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MDQHQRPDPMGPGSPRASARRPEPDPMGEPWWSRAVFYQVYPRSFADSNGDGVGDLDGLASRLDHLQQLG VDAIWINPVTVSPMADHGYDVADPRDIDPLFGGMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHPWFQAA LADLPGSPARDRYFFRDGRGPDGSLPPNNWESVFGGPAWTRVREPDGNPGQWYLHLFDTEQPDLNWDNPE ILDDFEKTLRFWLDRGVDGFRIDVAHGMAKPPGLPDSPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVI DEYPGAVTVGEVWVHDNARWAEYLRPDELHLGFNFRLARTEFDAAEIRDAVANSLAAAALQNATPTWTLA NHDVGREVSRYGGGEIGLRRAKAMAVVMLALPGVVFLYNGQELGLPDVDLPDEVLQDPTWERSGRTERGR DGCRVPIPWSGNIPPFGFSTCPDTWLPMPPEWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDGDVDW LAAPDDALIFRRHGGGLVCALNAAERPLALPAGEPILASAPLTDATLPPNAAAWLV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2471 | aglA | - | 100% (546) | PROBABLE ALPHA-GLUCOSIDASE AGLA (MALTASE) (GLUCOINVERTASE) (GLUCOSIDOSUCRASE) (MALTASE-GLUCOAMYLASE) (LYSOSOMAL ALPHA-GLUCOSIDASE) (ACID MALTASE) |
| M. tuberculosis H37Rv | Rv0126 | treS | 2e-56 | 33.20% (509) | trehalose synthase TRES |
| M. tuberculosis H37Rv | Rv1563c | treY | 3e-11 | 35.35% (99) | maltooligosyltrehalose synthase TreY |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2498 | aglA | 0.0 | 99.82% (546) | alpha-glucosidase AglA |
| M. gilvum PYR-GCK | Mflv_3849 | - | 1e-148 | 49.82% (546) | alpha amylase, catalytic region |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1565c | - | 0.0 | 66.09% (519) | Alpha-amylase family protein |
| M. marinum M | MMAR_3822 | aglA | 0.0 | 82.27% (519) | alpha-glucosidase AglA |
| M. avium 104 | MAV_1700 | - | 0.0 | 79.62% (530) | alpha-amylase family protein |
| M. smegmatis MC2 155 | MSMEG_4696 | - | 0.0 | 70.60% (517) | alpha-amylase family protein |
| M. thermoresistible (build 8) | TH_0920 | - | 0.0 | 70.39% (456) | PROBABLE ALPHA-GLUCOSIDASE AGLA (MALTASE) (GLUCOINVERTASE) |
| M. ulcerans Agy99 | MUL_4797 | treS | 3e-56 | 33.46% (511) | trehalose synthase TreS |
| M. vanbaalenii PYR-1 | Mvan_2546 | - | 1e-151 | 50.72% (552) | alpha amylase, catalytic region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3849|M.gilvum_PYR-GCK --------------------------------------MAP-KHPWWQTA
Mvan_2546|M.vanbaalenii_PYR-1 -------------------------MRKRLRTVWRSSPVAPEESPWWQTA
Rv2471|M.tuberculosis_H37Rv --------------MDQHQRPDPMGPGSPRASARRPEPDPM-GEPWWSRA
Mb2498|M.bovis_AF2122/97 --------------MDQHQRPDPMGPGSPRASARRPEPDPM-GEPWWSRA
MMAR_3822|M.marinum_M ------------------------------MAADGDE-----AKPWWSTA
MAV_1700|M.avium_104 -----------------------MMSAHEVMSAHETERGAMQSKPWWSSA
MSMEG_4696|M.smegmatis_MC2_155 ------------------------------------------MAQWWSHA
TH_0920|M.thermoresistible__bu ---------------------MSDTDGRDPMSGPARTTGRP-DRTWWRDA
MAB_1565c|M.abscessus_ATCC_199 ------------------------------MTAAYLG---QHDDPWWSRA
MUL_4797|M.ulcerans_Agy99 MELMNEATNTIEHNPAEGSHVEGGMVEHPDAKDFGNAAPLPADPTWFKHA
*: *
Mflv_3849|M.gilvum_PYR-GCK VVYQVYIRSFADGNGDGIGDIRGLRARVGYLGALGVDAIWINPWYPSPMA
Mvan_2546|M.vanbaalenii_PYR-1 VVYQVYIRSFADGNGDGVGDIAGLRARLPYLARLGVDAMWINPWYPSPMA
Rv2471|M.tuberculosis_H37Rv VFYQVYPRSFADSNGDGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMA
Mb2498|M.bovis_AF2122/97 VFYQVYPRSFADSNGDGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMA
MMAR_3822|M.marinum_M VFYQVYPRSFADSSGDGVGDLDGVAARLDHLAHLGVDGIWLNPVTVSPMA
MAV_1700|M.avium_104 VFYQVYPRSFADSDGDGVGDIDGVTAHLDHLEQLGVDAIWLNPVTVSPMA
MSMEG_4696|M.smegmatis_MC2_155 VFYQAYPRSFRDSNGDGVGDLDGVTTGLDHLADLGVDALWLNPVMVSPMA
TH_0920|M.thermoresistible__bu VFYQVYPRSFQDSNGDGVGDLDGITARLDHLRWLGVDALWLNPVTVSPMV
MAB_1565c|M.abscessus_ATCC_199 VFYQIYPRSFGDSDGDGVGDIDGISAKLGYLDLLGVEGIWLNPVTRSPMA
MUL_4797|M.ulcerans_Agy99 VFYEVLVRAFYDGTADGSGDLRGLMQRLDYLQWLGIDCIWLPPFYDSPLR
*.*: *:* *. .** **: *: : :* **:: :*: * **:
Mflv_3849|M.gilvum_PYR-GCK DAGYDVADYRDIEPAYGTLTEAQDLIDAAHAVGIRVILDIVPNHTSDRHA
Mvan_2546|M.vanbaalenii_PYR-1 DAGYDVADYRDIEPAYGTLEDARALIAEAHALGIRVILDIVPNHTSDQHA
Rv2471|M.tuberculosis_H37Rv DHGYDVADPRDIDPLFGGMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHP
Mb2498|M.bovis_AF2122/97 DHGYDVADPRDIDPLFGGMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHP
MMAR_3822|M.marinum_M DHGYDVSDPRDVDPLFGGMAALERLIAAAHRRGIKIIMDVVPNHTSSAHP
MAV_1700|M.avium_104 DHGYDVADPRDIDPLFGGMAAIERLIAAAHRRGIKITMDVVPNHTSSAHP
MSMEG_4696|M.smegmatis_MC2_155 DHGYDVADPRDVDPLFGGLDALDRLLDAAHARGIRVTMDLVPNHTSSAHP
TH_0920|M.thermoresistible__bu DHGYDVADPRDIDPLFGDLAAMDRLLRAARRSGIRVILDVVPNHTSSQHP
MAB_1565c|M.abscessus_ATCC_199 DHGYDVSNPREIDPLFGGSIAMHRLIASAHRHNIKVIMDLVPNHTSSEHP
MUL_4797|M.ulcerans_Agy99 DGGYDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVITDLVMNHTSESHP
* ***: : .: * :* *: *: .*:: *:* ****. *.
Mflv_3849|M.gilvum_PYR-GCK WFEAALAG--DPAARDRYHVRPGRGANGELPPNDWQSVFGGPAWTRITD-
Mvan_2546|M.vanbaalenii_PYR-1 WFRAALAG--ESGARRRYHFLAGRGADGELPPNDWQSVFGGPAWTRVDR-
Rv2471|M.tuberculosis_H37Rv WFQAALADLPGSPARDRYFFRDGRGPDGSLPPNNWESVFGGPAWTRVREP
Mb2498|M.bovis_AF2122/97 WFQAALADLPGSPARDRYFFRDGRGPDGSLPPNNWESVFGGPAWTRVREP
MMAR_3822|M.marinum_M WFQAALAAGPGSIDRDRYFFRDGRGPGGVRPPNNWESVFGGPAWTRVTDP
MAV_1700|M.avium_104 WFQAALAAGPGSDARQRYFFRDGRGTDGELPPNNWTSVFGGSAWTRVLEP
MSMEG_4696|M.smegmatis_MC2_155 WFVEALAN-PGR--RDRYIFRDGRGPDGAQPPNNWVSVFGGPAWTRVTEP
TH_0920|M.thermoresistible__bu WFREALAAGRNSPARQRYLFRDGRGTAGEHPPNNWVSVFGGPAWTRITEP
MAB_1565c|M.abscessus_ATCC_199 WFLEALQSPPGSDARERYIFRDGKGAHGELPPNNWPSVFGGPAWTRVTEA
MUL_4797|M.ulcerans_Agy99 WFQESRHD-PDGPYGDYYVWSD--SSEKYTDARIIFVDTEESNWT----F
** : * .. .. . **
Mflv_3849|M.gilvum_PYR-GCK GPLQGQWYLHLFAPGQPDLNWENPEVRAEFEDILAFWFDRGVDGFRIDVA
Mvan_2546|M.vanbaalenii_PYR-1 GPLEGQWYLHLFAPGQPDLNWENDEVRAEFEDILAFWFDRGVDGFRIDVA
Rv2471|M.tuberculosis_H37Rv DGNPGQWYLHLFDTEQPDLNWDNPEILDDFEKTLRFWLDRGVDGFRIDVA
Mb2498|M.bovis_AF2122/97 DGNPGQWYLHLFDTEQPDLNSDNPEILDDFEKTLRFWLDRGVDGFRIDVA
MMAR_3822|M.marinum_M NGTPGQWYLHLFDTEQPDLNWDNPDVFDDFEKTLRFWLERGVDGFRIDVA
MAV_1700|M.avium_104 DGNPGQWYLHLFDTEQPDLNWEHPDVFDDFEKTLRFWLERGVDGFRIDVA
MSMEG_4696|M.smegmatis_MC2_155 DGTPGQWYLHLFDPAQPDLNWNNPEVFEDLEKTLRFWLDRGVDGFRIDVA
TH_0920|M.thermoresistible__bu DGTPGQWYLHLFDPAQPDLNWENPEVFDDLEKTLRFWLERGVDGFRIDVA
MAB_1565c|M.abscessus_ATCC_199 DGTPGQWYLHLFAPEQPDVNWDNPEVFDDFADTLRFWLDRGIDGFRLDVA
MUL_4797|M.ulcerans_Agy99 DPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVLRFWLGLGIDGFRLDAV
. *:* * * . ***:* :: : : . * **: *:****:*..
Mflv_3849|M.gilvum_PYR-GCK HGLVKAEGLPDGAQADAP-QAMLQVEAQHPAWDQDGVHDIYRGWRSVAQR
Mvan_2546|M.vanbaalenii_PYR-1 HGLVKAAGLPDGAGVDAEPHTLLQVQGRHPAWDQDGVHDIYRGWRAVADR
Rv2471|M.tuberculosis_H37Rv HGMAKPPGLPD---SPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVIDE
Mb2498|M.bovis_AF2122/97 HGMAKPPGLPD---SPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVIDE
MMAR_3822|M.marinum_M HGMAKPPGLPD---TSDV-AEVLRHTDDDPRFNHPNVHAIHRDIRTVIDE
MAV_1700|M.avium_104 HGMAKPAGLPD---SPDLESKVLHHSDDDPRFNHPSVHDIHRDIRKVVND
MSMEG_4696|M.smegmatis_MC2_155 HGMAKPPDLPD---MSVTDTALLRNSDDDPRFDNDSVHDIHRFIRRVLDD
TH_0920|M.thermoresistible__bu HGMAKPGGLPD---MTVTDTRLLAESGDDPRFDNDHVHEIHRFIRRVLDD
MAB_1565c|M.abscessus_ATCC_199 HGMAKPPGLPD---IEDTETSMLHIADEDPRFNNEGVHEYHRKIRKVLDQ
MUL_4797|M.ulcerans_Agy99 P--------------------YLFEREGTNCENLPETHAFLKRVRKVVDD
* : .* : * * :
Mflv_3849|M.gilvum_PYR-GCK YTPERIFIAEA--WVSSNERLARYLRP--DELHTAFQFDFLRSPWRAA--
Mvan_2546|M.vanbaalenii_PYR-1 YAPERIFIAEA--WVSSNARLARYLRP--DELHTAFQFDFLRTPWRAQ--
Rv2471|M.tuberculosis_H37Rv Y-PGAVTVGEV--WVHDNARWAEYLRP--DELHLGFNFRLARTEFDAA--
Mb2498|M.bovis_AF2122/97 Y-PGAVTVGEV--WVHDNARWAEYLRP--DELHLGFNFRLARTEFDAA--
MMAR_3822|M.marinum_M Y-PAAVTVGEV--WVHDNARWAQYLRP--DELHLGFNFRLARTDFDAA--
MAV_1700|M.avium_104 Y-PGAVTVGEV--WVTDNARWAEYLRP--DELHLGFNFRLTKIDFDAA--
MSMEG_4696|M.smegmatis_MC2_155 Y-PDTVAVGEV--WVHGNERFARYLRA--DELHLGFNFRLVKADYDAA--
TH_0920|M.thermoresistible__bu Y-PHAVSVGEV--WVYDNTRFAAYLRH--DELHLGFNFRLVRAEFDAT--
MAB_1565c|M.abscessus_ATCC_199 Y-RDVVAVGEI--WVNDNTRFAEYVRP--DELHLGFNFKLVEADFDAD--
MUL_4797|M.ulcerans_Agy99 EFPGRLLLAEANQWPADVVEYFGEASTGGDECHMAFHFPLMPRIFMAVRR
: :.* * . . ** * .*:* : : *
Mflv_3849|M.gilvum_PYR-GCK NLRGVIDDAITSAASVGAPPTWVLSNHDVTRTVTRFSRSQPDHLVETDWE
Mvan_2546|M.vanbaalenii_PYR-1 MLREVIDDAIDSAASVGAPPTWVLSNHDVTRTVTRFSRSQPAHLIETDWE
Rv2471|M.tuberculosis_H37Rv EIRDAVANSLAAAALQNATPTWTLANHDVGREVSRYGGGE----------
Mb2498|M.bovis_AF2122/97 EIRDAVANSLAAAALQNATPTWTLANHDVGREVSRYGGGE----------
MMAR_3822|M.marinum_M EIHAAVQNSLQAAAMANAAPTWTLANHDVGREVTRYGGGT----------
MAV_1700|M.avium_104 QIHDAIQNSLAATALQDATPTWTLSNHDVGREVTRYGGGE----------
MSMEG_4696|M.smegmatis_MC2_155 EIRDAIDNAMTAAALEGATPTWTLSNHDVVREVTRYGGGA----------
TH_0920|M.thermoresistible__bu DIREAIDNSLAAVALTGAAPTWTLSNHDVDREVTRYGGGT----------
MAB_1565c|M.abscessus_ATCC_199 QIRAAIQNSLAAVDSVGATPTWTLSNHDVEREVTRYGDGQ----------
MUL_4797|M.ulcerans_Agy99 ESRFPISEILAKTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYA
: : : : . . * : :: . . . .
Mflv_3849|M.gilvum_PYR-GCK RGRWSGEEPDHELGRRRARAAALVQLALPGTAYVYQGEELGLEEIEDLPD
Mvan_2546|M.vanbaalenii_PYR-1 RGRWEDERPDHALGRRRARAAALVQLALPGTAYVYQGEELGLEEVEDLPD
Rv2471|M.tuberculosis_H37Rv ------------IGLRRAKAMAVVMLALPGVVFLYNGQELGLPDVD-LPD
Mb2498|M.bovis_AF2122/97 ------------IGLRRAKAMAVVMLALPGVVFLYNGQELGLPDVD-LPD
MMAR_3822|M.marinum_M ------------TGLHRARAMAMLMLALPGAVFLYNGEELGLPDVD-LPD
MAV_1700|M.avium_104 ------------VGLRRARAMAMVMLALPGAVFIYNGEELGLPDVE-LPD
MSMEG_4696|M.smegmatis_MC2_155 ------------QGLARARAMALVMLALPGAVFIYNGEELGLPNVE-LPD
TH_0920|M.thermoresistible__bu ------------LGQARARAMALVLLALPGAVFIYNGAELGLPNVD-LPD
MAB_1565c|M.abscessus_ATCC_199 ------------IGQWRARAMALVMLALPGTVFIYNGSELGLPNVE-LPD
MUL_4797|M.ulcerans_Agy99 K------DPRMKANVGIRRRLAPLLENDRNQIQLFNALLLSLPGSP---V
. : * : . :::. *.*
Mflv_3849|M.gilvum_PYR-GCK DVRQDPTWAQSGFTDVGRDGCRIPLPWNESEPTYGFADGPDAVTWLPQPG
Mvan_2546|M.vanbaalenii_PYR-1 EARQDPTWVQSGFTDVGRDGCRIPLPWTETSVPYGFAAHPAAVTWLPQPE
Rv2471|M.tuberculosis_H37Rv EVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFSTCPD--TWLPMPP
Mb2498|M.bovis_AF2122/97 EVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFSTCPD--TWLPMPP
MMAR_3822|M.marinum_M EVLQDPTWERSGRTERGRDRCRVPMPWSGTTPPFGFSSCAD--TWLPMPP
MAV_1700|M.avium_104 EVLQDPTWERSGHTERGRDKCRVPMPWSGQAPPFGFSSRTD--TWLPMPK
MSMEG_4696|M.smegmatis_MC2_155 AVLQDPVWERSGHTERGRDGCRVPMPWAGTAPPFGFSSTPD--TWLPMPD
TH_0920|M.thermoresistible__bu EVLQDPVWRRSGGGERGRDGCRVPMPWSGDTPPFGFSTTPD--TWLPMPS
MAB_1565c|M.abscessus_ATCC_199 EALQDPVWERSGHTERGRDGCRVPIPWEGTDPPYGFSSNAQ--TWLPMPH
MUL_4797|M.ulcerans_Agy99 LYYGDEIGMGDVIWLGDRDGVRTPMQWTPDR-NAGFSTANPGRLYLPPSQ
* . .** * *: * **: :** .
Mflv_3849|M.gilvum_PYR-GCK ----HWAEHSVEAQERDPDSMLHLYRAALKLRPSLWRDAG-EVTWLDVAA
Mvan_2546|M.vanbaalenii_PYR-1 ----HWAEHSVEAQERDPGSTLNLYRSALELRPTMWRDTG-DVKWLEVAS
Rv2471|M.tuberculosis_H37Rv ----EWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDG-DVDWLAAPD
Mb2498|M.bovis_AF2122/97 ----EWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDG-DVDWLAAPD
MMAR_3822|M.marinum_M ----EWAALTVEKQLEDAGSTLAFFRRALELRRERREFDGNEIRWLSAPR
MAV_1700|M.avium_104 ----EWAALTVQKQRDDPDSTLSFFRRALELRRRRVEFDGDGVEWLEATA
MSMEG_4696|M.smegmatis_MC2_155 ----EWAALTVERQLADPSSTLAFYRRAVQLRSARGEFDGSGIEWVDD--
TH_0920|M.thermoresistible__bu ----QWAGLTVQRQSGE-----------TRIR------------------
MAB_1565c|M.abscessus_ATCC_199 ----GWAEYTVERQLEHTDSMLSLYRRAIELRKSRKEFTGTSLEWYGSPP
MUL_4797|M.ulcerans_Agy99 DSVYGYQAVNVEAQRDTSTSLLNWTRTMLAVRRRHNAFAVGTFQELGGSN
: ..: * :*
Mflv_3849|M.gilvum_PYR-GCK EVAAFDRGGA-----------QCWVNTGTADVTLPAGASVVLASSPGVDG
Mvan_2546|M.vanbaalenii_PYR-1 DIAAFERGGA-----------QCWVNTGDAGVPLPAGAAVVLASEPGVDG
Rv2471|M.tuberculosis_H37Rv DALIFRRHGGG---------LVCALNAAERPLALPAGE-PILASAPLTDA
Mb2498|M.bovis_AF2122/97 DALIFRRHGGG---------LVCALNAAERPLALPAGE-PILASAPLTDA
MMAR_3822|M.marinum_M GALIFRRPAG----------LVCALNAGDRPLTLPDGE-LLLASAPLVDG
MAV_1700|M.avium_104 DAVTFRRPGG----------LVCALNSGEQPVPLPPGE-LVLASAPLLDG
MSMEG_4696|M.smegmatis_MC2_155 --QVFRRPGG----------LTCAFNTGTTPLPLPDGE-ILLTSGELVDG
TH_0920|M.thermoresistible__bu ---CCRSTGGP---------CGCGAPGPNSPDPVCTG----WTTDAMR--
MAB_1565c|M.abscessus_ATCC_199 GALAFRVKGGG---------LTCALNVSSDLVDLPEGE-VILTSGPLVNG
MUL_4797|M.ulcerans_Agy99 PSILAYVREAPGPAGEDGDVVLCVNNLSRFPQPIELNLQQWNSYTPVELT
. * : . :
Mflv_3849|M.gilvum_PYR-GCK ---------------VLPGDTAVWLQTRGKDFLL
Mvan_2546|M.vanbaalenii_PYR-1 ---------------MLPPDTAVWLR--------
Rv2471|M.tuberculosis_H37Rv ---------------TLPPNAAAWLV--------
Mb2498|M.bovis_AF2122/97 ---------------TLPPNAAAWLV--------
MMAR_3822|M.marinum_M ---------------ALAPDAAAWLV--------
MAV_1700|M.avium_104 ---------------KLPPDAAAWLA--------
MSMEG_4696|M.smegmatis_MC2_155 ---------------MLPPDTAAWLV--------
TH_0920|M.thermoresistible__bu ---------------WCSGETAG-----------
MAB_1565c|M.abscessus_ATCC_199 ---------------KLPRNTAAWIV--------
MUL_4797|M.ulcerans_Agy99 GQVEFRKIGHLPYLLTLPGHGFYWFQLSASEEER
. .