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VPVVIVGAGPTGITAATLLAQHGIRCLVLERWDDVYPQPRAVHLDDEVRRILARLGINDEFAAISRPALG LRLLDPEFGVLAQFNRDPAESVHGFPQANMFDQPEFEALLRRNLKNFPGAVMRGNSEVTDVTQTEVGRVR VTFADRATGEGHVVDADYVLGCDGANSVVRSAIGAAMDDLHFEQRWLVVDVATDVDLNQWDGVYQVCSPV RAATYMRIGATRYRWEFRLLPGETADDYRSCAALRSLISPWVGDVADEDLELVRVAEYTFRAQLANRWRD RNVFLLGDAAHLTPPFIGQGMGAGLRDAMNLAWKLAGVLGEDLPEEVLETYEQERKPHARALIALALGMG WAMTAGGGIGDAIRRTVVPRLHLVPGMRGRIVNSRTPALRRSALVVKSRLRRDLAGTLCPNPLLDNGARF DNVVGNRFALIASLPLTKGQRIELDHRGAVVLSVKPGCELDRWLRRGRVTSRGVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1804 | mhpA | - | 100% (475) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. avium 104 | MAV_0878 | mhpA | 2e-48 | 31.91% (445) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. avium 104 | MAV_2518 | - | 3e-32 | 31.97% (294) | monooxygenase, FAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 4e-12 | 25.44% (338) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 6e-54 | 33.71% (439) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. tuberculosis H37Rv | Rv1751 | - | 3e-12 | 25.44% (338) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2573c | mhpA | 1e-163 | 61.16% (466) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. marinum M | MMAR_2987 | mhpA | 1e-174 | 63.98% (472) | 3-(3-hydroxy-phenyl) propionate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_2485 | mhpA | 6e-48 | 36.03% (358) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 4e-51 | 33.18% (443) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 8e-12 | 26.05% (334) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_4906 | mhpA | 1e-173 | 63.06% (471) | 3-(3-hydroxyphenyl)propionate hydroxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1804|M.avium_104 --------------------------------------------------
MMAR_2987|M.marinum_M -----------------------------------------MSDKPFQTI
Mvan_4906|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2573c|M.abscessus_ATCC_199 --------------------------------------------MNASAQ
Mflv_2401|M.gilvum_PYR-GCK ----------------------------------------------MTEQ
TH_0968|M.thermoresistible__bu ----------------------------------------------MTER
MSMEG_2485|M.smegmatis_MC2_155 ----------------------------------------MNTSHASAHQ
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
MAV_1804|M.avium_104 --MPVVIVGAGPTGITAATLLAQHGIRCLVLERWDDVYPQPRAVHLDDEV
MMAR_2987|M.marinum_M RQVPVVIVGAGPTGITAATLLAQYGVESMVLERWTDVYPQPRAVHLDDEI
Mvan_4906|M.vanbaalenii_PYR-1 --MPVVVVGGGPTGVTAATLLAQYGVDTLVLDRWSQVYPQPRAVHLDDEI
MAB_2573c|M.abscessus_ATCC_199 LSFPVVIIGAGPTGVTAATLLAQHGVQCLLLERWATVYPQPRAVHLDDEI
Mflv_2401|M.gilvum_PYR-GCK TDVDVVIVGAGPAGLTLANILGLEGVRVLVVDERDKLIDYPRGVGLDDES
TH_0968|M.thermoresistible__bu --VDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVGLDDEA
MSMEG_2485|M.smegmatis_MC2_155 MTTEVVIVGFGPVGKLLAVQLGRRGHSVIVVDRNEASYPLPRAVTHCSDA
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
: * ** * . *. * :::. *.
MAV_1804|M.avium_104 RRILARLGINDEFAAISRP--ALGLRLLDPEFGVLAQFNRDPAESVHGFP
MMAR_2987|M.marinum_M YRVIARLGIADEFAAISRP--TQGLRLLDNRFNVLTEFHRDPARSLHGFP
Mvan_4906|M.vanbaalenii_PYR-1 CRILARLGVAEEFARISRP--ARGLRLVDRNLAVLAEFRRDTAVTRSGYP
MAB_2573c|M.abscessus_ATCC_199 YRILAQLGIAEQFATISRP--GAGMRLLDHRGQILSQIARAPIG-THGYP
Mflv_2401|M.gilvum_PYR-GCK LRTFQAIGLVDRVLPHTVP--NQILRFFDAKRNLLAEM-APP-DARFGWP
TH_0968|M.thermoresistible__bu LRTFQSIGLVDRILPHTVP--NQILRFFDAKRRLLAEM-APP-DARFGWP
MSMEG_2485|M.smegmatis_MC2_155 ARILQSVGLSPDKIPHITEPYDDMYRWRNGDDDTLLDV-DWSGRGESGWY
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYS----EVRTATLHSNGRAVTYIDFERLHQPYP
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYS----EVRTATLHSNGRAVTYIDFERLHQPYP
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHR----LIDTISMKVQGQPVD-LDLKHLPGAHQ
* : :*:
MAV_1804|M.avium_104 QANMFDQPEFEALLRRNLKNFPGAVMRGNSEVTDVTQTEVGRVRVTFADR
MMAR_2987|M.marinum_M QANMFDQPELETLLRANLKRYAHAQLRGGAEVIEICDTN-ELLRVTFTDR
Mvan_4906|M.vanbaalenii_PYR-1 AANMFDQPELENLLRRNLTRFRRARFRGDVEVLDIAVDAAGVTRVAFSDR
MAB_2573c|M.abscessus_ATCC_199 QANMFDQPELEQLLRANLTNYPQVSLRGGVEVTTIAHISASQVQVTFTDR
Mflv_2401|M.gilvum_PYR-GCK KRNGFVQPMVDAELFGGLQRFDNVEVRFG-HRMHQCTQTTDR----VEVE
TH_0968|M.thermoresistible__bu KRNGFVQPMVDAELYAGLDRFDHVEVRFG-HRMQNCVEASDAGEDGVTVE
MSMEG_2485|M.smegmatis_MC2_155 NTYFFNQPALEDALEALVARVDNVRVIRG-WEATALRQCEDRATVAIRSA
Mb1780|M.bovis_AF2122/97 YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVR
Rv1751|M.tuberculosis_H37Rv YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVR
MUL_3663|M.ulcerans_Agy99 HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSAT
. * . * .
MAV_1804|M.avium_104 ATGEGH---VVDADYVLGCDGANSVVRSAIGAAMDDL--HFEQRWLVVDV
MMAR_2987|M.marinum_M SDGRVH---HVDAEYVLGCDGANSMVRSHVGSTMADL--NFQQRWLVVDV
Mvan_4906|M.vanbaalenii_PYR-1 LSGRRS---VITADYVLGCDGANSMVRNAIGATMRNL--KFDQRWLVVDV
MAB_2573c|M.abscessus_ATCC_199 DSGDEH---KVTATYVLGCDGANSVVRAAIGASMTAR--RFAQRWLVVDL
Mflv_2401|M.gilvum_PYR-GCK FDGGQA---SVSARYVVGCDGGRSVTRRLMGVSFDGT--TSSTRWLVVDI
TH_0968|M.thermoresistible__bu FADGHP---PVRASYVVGCDGGRSTTRRLMGVSFDGT--TSSTRWLVVDV
MSMEG_2485|M.smegmatis_MC2_155 STGAEM---TIDAEWVIGADGANSKVREWAGLGWHND--GYYFDWLVVDV
Mb1780|M.bovis_AF2122/97 YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
MUL_3663|M.ulcerans_Agy99 YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
: * .:..** * .* * *: :
MAV_1804|M.avium_104 ATDVDLNQWDGVYQVCSPVRAATYMRIGATRYRWEFRLLPGETADDYRSC
MMAR_2987|M.marinum_M ATECDLAQWDGVYQVCDPFRAATYMRIGQSRYRWEFQLRPGERTEDFNSI
Mvan_4906|M.vanbaalenii_PYR-1 ATTADLQQWEGVHQICDPRRAGTYMRIGDTRYRWEFALSAGESADDFATL
MAB_2573c|M.abscessus_ATCC_199 NTDADLGHWDGVHHLCDPDRATTFMRVGERRYRWEFKLHPGETAADYDTV
Mflv_2401|M.gilvum_PYR-GCK AN-DPLGHPNSEVG-ADPRRPYVSIAIAHGIRRFEFMIHPDETDEEADDP
TH_0968|M.thermoresistible__bu AN-DPLGHPNSEVG-ADPARPYVSISIAHGIRRFEFMIHPHETDAEVDDP
MSMEG_2485|M.smegmatis_MC2_155 KPSHELNFPHIAVQSCDHRRPATMVPGGPGRRRWEFMRLPHESREELNTD
Mb1780|M.bovis_AF2122/97 EGDAEFSFLP-RFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Rv1751|M.tuberculosis_H37Rv EGDAEFSFLP-RFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
MUL_3663|M.ulcerans_Agy99 RPDDPTGLAG-IFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEAL
.
MAV_1804|M.avium_104 AALRSLISPWVGDVADEDLELVRVAEYTFRAQLANRWRDRNVFLLGDAAH
MMAR_2987|M.marinum_M SALRPLIAPWTTDIAEGDLTLLRVAEYTFRAQIADQWRRGNIFILGDAAH
Mvan_4906|M.vanbaalenii_PYR-1 SALLPLLAPWTRHVAEADLQLVRVAEYTFRAQIADHWRSGSIFLLGDAAH
MAB_2573c|M.abscessus_ATCC_199 EKLRPLIAVWTGASAISELTLIRVTEYTFRAHVASHWRDRNVFILGDAAH
Mflv_2401|M.gilvum_PYR-GCK AFVRRMLGQLI--PYPERVDMIRHRVYTHHSRIAGSFREGRLMLAGDAAH
TH_0968|M.thermoresistible__bu AFVRRMLGRRI--PYPERVDMIRYRVYTHHSRIAGSFRKGRLLLAGDAAH
MSMEG_2485|M.smegmatis_MC2_155 AKAWELLAPYG--VGPGNARLERHAVYTFKACWADRWRDGRVLVAGDAAH
Mb1780|M.bovis_AF2122/97 RRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Rv1751|M.tuberculosis_H37Rv RRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
MUL_3663|M.ulcerans_Agy99 HRALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAH
: : : : *****
MAV_1804|M.avium_104 LTPPFIGQGMGAGLRDAMNLAWKLAG-VLGEDLPEEVLETYEQERKPHAR
MMAR_2987|M.marinum_M LTPPFIGQGMGAGLRDAMNLSWKIAA-VRCGTLTADALDTYQQERKPHTR
Mvan_4906|M.vanbaalenii_PYR-1 LTPPFIGQGMGAGLRDAMNLAWKLAG-VHHGSLPPTVLDSYEQERKPHAR
MAB_2573c|M.abscessus_ATCC_199 LTPPFVGQGMGAGIRDAANLTWKLAG-VLDGQLPTRVLDTYEQERKPHAW
Mflv_2401|M.gilvum_PYR-GCK LMPVWQGQGYNSGIRDAANLGWKLAA-VVTGRAGEELLDTYDVERRKHAR
TH_0968|M.thermoresistible__bu LMPVWQGQGYNSGIRDAANLGWKLAA-VVNGHAHDALLDTYDLERREHAR
MSMEG_2485|M.smegmatis_MC2_155 LMPPFAGQGLGAGMRDAMNLSWKLDA-VLRGRADAGLLDTYGSERLHHAV
Mb1780|M.bovis_AF2122/97 AMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTA
Rv1751|M.tuberculosis_H37Rv AMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTA
MUL_3663|M.ulcerans_Agy99 AMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTA
. * * . .: ** : : * .* :
MAV_1804|M.avium_104 ALIALALGMGWAMTAGGGIGDAIRRTVVPRLHLVPGMRGRIVNSRTPALR
MMAR_2987|M.marinum_M QLIRLALAIGQFMTGGGRLGNVVRRALLPRVRFVPGLRDKISDSTTPALH
Mvan_4906|M.vanbaalenii_PYR-1 HMISLALNMGRAMTAGGRLGAAVRRLIVPRLHLIPGMRGKVIDSETPALK
MAB_2573c|M.abscessus_ATCC_199 KMITIALAVGAAMTARGTAATAIRNLLVPRLQYIPGLRSRIQHSGTPALT
Mflv_2401|M.gilvum_PYR-GCK AMIDLSTMVGRVISPTNRKVAALRDRVIHAASAVPSLKRYVLEMRFKPMP
TH_0968|M.thermoresistible__bu AMIDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLKRYVLEMRFKPMP
MSMEG_2485|M.smegmatis_MC2_155 AFVKFSTSLGQVICITDEHEAAARDERMIADWRAG--------MAPPAPP
Mb1780|M.bovis_AF2122/97 VTQAVQRVLHRRLLGPLLQGRDP----------------------TPPAA
Rv1751|M.tuberculosis_H37Rv VTQAVQRVLHRRLLGPLLQGRDP----------------------TPPAA
MUL_3663|M.ulcerans_Agy99 FLQGIQRAIHAAIVAVAVTGGPP----------------------QPPPV
. : : .
MAV_1804|M.avium_104 RSALVVKSR--------LRRDLAGTLCPNPLLDNGARFDNVVGNRFALIA
MMAR_2987|M.marinum_M ASALVHKTHR-----LCRSRQLAGTLCPNPLLPEGQRLDAVIGTRFAVIT
Mvan_4906|M.vanbaalenii_PYR-1 ASSLVRRTP--------ASRRVAGRLCPNPVLADGRRLDEALGSGFGVVT
MAB_2573c|M.abscessus_ATCC_199 RSALVNKTP--------RCRQLAGTQIPNLVLSQGHRIDTLLGSGFALVA
Mflv_2401|M.gilvum_PYR-GCK RYQQGAVLHHAHAAPNSPTGTLFIQPRVDTRDTQNALLDDVLGTGFAVVC
TH_0968|M.thermoresistible__bu RYLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDAENVLLDDVLGPGFAVLC
MSMEG_2485|M.smegmatis_MC2_155 RPGLGAGPHVGEAG-----GTLARQGRIRMGSAEPTLFDDALGGPGAVIT
Mb1780|M.bovis_AF2122/97 LLGLVERLP-----------------------------------------
Rv1751|M.tuberculosis_H37Rv LLGLVERLP-----------------------------------------
MUL_3663|M.ulcerans_Agy99 VR-LVSRSV-----------------------------------------
MAV_1804|M.avium_104 SLPLTKGQR-------------------------IELDHRGAVVLSVKPG
MMAR_2987|M.marinum_M STSLGEAQE-------------------------LLLRRRDVLVVVTPPA
Mvan_4906|M.vanbaalenii_PYR-1 TGALTPAQQ-------------------------ALVERCGARALCVAPA
MAB_2573c|M.abscessus_ATCC_199 SETVDADQQ-------------------------AQLRRRGAAIIVEPRG
Mflv_2401|M.gilvum_PYR-GCK WSNNLRAVLGEEAFGRWKALGAKFVEVRPMSQLRWPGHDDPDVAVIGDRT
TH_0968|M.thermoresistible__bu WSNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWPGHDDPDVVVVGDRT
MSMEG_2485|M.smegmatis_MC2_155 RTAATLAEISPDVRSGLADLG--------MASVALAGTPSAGIVVADDVD
Mb1780|M.bovis_AF2122/97 ----------------------------------WLSAVPAYFVGVGVRP
Rv1751|M.tuberculosis_H37Rv ----------------------------------WLSAVPAYFVGVGVRP
MUL_3663|M.ulcerans_Agy99 ----------------------------------PVRRIMGYLVAIGPLP
MAV_1804|M.avium_104 CELDRWLRRGRVTSRGVV--------------------------------
MMAR_2987|M.marinum_M SSLADWLRRGGVKAALVRPDRTVMRAARDTVALC----------SWADR-
Mvan_4906|M.vanbaalenii_PYR-1 TELASWLRRGRVTTAMIRPDRTVMSAGRDVDALCRQFLSGNLVGVWNSV-
MAB_2573c|M.abscessus_ATCC_199 SELDRWLRRGGARAALIRPDRTVMQTARSPSQIAFTTTLFAPTHQPAPT-
Mflv_2401|M.gilvum_PYR-GCK GALKAWFDVHTESVLFVRPDRCIAAACIAQRAPEISEGLFAALHLTSGAH
TH_0968|M.thermoresistible__bu GALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAALSEVMCLT----
MSMEG_2485|M.smegmatis_MC2_155 GTYRAWLDELGADTVVIRPDFHVYGAGPADRTHDLITGLLTSVSGQ----
Mb1780|M.bovis_AF2122/97 EHAPAFARRGPGNRKGP---------------------------------
Rv1751|M.tuberculosis_H37Rv EHAPAFARRGPGNRKGP---------------------------------
MUL_3663|M.ulcerans_Agy99 EHAPKYPRRAR---------------------------------------
:
MAV_1804|M.avium_104 ----------------------------------
MMAR_2987|M.marinum_M ------------------ALQAS-----------
Mvan_4906|M.vanbaalenii_PYR-1 ------------------AATPD-----------
MAB_2573c|M.abscessus_ATCC_199 ------------------YRETP-----------
Mflv_2401|M.gilvum_PYR-GCK LTQGGGTDGEKPDRAVLHVAQPAAESSGTGAGTS
TH_0968|M.thermoresistible__bu --QGGGNGAASP---VLHVAQSAAEPSGTATRST
MSMEG_2485|M.smegmatis_MC2_155 ---------------SVVSAHPVSR---------
Mb1780|M.bovis_AF2122/97 ----------------------------------
Rv1751|M.tuberculosis_H37Rv ----------------------------------
MUL_3663|M.ulcerans_Agy99 ----------------------------------