_1720|M.thermoresistible__bu RTDRR---------------------------------------------
MUL_4492|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0477|M.marinum_M TEHSAGQDIDREADAIAP--------------------------------
MAV_4410|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 SPHEDS--------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 LITLSVISFAMGPDALHHTDPAQTDTTNVSP-------------------
Mb0115|M.bovis_AF2122/97 LMHYLPPTPGFRFIDHTVIGCSLVRGTPYRYIGQTLEQRAECDGWPARWS
Rv0111|M.tuberculosis_H37Rv LMHYLPPTPGFRFIDHTVIGCSLVRGTPYRYIGQTLEQRAECDGWPARWS
MLBr_02670|M.leprae_Br4923 WMHYLPPTPGFAFIDHTVIGCSLVRGTPYQYIGQTLEQRPECDNWPIRWS
Mflv_1859|M.gilvum_PYR-GCK MMRYLPDTPGVDFADFTTIGCGIARGGPYEYVGQELQQKPECDEWPARWA
TH_1720|M.thermoresistible__bu --------------------------------------------------
MUL_4492|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0477|M.marinum_M --------------------------------------------------
MAV_4410|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0115|M.bovis_AF2122/97 AQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDPTFDAYLNAELQRALS
Rv0111|M.tuberculosis_H37Rv AQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDPTFDAYLNAELQRALS
MLBr_02670|M.leprae_Br4923 TQINKDHPNVALLIIGRWETVNRVNEGQWTHIGDPTFDSYLNAELQQALN
Mflv_1859|M.gilvum_PYR-GCK QRIGHQKPDVVLLMVGRWEVVDRMSEGRWTHIGEPGYDAYLRSELNRALD
TH_1720|M.thermoresistible__bu --------------------------------------------------
MUL_4492|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0477|M.marinum_M --------------------------------------------------
MAV_4410|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0115|M.bovis_AF2122/97 IVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQH
Rv0111|M.tuberculosis_H37Rv IVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQH
MLBr_02670|M.leprae_Br4923 ILGSSGVRVVVATVPYSRGGEKPDGQLYPEDQPDRVNQWNTMLRNTVSQH
Mflv_1859|M.gilvum_PYR-GCK ILGSTGARLVVATEPYNRRAEKADGSLYPEDQPDRVERWNTMLREVVDER
TH_1720|M.thermoresistible__bu --------------------------------------------------
MUL_4492|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0477|M.marinum_M --------------------------------------------------
MAV_4410|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0115|M.bovis_AF2122/97 SNVGMIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSV
Rv0111|M.tuberculosis_H37Rv SNVGMIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSV
MLBr_02670|M.leprae_Br4923 SNVQILDLNKKLCPDGVYTAKVDGIKVRSDGVHLTPEGVKWLTPWLEESL
Mflv_1859|M.gilvum_PYR-GCK PNATVLDLNEKLSPNGYYQMRVNGLKVRSDGVHPTPEAVEWMTPWLVEAI
TH_1720|M.thermoresistible__bu --------------------------------------------------
MUL_4492|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0477|M.marinum_M --------------------------------------------------
MAV_4410|M.avium_104 --------------------------------------------------
MAB_4110c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0390|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1670|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0115|M.bovis_AF2122/97 RVAS
Rv0111|M.tuberculosis_H37Rv RVAS
MLBr_02670|M.leprae_Br4923 K---
Mflv_1859|M.gilvum_PYR-GCK RTP-
TH_1720|M.thermoresistible__bu ----
MUL_4492|M.ulcerans_Agy99 ----
MMAR_0477|M.marinum_M ----
MAV_4410|M.avium_104 ----
MAB_4110c|M.abscessus_ATCC_199 ----
MSMEG_0390|M.smegmatis_MC2_155 ----
Mvan_1670|M.vanbaalenii_PYR-1 ----