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NIFGNVHLGYLVIETDRFADWRRFGRDAIGMHLDDVLPDAMRFRLDDNACRFLLQRGAGEDVTALGWQLD DHATFEEILARLTRHEMPVTEGTPEQAALRGVDRLVRFPGPNGLAHEIFTRARIGHTPLDMRVGGGFVTG EGGMGHVAIVSKEPQQMRGYYDTVFDARLSDYIDETISGLKFKIRFLRVNQRHHSVAIAAANRLPINPIR TRIQHCNIQVGDLDDMTASYQRVKALGFKMALSVGQHTNDRELSYYAISPSGFEWEVGWNPVVVDENTWE PTTYQGISIWGHTPEGQTIIDKLAQFKSAAISLLHRENTVPALARTGIPDD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2516 | - | - | 100% (332) | extradiol ring cleaving catechol dioxygenase |
| M. avium 104 | MAV_3021 | - | 4e-36 | 30.93% (291) | biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. avium 104 | MAV_0593 | - | 4e-34 | 30.38% (293) | extradiol ring-cleavage dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3599c | bphC | 6e-36 | 31.74% (293) | putative biphenyl-2,3-diol 1,2-dioxygenase BPHC (23OHBP |
| M. gilvum PYR-GCK | Mflv_0675 | - | 2e-37 | 30.61% (294) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. tuberculosis H37Rv | Rv3568c | bphC | 6e-36 | 31.74% (293) | biphenyl-2,3-diol 1,2-dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0585 | - | 4e-35 | 30.17% (295) | 2,3-dihydroxybiphenyl 1,2-dioxygenase |
| M. marinum M | MMAR_1501 | - | 1e-148 | 75.54% (323) | hypothetical protein MMAR_1501 |
| M. smegmatis MC2 155 | MSMEG_6036 | - | 2e-35 | 30.38% (293) | biphenyl-2,3-diol 1,2-dioxygenase |
| M. thermoresistible (build 8) | TH_4499 | - | 4e-35 | 28.12% (288) | PUTATIVE biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. ulcerans Agy99 | MUL_4139 | bphC | 2e-34 | 30.72% (293) | biphenyl-2,3-diol 1,2-dioxygenase BphC |
| M. vanbaalenii PYR-1 | Mvan_0591 | - | 1e-142 | 71.52% (323) | glyoxalase/bleomycin resistance protein/dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3599c|M.bovis_AF2122/97 -------MS-IRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYL
Rv3568c|M.tuberculosis_H37Rv -------MS-IRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYL
MUL_4139|M.ulcerans_Agy99 -------MS-IRSLGYLRIEATDMAAWREYGLKVLGMVEGKGSTEGALYL
MSMEG_6036|M.smegmatis_MC2_155 -------MS-IKSLGYLRIEATDVAAWREYGLKVLGMVEGKGNTDGALYL
MAB_0585|M.abscessus_ATCC_1997 -------MSIIKALGYMRIQATDVAAWREFGTKVLGMMEGTGDDPAALYL
TH_4499|M.thermoresistible__bu MRHERDTMGFIKSLGYVIVQATDMDRWRHFAYEVLGFAEGTGPNPEALYL
Mflv_0675|M.gilvum_PYR-GCK --------MLVKTLGYVGVESPDAKEWLAFGPEVLGMEAVEAAS-GSVLL
MAV_2516|M.avium_104 -----MNIFGNVHLGYLVIETDRFADWRRFGRDAIGMH-LDDVLPDAMRF
MMAR_1501|M.marinum_M MSTTGRSVFGNVQLGYIVIETNRFSDWRRFGRDAIGLH-VDDSLANTMRF
Mvan_0591|M.vanbaalenii_PYR-1 ---MTPDVFGKVHLGYLVIESDRFADWRRFGRDAIGMH-LDETLTDVMRF
***: ::: * :. ..:*: : :
Mb3599c|M.bovis_AF2122/97 RMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT
Rv3568c|M.tuberculosis_H37Rv RMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT
MUL_4139|M.ulcerans_Agy99 RMDDFPARLVIVPGTQDRLAEAGWECADAQGLQEIRNRLDVEGTPYKEAT
MSMEG_6036|M.smegmatis_MC2_155 RMDEFPARLVIVPGEHDRLQVSGWEAANAAELQDIRSRLDAAGTPFKEGT
MAB_0585|M.abscessus_ATCC_1997 RMDDFAARLVIVPGESDRLLASGWEVADAPALQAVRERLAKAGVEYAEGD
TH_4499|M.thermoresistible__bu RMDERTARITVEPGEVDRIVTIGWEVRDHAALEDVKRALAAAGVPHRQLS
Mflv_0675|M.gilvum_PYR-GCK RIDDADHRLAVHHGDRNRMLYAGWDVGSEEALEAAGELLHKRGIGFEVGT
MAV_2516|M.avium_104 RLDDNACRFLLQRGAGEDVTALGWQLDDHATFEEILARLTRHEMPVTEGT
MMAR_1501|M.marinum_M RLDGNECRFLLQHGPAEDVTALGWQLDDHNTFEEIINRVRRHGVPIIEGS
Mvan_0591|M.vanbaalenii_PYR-1 RLDDNACRFLLTRGPAEDTTALGWEVGDHDTFDAIAARIHDHGVPVSDGA
*:* *: : * : **: . :: :
Mb3599c|M.bovis_AF2122/97 AAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHR-FVTGEQ
Rv3568c|M.tuberculosis_H37Rv AAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHR-FVTGEQ
MUL_4139|M.ulcerans_Agy99 AAELADRRVDEMILFSDPSGNPLAVFHGAALEHRRVVSPYGHK-FVTGEQ
MSMEG_6036|M.smegmatis_MC2_155 SAELAERRVDEMIVFDDPSGNTLEVFHGVALEHRRVVSPYGHK-FVTEEQ
MAB_0585|M.abscessus_ATCC_1997 KAEVSDRKVEAFIQFSDPSGNTLEVFHGAQYMGRRFVSPYGHK-FVTAEQ
TH_4499|M.thermoresistible__bu TAEADARRVEEVVAFADPAGTALEVFHGPVLDHSPVVTPFGAR-FVTGDQ
Mflv_0675|M.gilvum_PYR-GCK EEDCAARGVLGFVTLSDPSGLRHELFYGQKVVPGSFRPGRAISGFVTGAQ
MAV_2516|M.avium_104 PEQAALRGVDRLVRFPGPNGLAHEIFTRARIGHTPLDMRVGGG-FVTGEG
MMAR_1501|M.marinum_M AEQAALRGVARLARFPGPNGLTQEIYAQPRPCPAPLNIGARGG-FVTGAG
Mvan_0591|M.vanbaalenii_PYR-1 AEEAEIRGVEHFIRFPGPNGLLQELYVTPRKGLQHLRLGVAGG-FVTGVD
: * * . : .* * :: . ***
Mb3599c|M.bovis_AF2122/97 GMGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPRMVGRPADGPPAWLR
Rv3568c|M.tuberculosis_H37Rv GMGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLR
MUL_4139|M.ulcerans_Agy99 GLGHVVLTTRDDAEALHFYRDVLGFKLRDSMRMPPQVVGRPADGAPAWLR
MSMEG_6036|M.smegmatis_MC2_155 GLGHVVLTTKDDRETLHFYRDILGFSLRDSMKLPPQLVGRPADGEPAWLR
MAB_0585|M.abscessus_ATCC_1997 GLGHVVLTCTDDVAAQEFYQDVLGFQLRDSMKLPPQLVGRPADGDPVWLR
TH_4499|M.thermoresistible__bu GLGHVVLPTVDVDGLFEFYTEVLGFRSRGAFRVP-----APEEFGPVRVR
Mflv_0675|M.gilvum_PYR-GCK GLGHVVLATPDLAQADRFLRGVLGFKKSD------------EIYTFMDLW
MAV_2516|M.avium_104 GMGHVAIVSKEPQQMRGYYDTVFDARLSDYIDET-------ISGLKFKIR
MMAR_1501|M.marinum_M GIGHVAITSKRPDQVRGYFDTVFDARLSDFIDET-------IGGIKFKIR
Mvan_0591|M.vanbaalenii_PYR-1 GMGHVAIATKKPHQMHGYYRTVFDARLSDYIDET-------ISGLKFKIR
*:***.: : ::. . :
Mb3599c|M.bovis_AF2122/97 FFGCNPRHHSLAFLPMPTS------SGIVHLMVEVEQADDVGLCLDRALR
Rv3568c|M.tuberculosis_H37Rv FFGCNPRHHSLAFLPMPTS------SGIVHLMVEVEQADDVGLCLDRALR
MUL_4139|M.ulcerans_Agy99 FFGCNPRHHSLAFLPLPTP------SGIVHLMVEVQNSDDVGLCLDRALR
MSMEG_6036|M.smegmatis_MC2_155 FLGVNPRHHSLAFMPGQTP------SGIVHLMVEVENSDDVGLCLDRALR
MAB_0585|M.abscessus_ATCC_1997 FYGCNPRHHALAFMPMPNP------TGIVHLMVEVENSDDVGLCLDRANR
TH_4499|M.thermoresistible__bu FLGINERHHSLALCPASTLRD----PGLIHLMVEVDTLDAVGQALDRVNR
Mflv_0675|M.gilvum_PYR-GCK FYHCNPRHHSIALTPMPGVR------GLHHVMVEVQSFDDVGMAYDLCMS
MAV_2516|M.avium_104 FLRVNQRHHSVAIAAANRLPINPIRTRIQHCNIQVGDLDDMTASYQRVKA
MMAR_1501|M.marinum_M FLRVNQRHHSVAIAAANRLPINPIRTRVQHVNVQVADLDDLTASYQRIRE
Mvan_0591|M.vanbaalenii_PYR-1 FLRVNERHHSVAIASVNRLPLNPIRTRIQHCNIQVAELDDMASAYRRVKE
* * ***::*: . : * ::* * : .
Mb3599c|M.bovis_AF2122/97 RKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIAREST
Rv3568c|M.tuberculosis_H37Rv RKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIAREST
MUL_4139|M.ulcerans_Agy99 RKVPMSATLGRHVNDLMLSFYMKTPGGFDVEFGCEGRQVDDHDWIAREST
MSMEG_6036|M.smegmatis_MC2_155 RKVKMSATLGRHVNDKMLSFYMKTPGGFDIEFGCEGLEVDDDNWVAREST
MAB_0585|M.abscessus_ATCC_1997 RKVKMSATLGRHINDKMLSFYMKTPGGFDMEFGCEGMEVDDESWVARESV
TH_4499|M.thermoresistible__bu DGYQLSSTLGRHTNDKMVSFYVRAPGDWDIEFGTAGMRVDETYYTAEEIT
Mflv_0675|M.gilvum_PYR-GCK RNIPLSMTLGRHVNDRMVSFYARTPSGFDIEYGWDAVTVDDDTWTVAQYD
MAV_2516|M.avium_104 LGFKMALSVGQHTNDRELSYYAISPSGFEWEVGWNPVVVDENTWEPTTYQ
MMAR_1501|M.marinum_M LGFGLALSVGQHTNDRELSYYAVTPSGFEWELGWNPIVVDESTWEPTTYQ
Mvan_0591|M.vanbaalenii_PYR-1 LGFEMALSVGQHTNDKELSFYAVTPSGFEWEVGWNPIVVDEATWEPTTHQ
:: ::*:* ** :*:* :*..:: * * **: :
Mb3599c|M.bovis_AF2122/97 AVSLWGH----DFTVGARG-------------------------------
Rv3568c|M.tuberculosis_H37Rv AVSLWGH----DFTVGARG-------------------------------
MUL_4139|M.ulcerans_Agy99 AVSLWGH----DFTVGARG-------------------------------
MSMEG_6036|M.smegmatis_MC2_155 AVSLWGH----DFSVGFK--------------------------------
MAB_0585|M.abscessus_ATCC_1997 GVSLWGH----DFSVGFK--------------------------------
TH_4499|M.thermoresistible__bu ADSYWGHQWVGDLPAAMRP-------------------------------
Mflv_0675|M.gilvum_PYR-GCK RPSVWGHQMVAQTPPGALEAATT---------------------------
MAV_2516|M.avium_104 GISIWGHTPEGQTIIDKLAQFKSAAISLLHRENTVPALARTGIPDD----
MMAR_1501|M.marinum_M GISIWGHTPEGQHIIDKLAQFKTAGRSLLRREDNVAPLCGPARSSRCGES
Mvan_0591|M.vanbaalenii_PYR-1 GISLWGHTPEGHTIVNLLERFKAGARSVFHAEDSVPALV-----------
* *** .
Mb3599c|M.bovis_AF2122/97 -----
Rv3568c|M.tuberculosis_H37Rv -----
MUL_4139|M.ulcerans_Agy99 -----
MSMEG_6036|M.smegmatis_MC2_155 -----
MAB_0585|M.abscessus_ATCC_1997 -----
TH_4499|M.thermoresistible__bu -----
Mflv_0675|M.gilvum_PYR-GCK -----
MAV_2516|M.avium_104 -----
MMAR_1501|M.marinum_M ILTTT
Mvan_0591|M.vanbaalenii_PYR-1 -----