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AAHSRDLGVVRYERDGAIARIVLDWPERANAQSSEMVSQVDSCLDEARQDYGVKVVIVKGSGKGFCAGHV MAPDAYPEFADSQLHMGSNYQGSKELFLWPTLRYWEFPKPMIAQVHGYAIGGGTYWALLPELTIASEDAY FQMPLVPGLGFAGGETMIEPWVFMNYKRAAEYLYTAQTLTAHEALRMGLVNRVVTRDELEPVTEALATKI ARAPLSTLMATKTMLVRAWEQMGMRQHLQLSADVMSVLENTSDAQALRAELVARGRLPRDQAGDG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1848 | - | - | 100% (276) | enoyl-CoA hydratase/isomerase |
| M. avium 104 | MAV_2954 | - | 8e-75 | 52.22% (270) | enoyl-CoA hydratase/isomerase family protein |
| M. avium 104 | MAV_2950 | - | 5e-72 | 48.29% (263) | enoyl-CoA hydratase/isomerase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0464c | echA2 | 3e-26 | 28.19% (259) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2433 | - | 2e-27 | 33.19% (235) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0456c | echA2 | 3e-26 | 28.19% (259) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 4e-19 | 31.25% (224) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1185c | - | 2e-20 | 30.60% (232) | enoyl-CoA hydratase |
| M. marinum M | MMAR_0778 | echA2 | 1e-25 | 27.49% (251) | enoyl-CoA hydratase EchA2 |
| M. smegmatis MC2 155 | MSMEG_4846 | - | 9e-29 | 36.68% (229) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3498 | - | 7e-91 | 60.22% (269) | PUTATIVE enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_1414 | echA2 | 8e-26 | 27.49% (251) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4219 | - | 1e-26 | 34.02% (241) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1848|M.avium_104 MAAHSRDLGVVRYERDGAIARIVLDWPERANAQSSEMVSQVDSCLDEARQ
TH_3498|M.thermoresistible__bu --LETRTLEHVIYEKDGPIARIILNNPDRANAQTSEMVHSVNTALDDAQY
Mflv_2433|M.gilvum_PYR-GCK --------MYIDYEVSDRIATITLNRPEAANAQNPELLDELDAAWTRAAE
Mvan_4219|M.vanbaalenii_PYR-1 --------MYIDYDVTDRIATITLNRPEAANAQNPELLDELDAAWTRAAE
MSMEG_4846|M.smegmatis_MC2_155 --------MYIDYGVADSIATITLNRPEAANAQNPELLDELDAAWTRAAE
MMAR_0778|M.marinum_M --MPTPEFQTLLYSTAGPVATITLNRPEHLNTIVPPMPDEIEAAVGLAER
MUL_1414|M.ulcerans_Agy99 --MPTPEFQTLLYSTAGPVATITLNRPEHLNTIVPPMPDEIEAAVGLAER
Mb0464c|M.bovis_AF2122/97 --MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIGLAER
Rv0456c|M.tuberculosis_H37Rv --MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIGLAER
MLBr_02402|M.leprae_Br4923 -----MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKELDI
MAB_1185c|M.abscessus_ATCC_199 --MTSHNFETILTERIDRVAVITLNRPKALNALNSQVMNEVTTAAAEFDA
: :. * *: *. *: . : .: .
MAV_1848|M.avium_104 DYGVKVVIVKGSGKGFCAGHVMAPDAYPE----FADSQLHMGSNYQGSKE
TH_3498|M.thermoresistible__bu DYDIKVVIIKANGKGFCSGHIPD-GSYPE----FKAEIEASGKVWRSAAQ
Mflv_2433|M.gilvum_PYR-GCK DNDVSVIVLRANGKHFSAGHDLRGGGP-------VPDKITLEFIIQHEAK
Mvan_4219|M.vanbaalenii_PYR-1 DNEVSVIVLRANGKHFSAGHDLRGGGP-------VPDKITLEFIIAHEAK
MSMEG_4846|M.smegmatis_MC2_155 DNEVKVIILRANGKHFSAGHDLRGGGE-------VPEKISLEFIIQHEAR
MMAR_0778|M.marinum_M DQGIKVIVLRGAGRAFSGGYDFGGGFQHWGETMMTDGQWDPGKDFAMVTA
MUL_1414|M.ulcerans_Agy99 DQGIKVIVLRGAGRAFSGGYDFGGGFQHWGETMMTDGQWDPGKDFAMVTA
Mb0464c|M.bovis_AF2122/97 DQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTA
Rv0456c|M.tuberculosis_H37Rv DQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTA
MLBr_02402|M.leprae_Br4923 DPDVGAILITGSPKVFAAGADIK--------------EMASLTFTDAFDA
MAB_1185c|M.abscessus_ATCC_199 DHGIGAIIITGSEKAFAAGADIK--------------EMSEQSFSDMFGS
* : .::: . : *..*
MAV_1848|M.avium_104 LFLWPTLRYWEFP---KPMIAQVHGYAIGGGTYWALLPELTIASEDAYFQ
TH_3498|M.thermoresistible__bu LFLWPVLKLWEFP---KPVIAQVHGYAIGGGTTWALIPEITVCSEDAWFQ
Mflv_2433|M.gilvum_PYR-GCK RYLEYTLRWRNVP---KPSIAAVQGRCISGGLLLCWPCDLIVAADDAQFS
Mvan_4219|M.vanbaalenii_PYR-1 RYLEYTLRWRNVP---KPSIAAVQGRCISGGLLLCWPCDLIVAADDAQFS
MSMEG_4846|M.smegmatis_MC2_155 RYLDYTLRWRNVP---KPSIAAVQGRCISGGLLLCWPCDLILASDDALFS
MMAR_0778|M.marinum_M RETAPTQKFMAIWRASKPVIAQIHGWCVGGASDYALCADIVIASDDAVIG
MUL_1414|M.ulcerans_Agy99 RETAPTQKFMAIWRASKPVIAQIHGWCVGGASDYALCADIVIASDDAVIG
Mb0464c|M.bovis_AF2122/97 RETGPTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIG
Rv0456c|M.tuberculosis_H37Rv RETGPTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIG
MLBr_02402|M.leprae_Br4923 DFFSAWGKLAAVR---TPMIAAVAGYALGGGCELAMMCDLLIAADTAKFG
MAB_1185c|M.abscessus_ATCC_199 DFFSAWGKLGAVR---TPTIAAVSGYALGGGCELAMMCDVIIAAENATFG
: . .* ** : * .:.*. . :: :.:: * :
MAV_1848|M.avium_104 MPLVPGLGFAGGETMIEPWVFMNYKRAAEYLYTAQTLTAHEALRMGLVNR
TH_3498|M.thermoresistible__bu MPLVPGFGLPGSETMFEPWVFMNYKRAAEYLYTAQKITAQQALEFGLVNR
Mflv_2433|M.gilvum_PYR-GCK DPVVL-MGIGGVEYHGHTWELG-PRKAKEILFTGRAMTADEVAATGMVNK
Mvan_4219|M.vanbaalenii_PYR-1 DPVVL-MGIGGVEYHGHTWELG-PRKAKEILFTGRAMTAEEVAATGMVNR
MSMEG_4846|M.smegmatis_MC2_155 DPVAL-MGIGGVEYHGHTWELG-PRKAKEILFTGRALTAEEAERTGMVNR
MMAR_0778|M.marinum_M TPYSRMWGAYLSGMWLYRLSFA---KAKWHSLTGRPLSGVQAAQIELINE
MUL_1414|M.ulcerans_Agy99 TPYSRMWGAYLSGMWLYRLSFA---KAKWHSLTGRPLSGVQAAQIELINE
Mb0464c|M.bovis_AF2122/97 TPYSRMWGAYLTGMWLYRLSLA---KVKWHSLTGRPLTGVQAAEAELINE
Rv0456c|M.tuberculosis_H37Rv TPYSRMWGAYLTGMWLYRLSLA---KVKWHSLTGRPLTGVQAAEAELINE
MLBr_02402|M.leprae_Br4923 QPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSR
MAB_1185c|M.abscessus_ATCC_199 QPEIKLGVLPGMGGSQRLTRAIGKAKAMDMILTGRNMDAAEAERSGLVSR
* :. *.: : . :. ::..
MAV_1848|M.avium_104 VVTRDELEPVTEALATKIARAPLSTLMATKTMLVRAWEQMGMRQHLQLSA
TH_3498|M.thermoresistible__bu VVPADELESTVEELAAKIAKAPLITLQATKAGILRAWETMGFRTHQQASN
Mflv_2433|M.gilvum_PYR-GCK VVPRAELDAETRALAEQIAKMPPFALRQAKRAVNQTLDVQGFYAAIQSVF
Mvan_4219|M.vanbaalenii_PYR-1 VVPRDQLDAETRTLAEQIAKMPPFALRQAKRAVNQTLDVQGFYAAIQSVF
MSMEG_4846|M.smegmatis_MC2_155 VVARDELDAQTRELAEQIATMPPFALRQAKRAVNQTLDVQGFYAAIQSVF
MMAR_0778|M.marinum_M AVPFERLEARVAEVAAELAQIPLSQLQAQKLIVNQAYENMGLASTQTLGG
MUL_1414|M.ulcerans_Agy99 AVPFERLEARVAEVAAELAQIPLSQLQAQKLIVNQAYENMGLASTQTLGG
Mb0464c|M.bovis_AF2122/97 AVPFERLEARVAEIATELARIPLSQLQAQKLIVNQAYENMGLASTQLLGG
Rv0456c|M.tuberculosis_H37Rv AVPFERLEARVAEIATELARIPLSQLQAQKLIVNQAYENMGLASTQLLGG
MLBr_02402|M.leprae_Br4923 VVLADDLLPEAKAVATTISQMSRSATRMAKEAVNRSFEST-LAEGLLHER
MAB_1185c|M.abscessus_ATCC_199 VVATESLLDEAKAVAKTISEMSLSASMMAKEAVNRAFESS-LAEGLLFER
.* * . :* :: . * : :: : :
MAV_1848|M.avium_104 DVMSVLENTSDAQALRAELVARGRLPRDQAGDG-----------------
TH_3498|M.thermoresistible__bu DLQAVVTGSREFQEYMAELMKRASKPADRV--------------------
Mflv_2433|M.gilvum_PYR-GCK DVHQTGHGNALSVGGWPVLVNLEEMKANIK--------------------
Mvan_4219|M.vanbaalenii_PYR-1 DVHQTGHGNALSVGGWPVLVNLEEMKANIK--------------------
MSMEG_4846|M.smegmatis_MC2_155 DIHQTGHGNALSVSGWPVLVDIEEMKANIK--------------------
MMAR_0778|M.marinum_M ILDGLMRNTPDALDFIKTAENQGVRAAVERRDGPFGDYSQAPPELRPNPN
MUL_1414|M.ulcerans_Agy99 ILDGLMRNTPDALDFIKTAENQGVRAAVERRDGPFGDYSQAPPELRPNPN
Mb0464c|M.bovis_AF2122/97 ILDGLMRNTPDALEFIRTAQTQGVRAAVERRDGPFGDYSQAPPELRPDPT
Rv0456c|M.tuberculosis_H37Rv ILDGLMRNTPDALEFIRTAQTQGVRAAVERRDGPFGDYSQAPPELRPDPT
MLBr_02402|M.leprae_Br4923 RLFHSTFVTDDQSEGMAAFIEKRAPQFTHR--------------------
MAB_1185c|M.abscessus_ATCC_199 RIFHSAFGTADQSEGMAAFVEKRPANFIHR--------------------
: .
MAV_1848|M.avium_104 ---------
TH_3498|M.thermoresistible__bu ---------
Mflv_2433|M.gilvum_PYR-GCK ---------
Mvan_4219|M.vanbaalenii_PYR-1 ---------
MSMEG_4846|M.smegmatis_MC2_155 ---------
MMAR_0778|M.marinum_M HVIVPDRDR
MUL_1414|M.ulcerans_Agy99 HVIVPDRDR
Mb0464c|M.bovis_AF2122/97 HVITPDGSM
Rv0456c|M.tuberculosis_H37Rv HVITPDGSM
MLBr_02402|M.leprae_Br4923 ---------
MAB_1185c|M.abscessus_ATCC_199 ---------