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ADRLPDDAFTAPQVVDPGLRKVARFLPRGYALHRGLKLQRAIMNLMGNAGRLRTVPVVAVNEHVTVRLHR PPNLAEHAPALLWTHGGGTVMGHAAQDDKYLRKLSHRTGVAIAAVEHRLAPEHPYPAPVEDCYAALLWLA RQPWVDPERVAVGGASAGGLFAATLAQRAHDRNDVKIAFQMLVYPMLDDRTGAQRDGPRRLMWTESDNQL AWQWYLNGADPDEAAPARRKDLSGLPPAWIGVGTLDLFYPECLEYARRLREAGVPVQEEIVPGAFHAFDQ IVDKAPISAKFFESQCDFLRGALAPNG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2513 | - | - | 100% (308) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_4954 | - | 2e-85 | 54.08% (294) | alpha/beta hydrolase fold |
| M. avium 104 | MAV_5118 | - | 4e-37 | 35.71% (308) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0223c | lipW | 9e-77 | 51.54% (293) | esterase LipW |
| M. gilvum PYR-GCK | Mflv_0442 | - | 6e-85 | 54.30% (291) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0217c | lipW | 4e-76 | 51.19% (293) | esterase LipW |
| M. leprae Br4923 | MLBr_00314 | - | 5e-13 | 25.21% (234) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0826c | - | 2e-82 | 53.08% (292) | esterase LipW |
| M. marinum M | MMAR_2621 | - | 1e-120 | 69.97% (293) | esterase/lipase |
| M. smegmatis MC2 155 | MSMEG_0280 | - | 8e-77 | 50.17% (301) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_2573 | - | 2e-80 | 52.58% (291) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_3141 | - | 5e-88 | 69.55% (220) | esterase/lipase |
| M. vanbaalenii PYR-1 | Mvan_0225 | - | 2e-79 | 51.14% (307) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2621|M.marinum_M -----------MQARSDGPPAFTKPDAIDPALRAISRILPRGYGLHRG--
MUL_3141|M.ulcerans_Agy99 MRTPRCAIVWCMQARPDGPPAFTKPDAIDPALRAISRILPRGYGLHRG--
MAV_2513|M.avium_104 -----------MADRLP-DDAFTAPQVVDPGLRKVARFLPRGYALHRG--
Mflv_0442|M.gilvum_PYR-GCK ----------------------MHGVDFHPELRRAARMLPRQVVTPVT--
Mvan_0225|M.vanbaalenii_PYR-1 ------------MPLPHTHTERVPDIEFHPELRRSARLLPKQVITPLT--
TH_2573|M.thermoresistible__bu ----------------VARSSKLP-LDFHPDLRRLARFIPRQAVSPVT--
MSMEG_0280|M.smegmatis_MC2_155 -------------------MTATTPTRFHPDLERVARYIPRHMVNRAT--
Mb0223c|M.bovis_AF2122/97 ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRT--
Rv0217c|M.tuberculosis_H37Rv ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRT--
MAB_0826c|M.abscessus_ATCC_199 ----------------------MSSPDIHPDLRLAARAFPRQVGLPRT--
MLBr_00314|M.leprae_Br4923 ----------MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSY
. . * : .
MMAR_2621|M.marinum_M ---LKLPRALMKLAGITGR--LRDVPVVAVNDAVSVRLHRPTGLPD---P
MUL_3141|M.ulcerans_Agy99 ---LKLPRALMKLAGITGR--LRDVPVVAVNDAVSVRSHRPAGLPD---P
MAV_2513|M.avium_104 ---LKLQRAIMNLMGNAGR--LRTVPVVAVNEHVTVRLHRPPNLAE---H
Mflv_0442|M.gilvum_PYR-GCK ---LPLLRRASRLMWRRAP-AP-DVEVLTLESGVGVRLFRPAGATR---P
Mvan_0225|M.vanbaalenii_PYR-1 ---LPFIRAASRLMWRRND-SPADVEVLTLSSGVGVRLFRPSGVAPG--R
TH_2573|M.thermoresistible__bu ---LPLMRLATRPMTRR---APRDIEVLTLSSGIGIRLFRPPGGGT----
MSMEG_0280|M.smegmatis_MC2_155 ---LPVFQRLTRLMGRR---VPPGCEVLTLPSGVGIRLFRPPASTTL--P
Mb0223c|M.bovis_AF2122/97 ---LPVMRALIVVAGLRMSRTPPDIEVLTLESGVGVRLYRPAGSNE---P
Rv0217c|M.tuberculosis_H37Rv ---LPVMRALIVVAGLRMSRTPPDIEVLTLESGVGVRLYRPAGSNE---P
MAB_0826c|M.abscessus_ATCC_199 ---LSILRASIYLTDLLPR---HGVRRIAVNDNVTVRAHVPKNLEE---P
MLBr_00314|M.leprae_Br4923 VPQLPWPFGLIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGS
* . . : .
MMAR_2621|M.marinum_M GPALLWIHGGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEHPYPT
MUL_3141|M.ulcerans_Agy99 GPALLWIHGGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEHPYPT
MAV_2513|M.avium_104 APALLWTHGGGTVMGHAAQDDKYLRKLSHRTGVAIAAVEHRLAPEHPYPA
Mflv_0442|M.gilvum_PYR-GCK GPALLWIHGGGYILGDAAQDDVLCRRFAHELGATVASVDYRLAPEFPYPA
Mvan_0225|M.vanbaalenii_PYR-1 GPALLWIHGGGYVIGDAAQDDVLCRRFARELGATVASVNYRLAPEYPYPV
TH_2573|M.thermoresistible__bu GAAMLWIHGGGYVIGCAAQDDALCRRYARELDVTVAAVDYRLAPENPYPI
MSMEG_0280|M.smegmatis_MC2_155 GPALVWIHGGGYVLGSAAQDDAQCLQFARQAGVTVASVEYRLAPQNPYPA
Mb0223c|M.bovis_AF2122/97 APALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPA
Rv0217c|M.tuberculosis_H37Rv APALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPA
MAB_0826c|M.abscessus_ATCC_199 SAALLWIHGGGYVMGTARQDDFFCRKVMHETGIPVVSVDYRLAPEHPYPI
MLBr_00314|M.leprae_Br4923 GRIVLYLHGGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGM
. ::: *.*. : * .. . .: *::** *: .
MMAR_2621|M.marinum_M PVEDCYAALLWLRQQQWVDPSRIAVAGASAGGLFAATLVQLACDRGDVEP
MUL_3141|M.ulcerans_Agy99 PVEDCYAALLWLRQQQWVDPSRIAVAGASAGDLFAATLVQLACDRGDVEP
MAV_2513|M.avium_104 PVEDCYAALLWLARQPWVDPERVAVGGASAGGLFAATLAQRAHDRNDVKI
Mflv_0442|M.gilvum_PYR-GCK PVEDCYSALKWLSALPAVDPSRVAIGGASAGGGIAAALAFLARDRGEIPL
Mvan_0225|M.vanbaalenii_PYR-1 PVEDCYSALHWLTQLPSVDPARVAIGGASAGGGLAAALALLTRDRGEIEL
TH_2573|M.thermoresistible__bu PLEDCYAALLWLTRLPTVDPQRVVIAGGSAGGGLAAALALLARDRGEVAP
MSMEG_0280|M.smegmatis_MC2_155 GLEDCFAALRWLTALPSVDPARVAIGGASAGGGLAASLALLARDRG-IDV
Mb0223c|M.bovis_AF2122/97 ALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALALLARDRGGITP
Rv0217c|M.tuberculosis_H37Rv ALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALALLARDRGGITP
MAB_0826c|M.abscessus_ATCC_199 PLEDCYAALRWLSVQGWIDPTRIAVGGASAGGGLAAALALLARDRGEVAP
MLBr_00314|M.leprae_Br4923 ALDDCHDGYQWLRRLG-YDPEQIVLAGDSAGGYLALALAQRLQDVGEEPA
: **. . ** ** ::.:.* ***. :* :*. * .
MMAR_2621|M.marinum_M VLQMLVYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLA-------G
MUL_3141|M.ulcerans_Agy99 VLQMLVYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLA-------G
MAV_2513|M.avium_104 AFQMLVYPMLDDRTGAQR--DGPRRLMWTESDNQLAWQWYLN-------G
Mflv_0442|M.gilvum_PYR-GCK AAQLLVYPMIDDRTVLRTGLDNPGHRLWNQAANRFGWQAYLG-------D
Mvan_0225|M.vanbaalenii_PYR-1 AAQLLVYPMIDDRTVHRKGLDHPGHRLWNQSSNRFGWRAYLG-------D
TH_2573|M.thermoresistible__bu VAQLLVYPMLDDRTLHRTDLDHPGLRLWNQSSNRFGWSAYLG-------D
MSMEG_0280|M.smegmatis_MC2_155 AAQLLVYPMLDDRSSFVPSLDHPGQRLWNQGSNRFGWKAYLG-------D
Mb0223c|M.bovis_AF2122/97 AFQLLVYPMLDDRTSIAP--ANPHYRLWNGRANRFGWRAYLG-------D
Rv0217c|M.tuberculosis_H37Rv AFQLLVYPMLDDRPSIAP--ANPHYRLWNGRANRFGWRAYLG-------D
MAB_0826c|M.abscessus_ATCC_199 AAQLLIYPMLDDRSSERTDIDGTNLRLWSGDSNRFGWDSYLG-------D
MLBr_00314|M.leprae_Br4923 ALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVD
. : : : :: .
MMAR_2621|M.marinum_M ADPSTAAPARRADLSNLPPAWIGVGTLDLFHQECLDYAARLRDAGVEVHE
MUL_3141|M.ulcerans_Agy99 ADPSTAAPA-----------------------------------------
MAV_2513|M.avium_104 ADPDEAAPARRKDLSGLPPAWIGVGTLDLFYPECLEYARRLREAGVPVQE
Mflv_0442|M.gilvum_PYR-GCK ADRDVAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRAAGVPCEV
Mvan_0225|M.vanbaalenii_PYR-1 ADPNEAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRVAGVQCEV
TH_2573|M.thermoresistible__bu ADPEVAVPARQTDLAGLPPAWIGVGTYDLFHDEDLAYAERLRAAGVPCEV
MSMEG_0280|M.smegmatis_MC2_155 ADPDVAVPARREDLSGLPPAWVGVGTLDLFHDEDLAYAGRLHAAGVPCEI
Mb0223c|M.bovis_AF2122/97 ADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQV
Rv0217c|M.tuberculosis_H37Rv ADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQV
MAB_0826c|M.abscessus_ATCC_199 ADRDIAVPGRRTDVAGLAPAWIGIGTADLFHDEDLAYAERLRTAGVPCEL
MLBr_00314|M.leprae_Br4923 DKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEI
.
MMAR_2621|M.marinum_M QIADGAFHAFDLLAPNAQVSLGFFASQCQFLRTHLHATVSDQPQAP
MUL_3141|M.ulcerans_Agy99 ----------------------------------------------
MAV_2513|M.avium_104 EIVPGAFHAFDQIVDKAPISAKFFESQCDFLRGALAPNG-------
Mflv_0442|M.gilvum_PYR-GCK EVVKGAFHGFDGIAPKAEVSQSFFRSQCALLRGAFEPAAA------
Mvan_0225|M.vanbaalenii_PYR-1 MVVDGAFHGFDGIAPKADVSQSFFNSQCALLRTVFASAAP------
TH_2573|M.thermoresistible__bu EVVPGAFHGFDAIAPRAGVSRQFFDSQCAMLRGLLRPEAA------
MSMEG_0280|M.smegmatis_MC2_155 DVVHGAFHGFDGVAPKAAVSRAFRNAQCAFLKRALT----------
Mb0223c|M.bovis_AF2122/97 EVVEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
Rv0217c|M.tuberculosis_H37Rv EVVEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
MAB_0826c|M.abscessus_ATCC_199 EVVPGAFHGFDKLVPWAGVSRDFVAKACRSLLGALS----------
MLBr_00314|M.leprae_Br4923 RVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL