For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. avium 104 MAV_1418 (-)

annotation: putative transcriptional regulator
coordinates: 1386437 - 1387582
length: 381

MAKRLEFGLLGPLEMTVDGDLVPLGTPKQRAVLAMLLMNRNNPVGIDRLITGLWDESPPSGARASLHSYV
SNLRKLLSNAGVDPRTVLVAAPPGYRLNIPDDRCDLGRFITEKTAGVQAAASGRFEQAGAHLAAALAQWR
GPVLEDLAEFRFVGTFATSLVEEKILTHIAQAEAEIACGRAFSVITELESLTREHPYREQLWAQLMTAYY
LTDRQSDALAAYRRVQKSLADDLGIDPGQNLRMLNDRILRQEPLDAKKNAMTTAAVTVTVLEHYTLASGR
NAGALLHDAAGRAFPLRGSTTIGRLDDNDIVLDSPKVSRHHAVIVDTGTSYIINDLRSSNGVHVQDQRIH
SAAVLQDGDRIRICEHEFTFRLAEENQHAG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_1418--100% (381)putative transcriptional regulator
M. avium 104MAV_0226-e-11456.91% (376) EmbR protein
M. avium 104MAV_3010-1e-0942.35% (85) ABC transporter, ATP-binding protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1298cembR1e-15973.73% (373) transcriptional regulatory protein EMBR
M. gilvum PYR-GCKMflv_4653-6e-3032.55% (255) transcriptional regulator
M. tuberculosis H37RvRv1267cembR1e-15973.73% (373) transcriptional regulatory protein EMBR
M. leprae Br4923MLBr_02076-7e-0735.63% (87) hypothetical protein MLBr_02076
M. abscessus ATCC 19977MAB_2276c-1e-0932.17% (115) putative regulatory protein
M. marinum MMMAR_4155embR1e-16073.88% (379) transcriptional regulatory protein EmbR
M. smegmatis MC2 155MSMEG_1963-6e-3738.55% (249) putative transcriptional regulatory protein
M. thermoresistible (build 8)TH_4260-8e-0944.59% (74) PUTATIVE ABC transporter, ATP-binding protein
M. ulcerans Agy99MUL_4018embR1e-15973.35% (379) transcriptional regulatory protein EmbR
M. vanbaalenii PYR-1Mvan_1815-4e-3133.06% (245) transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4653|M.gilvum_PYR-GCK          -------------MRYRLLGPLQVVHGEAAVDIGPRKQRSVLAALLLAQG
Mvan_1815|M.vanbaalenii_PYR-1       -----------------MLGPLQVVHGETVIDVGPRKQRAVLAVLLLAQG
MSMEG_1963|M.smegmatis_MC2_155      -----------------MLGPLQVVHSGTPVDIGAPKQRAVLAMLLLAQG
MMAR_4155|M.marinum_M               ---MAGSAMVDKRLEFGLLGPLEMTIDGELVPLGTPKQRAVLAMLVINRN
MUL_4018|M.ulcerans_Agy99           ---MAGSAMVDKRLEFGLLGPLEMTIDGELVPLGTPKQRAVLAMLVINRN
Mb1298c|M.bovis_AF2122/97           ---MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRN
Rv1267c|M.tuberculosis_H37Rv        ---MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRN
MAV_1418|M.avium_104                --------MMAKRLEFGLLGPLEMTVDGDLVPLGTPKQRAVLAMLLMNRN
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      VRSPEINNLATSMMKILRPGRAQEAPPGSIKIGRAVDNDIVIPDVLASRH
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          RVVSTDRLVDVVWGDDVPASATAS----LQVYISNLRRALRSGAGDRTVS
Mvan_1815|M.vanbaalenii_PYR-1       RVVSTDRLADAVWGDDVPASVTAS----LQVYISNLRRALRD-------S
MSMEG_1963|M.smegmatis_MC2_155      RVVSVDRLIDAVWGDDPPASATAS----LQAYISNLRRALRDGS---DTA
MMAR_4155|M.marinum_M               RPVGVDSLITALWEEWPPAGARAS----IHSYVSNLRKLLSGAG-----V
MUL_4018|M.ulcerans_Agy99           RPVGVDSLITALWEEWPPAGARAS----IHSYVSNLRKLLSGAG-----V
Mb1298c|M.bovis_AF2122/97           RPVGVDALITALWEEWPPSGARAS----IHSYVSNLRKLLGGAG-----I
Rv1267c|M.tuberculosis_H37Rv        RPVGVDALITALWEEWPPSGARAS----IHSYVSNLRKLLGGAG-----I
MAV_1418|M.avium_104                NPVGIDRLITGLWDESPPSGARAS----LHSYVSNLRKLLSNAG-----V
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      HATLVPTPAGMEIRDNRSINGTFVNGTRTETAVLNEGDVVTIGNVDLVFR
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          SVAQPIVRQPPGYFLDAGPDESDIAVFTAACARAAAAIDGERWDEALAEA
Mvan_1815|M.vanbaalenii_PYR-1       QMASPIVRQPPGYFLDVGPDEVDVSAFTAGCARAAAAIDAERWEEALTEA
MSMEG_1963|M.smegmatis_MC2_155      QVASPIVRQPPGYYLDAPADAVDLAQFTAGCQQAAQAVEEQRWVDALTAA
MMAR_4155|M.marinum_M               DPRAMLAAAPPGYRLSIPDSTCDLGRFIAEKTAGVHAAAAGKFEQASQHL
MUL_4018|M.ulcerans_Agy99           DPRAMLATAPPGYRLSIPDSTCDLGRFIAEKTAGVHAAAAGKFEQASQHL
Mb1298c|M.bovis_AF2122/97           DPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHL
Rv1267c|M.tuberculosis_H37Rv        DPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHL
MAV_1418|M.avium_104                DPRTVLVAAPPGYRLNIPDDRCDLGRFITEKTAGVQAAASGRFEQAGAHL
MAB_2276c|M.abscessus_ATCC_199      -----------------------------------------MPSIAVAML
MLBr_02076|M.leprae_Br4923          -----MTDMDSGRQEDQTSDEVTVETTSVFRADFLNELDAPAQAGAESVV
TH_4260|M.thermoresistible__bu      NGTLVRRTETEAATDAGGLDVRGVTWTIENNKTLLDNISITARPGTLTAI
                                                                                 :    

Mflv_4653|M.gilvum_PYR-GCK          DTALSLVRGELLEDIGDADWIREDAARFAEMRTECLAGKVMSLLALGKIP
Mvan_1815|M.vanbaalenii_PYR-1       DTALGLVRGELLEDMADADWVREAAARVAEMRTECLANKVMALLALGKVP
MSMEG_1963|M.smegmatis_MC2_155      DEALALWRGPFLDDLRDEQWVHEDAARAGELRSECVDHRITALLALGRVS
MMAR_4155|M.marinum_M               SRALTQWRGPVLDDLRDFQFVDAFATALVEDKILAHTAKAEAEIACGRAA
MUL_4018|M.ulcerans_Agy99           SRALAQWRGPVLDDLRDFQFVDAFATALVEDKILAHTAKAEAEIACGRAA
Mb1298c|M.bovis_AF2122/97           SAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEAEIACGRAS
Rv1267c|M.tuberculosis_H37Rv        SAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEAEIACGRAS
MAV_1418|M.avium_104                AAALAQWRGPVLEDLAEFRFVGTFATSLVEEKILTHIAQAEAEIACGRAF
MAB_2276c|M.abscessus_ATCC_199      ENALAQWRGAPLTAMSESVRAQGFLRELNSHKELAQEVLLDCYLALQRYQ
MLBr_02076|M.leprae_Br4923          SGVEGLLAGSALLVVKRG--PNAGSRFLLDQAITSAGRHPDSDIFLDDVT
TH_4260|M.thermoresistible__bu      IGPSGAGKSTFARLIAGYTHPTSGTVTFEGHNVHAEYASLRSRIGMVPQD
                                            .     :                          . :      

Mflv_4653|M.gilvum_PYR-GCK          AALTAASQLGALDPLADRGCRLQMLALYRAGRTADALEVYTRYARRLDAE
Mvan_1815|M.vanbaalenii_PYR-1       AALTEVSRLREVDPLGDRSCKLQMLTLYRAGRAAEALEAYTRHARLLDAE
MSMEG_1963|M.smegmatis_MC2_155      TALAAVTQLRSAEPLSDRACWLHMLTLYRAGRAPEALDAYTRHAQMLDNE
MMAR_4155|M.marinum_M               AVITELEALTAEHPYREPLWTQLITAYYLTDRQSDALGAYRRVKTTLAED
MUL_4018|M.ulcerans_Agy99           AVITELEALTAEHPYREPLWTQLITAYYLTDRQSDALGAYRRVKTTLAED
Mb1298c|M.bovis_AF2122/97           AVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADD
Rv1267c|M.tuberculosis_H37Rv        AVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADD
MAV_1418|M.avium_104                SVITELESLTREHPYREQLWAQLMTAYYLTDRQSDALAAYRRVQKSLADD
MAB_2276c|M.abscessus_ATCC_199      KAAVVAHQFTLEMPYNEKIWESHIVALRMLGRHAEAAHIFRQVQKLLYDE
MLBr_02076|M.leprae_Br4923          VSRRHAEFRLEGNEFHVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFR
TH_4260|M.thermoresistible__bu      DVVHGQLTVNQALMYAAELRLPPDTTEEDRRQVVAEVLEELEMTAHADTR
                                                             :                        

Mflv_4653|M.gilvum_PYR-GCK          LGLEPGPELRDLQTAVLRQAPELSGWPRSPGWTGAAAVTAT--EAVPVRL
Mvan_1815|M.vanbaalenii_PYR-1       LGLEPGPELRELQTAVLRQAPELAGWPRSPEWTGAAALPQPQPEPATVPP
MSMEG_1963|M.smegmatis_MC2_155      LGLVPGAELRELQTAILRQAPELAAWPRSPEWTGAEEVHTP----APPHP
MMAR_4155|M.marinum_M               LGIDPGPTLRALNERILRQE------------------------------
MUL_4018|M.ulcerans_Agy99           LSIDPGPTLRALNERILRQE------------------------------
Mb1298c|M.bovis_AF2122/97           LGIDPGPTLRALNERILRQQ------------------------------
Rv1267c|M.tuberculosis_H37Rv        LGIDPGPTLRALNERILRQQ------------------------------
MAV_1418|M.avium_104                LGIDPGQNLRMLNDRILRQE------------------------------
MAB_2276c|M.abscessus_ATCC_199      LRVAPSKSLRSALTDTRWATA-----------------------------
MLBr_02076|M.leprae_Br4923          LVFLIGSKQDDDTGRTAGK-------------------------------
TH_4260|M.thermoresistible__bu      VDKLSGGQRKRASVAMELLTG-----------------------------
                                    :    .                                            

Mflv_4653|M.gilvum_PYR-GCK          DTVESASHRAPLVGRRRELAAAADVLDRVTAGAARWLVLSGPPGIGKTRL
Mvan_1815|M.vanbaalenii_PYR-1       AAMEAVSHRAPLVGRERELARAADVLARAAAGATRWLVLSGPPGIGKTRL
MSMEG_1963|M.smegmatis_MC2_155      PVPEPGAQRGLLIGRKRELAVATDLLADVAAGETRWLVLSGPPGIGKTRL
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          AEEIAGLVAAGDGDVVWVNCPDERGTPPWWPMRQLVRALGADADEVLEIP
Mvan_1815|M.vanbaalenii_PYR-1       AEEIAGLVGARGGEVAWVSCPDERATPPWWPMRRLVRALGADADEVLEIP
MSMEG_1963|M.smegmatis_MC2_155      AEEIT---DGCDAEVVWVSCPDERSTPPWWPMRQLVRALGADADEVLEVP
MMAR_4155|M.marinum_M               -----------------------------------------------PLD
MUL_4018|M.ulcerans_Agy99           -----------------------------------------------PLD
Mb1298c|M.bovis_AF2122/97           -----------------------------------------------PLD
Rv1267c|M.tuberculosis_H37Rv        -----------------------------------------------PLD
MAV_1418|M.avium_104                -----------------------------------------------PLD
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      ------------------------------------PSLLILDEPTSGLD
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          PHADPDTARFLVYERIQRLLESAPRLLAVVVDDVQWADTTSAACLAYIAG
Mvan_1815|M.vanbaalenii_PYR-1       AHADPDTARFLVYERIQALLEAAPRLLAVVVDDVQWSDTASAACLAYIAG
MSMEG_1963|M.smegmatis_MC2_155      PHADPDTARFQVYERVQALLESTGRPAVVVIDDVQWADSTSASCLAYIAG
MMAR_4155|M.marinum_M               AKMNAKSTAVGTVTVLDQRTMVSGQQAVAYLHTIASGHDYPIRTAATRIG
MUL_4018|M.ulcerans_Agy99           AKMNAKSTAVGTVTVLDQRTMVSGQQAVAYLHTIASGHDYPIRTAATRIG
Mb1298c|M.bovis_AF2122/97           AKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIG
Rv1267c|M.tuberculosis_H37Rv        AKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIG
MAV_1418|M.avium_104                AKKNAMTTAAVTVTVLEHYTLASGRNAGALLHDAA-GRAFPLRGSTT-IG
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      PALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLLAPGGKTAFYG
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          TLRDRPVLVVVTVRDGEHPAEVSR----LLSTVARGEANRLIEVPALSSE
Mvan_1815|M.vanbaalenii_PYR-1       ALRDHPVLVIATVRDGEHAPEVAR----LLSTVARGEDNRHIEVPALSSA
MSMEG_1963|M.smegmatis_MC2_155      ALRDHPVAIVLTVRDVDHTAEVAR----LLATVARGDGNRHLALSSLSTD
MMAR_4155|M.marinum_M               RLSDNDIVLDSANVSRHHAVIIDT----GTNYIIN----------DLRSS
MUL_4018|M.ulcerans_Agy99           RLSDNDIVLDSANVSRHHAVIIDT----GTNYIIN----------DLRSS
Mb1298c|M.bovis_AF2122/97           RLHDNDIVLDSANVSRHHAVIVDT----GTNYVIN----------DLRSS
Rv1267c|M.tuberculosis_H37Rv        RLHDNDIVLDSANVSRHHAVIVDT----GTNYVIN----------DLRSS
MAV_1418|M.avium_104                RLDDNDIVLDSPKVSRHHAVIVDT----GTSYIIN----------DLRSS
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      PPSQIGPTMGTTNWADIFSTVAGDPDAANRRFLERQGPPRELPAESAKPT
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          DVATLANEVAEEVVTAAEAAELADRTGGNPFFVSEYARLPREERAGNEIP
Mvan_1815|M.vanbaalenii_PYR-1       DVATLANEVAEETVTAAEAAELAARTGGNPFFVSEYARLPREERAGNEIP
MSMEG_1963|M.smegmatis_MC2_155      DVAALANQISEDVVDHAEAQILAERTGGNPFFVSEYARLPRAERG--EIP
MMAR_4155|M.marinum_M               NGVHVQHQRIRGAVTLNDGDHIRICDHEFTFQLTARNPR-----------
MUL_4018|M.ulcerans_Agy99           NGVHVQHQRIRGAVTLNDGDHIRICDHDFTFQLTARNPR-----------
Mb1298c|M.bovis_AF2122/97           NGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT---------
Rv1267c|M.tuberculosis_H37Rv        NGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT---------
MAV_1418|M.avium_104                NGVHVQDQRIHSAAVLQDGDRIRICEHEFTFRLAEENQHAG---------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      DLGSPTRTSLRRQFSTIARRQIRLIVSDRGYFVFLALLPFIMGVLSLSVP
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          RAVRSVLDRRLAALDPAVMQVLRAAAVIADVLDSVTVPLLARTTALDLDT
Mvan_1815|M.vanbaalenii_PYR-1       RAVRSVLDRRLAALDPAVVQVLRAAAVIGDVIDASAVPVLAQATRLDLDT
MSMEG_1963|M.smegmatis_MC2_155      VAVKSVLDRRLAGLDPGVLAVLRVAAVIGDPIDADVVPVLARVAKIDFDT
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      GDVGFGVPN-PMGDAPNEPGQILVLLNVGAIFMGTALTIRDLIGERAIFR
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          LADYLDEAADERIIVNSHTGDGYVFAHGLLREQLLTGMPALRRQRVHAKV
Mvan_1815|M.vanbaalenii_PYR-1       LADYLDEAADERIVVAAHAGDGYAFAHGLLREQLLASMPALRRQRMHAKV
MSMEG_1963|M.smegmatis_MC2_155      LADHLDAAADERIVVNAHTGDGYTFAHGLLRDHLMAGLPALRRQRLHAQV
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      REQAVGLSTTAYLLAKVCVYSVFAIVQSAIVTAITIAGKGWDVDKGAVDH
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          ADVLADSALPDAPTWRAQHLVAAQPLVEPTVVVPACRLAAEQATQQWSSD
Mvan_1815|M.vanbaalenii_PYR-1       AEVLADSTAPDAPTRRAQHLIAAQPLVEPAAVVQACRLAAEQATAQWSSD
MSMEG_1963|M.smegmatis_MC2_155      AEVLAGNPSDDAITRRAQHLVAAQPLVDPVEVVAACRLAAEAATQRWSSD
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      GSVFGNPKLELFFGMAATTVAAAMLGLLLSALAKTSEQIMPLLVVAIMSQ
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          IAAGWWQAALDAYDRLPASERDDADRDALTVELLEAHSRAGRGQLVLDSV
Mvan_1815|M.vanbaalenii_PYR-1       IAAGWWQAALDAYDRLPASERDDTERDALTVELLEAHSRAGRGQLVLDSV
MSMEG_1963|M.smegmatis_MC2_155      IAAGWWQAALDAYDRVPVASRSETERDALTVAMLEAHSRAGRGRTVLGYV
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      LVFSGGMIPVTDRIGLDQLSWFTPARWGFAASASTADLITLVPGPLTPKD
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          TRYLGEALRTGRAASAGRVASALLRASGGWPWLAPGNDPGELLTLLSRAA
Mvan_1815|M.vanbaalenii_PYR-1       QRYLGEALRTGRAASAGRVASALLRASGGWPWLAPGHDPGELLALLGRAA
MSMEG_1963|M.smegmatis_MC2_155      ERHLTEALRNERADTAGLVASVLLRSSGGWPWLAPGDDPGALLTLLQRAA
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      RHWEHDSGTWLFDMAMLAVLSVFYLALVRWKIRLPRA-------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          TLSEGEPASAARVLPALAVGHCYHPDPTIAPELLDRAERLAEATGDPDVI
Mvan_1815|M.vanbaalenii_PYR-1       TLSEGQPASAARVLPALAVGHCYHPDRRVAEDLLDRAERLAEETGDPDVL
MSMEG_1963|M.smegmatis_MC2_155      EMAAEHPAAGARVLAALGVGCCYHPDPGVAAGHLDRAERLAERTEDPDVL
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          ADVLIGRLITFSGVATLSAQSLEWVQRLNALRHSRSREDAVIAHSVATMA
Mvan_1815|M.vanbaalenii_PYR-1       ADVLMGRLITFSGVATVSHETLQWVERLNALGHKRSREDSVIAHSVATMA
MSMEG_1963|M.smegmatis_MC2_155      ADVLMGRLITYSGVNERSHEIFEWVARLEVLQHSRSREDSVIAHSVATMS
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          AMNLGDVDGARRHVQAGIAGSEELQLPVLRAQLRWMEAVLAVWHGDFAEA
Mvan_1815|M.vanbaalenii_PYR-1       AMNLGDVAATRRHVEAGIAGSEELQLPVLRAQLRWMEAVLAMWIGDFAEA
MSMEG_1963|M.smegmatis_MC2_155      AMLLADTELTERHLRAGVVGSEELQLPVLRAQLRWMEAVLATWRGDFDEA
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          GRHHAIAAHVHEQTELYEAGSGLLARATLLRERGGPVDPSWTDLNA-QQA
Mvan_1815|M.vanbaalenii_PYR-1       ARHHAIAAHVHEQTELYEAGSGLLATASLVRERGGPVDAGWAAVQASKET
MSMEG_1963|M.smegmatis_MC2_155      QRHHSIAAHVHEQTELYGAGSGLLAEVTLLREIGGPVPAGFGVTPADVER
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          GGLGMVGVVRTGVLTLLSGPKARAEALATLRHWAQH-TDRAHIWTTLGHH
Mvan_1815|M.vanbaalenii_PYR-1       GGQDMVGVVRTALLTLESGPQARAEAVARLRKWARTSTGRGDIWTTLGHH
MSMEG_1963|M.smegmatis_MC2_155      GGQGMEAMVHVALLTIERGP--RAAAATRLDNWVNT--DRGQIWTNLGEA
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          TLLAHLAVDHDLPDFAEPLLAQLDPYRDRIAVIGQVGMAGPVALATARLH
Mvan_1815|M.vanbaalenii_PYR-1       ALLAHMAADHGLDEFAEPLLAELDPFRDRIAVLGQVGMAGPVALATARLH
MSMEG_1963|M.smegmatis_MC2_155      AWMAHLAVDYGLGEYAEPLLAVLQPFTDRIAVIGQVGHAGPVALATARLH
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          ALRGDKAAALADLALARSIAERSAGVPTLLRCRLLECELTEESPGRSTAA
Mvan_1815|M.vanbaalenii_PYR-1       ALRGDTRRALADVTVARQIAERSAGVPTLLRCRLLVCQLAEPSADRAADA
MSMEG_1963|M.smegmatis_MC2_155      ALRGDRARALEDLAKAEDVARRTGARPTLMRCALLACELAEDGAARRQAA
MMAR_4155|M.marinum_M               --------------------------------------------------
MUL_4018|M.ulcerans_Agy99           --------------------------------------------------
Mb1298c|M.bovis_AF2122/97           --------------------------------------------------
Rv1267c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_1418|M.avium_104                --------------------------------------------------
MAB_2276c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02076|M.leprae_Br4923          --------------------------------------------------
TH_4260|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_4653|M.gilvum_PYR-GCK          STLAAEAADLGMAAVAEAASRLL
Mvan_1815|M.vanbaalenii_PYR-1       AALATEADSVGMAAVAAAARRLA
MSMEG_1963|M.smegmatis_MC2_155      AKLAADAEAMGMHGIAAQARSLS
MMAR_4155|M.marinum_M               -----------------------
MUL_4018|M.ulcerans_Agy99           -----------------------
Mb1298c|M.bovis_AF2122/97           -----------------------
Rv1267c|M.tuberculosis_H37Rv        -----------------------
MAV_1418|M.avium_104                -----------------------
MAB_2276c|M.abscessus_ATCC_199      -----------------------
MLBr_02076|M.leprae_Br4923          -----------------------
TH_4260|M.thermoresistible__bu      -----------------------