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VNATPVPVPWAVQTPDRIPKQRYYDPEFYALEKEMFWPRVWQMACRLEEIPKPGDFVEYEILDESVIVVR LDSQTVRAYHNACRHRGVKLVEGNGNRRTFVCPFHGWCWSLDGRNTFVLRPETFAQENLAAADLRLVSVR CELWGGCAWINLDDDAPALRDWMEPFASTYDAWRVESLRVEWWQSCRLPVNWKLATAAFMEGYHVPQTHP QLLPGAQTGEPSAAVHPVVASSLYFMRTLGEGMAGMTHQNDIRIAEGLQTMRLPSDPAAAMAAWRSALND AVVDWHRARGSGMPDLNELDRRGITDAIGFAFPHHFILPTYSSASSYRIRPLGPEETLFEIWSLTRLPGD ASAGKPTPPEPMAPDDPRWPPIPAQDFSNLPRQQKGLHSKSFEFMRLSDRIEGLISNFERVIDGFLAGLR YDALLPAIHKTNTTIDVPVVDLGFGAVEAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2952 | - | - | 100% (450) | Rieske (2Fe-2S) domain-containing protein |
| M. avium 104 | MAV_5207 | - | 1e-43 | 30.88% (421) | Rieske (2Fe-2S) domain-containing protein |
| M. avium 104 | MAV_5278 | - | 1e-39 | 28.67% (422) | Rieske (2Fe-2S) domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 1e-22 | 33.00% (200) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1788 | - | 4e-41 | 29.74% (417) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 9e-23 | 33.00% (200) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 3e-13 | 27.27% (198) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_0307 | - | 2e-43 | 30.79% (432) | dioxygenase |
| M. smegmatis MC2 155 | MSMEG_5627 | - | 3e-35 | 36.15% (213) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_4380 | - | 7e-52 | 31.47% (448) | PUTATIVE putative Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_4884 | - | 1e-16 | 32.18% (202) | dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_0908 | - | 4e-52 | 32.01% (428) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 MLSTDNR--------AELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Rv3161c|M.tuberculosis_H37Rv MLSTDNR--------AELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Mflv_1788|M.gilvum_PYR-GCK MTHTESDLDAA---IEVEADPDDSTGQIAEDLSDPVTIPVEAYVSEAYAR
MSMEG_5627|M.smegmatis_MC2_155 MTDTQP--------------------RTDEALATPMTIGVEAYTSEAYAR
MMAR_0307|M.marinum_M MTDHNDG--------RAEPMDAAHHDDVEATLTGAVTFGVDAYTCADYAR
TH_4380|M.thermoresistible__bu MTDLTAQR------------------VPQKYACGETFVPKSRYIDPEFLQ
Mvan_0908|M.vanbaalenii_PYR-1 MTSTAEPR-----------------TNPEYRSKNKEFGISERYTSAEFAR
MAV_2952|M.avium_104 MNATPVP--------------------VPWAVQTPDRIPKQRYYDPEFYA
MUL_4884|M.ulcerans_Agy99 MSSPTKPLVAED--AEIVRRVLAHIDAGTTDEGEAWREPVENYASPERFA
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYR
* :
Mb3186c|M.bovis_AF2122/97 LERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDG----QL
Rv3161c|M.tuberculosis_H37Rv LERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDG----QL
Mflv_1788|M.gilvum_PYR-GCK AERDKLWRKVWQQVGRVEEIPEVGSYLTYDILDDSIIVVRTGEN----TF
MSMEG_5627|M.smegmatis_MC2_155 AERDRLWRRVWQQVGRVEELPEVGSYLTYDILDDSILVVRTGPGDSGGSF
MMAR_0307|M.marinum_M AERDKLWRKVWQQVGRVEDLPKVGSYLTYDILDDSIVVVRSAAD----TF
TH_4380|M.thermoresistible__bu LELDRLFTQVWQPACREEEIPDPGSYYEYCIGRQSIMVVRQKDR----SI
Mvan_0908|M.vanbaalenii_PYR-1 LENEKLWPKVWQVACRVEEVPNPGDYCEYTIADETILITRTREG----DV
MAV_2952|M.avium_104 LEKEMFWPRVWQMACRLEEIPKPGDFVEYEILDESVIVVRLDSQ----TV
MUL_4884|M.ulcerans_Agy99 AELR-LLRGMPSVFVPSAAIPNNGDHVERTAFGVPLFAVRGADG----RA
MAB_4370c|M.abscessus_ATCC_199 QELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNR----RI
* . . *.. .:.
Mb3186c|M.bovis_AF2122/97 HALSPICRHR--LMLMVEPGAG-----RIDTLTCQYHLWRYGLDGRLRGA
Rv3161c|M.tuberculosis_H37Rv HALSPICRHR--LMLMVEPGAG-----RIDTLTCQYHLWRYGLDGRLRGA
Mflv_1788|M.gilvum_PYR-GCK AAHHNVCMHRGRRLVDVPDGAKNAVGRARKSFVCGFHGWTYGLDGTCTHI
MSMEG_5627|M.smegmatis_MC2_155 AAHHNVCMHRGRRLVDTPAGAKNACARTRKSFMCGFHGWTYDLTGACTHI
MMAR_0307|M.marinum_M KAHHNVCMHRGRRLVDIPPGAKNVCG-HKKSFVCGFHGWTYDQDGNCIHI
TH_4380|M.thermoresistible__bu KAFHNTCAHRGMKIVCGTGVEAEG------ELRCRFHGWRYSLDGRSSFV
Mvan_0908|M.vanbaalenii_PYR-1 KALFNACQHRGMRLKEGRGSCS--------EIRCPSHSWCWNLDGSLNEV
MAV_2952|M.avium_104 RAYHNACRHRGVKLVEGNGNRR--------TFVCPFHGWCWSLDGRNTFV
MUL_4884|M.ulcerans_Agy99 RVFRNARRHRGFALVENAGCSH--------ALVCRYHGWIYRLDGSLSHV
MAB_4370c|M.abscessus_ATCC_199 RAFLNSCRHRGARVCRADYGVTR-------GFTCTYHGWAYDLEGKLISV
. ** : : * * * : *
Mb3186c|M.bovis_AF2122/97 P-HMAAN-LDFNRRECRLPQF-AVATWNGLVWIN-LDADAEPIAAHLDLT
Rv3161c|M.tuberculosis_H37Rv P-HMAAN-LDFNRRECRLPQF-AVATWNGLVWIN-LDADAEPIAAHLDLT
Mflv_1788|M.gilvum_PYR-GCK REQDDWK-GTLTPRNTHLAPV-QVDTWGGWLFVN-MDPDCEPLADYLFPA
MSMEG_5627|M.smegmatis_MC2_155 REQDDWQ-GTLTPENTHLPRV-HVDTWGGWLFIN-MDPDPEPLADYLFPA
MMAR_0307|M.marinum_M PEKPDWQ-GALTPENTHLAAV-NVDTWGGWIWIN-MDPAAQPLRQYLEPA
TH_4380|M.thermoresistible__bu PGREEFA-NRP-REQWGLRPV-HVGTWGGWVFIS-MADEPPELLEWLDPL
Mvan_0908|M.vanbaalenii_PYR-1 IDPQDFDPEAISPDALRLPEC-KVEVWAGFVFIN-MDPDAVPLTEYLGEA
MAV_2952|M.avium_104 LRPETFAQENLAAADLRLVSV-RCELWGGCAWIN-LDDDAPALRDWMEPF
MUL_4884|M.ulcerans_Agy99 PHAEAFP--DLDMSARGLVEV-ESHEVDGLIVIGPLDPVDAGLIEDEGAI
MAB_4370c|M.abscessus_ATCC_199 PNEEGYP-DSFSTDDWGLVEVPHVDSYHGLIFGT-WNPAPVGLRESLGDM
* * :
Mb3186c|M.bovis_AF2122/97 -----DDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHEN-YHVLGLHR
Rv3161c|M.tuberculosis_H37Rv -----DDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHEN-YHVLGLHR
Mflv_1788|M.gilvum_PYR-GCK -----SKILEPFGLENMRYKWRKWLYFDCNWKVAMEAFNET-YHVFTTHP
MSMEG_5627|M.smegmatis_MC2_155 -----AKILDPFGLENMRYKWRKWLYFDCNWKVALEAFNET-YHVFTTHP
MMAR_0307|M.marinum_M -----ATMLDPFRLQDMRCKWRKWLTFQCNWKVAMEAFNET-YHVATTHP
TH_4380|M.thermoresistible__bu -----PTALAPFRLQDMRFRWRKRTTLPANYKTVIDAFIEG-YHTPGTHP
Mvan_0908|M.vanbaalenii_PYR-1 -----GPRVENFGVHKMVCTRLRSTVIKANWKLCHEAFIET-YHAIGTHP
MAV_2952|M.avium_104 -----ASTYDAWRVESLRVEWWQSCRLPVNWKLATAAFMEG-YHVPQTHP
MUL_4884|M.ulcerans_Agy99 GWLTDGSPWRAKLVPAERLIVVESTLREINWKVLVEQFLEG-YHIRSTHK
MAB_4370c|M.abscessus_ATCC_199 AWY-MDAMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSHA
*:* ** *
Mb3186c|M.bovis_AF2122/97 QT-----LEPFVPGGGDLDVRQYSR--------WALRLRVPFTVPVEA--
Rv3161c|M.tuberculosis_H37Rv QT-----LEPFVPGGGDLDVRQYSR--------WALRLRVPFTVPVEA--
Mflv_1788|M.gilvum_PYR-GCK EFNKFGEFKGWAKAQGRHSNIGYDAPKGMDETKSKIRLGTGD-PRIST--
MSMEG_5627|M.smegmatis_MC2_155 EFNKFGEFKGWAKAQGKHSNIGYDAPKDMEATKSKIRLGTGDDPRVST--
MMAR_0307|M.marinum_M QFNKFGNFRGWAAAHGRHSNIGYDAPKDLAQTKSKIRLGTGADPRVST--
TH_4380|M.thermoresistible__bu QTLRTAQSPHPSTEPAKPQEYVYAPYTPTIAYKNHSRFIYTQRPETAERD
Mvan_0908|M.vanbaalenii_PYR-1 QSLRYLDDTGMIFEQYGDHGMHRIAPGHMGKPSARLDGDDIDRRDVLMAL
MAV_2952|M.avium_104 QLLP--GAQTGEPSAAVHPVVASSLYFMRTLGEGMAGMTHQNDIRIAEG-
MUL_4884|M.ulcerans_Agy99 DTFFPVQYDDLNVVEAFGPNTRITFP-----YRNIERLRDRPEHTWTTG-
MAB_4370c|M.abscessus_ATCC_199 SALMVMAPQGKAPKDEIVHRTGRQYVDP---NGHGAGFPVHPKNRFDAR-
.
Mb3186c|M.bovis_AF2122/97 -------------KSLQLNEVQKSNLVVLWTFPNSALAIAGER-------
Rv3161c|M.tuberculosis_H37Rv -------------KSLQLNEVQKSNLVVLWTFPNSALAIAGER-------
Mflv_1788|M.gilvum_PYR-GCK -------------AEMQVYTMEETNATTTQTLVNAAKRLVDELPEGTPAD
MSMEG_5627|M.smegmatis_MC2_155 -------------AEMQMYTWEQTNATTTETLVNAAKRLVDELPEGTPPD
MMAR_0307|M.marinum_M -------------AEMQRYTLEETNATTTRTLVDAALRLVEELPEDAPAG
TH_4380|M.thermoresistible__bu KGRQEQASRPEVFANAMQYNYIGVNALVTERDYRAAQKLATMEPSEVPP-
Mvan_0908|M.vanbaalenii_PYR-1 MG-----------DLAEFDFYNEEDVAQANALIETVMDLPEEVTVG----
MAV_2952|M.avium_104 ---------------LQTMRLPSDPAAAMAAWRSALNDAVVDWHR-----
MUL_4884|M.ulcerans_Agy99 --------------ARVTYLYQLFPNVMLATFPDVIAMVVIDP-------
MAB_4370c|M.abscessus_ATCC_199 ----------------VVHQWTDYGALRERLGEARVQGPLTNG-------
Mb3186c|M.bovis_AF2122/97 ------------------VVWFGFIPQSIDR-----------VQVLGGVL
Rv3161c|M.tuberculosis_H37Rv ------------------VVWFGFIPQSIDR-----------VQVLGGVL
Mflv_1788|M.gilvum_PYR-GCK QVLQHWLASARRDDEARGVIWPTIPPDILGQSGTAW-QVFPNFQIGQGLT
MSMEG_5627|M.smegmatis_MC2_155 KVLEHWLASARRDDEARGVIWPTIPADILGQAGTAW-QIFPNFQIGQGLT
MMAR_0307|M.marinum_M QVLDHWLTSARRDDAARGVLWPTIDPEHLAQSGTAW-QIFPNFQIGQGLT
TH_4380|M.thermoresistible__bu --FVLYHQLCEELALAEGVDFPRMSMEEYFAGNGDW-HIFPTMVILVEKS
Mvan_0908|M.vanbaalenii_PYR-1 ---TFFAGLRRQQAEAEGVDLSVYSDADLLAG-ELW-NIFPNVTIPCNAG
MAV_2952|M.avium_104 ---------------ARGSGMPDLNELDRRGITDAIGFAFPHHFILPTYS
MUL_4884|M.ulcerans_Agy99 ------------------------------------------VSVDRTAV
MAB_4370c|M.abscessus_ATCC_199 ----------------HATVFPNLSYLPVNGSVRIW------HPKGPDKM
Mb3186c|M.bovis_AF2122/97 TTPELAADAAATAQTSQFVMAMIN--------------------------
Rv3161c|M.tuberculosis_H37Rv TTPELAADAAATAQTSQFVMAMIN--------------------------
Mflv_1788|M.gilvum_PYR-GCK SALCYSARPDPSYDPNKCIFEVAVFELYPK-GEEPGTEWAYTP--KDSPN
MSMEG_5627|M.smegmatis_MC2_155 TALCYSAKPHPSYNPDKCIFEVATFELFPK-GQEPRTEWEYTP--ADSPN
MMAR_0307|M.marinum_M TALCYSARPHG-YDPDQCVFEASCYELYPK-GEEPHTEWVYAP--PDDPG
TH_4380|M.thermoresistible__bu CLLGYRMLPDA-EDPDKCTFEMFTLEHFAP-GEVPETSWQVFERWQDHDG
Mvan_0908|M.vanbaalenii_PYR-1 NALTLRFRPNG-LNHEECIFDIFYLKVFPEGATIPPMEHEFYPDWQETKV
MAV_2952|M.avium_104 SASSYRIRPLG---PEETLFEIWSLTRLPG-DASAGKPTPPEPMAPDDPR
MUL_4884|M.ulcerans_Agy99 TIYSMVTPDVAERDSLDASSNLAGAGSFIG--------------------
MAB_4370c|M.abscessus_ATCC_199 EVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGIFEQDDGENWSEVQSISR
Mb3186c|M.bovis_AF2122/97 -----DEDRLGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVG
Rv3161c|M.tuberculosis_H37Rv -----DEDRLGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVG
Mflv_1788|M.gilvum_PYR-GCK WLSVLPQDFSNMAAVQQGMKSAGFPGTLPNPYRERSTVNLHHQLSKYMGT
MSMEG_5627|M.smegmatis_MC2_155 WLSVLPQDFSNMAAVQQGMKSMGFPGTKPNPYRERSTVNLHYQLSKYMGT
MMAR_0307|M.marinum_M WRSVLPQDFSNMAAVQQGMKSGGFGGPKPNPYMERSTANLHRNLAEYMGT
TH_4380|M.thermoresistible__bu WGELPTQDLQNIEAIHAGMHSHGFEGLWLNTAQEMSIRNEHAIADRFIFG
Mvan_0908|M.vanbaalenii_PYR-1 WGTIVTQDFTNLPKWQAGVHSRGYRGPVWG-RPDGNVSNLHRVISEYLAQ
MAV_2952|M.avium_104 WPPIPAQDFSNLPRQQKGLHSKSFEFMRLSDRIEGLISNFERVIDGFLAG
MUL_4884|M.ulcerans_Agy99 --QGLFEDNEMSEGVQRGLAAGANAFVEFG-RHESAVGRFHAALGRRLAR
MAB_4370c|M.abscessus_ATCC_199 GFVTNSVALNYQMGLDSEREDGRHPGLTSELYSDAAGRSFYARWRDLMNT
. :
Mb3186c|M.bovis_AF2122/97 DHPGAS--------------------------
Rv3161c|M.tuberculosis_H37Rv DHPGAS--------------------------
Mflv_1788|M.gilvum_PYR-GCK GDPREI--------------------------
MSMEG_5627|M.smegmatis_MC2_155 GEPRDLQENA----------------------
MMAR_0307|M.marinum_M GAPREL--------------------------
TH_4380|M.thermoresistible__bu LDKQ----------------------------
Mvan_0908|M.vanbaalenii_PYR-1 --------------------------------
MAV_2952|M.avium_104 LRYDALLPAIHKTNTTIDVPVVDLGFGAVEAR
MUL_4884|M.ulcerans_Agy99 LTSAG---------------------------
MAB_4370c|M.abscessus_ATCC_199 KAWHEEHV------------------------