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ATDGFAPIEIRGLTKNFGAVRALDGLDLTVREGEVHGFLGPNGAGKSTTIRILLGLVKADGGTVRLLGGD PWTQAVELHRQIAYVPGDVTLWPSLTGGEIIDLLARMRGGIDKRRRAELIERFDLDPHKKARTYSKGNRQ KVSLISAFSSRARLLLLDEPSSGLDPLMENVFQQCVAQARDRGTTVLLSSHILAETEALCERVTIIRAGK TIESGSLSSMRHLSRTSIKAEMTGDPGDLRRIKGVEDISIEGNTLRAQVDSESLGELIRVLGDAGVRSLV SQPPTLEELFLRHYDTSGTDGERGAHEAEVSLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1362 | - | - | 100% (314) | ABC transporter, ATP-binding protein |
| M. avium 104 | MAV_3250 | - | 1e-34 | 34.00% (300) | daunorubicin resistance ATP-binding protein DrrA |
| M. avium 104 | MAV_5181 | - | 2e-29 | 33.48% (233) | daunorubicin resistance ABC transporter ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1250c | - | 1e-144 | 88.89% (288) | tetronasin-transport ATP-binding protein ABC transporter |
| M. gilvum PYR-GCK | Mflv_2197 | - | 3e-95 | 59.03% (288) | ABC transporter related |
| M. tuberculosis H37Rv | Rv1218c | - | 1e-143 | 88.54% (288) | tetronasin-transport ATP-binding protein ABC transporter |
| M. leprae Br4923 | MLBr_00590 | - | 1e-29 | 32.87% (216) | putative ABC transporter ATP-binding protein |
| M. abscessus ATCC 19977 | MAB_1359c | - | 1e-100 | 63.32% (289) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_4220 | - | 1e-150 | 88.16% (304) | antibiotic ABC transporter ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_5075 | - | 3e-96 | 60.76% (288) | ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_2745 | - | 3e-95 | 57.88% (292) | PUTATIVE ABC transporter related |
| M. ulcerans Agy99 | MUL_2014 | drrA | 1e-30 | 31.36% (287) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. vanbaalenii PYR-1 | Mvan_4499 | - | 1e-100 | 60.13% (301) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1250c|M.bovis_AF2122/97 MSADN-----HQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPNG
Rv1218c|M.tuberculosis_H37Rv MSADN-----HQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPNG
MMAR_4220|M.marinum_M MATDI-----GSTPIEIRGLTKNFGSVRALDELDLTVREGEVHGFLGPNG
MAV_1362|M.avium_104 MATD------GFAPIEIRGLTKNFGAVRALDGLDLTVREGEVHGFLGPNG
Mflv_2197|M.gilvum_PYR-GCK MPDTS-------PVVEIRGLRKAFGRTQALDGLDLAVAPGDVTGFLGPNG
Mvan_4499|M.vanbaalenii_PYR-1 MTDTG-------FAVDIHGLRKSFGHTKALDGLDLTVAPGDVAGFLGPNG
MSMEG_5075|M.smegmatis_MC2_155 MTRSS-------VAVEIHGLTKSFGRTRALDGLDMTVPYGHIVGFLGPNG
TH_2745|M.thermoresistible__bu MTTTSPR-FDAEPAVEIHGLKKSFGRTRAVDGLDLRVERGSVAGFLGPNG
MAB_1359c|M.abscessus_ATCC_199 MTYPN-------LAVEIRGLTKLFGKTKALDGLDLSVAHGEVAGFLGPNG
MUL_2014|M.ulcerans_Agy99 MRNND-------LAVEVRGVRKAFGDVVALNDISFEVGRGEVIGLLGPNG
MLBr_00590|M.leprae_Br4923 MSSACTVPETPEVVIRLRGVCKHYGSILAVSNLDLDIHSAEVLALLGPNG
* : ::*: * :* *:. :.: : . : .:*****
Mb1250c|M.bovis_AF2122/97 AGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWP
Rv1218c|M.tuberculosis_H37Rv AGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWP
MMAR_4220|M.marinum_M AGKSTTIRILLGLVKADSGSVRLLGGNPWTDAVELHRQIAYVPGDVTLWP
MAV_1362|M.avium_104 AGKSTTIRILLGLVKADGGTVRLLGGDPWTQAVELHRQIAYVPGDVTLWP
Mflv_2197|M.gilvum_PYR-GCK AGKSTAIRVLLGLLRADGGDVRLLGADPWRDAVALHRRIAYVPGDVTLWP
Mvan_4499|M.vanbaalenii_PYR-1 AGKSTTIRVLLGLLRADGGTVRLLGRDPWRDAVDLHRRIAYVPGDVTLWP
MSMEG_5075|M.smegmatis_MC2_155 AGKSTTIRVLLGLLRAERGTVRLLGGDPWHDAVELHRRIAYVPGDVMLWP
TH_2745|M.thermoresistible__bu SGKSTTIRVLLGLLRADGGTARLLGGDPWHDAVELHRRLAYVPGDVTLWP
MAB_1359c|M.abscessus_ATCC_199 AGKSTTIRVLLGLLRADAGTVQLLGGDPWVNAVDLHRLIAYVPGDVTLWP
MUL_2014|M.ulcerans_Agy99 AGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRRSIMVTGQQVAVDD
MLBr_00590|M.leprae_Br4923 AGKTTTVEMCEGFVRPDAGTIEVLGLDPITDNARLRARIGVMLQGGGGYP
:**:* : : : :.: * .: * : : . :: :
Mb1250c|M.bovis_AF2122/97 SLTGGETIDLLARMRGGI---DNARRAELIERFGLDPTKK--ARTYSKGN
Rv1218c|M.tuberculosis_H37Rv SLTGGETIDLLARMRGGI---DNARRAELIERFGLDPTKK--ARTYSKGN
MMAR_4220|M.marinum_M SLTGGEIIDLLARMRGGI---DQDRRAELIERFGLDPHKK--SRTYSKGN
MAV_1362|M.avium_104 SLTGGEIIDLLARMRGGI---DKRRRAELIERFDLDPHKK--ARTYSKGN
Mflv_2197|M.gilvum_PYR-GCK NLTGMQAIDFLTALRGDG--VDTRRRDELIERFELDPHKK--ARTYSKGN
Mvan_4499|M.vanbaalenii_PYR-1 NLTGMQAIDFLAALRGDGT-VDTRRRDQLIERFELDPHKK--ARTYSKGN
MSMEG_5075|M.smegmatis_MC2_155 NLTGMQAIDFLCGLRGDG--VDVRRRNQLIDRFELDPHKK--ARTYSKGN
TH_2745|M.thermoresistible__bu NLTGGQAIDFLAGLRDNF---DTKRRDELIERFELDPDKK--ARTYSKGN
MAB_1359c|M.abscessus_ATCC_199 NLTGGQAIDFLTRMLGTEH-ISIRRRNELIERFELDPTKK--ARTYSKGN
MUL_2014|M.ulcerans_Agy99 GLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTYSGGM
MLBr_00590|M.leprae_Br4923 AARAGEMLNLVASYAADP-----LDPEWLLETLGLTDVARTTYRRLSGGQ
. : : :. *:: : * : * * *
Mb1250c|M.bovis_AF2122/97 RQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVLL
Rv1218c|M.tuberculosis_H37Rv RQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVLL
MMAR_4220|M.marinum_M RQKVSLISAFSSRARLLLLDEPSSGLDPLMENVFQQCVDEARGRGVTVLL
MAV_1362|M.avium_104 RQKVSLISAFSSRARLLLLDEPSSGLDPLMENVFQQCVAQARDRGTTVLL
Mflv_2197|M.gilvum_PYR-GCK RQKVAIVAAFSTRSELFILDEPTSGLDPLMEKTFQECVREVAGRGAAVLL
Mvan_4499|M.vanbaalenii_PYR-1 RQKVAIVAAFSTRSELFVLDEPTSGLDPLMEQAFQQCVHEVAGQGAAVLL
MSMEG_5075|M.smegmatis_MC2_155 RQKVAIIAAFSCEADLYILDEPTSGLDPLMEQAFQQCVTEVAGRGAAVLL
TH_2745|M.thermoresistible__bu RQKVALVAAFSTNAEIYILDEPTSGLDPLMDKAFQMCVREAADNGAAVLL
MAB_1359c|M.abscessus_ATCC_199 RQKVALIAAFCSDADLFILDEPTSGLDPLMETVFQECVAEVSTRGCAVLL
MUL_2014|M.ulcerans_Agy99 RRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFKKLGIATLL
MLBr_00590|M.leprae_Br4923 QQRLALACTLVGRPELVFLDEPTAGMDTHARLLVWELIDTLRRDGVTVVL
:::: : . : . : .****::*:*. . : * :.:*
Mb1250c|M.bovis_AF2122/97 SSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPGD
Rv1218c|M.tuberculosis_H37Rv SSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPGD
MMAR_4220|M.marinum_M SSHILAETEALCERITIIRAGRTVESGSLASMRHLSRTSIKAEMIGDPGD
MAV_1362|M.avium_104 SSHILAETEALCERVTIIRAGKTIESGSLSSMRHLSRTSIKAEMTGDPGD
Mflv_2197|M.gilvum_PYR-GCK SSHILAEVEKLCDSVTIVRSGRTVRSGTLAQMRQFMRTTVTVRVRGDGRA
Mvan_4499|M.vanbaalenii_PYR-1 SSHILAEVEKLCDTVTIVRAGRTVRSGALAQMRHLMRTTVTARTRGDGEH
MSMEG_5075|M.smegmatis_MC2_155 SSHILAEVEKLCDDVTIIRSGRTVRSGTLAELRHLMRTTVTVRTHSDGRV
TH_2745|M.thermoresistible__bu SSHILAEVERLCDSVTIIRSGRTVRAGRLDELRHLMRTTVKVRTRAPIDA
MAB_1359c|M.abscessus_ATCC_199 SSHILAEVEKLCHRVTIVRAGRTVLSGSLAELRHFMRTSVTVRTLANPSG
MUL_2014|M.ulcerans_Agy99 TTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVPRHLKD
MLBr_00590|M.leprae_Br4923 TTHQLKEAEELADRLVIIDHGRMIAAGTPTELMHTGAKDQLRFSAPPRLD
::: * *.: *.. : :: *: : * : :
Mb1250c|M.bovis_AF2122/97 LSR--------IKGVEDISIEGTTV-RAQVDSESLRELIQVLG------H
Rv1218c|M.tuberculosis_H37Rv LSQ--------IKGVEDISIEGTTV-RAQVDSESLRELIQVLG------H
MMAR_4220|M.marinum_M LTR--------IQGVEDVTVDGNTL-HVQVDSESLGELVRVLG------E
MAV_1362|M.avium_104 LRR--------IKGVEDISIEGNTL-RAQVDSESLGELIRVLG------D
Mflv_2197|M.gilvum_PYR-GCK LVD--------APYVHDLRTDDGAL-RFSVDRDHLDRAVLDLT------A
Mvan_4499|M.vanbaalenii_PYR-1 LRQ--------APYVHDLRSDDGHL-RFSVDRDDLDRVMADLS------G
MSMEG_5075|M.smegmatis_MC2_155 LRD--------VPYVHDFDCRDGQL-RFSVDRTDLEFVMEHLI------D
TH_2745|M.thermoresistible__bu LRT--------APYIHEFSTDDGLH-TFSVDRTDLDRTMTELT------T
MAB_1359c|M.abscessus_ATCC_199 LKS--------IPQLRDVTIGGNRA-SFTVDRSDLDRTMEQLA------G
MUL_2014|M.ulcerans_Agy99 LDATVAALGSLLPEHNRAMVTSESD-RITMPAPDGTRTLIEAARKIDEAN
MLBr_00590|M.leprae_Br4923 LSLLA------FALPEDYKTTELTPGEYLVAGPIDPQVLATVTAWCAQIN
* . : :
Mb1250c|M.bovis_AF2122/97 AGVRSLVSQPPTLEELFLRHYS-LGPEVA-AEQQVATP----
Rv1218c|M.tuberculosis_H37Rv AGVRSLVSQPPTLEELFLRHYS-LGPEVA-AEQQVATP----
MMAR_4220|M.marinum_M AGVRSLVSQPPTLEELFLRHYS-VGPDGE-AQHRSGTGVAAR
MAV_1362|M.avium_104 AGVRSLVSQPPTLEELFLRHYDTSGTDGERGAHEAEVSLS--
Mflv_2197|M.gilvum_PYR-GCK LGIEDLAVAPASLEDMFLQEYQGANR----------------
Mvan_4499|M.vanbaalenii_PYR-1 LGIDELTVAPASLEDMFLREYQGAGR----------------
MSMEG_5075|M.smegmatis_MC2_155 LGIDDLTVTPASLEDMFLREYQGAVP----------------
TH_2745|M.thermoresistible__bu LGIEELTVTPASLEDLFLREYQEVPR----------------
MAB_1359c|M.abscessus_ATCC_199 LGIVDLSVAPASLEELFMREYQGASR----------------
MUL_2014|M.ulcerans_Agy99 IELADIALRRPSLDDVFLSMTTDPSEAHVLSHVASGAML---
MLBr_00590|M.leprae_Br4923 VLTTNMRVEQHSLEDVFLDLTGRKLR----------------
.: :*:::*: