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FLGTVEDWTAEGTVVAWYPTAATYRRAAQAQYHPAPVSYQQAQHLRYYRRQVSRGRDIPRLCIGAWEISG TCDIDAMTQAVNTHLRRHDTYHDRFVFGDGDEILRYVIPEPEAITLAPTDLGRMAPPQIRKLLLDTPDPL QWDCFTFGIVQAQDRFTIYIAVDHLRADGMSAGVIFLDIQTTYFAALQRTHFALPPAPSHREYSARQHTY TRSLNEESPEIRSWHAFLAANNGALPRFPLELGESNADTPGAIEVFDLIDDEQGRRFEAACRAAGARFSG GVFACAARTEHRLTGAATYFGLTPFDNRRDPAHATAVGWLASFVPLAIPTAGASFNEVVSAAQASFDSNA ALGAVPYYHLLETTGPSSTPIEVPDRPVPMLSYIDIRKLPFGDYFDGLRAGVWGYNRLSETVCMWVNRMH DRTQLVVAYPGTDVARGSVRRYVETMRAEFARVCDAGPRSDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2005 | - | - | 100% (463) | PapA2 protein |
| M. avium 104 | MAV_2723 | - | e-113 | 48.23% (423) | PapA2 protein |
| M. avium 104 | MAV_1762 | - | 3e-93 | 39.44% (464) | condensation domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1214 | papA3 | 1e-102 | 39.83% (467) | polyketide synthase associated protein PapA3 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 5e-87 | 36.19% (467) | condensation domain-containing protein |
| M. tuberculosis H37Rv | Rv1182 | papA3 | 1e-102 | 39.83% (467) | polyketide synthase associated protein PapA3 |
| M. leprae Br4923 | MLBr_01230 | papA3 | 2e-99 | 39.83% (462) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0852 | - | 1e-113 | 43.98% (457) | polyketide synthase associated protein PapA2 |
| M. marinum M | MMAR_2343 | - | 2e-99 | 40.90% (467) | hypothetical protein MMAR_2343 |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 4e-96 | 40.00% (460) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-107 | 44.32% (458) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 3e-89 | 38.91% (460) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 2e-85 | 37.23% (462) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1214|M.bovis_AF2122/97 --MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYM
Rv1182|M.tuberculosis_H37Rv --MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYM
MLBr_01230|M.leprae_Br4923 ---MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVAYM
Mflv_0404|M.gilvum_PYR-GCK ---MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQAPVSSVPVSYM
Mvan_0270|M.vanbaalenii_PYR-1 ---MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRAQVSSVPVSYM
MUL_1531|M.ulcerans_Agy99 --MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYM
MMAR_2343|M.marinum_M MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQAPVSAVPPSHI
TH_2204|M.thermoresistible__bu --MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQAPVSSVPVSYM
MSMEG_4728|M.smegmatis_MC2_155 -------MFELTDIQNWDDAPGKHVSWGPSPSTVAKVAEAPVSDVPASYQ
MAB_0852|M.abscessus_ATCC_1997 -------MVALGTIHDWRPTPGTVISWSASPRAREVAAQAPASTIPPSYQ
MAV_2005|M.avium_104 --------MFLGTVEDWT-AEGTVVAWYPTAATYRRAAQAQYHPAPVSYQ
. : :* * * .: : . .* * ::
Mb1214|M.bovis_AF2122/97 QAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDT
Rv1182|M.tuberculosis_H37Rv QAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDT
MLBr_01230|M.leprae_Br4923 QAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDT
Mflv_0404|M.gilvum_PYR-GCK QGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHAVNAYLRRHDT
Mvan_0270|M.vanbaalenii_PYR-1 QGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHAVNAYLRRHDT
MUL_1531|M.ulcerans_Agy99 QAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDT
MMAR_2343|M.marinum_M QARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYVINSHLRRHDT
TH_2204|M.thermoresistible__bu QAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYVINAHMRRHDT
MSMEG_4728|M.smegmatis_MC2_155 QAQHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHVINAYLRRHDT
MAB_0852|M.abscessus_ATCC_1997 QAQHLRSYRDLARQDREMARLGIGSWDVPGVCDIDAMTAAINAHLRRHDT
MAV_2005|M.avium_104 QAQHLRYYRRQVSRGRDIPRLCIGAWEISGTCDIDAMTQAVNTHLRRHDT
*.:*:* : . .* : : . **: : :*:::*****
Mb1214|M.bovis_AF2122/97 YRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLP-QIREIVQNTP-D
Rv1182|M.tuberculosis_H37Rv YRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLP-QIREIVQNTP-D
MLBr_01230|M.leprae_Br4923 YRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLA-QIRELAVSTP-D
Mflv_0404|M.gilvum_PYR-GCK FRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVD-EIHAHVVAIP-S
Mvan_0270|M.vanbaalenii_PYR-1 FRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVD-EIFAHVVDIP-S
MUL_1531|M.ulcerans_Agy99 FRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRERLLATP-S
MMAR_2343|M.marinum_M YRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QWQDYILATP-G
TH_2204|M.thermoresistible__bu YRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QWQQHLLSTP-D
MSMEG_4728|M.smegmatis_MC2_155 YHSRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQTCD-QWREHILDTP-G
MAB_0852|M.abscessus_ATCC_1997 YHSWFEFDPVDKIVRHVIDDPASIDFVPQDHGLQGPD-EIRAHLLRTSGT
MAV_2005|M.avium_104 YHDRFVFGDGDEILRYVIPEPEAITLAPTDLGRMAPP-QIRKLLLDTP-D
::. * .: * : * : :.. * : .
Mb1214|M.bovis_AF2122/97 PLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVG
Rv1182|M.tuberculosis_H37Rv PLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVG
MLBr_01230|M.leprae_Br4923 PLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEFHMMYSALVS
Mflv_0404|M.gilvum_PYR-GCK PLEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEANGMYSALSS
Mvan_0270|M.vanbaalenii_PYR-1 PLEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEANGMYSALSG
MUL_1531|M.ulcerans_Agy99 PLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVS
MMAR_2343|M.marinum_M PLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEIEAMYNTLAD
TH_2204|M.thermoresistible__bu PLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEIHMQYAALVG
MSMEG_4728|M.smegmatis_MC2_155 PLQWDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEIHLMYAALVS
MAB_0852|M.abscessus_ATCC_1997 PLSWDCFTFGVIQRADHFTVYISVDHLHTDGMSTGILYIEIQLMYASLVH
MAV_2005|M.avium_104 PLQWDCFTFGIVQAQDRFTIYIAVDHLRADGMSAGVIFLDIQTTYFAALQ
**.*.*. *.::* :*: .:**:. *. . : . * :
Mb1214|M.bovis_AF2122/97 GHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPD
Rv1182|M.tuberculosis_H37Rv GHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPD
MLBr_01230|M.leprae_Br4923 GAGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFAEPNEGSFPD
Mflv_0404|M.gilvum_PYR-GCK GGAALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFAENNSDGFPE
Mvan_0270|M.vanbaalenii_PYR-1 GGAALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFAENSGGGFPE
MUL_1531|M.ulcerans_Agy99 GGAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPK
MMAR_2343|M.marinum_M GGAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFFESNDGALPS
TH_2204|M.thermoresistible__bu GGAPIPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFAGQMGGTLPN
MSMEG_4728|M.smegmatis_MC2_155 GGAPITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFLEGNNGTMPK
MAB_0852|M.abscessus_ATCC_1997 G-SALQLPPPAGYLDFSARELAHNQAMTLDSFEVQTWLRYARDNGGTLPD
MAV_2005|M.avium_104 R-THFALPPAPSHREYSARQHTYTRSLNEESPEIRSWHAFLAANNGALPR
: * . .. ::. *: . :. :* : * : . :*
Mb1214|M.bovis_AF2122/97 FPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCG
Rv1182|M.tuberculosis_H37Rv FPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCG
MLBr_01230|M.leprae_Br4923 FPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARFVGGVLACCG
Mflv_0404|M.gilvum_PYR-GCK FPLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARFVGGLFACLA
Mvan_0270|M.vanbaalenii_PYR-1 FPLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARFVGGLFACLA
MUL_1531|M.ulcerans_Agy99 FPLPLGDT--SAQCEMMGVRLMDERQTLALEAACMSAGARFCGGVFAISA
MMAR_2343|M.marinum_M FPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARFSGGVFACAA
TH_2204|M.thermoresistible__bu FPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARFVGGVFACAA
MSMEG_4728|M.smegmatis_MC2_155 FPLPLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRFIGGVFAAAA
MAB_0852|M.abscessus_ATCC_1997 FALPLGDRTAPNVGAMVAIPLLDAHGTVAFEKACEQAGVRFSGGVFACTA
MAV_2005|M.avium_104 FPLELGESNADTPGAIEVFDLIDDEQGRRFEAACRAAGARFSGGVFACAA
*.* **: : ::* :: .. ** ** **::* .
Mb1214|M.bovis_AF2122/97 LAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGD
Rv1182|M.tuberculosis_H37Rv LAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGD
MLBr_01230|M.leprae_Br4923 LAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAGSSFGD
Mflv_0404|M.gilvum_PYR-GCK QVEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITVPIGAASFGE
Mvan_0270|M.vanbaalenii_PYR-1 QVEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITVPIGATSFAD
MUL_1531|M.ulcerans_Agy99 VVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGE
MMAR_2343|M.marinum_M LAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTVAVA-SSFDE
TH_2204|M.thermoresistible__bu LTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITVPAAGVSFGE
MSMEG_4728|M.smegmatis_MC2_155 LAQYQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITVPVG-SSFAE
MAB_0852|M.abscessus_ATCC_1997 LIDRELTGAGTFYGITPYDTRGTAEEQMSVGWYASFIPFIVDMSDDSFAT
MAV_2005|M.avium_104 RTEHRLTGAATYFGLTPFDNRRDPAHATAVGWLASFVPLAIPTAGASFNE
: .*:. :. :.* * . : ** .. :*: : :*
Mb1214|M.bovis_AF2122/97 AARAAQTSFDSGVKLAEVPYDRVVELSS----TLTMP--RPNFPVVNFLD
Rv1182|M.tuberculosis_H37Rv AARAAQTSFDSGVKLAEVPYDRVVELSS----TLTMP--RPNFPVVNFLD
MLBr_01230|M.leprae_Br4923 AARAAQNCFDTDVHLAEVPYDRVVELAP----TVHKP--RPNFPVINFLD
Mflv_0404|M.gilvum_PYR-GCK AAWAAQSSFDSGLNMAKVPYYRVLELAP----WLGWP--RPNFPVSNFFH
Mvan_0270|M.vanbaalenii_PYR-1 AAWAAQASFDSNLFMAKVPYYRVLELAP----WLSWP--RPNFPVSNFFH
MUL_1531|M.ulcerans_Agy99 IVKAAQGSFDSGRDLAEVPLDCVMELVL----WLREG--QWGAPLLFYLD
MMAR_2343|M.marinum_M TVRGAQANFDASAHLANVPFERVLELAP----WLKKPPPRGGFPMVSFLD
TH_2204|M.thermoresistible__bu AARAAQQSFDSGIGLGHVPYDRVLELVP----SLRRAETCS--PMMSFLD
MSMEG_4728|M.smegmatis_MC2_155 TARTAQRSFDSGLYLAHVPFDRVLELGATE-RGLRAP--DPGVPMVSYLD
MAB_0852|M.abscessus_ATCC_1997 VARSAQKSFDECQPLAKVPFERALELAGPD-SGLTAP--EYVVPMVSFLD
MAV_2005|M.avium_104 VVSAAQASFDSNAALGAVPYYHLLETTGPSSTPIEVP--DRPVPMLSYID
. ** ** :. ** :* : *: ::.
Mb1214|M.bovis_AF2122/97 AGAAPLSVLLTAELTGT--NIGVYSDGRYSYQLSIYVIRVEQGTAVAVMF
Rv1182|M.tuberculosis_H37Rv AGAAPLSVLLTAELTGT--NIGVYSDGRYSYQLSIYVIRVEQGTAVAVMF
MLBr_01230|M.leprae_Br4923 AGTAPLSVLLTAGLDGL--NIGVYSDGRYSYQMSIYVIRVEQETAVAVMF
Mflv_0404|M.gilvum_PYR-GCK GGAAPLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTEMAIMH
Mvan_0270|M.vanbaalenii_PYR-1 GGAAPLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTVMAIMH
MUL_1531|M.ulcerans_Agy99 AGIPPLSAMANSHVEGL--RARLCHDGGMMGQIDIRVNRLEKETQLTVLF
MMAR_2343|M.marinum_M GGVPPLSGVVAMQLDRI--NARAFSDGRVAARVCIWVNKFQEETTVTASF
TH_2204|M.thermoresistible__bu AGVPPLSALVASQLDGL--NARVYGDGKVPAQLCMWVNRMDNETSVTVFF
MSMEG_4728|M.smegmatis_MC2_155 ATAAPLSPAVVAEWNRI--NGRIFSEMGAANQVGMWVNQFGSGTWITVAF
MAB_0852|M.abscessus_ATCC_1997 ARKIPVS----AEWDRI--NGGIYGDSRSSDQVCMWVNRFENETNLTISF
MAV_2005|M.avium_104 IRKLPFG----DYFDGL--RAGVWGYNRLSETVCMWVNRMHDRTQLVVAY
*.. . : : : : . * :. .
Mb1214|M.bovis_AF2122/97 PDNPIARESVARYLATLKSVFQRVAE----------SGQQQNVA------
Rv1182|M.tuberculosis_H37Rv PDNPIARESVARYLATLKSVFQRVAE----------SGQQQNVA------
MLBr_01230|M.leprae_Br4923 PDNPEAQESVARYLETLKSVFECVAE----------SGHWRNVA------
Mflv_0404|M.gilvum_PYR-GCK PDNPVAKRSVERYMQTMSSVASLVAD----------TGHWGRVA------
Mvan_0270|M.vanbaalenii_PYR-1 PDNPVAKKSVTRYMKVMKSVAGLVAD----------SGTWGLVA------
MUL_1531|M.ulcerans_Agy99 PNNPVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTY
MMAR_2343|M.marinum_M PNNPIAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL-------
TH_2204|M.thermoresistible__bu PDNPVARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQPA-----
MSMEG_4728|M.smegmatis_MC2_155 PNNPVARASVQEYVDAFRSVCVAVAEGRHDDVPTPRVNELDLRSA-----
MAB_0852|M.abscessus_ATCC_1997 PDNAVARESVSRYFEVARVVYQRVAQS-------------QFVS------
MAV_2005|M.avium_104 PGTDVARGSVRRYVETMRAEFARVCD----------AGPRSDA-------
*.. * ** .*. . :.:
Mb1214|M.bovis_AF2122/97 ---------------
Rv1182|M.tuberculosis_H37Rv ---------------
MLBr_01230|M.leprae_Br4923 ---------------
Mflv_0404|M.gilvum_PYR-GCK ---------------
Mvan_0270|M.vanbaalenii_PYR-1 ---------------
MUL_1531|M.ulcerans_Agy99 EPPATVSPLTSWRTG
MMAR_2343|M.marinum_M ---------------
TH_2204|M.thermoresistible__bu ---------------
MSMEG_4728|M.smegmatis_MC2_155 ---------------
MAB_0852|M.abscessus_ATCC_1997 ---------------
MAV_2005|M.avium_104 ---------------