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QPLIGVTVVSLAVNLPGPLAAARLAELGAAVTKVEPATGDPLAAAAPDWYARLIEHQNVLTLDLKDTGDR AKLDELLAGADLLITSMRPSALHRSGLARPQQRFPRLSLIEIVGHHGEHAETPGHDLNYQAAQGTLTPPH MPKVPIADVLGAERAVSSALAALLQAAKAGAGQRYRVVLEEAAARAGDAVRYGLMGEGAVLGGAYPGYGI YASADGYVALGAIEPHFFARTCQVFGADGSHESLGAAFAAKTTAELEDLARHMDIPLNEVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2704 | - | - | 100% (272) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. avium 104 | MAV_0976 | - | 1e-21 | 35.20% (250) | alpha-methylacyl-CoA racemase |
| M. avium 104 | MAV_2653 | - | 1e-19 | 32.20% (236) | fatty acid-CoA racemase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0878 | far | 5e-19 | 33.99% (253) | fatty-acid-CoA racemase |
| M. gilvum PYR-GCK | Mflv_2390 | - | 4e-19 | 27.67% (253) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv0855 | far | 5e-19 | 33.99% (253) | fatty-acid-CoA racemase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1862 | - | 1e-105 | 70.00% (270) | hypothetical protein MAB_1862 |
| M. marinum M | MMAR_4795 | - | 4e-19 | 28.09% (299) | acyl-CoA transferase |
| M. smegmatis MC2 155 | MSMEG_4111 | - | 4e-28 | 33.92% (286) | alpha-methylacyl-CoA racemase |
| M. thermoresistible (build 8) | TH_4477 | - | 8e-20 | 32.20% (264) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_4811 | - | 3e-18 | 26.38% (307) | hypothetical protein MUL_4811 |
| M. vanbaalenii PYR-1 | Mvan_4258 | - | 1e-19 | 27.91% (301) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2704|M.avium_104 --------MQPLIGVTVVSLAVNLPGPLAAARLAELGAAVTKVEPATG--
MAB_1862|M.abscessus_ATCC_1997 --------MLPLTGVNVVSLAINLPGPAACARLAEFGAAVTKVEPPGG--
Mb0878|M.bovis_AF2122/97 -----MTTGGPLAGVKVIELGGIGPGPHAGMVLADLGADVVRVRRPG---
Rv0855|M.tuberculosis_H37Rv -----MTTGGPLAGVKVIELGGIGPGPHAGMVLADLGADVVRVRRPG---
TH_4477|M.thermoresistible__bu -------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPRN--
MSMEG_4111|M.smegmatis_MC2_155 -----MTGTLPLAGIKVLDLSTLLPGPLATLMLAEAGADVIKLERPGRGD
Mflv_2390|M.gilvum_PYR-GCK -----MSAGAPLAGIRILEVGVMLAGPYATMMLADLGAEVIKIEPPGG--
Mvan_4258|M.vanbaalenii_PYR-1 -----MSSG-PLAGIRILEVGVMLAGPYATMMLADLGAEVIKIEPPGG--
MMAR_4795|M.marinum_M -----MTAAGPLTGIRVIEVGTMLAGPYATLLLADLGAEVVKIEPPGG--
MUL_4811|M.ulcerans_Agy99 MGAGAGNRTGPLSGVRVVDLTAMVMGPYCTQIMADMGADVIKIEPPQGDD
** *: ::.: ** . :.: ** * ::. .
MAV_2704|M.avium_104 -----DPLAAAAPDWYARLIEHQNVLTLDLKDTGDRAKLDELLAGADLLI
MAB_1862|M.abscessus_ATCC_1997 -----DPLARAASGWYAELAGRQTVLTLDLKAAADRATLDELLTGADLLI
Mb0878|M.bovis_AF2122/97 -------GLTMPSEDRDLLHRGKRIVDLDVKTQP--QAMLELAAKADVLL
Rv0855|M.tuberculosis_H37Rv -------GLTMPSEDRDLLHRGKRIVDLDVKTQP--QAMLELAAKADVLL
TH_4477|M.thermoresistible__bu -----TPGPGIPRGAKDHLLRNRRSVAADLKTEEGKELVRKLIAKADVLI
MSMEG_4111|M.smegmatis_MC2_155 EMRTYEPTFGEASANYAILNRGKRAYAVDFKDPAQRDRVLEIAADADIVM
Mflv_2390|M.gilvum_PYR-GCK -----EISRQVSDSYFASLNRNKQSVVIDLRSDAGRQKLGELVADSHALL
Mvan_4258|M.vanbaalenii_PYR-1 -----EISRQVSDSYFASLNRNKQSVVLDLRSEQGRRRLGELVADSHALL
MMAR_4795|M.marinum_M -----EISRTVGESYFASLNRNKSGLCLDLNSEVGQHRLAELAAESDALV
MUL_4811|M.ulcerans_Agy99 TRYVSVGPAAGMSGVFVNVNRGKRSAVIDLKSDSGQAAVRALIEGADVFI
: : *.. : : :. .:
MAV_2704|M.avium_104 TSMRPSALHRSGLARP--QQRFPRLSLIEIVGH--HGEHAETPGHDLNYQ
MAB_1862|M.abscessus_ATCC_1997 TSMRPTALQRLGLAAP--HEQFPRLSLIEIVGH--DGDLADEPGHDLNYQ
Mb0878|M.bovis_AF2122/97 DCFRPGTCERLGIGPDDCASVNPRLIFARITGWGQDGPLASTAGHDINYL
Rv0855|M.tuberculosis_H37Rv DCFRPGTCERLGIGPDDCASVNPRLIFARITGWGQDGPLASTAGHDINYL
TH_4477|M.thermoresistible__bu EGYRPGVTERLGLGPEDCAKINPRLIYGRMTGWGQDGPRAQQAGHDINYI
MSMEG_4111|M.smegmatis_MC2_155 EQFRPGVAERLGLSYDAMRERNPRIVYCSISGYGPTGQHASRAGHDLNYL
Mflv_2390|M.gilvum_PYR-GCK VNMKPSAIRRLGLTYDSLKEFNERIVCVAMTGFGLDGGDD--PAFDYVIQ
Mvan_4258|M.vanbaalenii_PYR-1 VNMKPSAIRRLGLTYDSLREFNESIVCVAMTGFGLDGGDD--PAFDYVIQ
MMAR_4795|M.marinum_M VNLRPSSIRRLGLTYEALRRFNERIVCVAITGYGLHGGDD--PAFDYVIQ
MUL_4811|M.ulcerans_Agy99 HSMRAKAIARLGLSYPEVAAINPAIVYTNCYGYGRRGPNRDLPAYDDTIQ
:. * *: : * * ...*
MAV_2704|M.avium_104 AAQGTLT-------PPHMPKVPIADVLG-AERAVSSALAALLQAAKAGAG
MAB_1862|M.abscessus_ATCC_1997 AAQGTLT-------PPHMPRVPLADLLG-AERAVSTALAALQARDRSGGG
Mb0878|M.bovis_AF2122/97 SQTGALAAFGYADRPPMPPLNLVADFGGGSMLVLLGIVVALYERERSGVG
Rv0855|M.tuberculosis_H37Rv SQTGALAAFGYADRPPMPPLNLVADFGGGSMLVLLGIVVALYERERSGVG
TH_4477|M.thermoresistible__bu SLNGTLHAVGRKGERPVPPLNLAGDFGGGSMFLLVGILAALFERQTSGKG
MSMEG_4111|M.smegmatis_MC2_155 AESGLLGVVTDANGSPNLPVSVLADIAAGTYPAVMNVLLALRMAERTGEG
Mflv_2390|M.gilvum_PYR-GCK AATGVAAMTGDPDGPPTLPGYSSADNSTGLTAALG-----LLAQIVSGRG
Mvan_4258|M.vanbaalenii_PYR-1 AATGVAAMTGDPQGPPTLPGYSSADNSTGLTAALG-----LLAQIVSGRG
MMAR_4795|M.marinum_M AAAGSAALTGEPGGPPTLPGYSSADNSTGMCAALG-----LLAAIISGRG
MUL_4811|M.ulcerans_Agy99 AACGLPSVQEQLTGEPSYVGTIMADKVAGLTALYAT-MMALFHRERTGQG
: * * .* * :* *
MAV_2704|M.avium_104 QRYRVVLEEAAARAG-------DAVRYGLMGEGAVLGGAYPGYGIYASAD
MAB_1862|M.abscessus_ATCC_1997 AVFRVALADAAAWAG-------GAVRHGLMGDNAILGGAFPGYGIYECAD
Mb0878|M.bovis_AF2122/97 QVVDAAMVDGVSVLAQMMWTMKGIGSLRDQRESFLLDGGAPFYRCYETSD
Rv0855|M.tuberculosis_H37Rv QVVDAAMVDGVSVLAQMMWTMKGIGSLRDQRESFLLDGGAPFYRCYETSD
TH_4477|M.thermoresistible__bu QVVDAAMIDGSAVLMQMMWAFRAMGMWSDERGVNMLDTGAPYYDTYETAD
MSMEG_4111|M.smegmatis_MC2_155 AHLQVSMTHNLQVLAYGYIATHQAAGTWPQPSAELLTGGSPRYQIYPAAD
Mflv_2390|M.gilvum_PYR-GCK GQVDVSLQDVMLSQLNYRAAAYLNDGAEPKRHPFGAHSYYVPAQLFSTAE
Mvan_4258|M.vanbaalenii_PYR-1 GQVDVSLQDVMLSQLNYRAAAYLNDGIEPQRHPNGAHSYYVPAQLFPTAD
MMAR_4795|M.marinum_M GQVDVSLFDVMVSQLNYHAAAYLNDGTEPQRRPHGAHPYYVPAQLFPTAD
MUL_4811|M.ulcerans_Agy99 QEVEIGMFEAVASFMLVEHANGAMFDP-PLGPAVYPRTVAPNRRPYRTSD
: . : ::
MAV_2704|M.avium_104 G-YVALGAIEPHFFARTCQVFG---ADGS--------------HESLGAA
MAB_1862|M.abscessus_ATCC_1997 G-HVALGALESHFYVRTLEIFG---ADGT--------------HESLRTA
Mb0878|M.bovis_AF2122/97 GKYMAVGAIEPQFFAALLSGLG---LSAADVPTQLDVAGYPQMYDIFAER
Rv0855|M.tuberculosis_H37Rv GKYMAVGAIEPQFFAALLSGLG---LSAADVPTQLDVAGYPQMYDIFAER
TH_4477|M.thermoresistible__bu GKYVAVGAIEPQFYAEMLKGLG---LEGEDLPDQNDMSRWDELRARFAEV
MSMEG_4111|M.smegmatis_MC2_155 GRYIACAALEEKFWQRLVTLVG---LDKR---FHDDVGQEQAVTAALTDI
Mflv_2390|M.gilvum_PYR-GCK G-FLALFITHDGFWASFAREAG---IEGFAT-MAERASRRDEVLALVSAA
Mvan_4258|M.vanbaalenii_PYR-1 G-YLALFITHDGFWAAFAAEAG---IEGFPT-MAERAERRDEVLALVSAA
MMAR_4795|M.marinum_M G-YLGLFVTHDGFWKAFAAEAG---IHGFET-MAERASRRAEVLTVVASA
MUL_4811|M.ulcerans_Agy99 G-YLAALIYNDKHWAAFVDAVRPPWASEQYATLEGRARQIDTVYALLAET
* .:. . .: .
MAV_2704|M.avium_104 FAAKTTAELEDLARHMDIPLNEVR--------------------------
MAB_1862|M.abscessus_ATCC_1997 FSGKTIAQLEAIAAEADIPLNGVK--------------------------
Mb0878|M.bovis_AF2122/97 FASRTRDEWTRVFAGTDACVTPVLAWSEAANNDHLKARSTVITAHGVQ--
Rv0855|M.tuberculosis_H37Rv FASRTRDEWTRVFAGTDACVTPVLAWSEAANNDHLKARSTVITAHGVQ--
TH_4477|M.thermoresistible__bu FKSKDRDHWAQVFAGTDACVTPVLSFAEVESEAHVVERNTFYREGDHL--
MSMEG_4111|M.smegmatis_MC2_155 FASQPSSYWRELLAGEDVCTVVVNTWEEAVEAGHVNINSADRVCVPGD--
Mflv_2390|M.gilvum_PYR-GCK LAGDTAVGWKNRLQPLGIPAAAVRTLPEALEA----MPEVVVTAGDFR--
Mvan_4258|M.vanbaalenii_PYR-1 LETDTAANWQHRLRPLGIPVAAVRTLPEALTA----TPEALITAGEFR--
MMAR_4795|M.marinum_M LATDTAAGWERRLRPLGVPAAAVRTLPEALAE----NPQVIVRAGELR--
MUL_4811|M.ulcerans_Agy99 FAARTTQEWLDLLEELEIPASALSSPAELFDNQHLNAVGFFETIDTAHGP
: :
MAV_2704|M.avium_104 ------------------------------------------------
MAB_1862|M.abscessus_ATCC_1997 ------------------------------------------------
Mb0878|M.bovis_AF2122/97 -QAAPAPRFSRTPAGPVRPP-------PAAATPIDEINW---------
Rv0855|M.tuberculosis_H37Rv -QAAPAPRFSRTPAGPVRPP-------PAAATPIDEINW---------
TH_4477|M.thermoresistible__bu -LPAPAPRFSRSVPSAPTPPR-----DPGADTDAVLQDWQ--------
MSMEG_4111|M.smegmatis_MC2_155 -PDLSIPTLTTSVDPTLRIPDNTRAYPSLAPLPDGHVVWA--------
Mflv_2390|M.gilvum_PYR-GCK -LVRSPIRIAGYTPEYRPAPTLDEHADAPAHSS---------------
Mvan_4258|M.vanbaalenii_PYR-1 -LVGSPIRIAGYQPAYRPAPRLDEHADAAAHSS---------------
MMAR_4795|M.marinum_M -LVGNPIRVSGYRPEYRPAPLLGEHCR---------------------
MUL_4811|M.ulcerans_Agy99 VRFPGVPTWFSRTPGRVLGPAPQLGADTSAVLEELGINAADAQPAGPA