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KTAIITGAGSGIGRETARLFASQGHRVVLADIDIHAAEAATDQIVAAGGRASAYQLDVADEQQWETFGKW TDSEFGPADLLVNNAGIMDWGGFVDMTAEQWQRTMDIDLMSVIYGSRIFAQQMIDAGVRGHIVNISSGAA FLPHKMIAAYGTAKAAVLMASQSLRVELRRHRIGVSAICPGVINTNLIANGQRAGISEDDQQRWHAQAGK IQSISYAGPDKVARAIERSVRHNWAVVPVNPESWFIYGLYRLSPSFSRTLTGIGSFELADGLMSRLQPLL NRVAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0143c | - | - | 100% (286) | putative oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_0144c | - | 5e-64 | 45.39% (271) | putative oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_4022c | - | 2e-61 | 46.15% (273) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 9e-52 | 42.02% (257) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 4e-47 | 40.53% (264) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 9e-52 | 42.02% (257) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-50 | 41.60% (262) | short chain dehydrogenase |
| M. marinum M | MMAR_3259 | ephD | 2e-52 | 42.64% (258) | short-chain dehydrogenase EphD |
| M. avium 104 | MAV_2275 | - | 5e-52 | 43.08% (253) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 1e-45 | 40.38% (260) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 6e-50 | 41.25% (257) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 1e-52 | 42.64% (258) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 3e-46 | 39.92% (258) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
MMAR_3259|M.marinum_M MSATR---QAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWD
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEGNPDSPTVVLVHGFPDSHVLWD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAV_2275|M.avium_104 MPAPQ---HSPQHFVHSADGTRIAVYDEGNPEGPTVVLVHGFPDSHVLWD
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWD
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWD
Mflv_2937|M.gilvum_PYR-GCK --------MSSQRFVVSRDGVRIAVYEEGAADGPTVVLVHGHADTHEAWD
Mvan_3576|M.vanbaalenii_PYR-1 --------MSTQRFVESSDGVRIAVSEQGNPDGPTLVLVHGLRDTHRVWD
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
Rv2214c|M.tuberculosis_H37Rv GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
MMAR_3259|M.marinum_M GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MUL_3574|M.ulcerans_Agy99 GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAV_2275|M.avium_104 GVVPLLAERFRILRYDNRGVGASSAPKPVSAYRMDRFADDFAAVIGELSP
TH_4323|M.thermoresistible__bu SVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAP
MSMEG_4280|M.smegmatis_MC2_155 GVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSP
Mflv_2937|M.gilvum_PYR-GCK AVVALLAARFRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDAVSA
Mvan_3576|M.vanbaalenii_PYR-1 PVVALLADRFRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAAVGG
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
Rv2214c|M.tuberculosis_H37Rv GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
MMAR_3259|M.marinum_M GQPVHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MUL_3574|M.ulcerans_Agy99 GQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAV_2275|M.avium_104 GGPVHVLAHDWGSVGVWHYLKRPGANDRVATFTSVSGPSQDQLVDYIFSG
TH_4323|M.thermoresistible__bu GQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDG
MSMEG_4280|M.smegmatis_MC2_155 DAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRG
Mflv_2937|M.gilvum_PYR-GCK EAPVHVLAHDRGSAGVWRYLARPESRGRLASFTSVSGPAPEHVARYLRDT
Mvan_3576|M.vanbaalenii_PYR-1 DTPVHVLAHGWGAAGVWQYLKRADAPERVASLTSVSGPSPEHVAGYVRAA
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
Rv2214c|M.tuberculosis_H37Rv LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
MMAR_3259|M.marinum_M LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR-RNM
MUL_3574|M.ulcerans_Agy99 LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR-RNM
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTM
MAV_2275|M.avium_104 LRAPWRPRAFARALGQALRLSYMILLSIPVLAPLALRLTLSIPALR-RNA
TH_4323|M.thermoresistible__bu LAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRL
MSMEG_4280|M.smegmatis_MC2_155 LARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RGAARR-LQA
Mflv_2937|M.gilvum_PYR-GCK LARPQHPARFAGGLGHLARL--------------------AAAAPR----
Mvan_3576|M.vanbaalenii_PYR-1 LTSPR---RFVRGAGQLVRL--------------------AAAAPR----
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
Rv2214c|M.tuberculosis_H37Rv VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
MMAR_3259|M.marinum_M VDNLPLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPV
MUL_3574|M.ulcerans_Agy99 VDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPV
MLBr_00862|M.leprae_Br4923 VDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPV
MAV_2275|M.avium_104 VDNIPIEQIHHSDRLAADAARSVKTYPANYFRSFAIRK--QGVAVIDVPV
TH_4323|M.thermoresistible__bu RDGVPADRLHHSDTFAADAARSIKVYGANFLRTL---RHARTDHFVRVPV
MSMEG_4280|M.smegmatis_MC2_155 IDTP--GPKFQSENLDIDAANSLKIYRANAIRSFTHVRR---DHYVQVPV
Mflv_2937|M.gilvum_PYR-GCK -------------------AVTDKTLRANLFPVSSGGDA----HDVDIPV
Mvan_3576|M.vanbaalenii_PYR-1 -------------------AATAKPYRANLRPAAPAG------VPVDVPV
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
Rv2214c|M.tuberculosis_H37Rv QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MMAR_3259|M.marinum_M QLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MUL_3574|M.ulcerans_Agy99 QLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MLBr_00862|M.leprae_Br4923 QLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MAV_2275|M.avium_104 QLIVNTEDRYVRPYGYDHTPRFVPRLWRRDIRAGHFSPMSHPQVMAAAVH
TH_4323|M.thermoresistible__bu QLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVT
MSMEG_4280|M.smegmatis_MC2_155 QLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVG
Mflv_2937|M.gilvum_PYR-GCK QLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSHPGILARALT
Mvan_3576|M.vanbaalenii_PYR-1 QLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSHPQVLARAVD
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
Rv2214c|M.tuberculosis_H37Rv DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
MMAR_3259|M.marinum_M DFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFA
MUL_3574|M.ulcerans_Agy99 DFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFA
MLBr_00862|M.leprae_Br4923 DLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALA
MAV_2275|M.avium_104 DFADMAEGKPASRALLRAQVGRPRKAFGDTLVSVTGAGSGIGRATAFAFA
TH_4323|M.thermoresistible__bu ELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFA
MSMEG_4280|M.smegmatis_MC2_155 EFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFA
Mflv_2937|M.gilvum_PYR-GCK QLVDHLDGAPAARELLRAQVGRPRKAFGDTLVAVTGAASGIGRATALAFA
Mvan_3576|M.vanbaalenii_PYR-1 QLVDHLGGAPAPRELLRAQVGRARKVFGDTLVSVTGAASGIGRETALAFA
MAB_0143c|M.abscessus_ATCC_199 ----------------------------MKTAIITGAGSGIGRETARLFA
. :***..**** ** :*
Mb2237c|M.bovis_AF2122/97 REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
Rv2214c|M.tuberculosis_H37Rv REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
MMAR_3259|M.marinum_M REGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQV
MUL_3574|M.ulcerans_Agy99 REGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQV
MLBr_00862|M.leprae_Br4923 RRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
MAV_2275|M.avium_104 REGAELIVSDIDEAAVKATAAEIAGRGGVAHAYVLDVSDAQAVEEFAERV
TH_4323|M.thermoresistible__bu REGAEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEV
MSMEG_4280|M.smegmatis_MC2_155 RLGAEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDV
Mflv_2937|M.gilvum_PYR-GCK HHGADVVISDVNAAGLDETARLVTSAGVHAYPYTVDVADAAAVEAFAEQV
Mvan_3576|M.vanbaalenii_PYR-1 RAGADVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVADAAAVEAMAELV
MAB_0143c|M.abscessus_ATCC_199 SQGHRVVLADIDIHAAEAATDQIVAAGGRASAYQLDVADEQQWETFGKWT
* ::::*:: . :: : * * .* :**:* : : . .
Mb2237c|M.bovis_AF2122/97 SAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQ
Rv2214c|M.tuberculosis_H37Rv SAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQ
MMAR_3259|M.marinum_M SATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MUL_3574|M.ulcerans_Agy99 SATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MLBr_00862|M.leprae_Br4923 SAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
MAV_2275|M.avium_104 SAAHGVPDIVVNNAGIGQAGGFLDTPAEEFDRVLAVNLGGVVNGCRSFAR
TH_4323|M.thermoresistible__bu CARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNLGGVVNGCRAFAP
MSMEG_4280|M.smegmatis_MC2_155 CATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNFGGVVNCCRAFGR
Mflv_2937|M.gilvum_PYR-GCK CAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINFGGVVNGCRSFGK
Mvan_3576|M.vanbaalenii_PYR-1 CAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINFGGVVNGCRSWGR
MAB_0143c|M.abscessus_ATCC_199 DSEFGPADLLVNNAGIMDWGGFVDMTAEQWQRTMDIDLMSVIYGSRIFAQ
: .* .*::*****: . * *:* . ::::*.: ::: .*: .* :.
Mb2237c|M.bovis_AF2122/97 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAA
Rv2214c|M.tuberculosis_H37Rv RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAA
MMAR_3259|M.marinum_M RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MUL_3574|M.ulcerans_Agy99 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MLBr_00862|M.leprae_Br4923 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAV
MAV_2275|M.avium_104 RMVQRGTGGHLVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
TH_4323|M.thermoresistible__bu RLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAELDSA
MSMEG_4280|M.smegmatis_MC2_155 RLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRAELAHA
Mflv_2937|M.gilvum_PYR-GCK RLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSF
Mvan_3576|M.vanbaalenii_PYR-1 RLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSA
MAB_0143c|M.abscessus_ATCC_199 QMIDAGVRGHIVNISSGAAFLPHKMIAAYGTAKAAVLMASQSLRVELRRH
:: : *. **:**::* *:: * : ** *:***. * *:.**.**
Mb2237c|M.bovis_AF2122/97 GVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALRSYG
Rv2214c|M.tuberculosis_H37Rv GVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALRSYG
MMAR_3259|M.marinum_M DVGLTTICPGVINTNIVNTTRFDAPPGKGGDQVDGRRGQIDKMFALRSYG
MUL_3574|M.ulcerans_Agy99 DVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDKMFALRSYG
MLBr_00862|M.leprae_Br4923 GVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRGQLDMMFRLRRYG
MAV_2275|M.avium_104 GVGLTTICPGLIDTNIINTTRFDAPAGARAERVDDRRGQLGKMFALRHYG
TH_4323|M.thermoresistible__bu GIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRREQLQKLFALRRFG
MSMEG_4280|M.smegmatis_MC2_155 GIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRAQVKKTFQARRYG
Mflv_2937|M.gilvum_PYR-GCK GIGLTTICPGFISTNIVDTTRFSLA-QGRDDDVDVLRGRAQKGFSARKYG
Mvan_3576|M.vanbaalenii_PYR-1 GIGVTTICPGVIGTNIVDTTRFSLP-EARRDDAESIRRRARQGFAVRRVG
MAB_0143c|M.abscessus_ATCC_199 RIGVSAICPGVINTNLIANG---QRAGISEDDQQRWHAQAGKIQSISYAG
: ::::**. :.*.:: . : : *
Mb2237c|M.bovis_AF2122/97 PDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI--
Rv2214c|M.tuberculosis_H37Rv PDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI--
MMAR_3259|M.marinum_M PDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRVI--
MUL_3574|M.ulcerans_Agy99 PDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRVI--
MLBr_00862|M.leprae_Br4923 PDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI--
MAV_2275|M.avium_104 PDKVADAILSSVQKKKPIRPVAPEAYALYGLSRVMPQGLRNAARLRVI--
TH_4323|M.thermoresistible__bu PDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTARGRVL--
MSMEG_4280|M.smegmatis_MC2_155 PEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRAARSQVL--
Mflv_2937|M.gilvum_PYR-GCK PEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQVLRSTARGGNFV-
Mvan_3576|M.vanbaalenii_PYR-1 PDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQAMRSAARGGNIM-
MAB_0143c|M.abscessus_ATCC_199 PDKVARAIERSVRHNWAVVPVNPESWFIYGLYRLSPSFSRTLTGIGSFEL
*:*.* :: :: : .: ** .*: **: : * * : :
Mb2237c|M.bovis_AF2122/97 -----------------
Rv2214c|M.tuberculosis_H37Rv -----------------
MMAR_3259|M.marinum_M -----------------
MUL_3574|M.ulcerans_Agy99 -----------------
MLBr_00862|M.leprae_Br4923 -----------------
MAV_2275|M.avium_104 -----------------
TH_4323|M.thermoresistible__bu -----------------
MSMEG_4280|M.smegmatis_MC2_155 -----------------
Mflv_2937|M.gilvum_PYR-GCK -----------------
Mvan_3576|M.vanbaalenii_PYR-1 -----------------
MAB_0143c|M.abscessus_ATCC_199 ADGLMSRLQPLLNRVAK