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PDTSPVVEIRGLRKAFGRTQALDGLDLAVAPGDVTGFLGPNGAGKSTAIRVLLGLLRADGGDVRLLGADP WRDAVALHRRIAYVPGDVTLWPNLTGMQAIDFLTALRGDGVDTRRRDELIERFELDPHKKARTYSKGNRQ KVAIVAAFSTRSELFILDEPTSGLDPLMEKTFQECVREVAGRGAAVLLSSHILAEVEKLCDSVTIVRSGR TVRSGTLAQMRQFMRTTVTVRVRGDGRALVDAPYVHDLRTDDGALRFSVDRDHLDRAVLDLTALGIEDLA VAPASLEDMFLQEYQGANR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2197 | - | - | 100% (300) | ABC transporter related |
| M. gilvum PYR-GCK | Mflv_3389 | - | 3e-30 | 32.16% (227) | daunorubicin resistance ABC transporter ATPase subunit |
| M. gilvum PYR-GCK | Mflv_1936 | - | 7e-30 | 28.85% (305) | daunorubicin resistance ABC transporter ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1250c | - | 8e-91 | 57.29% (288) | tetronasin-transport ATP-binding protein ABC transporter |
| M. tuberculosis H37Rv | Rv1218c | - | 5e-91 | 57.29% (288) | tetronasin-transport ATP-binding protein ABC transporter |
| M. leprae Br4923 | MLBr_02352 | - | 2e-27 | 32.46% (228) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_1359c | - | 1e-111 | 69.73% (294) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_4220 | - | 2e-94 | 59.11% (291) | antibiotic ABC transporter ATP-binding protein |
| M. avium 104 | MAV_1362 | - | 3e-95 | 59.03% (288) | ABC transporter, ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_5075 | - | 1e-127 | 76.17% (298) | ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_2745 | - | 1e-122 | 73.49% (298) | PUTATIVE ABC transporter related |
| M. ulcerans Agy99 | MUL_2014 | drrA | 3e-29 | 29.84% (315) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. vanbaalenii PYR-1 | Mvan_4499 | - | 1e-142 | 84.05% (301) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1250c|M.bovis_AF2122/97 MSADN----HQVPIEIRGLTKHFG--SVRALDGLDLTVREGEVHGFLGPN
Rv1218c|M.tuberculosis_H37Rv MSADN----HQVPIEIRGLTKHFG--SVRALDGLDLTVREGEVHGFLGPN
MMAR_4220|M.marinum_M MATDI----GSTPIEIRGLTKNFG--SVRALDELDLTVREGEVHGFLGPN
MAV_1362|M.avium_104 MATD-----GFAPIEIRGLTKNFG--AVRALDGLDLTVREGEVHGFLGPN
Mflv_2197|M.gilvum_PYR-GCK MPDTS------PVVEIRGLRKAFG--RTQALDGLDLAVAPGDVTGFLGPN
Mvan_4499|M.vanbaalenii_PYR-1 MTDTG------FAVDIHGLRKSFG--HTKALDGLDLTVAPGDVAGFLGPN
MSMEG_5075|M.smegmatis_MC2_155 MTRSS------VAVEIHGLTKSFG--RTRALDGLDMTVPYGHIVGFLGPN
TH_2745|M.thermoresistible__bu MTTTSPRFDAEPAVEIHGLKKSFG--RTRAVDGLDLRVERGSVAGFLGPN
MAB_1359c|M.abscessus_ATCC_199 MTYPN------LAVEIRGLTKLFG--KTKALDGLDLSVAHGEVAGFLGPN
MLBr_02352|M.leprae_Br4923 MRNND------KAVMVRGVRKTYGKGKIIALDDVSFDVDRGEVIGLLGPN
MUL_2014|M.ulcerans_Agy99 MRNND------LAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLLGPN
* : ::*: * :* *:: :.: * * : *:****
Mb1250c|M.bovis_AF2122/97 GAGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLW
Rv1218c|M.tuberculosis_H37Rv GAGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLW
MMAR_4220|M.marinum_M GAGKSTTIRILLGLVKADSGSVRLLGGNPWTDAVELHRQIAYVPGDVTLW
MAV_1362|M.avium_104 GAGKSTTIRILLGLVKADGGTVRLLGGDPWTQAVELHRQIAYVPGDVTLW
Mflv_2197|M.gilvum_PYR-GCK GAGKSTAIRVLLGLLRADGGDVRLLGADPWRDAVALHRRIAYVPGDVTLW
Mvan_4499|M.vanbaalenii_PYR-1 GAGKSTTIRVLLGLLRADGGTVRLLGRDPWRDAVDLHRRIAYVPGDVTLW
MSMEG_5075|M.smegmatis_MC2_155 GAGKSTTIRVLLGLLRAERGTVRLLGGDPWHDAVELHRRIAYVPGDVMLW
TH_2745|M.thermoresistible__bu GSGKSTTIRVLLGLLRADGGTARLLGGDPWHDAVELHRRLAYVPGDVTLW
MAB_1359c|M.abscessus_ATCC_199 GAGKSTTIRVLLGLLRADAGTVQLLGGDPWVNAVDLHRLIAYVPGDVTLW
MLBr_02352|M.leprae_Br4923 GAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSIMVTGQQVAVD
MUL_2014|M.ulcerans_Agy99 GAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRRSIMVTGQQVAVD
*:**:* : :* * :.: * . : * : :.. ::* : . :* :
Mb1250c|M.bovis_AF2122/97 PSLTGGETIDLLARMRGGI---DNARRAELIERFGLDPTKK--ARTYSKG
Rv1218c|M.tuberculosis_H37Rv PSLTGGETIDLLARMRGGI---DNARRAELIERFGLDPTKK--ARTYSKG
MMAR_4220|M.marinum_M PSLTGGEIIDLLARMRGGI---DQDRRAELIERFGLDPHKK--SRTYSKG
MAV_1362|M.avium_104 PSLTGGEIIDLLARMRGGI---DKRRRAELIERFDLDPHKK--ARTYSKG
Mflv_2197|M.gilvum_PYR-GCK PNLTGMQAIDFLTALRGDG--VDTRRRDELIERFELDPHKK--ARTYSKG
Mvan_4499|M.vanbaalenii_PYR-1 PNLTGMQAIDFLAALRGDGT-VDTRRRDQLIERFELDPHKK--ARTYSKG
MSMEG_5075|M.smegmatis_MC2_155 PNLTGMQAIDFLCGLRGDG--VDVRRRNQLIDRFELDPHKK--ARTYSKG
TH_2745|M.thermoresistible__bu PNLTGGQAIDFLAGLRDNF---DTKRRDELIERFELDPDKK--ARTYSKG
MAB_1359c|M.abscessus_ATCC_199 PNLTGGQAIDFLTRMLGTEH-ISIRRRNELIERFELDPTKK--ARTYSKG
MLBr_02352|M.leprae_Br4923 DQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAGKRRVGTYSGG
MUL_2014|M.ulcerans_Agy99 DGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTYSGG
*:* : : :: : . * :*:::* * * *** *
Mb1250c|M.bovis_AF2122/97 NRQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVL
Rv1218c|M.tuberculosis_H37Rv NRQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVL
MMAR_4220|M.marinum_M NRQKVSLISAFSSRARLLLLDEPSSGLDPLMENVFQQCVDEARGRGVTVL
MAV_1362|M.avium_104 NRQKVSLISAFSSRARLLLLDEPSSGLDPLMENVFQQCVAQARDRGTTVL
Mflv_2197|M.gilvum_PYR-GCK NRQKVAIVAAFSTRSELFILDEPTSGLDPLMEKTFQECVREVAGRGAAVL
Mvan_4499|M.vanbaalenii_PYR-1 NRQKVAIVAAFSTRSELFVLDEPTSGLDPLMEQAFQQCVHEVAGQGAAVL
MSMEG_5075|M.smegmatis_MC2_155 NRQKVAIIAAFSCEADLYILDEPTSGLDPLMEQAFQQCVTEVAGRGAAVL
TH_2745|M.thermoresistible__bu NRQKVALVAAFSTNAEIYILDEPTSGLDPLMDKAFQMCVREAADNGAAVL
MAB_1359c|M.abscessus_ATCC_199 NRQKVALIAAFCSDADLFILDEPTSGLDPLMETVFQECVAEVSTRGCAVL
MLBr_02352|M.leprae_Br4923 MRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKQIGIATL
MUL_2014|M.ulcerans_Agy99 MRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFKKLGIATL
*::: : ..: . : .****::**** .: : . * :.*
Mb1250c|M.bovis_AF2122/97 LSSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPG
Rv1218c|M.tuberculosis_H37Rv LSSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPG
MMAR_4220|M.marinum_M LSSHILAETEALCERITIIRAGRTVESGSLASMRHLSRTSIKAEMIGDPG
MAV_1362|M.avium_104 LSSHILAETEALCERVTIIRAGKTIESGSLSSMRHLSRTSIKAEMTGDPG
Mflv_2197|M.gilvum_PYR-GCK LSSHILAEVEKLCDSVTIVRSGRTVRSGTLAQMRQFMRTTVTVRVRGDGR
Mvan_4499|M.vanbaalenii_PYR-1 LSSHILAEVEKLCDTVTIVRAGRTVRSGALAQMRHLMRTTVTARTRGDGE
MSMEG_5075|M.smegmatis_MC2_155 LSSHILAEVEKLCDDVTIIRSGRTVRSGTLAELRHLMRTTVTVRTHSDGR
TH_2745|M.thermoresistible__bu LSSHILAEVERLCDSVTIIRSGRTVRAGRLDELRHLMRTTVKVRTRAPID
MAB_1359c|M.abscessus_ATCC_199 LSSHILAEVEKLCHRVTIVRAGRTVLSGSLAELRHFMRTSVTVRTLANPS
MLBr_02352|M.leprae_Br4923 LTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGETFCEIVPRDLK
MUL_2014|M.ulcerans_Agy99 LTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVPRHLK
*::: * *.: *.. : :: * : * ::: :.
Mb1250c|M.bovis_AF2122/97 DLSRIKGVEDISIEG--------TTVRAQVDSESLRELIQVLG------H
Rv1218c|M.tuberculosis_H37Rv DLSQIKGVEDISIEG--------TTVRAQVDSESLRELIQVLG------H
MMAR_4220|M.marinum_M DLTRIQGVEDVTVDG--------NTLHVQVDSESLGELVRVLG------E
MAV_1362|M.avium_104 DLRRIKGVEDISIEG--------NTLRAQVDSESLGELIRVLG------D
Mflv_2197|M.gilvum_PYR-GCK ALVDAPYVHDLRTDD--------GALRFSVDRDHLDRAVLDLT------A
Mvan_4499|M.vanbaalenii_PYR-1 HLRQAPYVHDLRSDD--------GHLRFSVDRDDLDRVMADLS------G
MSMEG_5075|M.smegmatis_MC2_155 VLRDVPYVHDFDCRD--------GQLRFSVDRTDLEFVMEHLI------D
TH_2745|M.thermoresistible__bu ALRTAPYIHEFSTDD--------GLHTFSVDRTDLDRTMTELT------T
MAB_1359c|M.abscessus_ATCC_199 GLKSIPQLRDVTIGG--------NRASFTVDRSDLDRTMEQLA------G
MLBr_02352|M.leprae_Br4923 DLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTLIEAARRIDEVS
MUL_2014|M.ulcerans_Agy99 DLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARKIDEAN
* : :
Mb1250c|M.bovis_AF2122/97 AGVRSLVSQPPTLEELFLRHYS-LGPEVA-AEQQVATP----
Rv1218c|M.tuberculosis_H37Rv AGVRSLVSQPPTLEELFLRHYS-LGPEVA-AEQQVATP----
MMAR_4220|M.marinum_M AGVRSLVSQPPTLEELFLRHYS-VGPDGE-AQHRSGTGVAAR
MAV_1362|M.avium_104 AGVRSLVSQPPTLEELFLRHYDTSGTDGERGAHEAEVSLS--
Mflv_2197|M.gilvum_PYR-GCK LGIEDLAVAPASLEDMFLQEYQGANR----------------
Mvan_4499|M.vanbaalenii_PYR-1 LGIDELTVAPASLEDMFLREYQGAGR----------------
MSMEG_5075|M.smegmatis_MC2_155 LGIDDLTVTPASLEDMFLREYQGAVP----------------
TH_2745|M.thermoresistible__bu LGIEELTVTPASLEDLFLREYQEVPR----------------
MAB_1359c|M.abscessus_ATCC_199 LGIVDLSVAPASLEELFMREYQGASR----------------
MLBr_02352|M.leprae_Br4923 VELADIALRRPSLDDVFLSMTTDPSES--LSHLAAGAMR---
MUL_2014|M.ulcerans_Agy99 IELADIALRRPSLDDVFLSMTTDPSEAHVLSHVASGAML---
: .: .:*:::*: