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SATDIDEQQFAPLIDLKWWQKRPGERTELYRRLRDAGGPVFVRTNRPDSPRVRGFWAVGTHRDVTDISRR PAEFCSGHGTQIFDQTAEMREYRGSIIDMDDPEHQRLRKIVSRGFSPRMVSELRGLVQETTAEILEEMPR SGSCDFVSSFATLLPLRIIDDMLGVPREHEQFIVRATNVVLGASDPEYVPDQTVTGIERAVSQTSEQLIE LLRGIAEDRIANPRDDVISKLVTSNEENLTPQELAKFFILLIGAGNETTRNALTHGLLILSEHPEQRNRL IANYDELAPTAVEEILRYASPVIHMRRTVTRDGVTLTDGDGQVTHTFNEGDKVVMWYPAANRDPAVFDDP ECFDIARKPNNHIAFGGPGPHYCLGAHLARLELNVAFQMLYARYPDITAAGEPVMLRSNFVNGIKHLKAT YTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1940 | - | - | 100% (424) | NikQ protein |
| M. avium 104 | MAV_2642 | - | 0.0 | 88.44% (424) | cytochrome P450 |
| M. avium 104 | MAV_2174 | - | 4e-87 | 45.33% (375) | P450 heme-thiolate protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 1e-84 | 46.26% (374) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_3307 | - | 3e-85 | 45.55% (382) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 1e-84 | 46.26% (374) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-43 | 34.64% (332) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0101 | - | 8e-65 | 38.99% (377) | cytochrome P450 |
| M. marinum M | MMAR_3361 | cyp124A1 | 1e-79 | 43.88% (376) | cytochrome P450 124A1, Cyp124A1 |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 2e-80 | 44.56% (377) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_4175 | - | 1e-77 | 43.51% (370) | PUTATIVE linalool 8-monooxygenase |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 4e-79 | 43.62% (376) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 1e-82 | 44.30% (386) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3307|M.gilvum_PYR-GCK -MDGMSLDAHPVRR-NGIAPPEVPLADIDLGSWEFWGLDDDFRDGAFATL
Mvan_3029|M.vanbaalenii_PYR-1 MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATL
MSMEG_3551|M.smegmatis_MC2_155 ----MGIAP----RVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATL
TH_4175|M.thermoresistible__bu ----MGIAA----RVNGAAPPPVPLADINLGDWTFWALDDDIRDGAFATL
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
MMAR_3361|M.marinum_M MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
MAV_1940|M.avium_104 --------------MSATDIDEQQFAP--LIDLKWWQKRPGERTELYRRL
MAB_0101|M.abscessus_ATCC_1997 -------------MTTCPFTPGFDFTDPDLIQHR-------IPAEEFAYL
MLBr_02088|M.leprae_Br4923 -----------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLL
: . *
Mflv_3307|M.gilvum_PYR-GCK RREAP-------VSFHRAYITDEDA-EVAGHWALTRHDDVFFASRHPEIF
Mvan_3029|M.vanbaalenii_PYR-1 RREAP-------ISFHEAYVIDPDN-EVAGHWALTRHDDVFYASRHPEIF
MSMEG_3551|M.smegmatis_MC2_155 RREAP-------ISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELF
TH_4175|M.thermoresistible__bu RREAP-------ISFHPEYVDGGGT----GHWALTRYDDVFHASRHPEVF
Mb2289|M.bovis_AF2122/97 RREAP-------ISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIF
Rv2266|M.tuberculosis_H37Rv RREAP-------ISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIF
MMAR_3361|M.marinum_M RREAP-------ISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIF
MUL_1282|M.ulcerans_Agy99 RREAP-------ISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIF
MAV_1940|M.avium_104 RDAGG-------PVFVRTNRPDSPR--VRGFWAVGTHRDVTDISRRPAEF
MAB_0101|M.abscessus_ATCC_1997 RKTEP-------IWWNAQPRGVAGF-DDDGYWVVTKHADVKEVSRLNEVF
MLBr_02088|M.leprae_Br4923 RLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSA
* : .. . * *
Mflv_3307|M.gilvum_PYR-GCK SSALGITVG----DQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPR
Mvan_3029|M.vanbaalenii_PYR-1 SSALGITVG----DQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPR
MSMEG_3551|M.smegmatis_MC2_155 SSASGIVIG----DQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPR
TH_4175|M.thermoresistible__bu SSASGITLG----EQNPDLTEYFGS--MIAMDDPRHGRLRGIVRSAFTPR
Mb2289|M.bovis_AF2122/97 SSYPNITIN----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPK
Rv2266|M.tuberculosis_H37Rv SSYPNITIN----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPK
MMAR_3361|M.marinum_M HSSPNIVIH----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPK
MUL_1282|M.ulcerans_Agy99 HSSPNIVIH----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPK
MAV_1940|M.avium_104 CSGHGTQIF----DQTAEMREYRGS--IIDMDDPEHQRLRKIVSRGFSPR
MAB_0101|M.abscessus_ATCC_1997 SNSVNTTVVRYNEDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLFTPK
MLBr_02088|M.leprae_Br4923 SDRLKATLAQQAIAAGAEPRPFYASS-FMFLDPPDHTRLRKLVSKAFAPK
. : .: . :: :* * * ** :* *:*:
Mflv_3307|M.gilvum_PYR-GCK VLALIEDSVRQRARRLVEDMVAAHPDGRGELVSELAGPLPLQIICDMMGI
Mvan_3029|M.vanbaalenii_PYR-1 VLALIEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGI
MSMEG_3551|M.smegmatis_MC2_155 VLAVIEDSVRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGI
TH_4175|M.thermoresistible__bu VVARTEESVRRRARRLVAAMVAGHPAGAAELVSAFAGPLPLQVICDMMGI
Mb2289|M.bovis_AF2122/97 VVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGI
Rv2266|M.tuberculosis_H37Rv VVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGI
MMAR_3361|M.marinum_M VVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGI
MUL_1282|M.ulcerans_Agy99 VVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGI
MAV_1940|M.avium_104 MVSELRGLVQETTAEILEEMPRS---GSCDFVSSFATLLPLRIIDDMLGV
MAB_0101|M.abscessus_ATCC_1997 AVNGLHARLVERAHGIVEEAAEK---SSGNFVSDIASVLPMHAIADLVGI
MLBr_02088|M.leprae_Br4923 VVQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLGV
: . : . :: :.:: :* *.: * ::*:
Mflv_3307|M.gilvum_PYR-GCK PPRDHQKIFHWTNVILGFGDPDIATDF------DEFVSVAMGIGAYASEL
Mvan_3029|M.vanbaalenii_PYR-1 PEEDHQKIFHWTNVILGFGDPDIATDF------DEFVSVAMGIGAYATQL
MSMEG_3551|M.smegmatis_MC2_155 PESDHQQIFHWTNVILGFGDPDLTTDF------DEFVTVAMDIGAYATAL
TH_4175|M.thermoresistible__bu PETDHQQIFHWTNVILGFGDPDLTTDY------DEFVQVAVDIGGYATDL
Mb2289|M.bovis_AF2122/97 PKADHQRIFHWTNVILGFGDPDLATDF------DEFMQVSADIGAYATAL
Rv2266|M.tuberculosis_H37Rv PKADHQRIFHWTNVILGFGDPDLATDF------DEFMQVSADIGAYATAL
MMAR_3361|M.marinum_M PEEDHEQIFHWTNVILGFGDPDLTTDF------DEFLQVSMAIGGYATAL
MUL_1282|M.ulcerans_Agy99 PEEDHEQIFHWTNVILGFGDPDLTTDF------DDFLQVSMAIGGYATAL
MAV_1940|M.avium_104 PREHEQFIVRATNVVLGASDPEYVPDQTVTGIERAVSQTSEQLIELLRGI
MAB_0101|M.abscessus_ATCC_1997 PESDRQQVLDWTNQMFAYDDPAIGRDT--------ATTATVSMLGYAYAM
MLBr_02088|M.leprae_Br4923 PYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
* . . : :. ** . : :
Mflv_3307|M.gilvum_PYR-GCK ADDRRAHPGDDLTTALIEAELDGERLTSAEVASFFILLVVAGNETTRNAI
Mvan_3029|M.vanbaalenii_PYR-1 ADDRRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAI
MSMEG_3551|M.smegmatis_MC2_155 ADQRRSAPADDLTTSLVQAEVDGERLTSAEVASFFILLVVAGNETTRNAI
TH_4175|M.thermoresistible__bu AEQRRKNPGPDLTTSLVQAEVDGEQLTSADIASFFILLVVAGNETTRNAI
Mb2289|M.bovis_AF2122/97 AEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
Rv2266|M.tuberculosis_H37Rv AEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
MMAR_3361|M.marinum_M ADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAI
MUL_1282|M.ulcerans_Agy99 ADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTI
MAV_1940|M.avium_104 AEDRIANPRDDVISKLVTSNE--ENLTPQELAKFFILLIGAGNETTRNAL
MAB_0101|M.abscessus_ATCC_1997 AEERQLNPQDDILTGLVRGAYDDRPLTPLEFAYFVIQLMVAGNETSRNAI
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLI
.. * *: : *: *: :. *: **:**: * :
Mflv_3307|M.gilvum_PYR-GCK SHGVLALSRYPEERDRWWSDYAGLAPTAVEEIVRWASPVAYMRRTATRD-
Mvan_3029|M.vanbaalenii_PYR-1 SHGVLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRD-
MSMEG_3551|M.smegmatis_MC2_155 SHGVLALTRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVTRD-
TH_4175|M.thermoresistible__bu SHGMLALTRHPDQRQDWWDHFDEVTPTAVEEIVRWASPVTYMRRTVTRD-
Mb2289|M.bovis_AF2122/97 THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQD-
Rv2266|M.tuberculosis_H37Rv THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQD-
MMAR_3361|M.marinum_M SHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQD-
MUL_1282|M.ulcerans_Agy99 SHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQD-
MAV_1940|M.avium_104 THGLLILSEHPEQRNRLIANYDELAPTAVEEILRYASPVIHMRRTVTRDG
MAB_0101|M.abscessus_ATCC_1997 THGVLAFADNPAQWRLYR---ERRPSTAADEIIRWASPIIAFQRTALQD-
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKD-
::.:* : * : .. ..:* :*: ..: : *. :*
Mflv_3307|M.gilvum_PYR-GCK VEVGG------QTIAAGDKVTLWYGSANRDETKFDNPWLFDVGRHPNPHV
Mvan_3029|M.vanbaalenii_PYR-1 VEMSG------VRIAAGDKVSLWYGSANRDESKFENPWLFDVGRHPNPHV
MSMEG_3551|M.smegmatis_MC2_155 TELAG------TALPAGSKVTLWYGSANRDETKFDNPWMFDVQRHPNPHV
TH_4175|M.thermoresistible__bu TELRG------VRMAAGDKVTLWYGSANRDESRFSDPWLFDVRRHPNPHV
Mb2289|M.bovis_AF2122/97 IELRG------TKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHL
Rv2266|M.tuberculosis_H37Rv IELRG------TKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHL
MMAR_3361|M.marinum_M VDLRG------TKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQV
MUL_1282|M.ulcerans_Agy99 VDLRG------TKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQV
MAV_1940|M.avium_104 VTLTDGDGQVTHTFNEGDKVVMWYPAANRDPAVFDDPECFDIARKPNNHI
MAB_0101|M.abscessus_ATCC_1997 VELGG------VQIRKDQRVGMFYASANFDEDVFDDPFAFNIERDPNPHL
MLBr_02088|M.leprae_Br4923 MTIGQ------TTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHL
: : .. : : :** * : * *: * .. ::
Mflv_3307|M.gilvum_PYR-GCK GFGGGGAHFCLGANLARREITVAFEELHRLVPDIHATEEPGRLHSAFIHG
Mvan_3029|M.vanbaalenii_PYR-1 GFGGGGAHFCLGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAFIHG
MSMEG_3551|M.smegmatis_MC2_155 GFGGGGAHFCLGANLARREITVLFSELHRHLPDIVATEEPDRLQSAFIHG
TH_4175|M.thermoresistible__bu GFGGGGVHFCLGANLARREIAVAFDELRRQVPDIEVTEEPDRLHSAFIHG
Mb2289|M.bovis_AF2122/97 GFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHG
Rv2266|M.tuberculosis_H37Rv GFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHG
MMAR_3361|M.marinum_M GFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHG
MUL_1282|M.ulcerans_Agy99 GFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHG
MAV_1940|M.avium_104 AFGGPGPHYCLGAHLARLELNVAFQMLYARYPDITAAGEPVMLRSNFVNG
MAB_0101|M.abscessus_ATCC_1997 AFGGHGIHYCLGANLARLEIGIMFDALADRLPDLMPTGAPTRFRSGWING
MLBr_02088|M.leprae_Br4923 AFAVG-SHFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRG
.*. *:**** *** * : :. : * : . . :.*
Mflv_3307|M.gilvum_PYR-GCK IKT--------------------------------------------LPV
Mvan_3029|M.vanbaalenii_PYR-1 IKR--------------------------------------------LPV
MSMEG_3551|M.smegmatis_MC2_155 IKR--------------------------------------------LPV
TH_4175|M.thermoresistible__bu IXXXAEPESLPEPPPVASPSEALVNPRFLVAPPEPPAVGPSAFVPPMLGV
Mb2289|M.bovis_AF2122/97 IKT--------------------------------------------LPV
Rv2266|M.tuberculosis_H37Rv IKT--------------------------------------------LPV
MMAR_3361|M.marinum_M IKR--------------------------------------------LPV
MUL_1282|M.ulcerans_Agy99 IKR--------------------------------------------LPV
MAV_1940|M.avium_104 IKH--------------------------------------------LKA
MAB_0101|M.abscessus_ATCC_1997 VVA--------------------------------------------LPA
MLBr_02088|M.leprae_Br4923 MSA--------------------------------------------LPV
: * .
Mflv_3307|M.gilvum_PYR-GCK AWTPPTR-------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 SWSA----------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 AWR-----------------------------------------------
TH_4175|M.thermoresistible__bu SSSAPTSTERSSSSEPASVSTTSTPPFSEVASVRAALLAFLAGLSTKPAT
Mb2289|M.bovis_AF2122/97 TWS-----------------------------------------------
Rv2266|M.tuberculosis_H37Rv TWS-----------------------------------------------
MMAR_3361|M.marinum_M AWSR----------------------------------------------
MUL_1282|M.ulcerans_Agy99 AWSR----------------------------------------------
MAV_1940|M.avium_104 TYTP----------------------------------------------
MAB_0101|M.abscessus_ATCC_1997 NYHGSGPRG-----------------------------------------
MLBr_02088|M.leprae_Br4923 QV------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu STVSASDPWPVLSPTASPPLASPSPSSKPTATNSPLPVLGSPTPPAADGA
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MAV_1940|M.avium_104 --------------------------------------------------
MAB_0101|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu DFSAALNNPPKGFVGTPPEAPSASAIARGRVTVSTSTSPGIPSAPTRSPG
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MAV_1940|M.avium_104 --------------------------------------------------
MAB_0101|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------