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LTATPHVGGVLEELLERSGRFFTPGEFSADLRTVTRQGGREADVFYRDRWSHDKVVRSTHGVNCTGSCSW KIYVKDGIITWETQQTDYPSVGPDRPEYEPRGCPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKARLG DPVLAWADIQADPERRRRYQRARGKGGLVRITWAEATELIAAAHVHTIKTYGPDRVAGFSPIPAMSMVSY TAGSRFFELIGAPMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDAAYLMMWGSNVPITRTPDAHWMAE ARYRGTKVVTVSPDYADNTKFADEWMPCAAGTDGALAMAMGHVILSECYVQKQVPFFTDYARRYTDLPFL IKLEERGDMLVPGKNLTAADLGEAVENAALKPALLDETTNSVAVPHGSLGFRYGESGVGKWNLDLGDLVP ALSVRAAPTEDGETALVHLPSFDTVDGEGTTVARGVPVRRVGKHLVCTVFDLMLAQYGVARPGLPGEWPT GYDDATQQNTPAWQEAITGVSAAQATRVAREFARSAEESGGRSMIIMGGGICHWFHSDAIYRAVLALLML TGSMGRNGGGWAHYVGQEKVRPLTGFQTMAMATDWVRPPRQVPGASYWYAHTDQWRYDGYGADKLASPVG RGRFAGRHTMDLLASAVAMGWSPYYPQFDRSSLDVADEARAAGRDVADYVAEQLGRRNLKLAVTDPDNPV NWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNASAVPPEDGVRPVDVTCGADIPEGKLDLMMSIDFRM TSTTLVSDVVLPAATWYEKADISSTDMHPYVHAFSAATDPPWETRSDFDAFGAIARAFSTMAKEHLGTRT DVVLTALQHDTPDAMAYPDGAEHDWLRSGATPVPGRTMGKLTVVERDYAAVYDKWRTLGPLVDKFGLTTK GVTVHPFREVEELAARFGVLKSGVAAGRPAITTAARMADVLLLLSGTTNGRLAVEGFHELEKRTGQRLVH LAEGSEDKRISYADTQARPVPVVTSPEWSGSETGGRRYAPFTINIENLKPFHTLTGRMHFYLAHDWVEEL GEHLPVFRPPLDMARLFGQPRLGACEDGIGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGD AAKIQVRDNDWVEAVNANGIYVCRAIVSHRMPDGVVYVYHVQERTVDTPRTETNDKRGGNHNALTRVRIK PSHLAGGYAQHAFAFNYLGPTGNQRDEVTIVRRRSQEVVY
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_1303 | - | - | 100% (1230) | nitrate reductase, alpha subunit |
M. avium 104 | MAV_4535 | - | 3e-05 | 38.24% (68) | nitrate reductase NarB |
M. avium 104 | MAV_0422 | - | 3e-05 | 28.74% (87) | formate dehydrogenase, alpha subunit |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1193 | narG | 0.0 | 87.18% (1232) | respiratory nitrate reductase subunit alpha NarG |
M. gilvum PYR-GCK | Mflv_2156 | - | 0.0 | 79.56% (1233) | nitrate reductase, alpha subunit |
M. tuberculosis H37Rv | Rv1161 | narG | 0.0 | 87.34% (1232) | respiratory nitrate reductase subunit alpha NarG |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3041 | - | 1e-05 | 24.03% (258) | putative biotin sulfoxide reductase BisC |
M. marinum M | MMAR_2605 | - | 4e-06 | 23.94% (284) | anaerobic dehydrogenase |
M. smegmatis MC2 155 | MSMEG_5140 | - | 0.0 | 81.43% (1228) | nitrate reductase, alpha subunit |
M. thermoresistible (build 8) | TH_1885 | narX | 0.0 | 80.37% (1233) | PROBABLE NITRATE REDUCTASE NARX |
M. ulcerans Agy99 | MUL_3154 | - | 1e-06 | 24.09% (274) | dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_4546 | - | 0.0 | 80.86% (1233) | nitrate reductase, alpha subunit |
CLUSTAL 2.0.9 multiple sequence alignment Mb1193|M.bovis_AF2122/97 MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRW Rv1161|M.tuberculosis_H37Rv MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRW MAV_1303|M.avium_104 MTATPHVGGVLEELLERSGRFFTPGEFSADLRTVTRQGGREADVFYRDRW Mflv_2156|M.gilvum_PYR-GCK MSTPPRTGGVVEDLLARSGRFFTPGEFSDDLRTVTRRGGRDGDIFYRDRW Mvan_4546|M.vanbaalenii_PYR-1 MTSPPRTGGVVEELLQRSGRFFTPGDFSEDLRTVTRRGGRDGDVFYRDRW TH_1885|M.thermoresistible__bu VTSPPRVGGPIEDLLQRSGRFFTPGDVSDDGRIVHRRGGREGDVFYRDRW MSMEG_5140|M.smegmatis_MC2_155 ----------MEELLQRSGRFFTPGTFSSDLRTVSRQGGREGDVFYRDRW MMAR_2605|M.marinum_M ------------------------------------------------MA MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1193|M.bovis_AF2122/97 SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEP Rv1161|M.tuberculosis_H37Rv SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEP MAV_1303|M.avium_104 SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEP Mflv_2156|M.gilvum_PYR-GCK SHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQETDYPSVGPDRPEYEP Mvan_4546|M.vanbaalenii_PYR-1 SHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQETDYPSVGPDRPEYEP TH_1885|M.thermoresistible__bu SHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQETDYPSVGPDRPEYEP MSMEG_5140|M.smegmatis_MC2_155 SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQETDYPSVGPDRPEYEP MMAR_2605|M.marinum_M TVDDGRHLHTCPLCEAMCGLEIRVADGPS-----GGRVVGIRGNRDDVWS MUL_3154|M.ulcerans_Agy99 ----------------MCGLEIRVADGLS-----GGRVVSIRGNRDDVWS MAB_3041|M.abscessus_ATCC_1997 ----MIRPAFSAVQVSGSARLSHTHWGAFTPEVRDGEVIGVTPIETDLDP .. . * .: . : . Mb1193|M.bovis_AF2122/97 RG--CPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWAD Rv1161|M.tuberculosis_H37Rv RG--CPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWAD MAV_1303|M.avium_104 RG--CPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKARLGDPVLAWAD Mflv_2156|M.gilvum_PYR-GCK RG--CPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARIGDPVLAWAD Mvan_4546|M.vanbaalenii_PYR-1 RG--CPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARLGDPVLAWAD TH_1885|M.thermoresistible__bu RG--CPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARLTDPVLAWAD MSMEG_5140|M.smegmatis_MC2_155 RG--CPRGAAFSWYTYSPTRVRYPYARGVLVEMYREARARLGDPVLAWAD MMAR_2605|M.marinum_M RGHICPKGASLGALHDDPDRIRHPMIK----------------------- MUL_3154|M.ulcerans_Agy99 RGHICPKGASLGALHDDPDRIRHPMIR----------------------- MAB_3041|M.abscessus_ATCC_1997 SP----LLQNIPGSIRHQARVTAPAVRSGWLREGPGPSDK---------- : *: * : Mb1193|M.bovis_AF2122/97 IQADPERRRRYQQARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAG Rv1161|M.tuberculosis_H37Rv IQADPERRRRYQQARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAG MAV_1303|M.avium_104 IQADPERRRRYQRARGKGGLVRITWAEATELIAAAHVHTIKTYGPDRVAG Mflv_2156|M.gilvum_PYR-GCK IQADPQRRRRYQQARGKGGLVRVTWAEATEMIAAAHVHTVKTYGPDRVAG Mvan_4546|M.vanbaalenii_PYR-1 IQADPQRRRRYQQARGKGGLVRVTWAEATEMIAAAHVHTIKTYGPDRVAG TH_1885|M.thermoresistible__bu IQADPQRRRRYQQARGKGGLVRISWAEATEMIAAAHVHTIKTHGPDRVAG MSMEG_5140|M.smegmatis_MC2_155 IQADPERRRRYQSARGKGGLVRVSWAEATEMIAAAHVHTIKTYGPDRIAG MMAR_2605|M.marinum_M ---------------IDGQWHEVSWDAAFRRCTELLAPVIDTYGIGAVTA MUL_3154|M.ulcerans_Agy99 ---------------IDGQWHEVSWDAAFRRCTELLAPVIDTYGIGAVTA MAB_3041|M.abscessus_ATCC_1997 --------------RGADEYVEVSWDELTELLADELRRVVDTHGNEAIYG . .::* . : .:.*:* : . Mb1193|M.bovis_AF2122/97 FSP---IPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLP---VASPQVF Rv1161|M.tuberculosis_H37Rv FSP---IPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLP---VASPQVF MAV_1303|M.avium_104 FSP---IPAMSMVSYTAGSRFFELIGAPMTSFYDWYADLP---VASPQVF Mflv_2156|M.gilvum_PYR-GCK FSP---IPAMSMVSHAAGARFVSLIGGAMTSFYDWYADLP---VASPQVF Mvan_4546|M.vanbaalenii_PYR-1 FSP---IPAMSMVSHAAGSRFVELVGGAMTSFYDWYADLP---VASPQVF TH_1885|M.thermoresistible__bu FSP---IPAMSMVSFAAGSRFIELLGGVMTSFYDWYADLP---VASPQVF MSMEG_5140|M.smegmatis_MC2_155 FSP---IPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLP---VASPQVF MMAR_2605|M.marinum_M YTG---NPLAHSFSLARYAGVLLGMSGMPVTYSPGTVDQWPKNLSSHLMY MUL_3154|M.ulcerans_Agy99 YTG---NPLAHSFSLARYAGVLLGMSGMPVTYSPGTVDQWPKNLSSHLMY MAB_3041|M.abscessus_ATCC_1997 GSYGWASAGRFHHAQSQVHRFLKLLGGYTFSRHSYSLGATG--VIMPHVI : . : : .. :.. : . : : Mb1193|M.bovis_AF2122/97 GDQTDVPESGDWWDAS-----YLVMWG----SNVPITR-----TPDAHWM Rv1161|M.tuberculosis_H37Rv GDQTDVPESGDWWDAS-----YLVMWG----SNVPITR-----TPDAHWM MAV_1303|M.avium_104 GDQTDVPESGDWWDAA-----YLMMWG----SNVPITR-----TPDAHWM Mflv_2156|M.gilvum_PYR-GCK GDQTDVPESGDWWDAT-----YLMMWG----SNVPVTR-----TPDAHWM Mvan_4546|M.vanbaalenii_PYR-1 GDQTDVPESGDWWDAS-----YLMMWG----SNVPVTR-----TPDAHWM TH_1885|M.thermoresistible__bu GDQTDVPESGDWWDAA-----YLMMWG----SNVPVTR-----TPDAHWM MSMEG_5140|M.smegmatis_MC2_155 GDQTDVPESGDWWDAA-----YLMMWG----SNVPVTR-----TPDAHWM MMAR_2605|M.marinum_M GGWWTFPVP-DIERTD-----LLVIMG----ANPAASQGSLLAAPDVMGL MUL_3154|M.ulcerans_Agy99 GGWWTFPEP-DIERTG-----LLVIMD----ANPAASQGSLLAAPDVMGL MAB_3041|M.abscessus_ATCC_1997 GTHDGLFKRSTSWDVIVENTDLLIAFGGIALKNTGVNHGGTTAHPARDAL * . . *: . * .: * : Mb1193|M.bovis_AF2122/97 AEARYRGAKVVVVSPDYADNTKFADEWVRCAAGTDTALAMAMGHVILSEC Rv1161|M.tuberculosis_H37Rv AEARYRGAKVVVVSPDYADNTKFADEWVRCAAGTDTALAMAMGHVILSEC MAV_1303|M.avium_104 AEARYRGTKVVTVSPDYADNTKFADEWMPCAAGTDGALAMAMGHVILSEC Mflv_2156|M.gilvum_PYR-GCK AEVRYRGTKVVSVSPDYADNTKFADEWMPCAAGTDGALAMAMGHVILTEN Mvan_4546|M.vanbaalenii_PYR-1 AEVRYRGTKVVSVSPDYADNTKFADEWMPCAAGTDGALAMAMGHVILTEN TH_1885|M.thermoresistible__bu AEVRYRGTKVVAVSPDYADNTKFADEWMPCAAGTDGAMAMAMGHVILSEF MSMEG_5140|M.smegmatis_MC2_155 AEVRYRGTKVVSVSPDYADNTKFADEWMPCAAGTDGALAMAMGHVILSEC MMAR_2605|M.marinum_M IDAIRQRGKVIVIDPVRTVTAARADEWLPIVPGTDAALLLAVAHTLFDED MUL_3154|M.ulcerans_Agy99 IDAIRQRGKVIVIDPVRTVTAARADEWLPIVPGTDAALLLAVAHTLFDED MAB_3041|M.abscessus_ATCC_1997 NRFRDRGGRIVSFSPLHDDIDG-ECEWHAPIPGTDVAVMLALAHVLAVEK : ::: ..* ** .*** *: :*:.*.: * Mb1193|M.bovis_AF2122/97 YVRNQVPFFVDYVRRYTDLPFLIKLEKRGDLLVPGKFLTAADIG---EES Rv1161|M.tuberculosis_H37Rv YVRNQVPFFVDYVRRYTDLPFLIKLEKRGDLLVPGKFLTAADIG---EES MAV_1303|M.avium_104 YVQKQVPFFTDYARRYTDLPFLIKLEERGDMLVPGKNLTAADLG---EAV Mflv_2156|M.gilvum_PYR-GCK YVRQRVPFFDEYVRTYTDLPFLVKLEERGGVTVPGKMLTAADLGPAYGG- Mvan_4546|M.vanbaalenii_PYR-1 FVRRRVPFFVDYVRTYTDLPFLVKLEERDGVLVPGKMLTAADLGPGYDGQ TH_1885|M.thermoresistible__bu FVRKQVPFFTDYVRRYTDLPFLVKLEERDGALVPGKMLTVADLGEVFGQH MSMEG_5140|M.smegmatis_MC2_155 FVQNEVPYFTDFARRFTDLPFLAKLEERDGALVPGKNLTAADLTPDVAAQ MMAR_2605|M.marinum_M LVN------------------------------PGPHVDGVDTMRR---- MUL_3154|M.ulcerans_Agy99 LVN------------------------------PGQHVDGVDTMRR---- MAB_3041|M.abscessus_ATCC_1997 LAD---------------------------LTFLSSYCTGYERFER---- . . : Mb1193|M.bovis_AF2122/97 ENAAFKPALLDELTNTVVVPQGSLGFRFGEDGVGKWNLDLGSVVPALSVE Rv1161|M.tuberculosis_H37Rv ENAAFKPALLDELTNTVVVPQGSLGFRFGEDGVGKWNLDLGSVVPALSVE MAV_1303|M.avium_104 ENAALKPALLDETTNSVAVPHGSLGFRYGESGVGKWNLDLGDLVPALSVR Mflv_2156|M.gilvum_PYR-GCK ENAEFKPALLNLATDSVTVPPGSLGFRYGDEGVGRWNLDLGDVVPALTVA Mvan_4546|M.vanbaalenii_PYR-1 ENAAFKPVLLDGATDSVVVPPGSLGFRYGDEGVGKWNLDLGDVVPALTVA TH_1885|M.thermoresistible__bu ENAAFKPMLLDEATDTVTVPHGSLGFRYGTDGAGKWNLDLGPVVPALTVR MSMEG_5140|M.smegmatis_MC2_155 ENAAFKPALLDSASDSIAIPQGSLGFRFGESGLGNWNLDLENLAPALTVA MMAR_2605|M.marinum_M -------------------------------------------------- MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1193|M.bovis_AF2122/97 MDKAVNGDRSAELVTLPSFDTIDGHGETVSRGLPVRRAGKHLVCTVFDLM Rv1161|M.tuberculosis_H37Rv MDKAVNGDRSAELVTLPSFDTIDGHGETVSRGVPVRRAGKHLVCTVFDLM MAV_1303|M.avium_104 AAPTEDGE--TALVHLPSFDTVDGEGTTVARGVPVRRVGKHLVCTVFDLM Mflv_2156|M.gilvum_PYR-GCK TGDVHDGG--SAAVTLSRFDTVDGHGATMLRGVPVRQVGAHRVCTVFDLM Mvan_4546|M.vanbaalenii_PYR-1 PPDGQSGE--TTSISLTRFDTVDGRGATLQRGVPVRRVGEHRVCTVFDLM TH_1885|M.thermoresistible__bu TGD---GP--VTEVRLPCFDSVDGHGTTVTRGVPVRHVGDHRVCTVFDLM MSMEG_5140|M.smegmatis_MC2_155 ADT---GE--TAEVTLPRFDTLDGHGDTMVRGVPVRRVGEHLVCTVFDLM MMAR_2605|M.marinum_M -------------------------------------------------- MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1193|M.bovis_AF2122/97 LAHYGVARAGLPGEWPTGYHDRTQQNTPAWQESITGVPAAQAIRFAKEFA Rv1161|M.tuberculosis_H37Rv LAHYGVARAGLPGEWPTGYHDRTQQNTPAWQESITGVPAAQAIRFAKEFA MAV_1303|M.avium_104 LAQYGVARPGLPGEWPTGYDDATQQNTPAWQEAITGVSAAQATRVAREFA Mflv_2156|M.gilvum_PYR-GCK LAQYGVARPGLPGDWPTGYDDPRSPYTPAWQEPITGVSAGQAIRVAREFA Mvan_4546|M.vanbaalenii_PYR-1 LAQYGVARPGLPGDWPAGYDDPDQPYTPAWQESITGVSASQAIRVAREFA TH_1885|M.thermoresistible__bu LAQYGVSRPGLPGDWPTGYDDATRPYTPAWQEPITGVSAAQVIRIATEFA MSMEG_5140|M.smegmatis_MC2_155 LAQYGVARPGLPGDWPTGFDDATRPYTPAWQEPITGVAAAQAIRVAREFA MMAR_2605|M.marinum_M ----------VAADWPP-----------ARVSAVTGIEEERIRRLARELA MUL_3154|M.ulcerans_Agy99 ----------VAGSS-----------------------RDKTARKVFSLG MAB_3041|M.abscessus_ATCC_1997 ------YLLGVDDGVPK---------SPEWAAPISGLDAAELRTLARRMA : . . :. Mb1193|M.bovis_AF2122/97 RNATESGGRSMIIMGGGICHWFHSDVMYRSVLALLMLTGSMGRNGGGWAH Rv1161|M.tuberculosis_H37Rv RNATESGGRSMIIMGGGICHWFHSDVMYRSVLALLMLTGSMGRNGGGWAH MAV_1303|M.avium_104 RSAEESGGRSMIIMGGGICHWFHSDAIYRAVLALLMLTGSMGRNGGGWAH Mflv_2156|M.gilvum_PYR-GCK RNAEESGGRSMIIMGAGICQWFHGDTTYRAVLAMLLLTGSMGRNGGGWAH Mvan_4546|M.vanbaalenii_PYR-1 RNAEESGGRSMIIMGAGICQWFHGDTTYRAVLAMLLLTGSMGRNGGGWAH TH_1885|M.thermoresistible__bu RNAEESGGRSMIIMGAGICQWFHGDATYRAVLALLLLTGSMGRNGGGWAH MSMEG_5140|M.smegmatis_MC2_155 RNAEETRGRSMIIMGAGICQWFHGDATYRAVLALLLLTGSMGRNGGGWAH MMAR_2605|M.marinum_M G-----THKSVVYGRIGLCNQEFGSLASWLVDVINILTGHFDTPGG---- MUL_3154|M.ulcerans_Agy99 R-----RNR---------------------------------TPN----- MAB_3041|M.abscessus_ATCC_1997 AG------RTLVTVSWSLQRVRHGEQAPWMGLTLAAMLGQIGLPGGGFGH : . Mb1193|M.bovis_AF2122/97 YVGQEKVRPLTGWQTMAMATDWSRPPRQVPGASYWYAHTDQWRYDGYGAD Rv1161|M.tuberculosis_H37Rv YVGQEKVRPLTGWQTMAMATDWSRPPRQVPGASYWYAHTDQWRYDGYGAD MAV_1303|M.avium_104 YVGQEKVRPLTGFQTMAMATDWVRPPRQVPGASYWYAHTDQWRYDGYGAD Mflv_2156|M.gilvum_PYR-GCK YVGQEKCRPVTGWATMGSALDWSRPPRQMPGTSYWYAHTDQWRYDGYRAD Mvan_4546|M.vanbaalenii_PYR-1 YVGQEKCRPVTGWATMAMATDWTRPPRQMPGTSYWYAHTGQWRYDGYRAD TH_1885|M.thermoresistible__bu YVGQEKCRPVTGWATMAMATDWSRPPRQMPGTSYWYVHTDQWNYDGYRAD MSMEG_5140|M.smegmatis_MC2_155 YVGQEKCRPVTGWATMAMATDWSRPPRQMAGTSYWYAHTDQWRYDGYQAD MMAR_2605|M.marinum_M -------------AMFPRPAAWSITTQPLPGLEGGVAEFGRWHTRVRGAK MUL_3154|M.ulcerans_Agy99 ---------------------WANTSS----------------------- MAB_3041|M.abscessus_ATCC_1997 GYG------------SMNEPGLAPVSCPLPTFPQGPNPVETFIPVAAISE . Mb1193|M.bovis_AF2122/97 KLASPVGRGRFAGKHTMDLLTSATAMGWSPFYPQFDRSSLDVADEARAAG Rv1161|M.tuberculosis_H37Rv KLASPVGRGRFAGKHTMDLLTSATAMGWSPFYPQFDRSSLDVADEARAAG MAV_1303|M.avium_104 KLASPVGRGRFAGRHTMDLLASAVAMGWSPYYPQFDRSSLDVADEARAAG Mflv_2156|M.gilvum_PYR-GCK TLASPTARGRFTGKHTMDVVAAAAAMGWMPFYPQFDRNSLDIADEALAAG Mvan_4546|M.vanbaalenii_PYR-1 ALASPTARGRFAGKHTMDVVAAAAAMGWMPFYPQFDRNSLDVADEARAAG TH_1885|M.thermoresistible__bu ALASPIGRGRFRGKHTMDVLASATAMGWSPFYPQFDRSSLDIADEARAAG MSMEG_5140|M.smegmatis_MC2_155 ALSSPVGRGRFRGRHTMDVLASAAAMGWSPFFPQFDRSSLDVADEARAAD MMAR_2605|M.marinum_M EVLGQAPVSCLAEEIATPGDGQLRALITIAGNPVLSTPGGDKLDEALSS- MUL_3154|M.ulcerans_Agy99 --------EAVAAHVAKPA------------------------------- MAB_3041|M.abscessus_ATCC_1997 LLLRPGQTLAYNGQTLT--LPDIRCVYWAGGNPFHHHQNLPRLRRALSR- . Mb1193|M.bovis_AF2122/97 RDVGDYVAEQLAQHKLKLSITDPDNPVNWPRVLTVWRANLIGSSGKGGEY Rv1161|M.tuberculosis_H37Rv RDVGDYVAEQLAQHKLKLSITDPDNPVNWPRVLTVWRANLIGSSGKGGEY MAV_1303|M.avium_104 RDVADYVAEQLGRRNLKLAVTDPDNPVNWPRVLTVWRANLIGSSGKGGEY Mflv_2156|M.gilvum_PYR-GCK RDIPQYLCEKLASGELKMAVTDPDNPANWPRVLNVWRANLLGSSSKGNEY Mvan_4546|M.vanbaalenii_PYR-1 QDIGKYVCEKLASGELKMAVTDPDNPANWPRVLNVWRANLLGSSSKGNEY TH_1885|M.thermoresistible__bu KEIGAYVCEQLASGGLKLAVTDPDDPRNWPRVLSVWRSNLLGSSSKGNEY MSMEG_5140|M.smegmatis_MC2_155 QEIPAYVTAKLADGSLKLAVTDPDNPANWPRVLDVWRANLLGSSSKGNEY MMAR_2605|M.marinum_M -------------------------------------------------- MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1193|M.bovis_AF2122/97 FLRHLLGTDSNVQSDPPTDGVHPRDVVWDSDIPEGKLDLIMSIDFRMTST Rv1161|M.tuberculosis_H37Rv FLRHLLGTDSNVQSDPPTDGVHPRDVVWDSDIPEGKLDLIMSIDFRMTST MAV_1303|M.avium_104 FLRHLLGTDSNASAVPPEDGVRPVDVTCGADIPEGKLDLMMSIDFRMTST Mflv_2156|M.gilvum_PYR-GCK FLRHLLGTDSNLQASPTPEALRPADVVWPDDIPEGKLDLLMSIDFRMTST Mvan_4546|M.vanbaalenii_PYR-1 FLRHLLGADSNLQATPTEEALRPKDVTWPDDIPEGKLDLLMSVDFRMTST TH_1885|M.thermoresistible__bu FLRHLLGTDSNLRATRTPEALRPNDVRSPDEIPEGKLDLLMSIDFRMTST MSMEG_5140|M.smegmatis_MC2_155 FLRHLLGTTSNLQAAPN--GVRPSSVTCTDDIPEGKLDLLMSIDFRMTST MMAR_2605|M.marinum_M ------------------------------------LEAMISVDLWLNET MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 ------------------------------------VDTVVVHDPVWTAM Mb1193|M.bovis_AF2122/97 TLVSDVVLPAATWYEKSDLSSTDMHPYVHSFSPAIDPPWETRSDFGAFAA Rv1161|M.tuberculosis_H37Rv TLVSDVVLPAATWYEKSDLSSTDMHPYVHSFSPAIDPPWETRSDFDAFAA MAV_1303|M.avium_104 TLVSDVVLPAATWYEKADISSTDMHPYVHAFSAATDPPWETRSDFDAFGA Mflv_2156|M.gilvum_PYR-GCK TLLSDVVLPAATWYEKADLSSTDMHPYVHAFSPAIDPPWETRSDFDAFGA Mvan_4546|M.vanbaalenii_PYR-1 TLLSDVVLPAATWYEKADLSSTDMHPYVHAFSPAIDPPWETRSDFEAFGA TH_1885|M.thermoresistible__bu TLLSDIVLPAATWYEKHDLSSTDMHPYVHAFSPAIDPPWETRSDYDAFGA MSMEG_5140|M.smegmatis_MC2_155 TLLSDVVLPAATWYEKADLSSTDMHPYVHAFSPAVDPPWETRSDFEAFGA MMAR_2605|M.marinum_M TRHADVILPGLSPLEQPHHDDLVLQFAIRSFANYSAPVFDPGDRPHEWEI MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 AKHADIVVPSTTSLERDDFSGSRNDPLLVAMKAVAPPYANSRDDYTTFSA Mb1193|M.bovis_AF2122/97 IARAFSALAKRHLGTRTDVVLTALQHDTPDEMAYPDGTERDWLATGEVPV Rv1161|M.tuberculosis_H37Rv IARAFSALAKRHLGTRTDVVLTALQHDTPDEMAYPDGTERDWLATGEVPV MAV_1303|M.avium_104 IARAFSTMAKEHLGTRTDVVLTALQHDTPDAMAYPDGAEHDWLRSGATPV Mflv_2156|M.gilvum_PYR-GCK VASAFSALARTHLGTRTDVVLGALQHDTPGAMAYPAGTQRDWRETGEVPV Mvan_4546|M.vanbaalenii_PYR-1 IARTFSTLARSHLGTRTDVVLGALQHDTPGAMAYPAGTQRDWRETGETPV TH_1885|M.thermoresistible__bu IARAFSALARKHLGTRTDVVLGALQHDTPGAMAYAGGTERDWRVTGEVPV MSMEG_5140|M.smegmatis_MC2_155 IARAFSTLAARHLGVRTDVVLGTLQHDTLGAMAYPSGTEHDWRVTGETPV MMAR_2605|M.marinum_M LIRLTGLCTGTPA---EDVDVAAIDDGFFDYLAFTKGFDGAAIRKRYEHD MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 LADRLGFGEQFSEGRTAAQWLRHIYTEWAGALNFSVPSFDEFWDRGYLEL Mb1193|M.bovis_AF2122/97 PGRTMSKLTVVERDYTAIYDKWLTLGPLIDQFGMTTKGYTVHPFREVSEL Rv1161|M.tuberculosis_H37Rv PGRTMSKLTVVERDYTAIYDKWLTLGPLIDQFGMTTKGYTVHPFREVSEL MAV_1303|M.avium_104 PGRTMGKLTVVERDYAAVYDKWRTLGPLVDKFGLTTKGVTVHPFREVEEL Mflv_2156|M.gilvum_PYR-GCK PGATIGPIAVVERDYTAIADKWSTLGPLVEKLGLTTKGVTTHPDREADEL Mvan_4546|M.vanbaalenii_PYR-1 PGKTIGPITVVERDYAAIADKWSTLGPLVERLGVTTKGVTTWPVQETAEL TH_1885|M.thermoresistible__bu PGKTIGPLAVVERDYTAIADKWAALGPLVEELGVTTKGVTTWPVQEVAEL MSMEG_5140|M.smegmatis_MC2_155 PGRTMGPLAVVERDYGAIAQKWAALGPLVEGLGVTTKGLTTHPTREVAEL MMAR_2605|M.marinum_M G---------WAGGPERILDLTLRTGPFGDRYGQNPGGLTLDMLK----- MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 PTDAGLTLLSDFRENPAAHPLHTPSG-RIEIFSETIDGFGYSDCG----- Mb1193|M.bovis_AF2122/97 AANFGVMNSGVAVGRPAITTAKRMADVILALSGTCNGRLAVEGFLELEKR Rv1161|M.tuberculosis_H37Rv AANFGVMNSGVAVGRPAITTAKRMADVILALSGTCNGRLAVEGFLELEKR MAV_1303|M.avium_104 AARFGVLKSGVAAGRPAITTAARMADVLLLLSGTTNGRLAVEGFHELEKR Mflv_2156|M.gilvum_PYR-GCK ARKFGVFDSGPAAGRPAITTAERMADVILALSGTSNGRLAVEGFRELQRR Mvan_4546|M.vanbaalenii_PYR-1 AQKFGVLDSGPAAGQPAITTAERMADVILALSGTSNGRLAVEGFRELERR TH_1885|M.thermoresistible__bu AKAFGVMDSGPAAGRPAITTAARMAEVILALSGTSNGRLAVEGFRELEKR MSMEG_5140|M.smegmatis_MC2_155 GAKFGVMDSGAAQGRPAITTGERMADVILALSGTSNGRLAVEGFAELERR MMAR_2605|M.marinum_M -------------ANPNGIDFGPMVSQLPDILGTPEKKIRLAPQYLLDDL MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------GHPQWYEPTEWLGGERAQR------------ Mb1193|M.bovis_AF2122/97 TGQRLAHLAEGSEERRITYADTQARPVPVITSPEWSGSESGGRRYAPFTI Rv1161|M.tuberculosis_H37Rv TGQRLAHLAEGSEERRITYADTQARPVPVITSPEWSGSESGGRRYAPFTI MAV_1303|M.avium_104 TGQRLVHLAEGSEDKRISYADTQARPVPVVTSPEWSGSETGGRRYAPFTI Mflv_2156|M.gilvum_PYR-GCK TGTPLAHLAEGSEERRITYADTQARPVPVITSPEWSGSETGGRRYAPFTV Mvan_4546|M.vanbaalenii_PYR-1 TGRPLAHLAEGSEERRITYADTQARPVPVITSPEWSGSETGGRRYAPFTV TH_1885|M.thermoresistible__bu TGQRLAQLAEGSEERRITFADTQARPVPVITSPEWSGSETAGRRYAPFTV MSMEG_5140|M.smegmatis_MC2_155 TGRKLVHLALGSEERRITYADAQARPVPVITSPEWSGSETGGRRYAPFTV MMAR_2605|M.marinum_M P---------------------------------------------RLAS MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -----------------------------------------------FPL Mb1193|M.bovis_AF2122/97 NIEHLKPFHTLTGRMHFYLAHDWVEELGEQLPVYRPPLDMARLFNQPELG Rv1161|M.tuberculosis_H37Rv NIEHLKPFHTLTGRMHFYLAHDWVEELGEQLPVYRPPLDMARLFNQPELG MAV_1303|M.avium_104 NIENLKPFHTLTGRMHFYLAHDWVEELGEHLPVFRPPLDMARLFGQPRLG Mflv_2156|M.gilvum_PYR-GCK NIEQLKPFHTLTGRMHFYLDHDWLEELGEQLPVYRPPLDLGRLFGEPAIG Mvan_4546|M.vanbaalenii_PYR-1 NIEALKPFHTLTGRMHFYLDHDWLEELGEQLPVYRPPLDMARLFGEPAIG TH_1885|M.thermoresistible__bu NIEHLKPFHTLTGRMHFYLDHDWLEELGEQLPVYRPPLDMARLFGAQQIG MSMEG_5140|M.smegmatis_MC2_155 NIEELKPFHTLTGRMHFYVDHDWLEELGEQLPVYRPPLDMARLFGESRLG MMAR_2605|M.marinum_M RMDRPAEQLVLVNRRHLRSNNSWLHNV----------------------- MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 HLIANQPRTRLHSQLDFGGTS----------------------------- Mb1193|M.bovis_AF2122/97 -----PTDDGLGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSP Rv1161|M.tuberculosis_H37Rv -----PTDDGLGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSP MAV_1303|M.avium_104 -----ACEDGIGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSP Mflv_2156|M.gilvum_PYR-GCK ----APGATGVGLTVRYLTPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSP Mvan_4546|M.vanbaalenii_PYR-1 ----ARG--ELGLTVRYLTPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSP TH_1885|M.thermoresistible__bu ----HSD--GVGLTVRYLTPHSKWSIHSEYQDNLLMLSLSRGGPTMWMSP MSMEG_5140|M.smegmatis_MC2_155 AGPGADGAGGVGLTVRYLTPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSP MMAR_2605|M.marinum_M ----------------------------------PALMKGKDRCTLLMHP MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -----------------------------------QGSKVRGREPLRIHP Mb1193|M.bovis_AF2122/97 GDAAKINVRDNDWVEAVNANGIYVCRAIVSHRMPEGVVFVYHVQERTVDT Rv1161|M.tuberculosis_H37Rv GDAAKINVRDNDWVEAVNANGIYVCRAIVSHRMPEGVVFVYHVQERTVDT MAV_1303|M.avium_104 GDAAKIQVRDNDWVEAVNANGIYVCRAIVSHRMPDGVVYVYHVQERTVDT Mflv_2156|M.gilvum_PYR-GCK ADAEKIEVRDNDWVEAVNRNGVLVCRAIVSHRMPEGVVYVYHAQERTIDV Mvan_4546|M.vanbaalenii_PYR-1 ADAAKIQVRDNDWVEAVNRNGVLVCRAIVSHRMPEGVVYVYHAQERTIDV TH_1885|M.thermoresistible__bu ADAAKIGVADNDWVEAVNPNGVLVCRAIVSHRMPEGVVYVYHVQERTIDV MSMEG_5140|M.smegmatis_MC2_155 GDADKIAVRDNDWVEAVNRNGVLVCRAIVSHRMPDGVVYVYHAQERTIDV MMAR_2605|M.marinum_M DDAARNGITDNDTVTVRSSAGEITVPVELTSAIKPGVVSMPHGWGHGKPG MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 QDAATRGIADGDVVRVFNDRGACLAGAVLDEGLRRQVVQLSTGAWFDPIE Mb1193|M.bovis_AF2122/97 PRTETNGKRGGNHNALTRVRIKPSHLAGGYGQHAFAFNYLGPTGNQRDEV Rv1161|M.tuberculosis_H37Rv PRTETNGKRGGNHNALTRVRIKPSHLAGGYGQHAFAFNYLGPTGNQRDEV MAV_1303|M.avium_104 PRTETNDKRGGNHNALTRVRIKPSHLAGGYAQHAFAFNYLGPTGNQRDEV Mflv_2156|M.gilvum_PYR-GCK PLTETTGRRGGIHNSLTRLLVKPSHLAGGYAQTAFAFNYLGPTGNQRDEV Mvan_4546|M.vanbaalenii_PYR-1 PLTETTGRRGGIHNSLTRLLVKPSHLAGGYAQTAFAFNYLGPTGNQRDEV TH_1885|M.thermoresistible__bu PIAETTGKRGGIHNSLTRLLIKPSHLAGGYAQNAFAFNYLGPTGNQRDEV MSMEG_5140|M.smegmatis_MC2_155 PLTETTGTRGGIHNSLTRLLIKPSHLAGGYAQHSYAFNYLGPTGNQRDEV MMAR_2605|M.marinum_M TRLAVANSAPGVNTNVLSPPTLLDEPSGNGVLNGIPVTVS---------- MUL_3154|M.ulcerans_Agy99 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 PADPNSACAHGNPNVLTDDSGTSSLAQGCTGQHVLVQIERFEGTPPPVRA Mb1193|M.bovis_AF2122/97 TVVRRRSQEVRY- Rv1161|M.tuberculosis_H37Rv TVVRRRSQEVRY- MAV_1303|M.avium_104 TIVRRRSQEVVY- Mflv_2156|M.gilvum_PYR-GCK TVVRRRSQEVVY- Mvan_4546|M.vanbaalenii_PYR-1 TIVRRRSQEVVYQ TH_1885|M.thermoresistible__bu TVVRRRSQRVVF- MSMEG_5140|M.smegmatis_MC2_155 TVVRRRSQEVTYR MMAR_2605|M.marinum_M ------------- MUL_3154|M.ulcerans_Agy99 ------------- MAB_3041|M.abscessus_ATCC_1997 HTPPRFVARD---