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M. vanbaalenii PYR-1 Mvan_4546 (-)

annotation: nitrate reductase, alpha subunit
coordinates: 4885736 - 4889437
length: 1233

TSPPRTGGVVEELLQRSGRFFTPGDFSEDLRTVTRRGGRDGDVFYRDRWSHDKVVRSTHGVNCTGSCSWK
VYVKDGIITWETQETDYPSVGPDRPEYEPRGCPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARLGD
PVLAWADIQADPQRRRRYQQARGKGGLVRVTWAEATEMIAAAHVHTIKTYGPDRVAGFSPIPAMSMVSHA
AGSRFVELVGGAMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDASYLMMWGSNVPVTRTPDAHWMAEV
RYRGTKVVSVSPDYADNTKFADEWMPCAAGTDGALAMAMGHVILTENFVRRRVPFFVDYVRTYTDLPFLV
KLEERDGVLVPGKMLTAADLGPGYDGQENAAFKPVLLDGATDSVVVPPGSLGFRYGDEGVGKWNLDLGDV
VPALTVAPPDGQSGETTSISLTRFDTVDGRGATLQRGVPVRRVGEHRVCTVFDLMLAQYGVARPGLPGDW
PAGYDDPDQPYTPAWQESITGVSASQAIRVAREFARNAEESGGRSMIIMGAGICQWFHGDTTYRAVLAML
LLTGSMGRNGGGWAHYVGQEKCRPVTGWATMAMATDWTRPPRQMPGTSYWYAHTGQWRYDGYRADALASP
TARGRFAGKHTMDVVAAAAAMGWMPFYPQFDRNSLDVADEARAAGQDIGKYVCEKLASGELKMAVTDPDN
PANWPRVLNVWRANLLGSSSKGNEYFLRHLLGADSNLQATPTEEALRPKDVTWPDDIPEGKLDLLMSVDF
RMTSTTLLSDVVLPAATWYEKADLSSTDMHPYVHAFSPAIDPPWETRSDFEAFGAIARTFSTLARSHLGT
RTDVVLGALQHDTPGAMAYPAGTQRDWRETGETPVPGKTIGPITVVERDYAAIADKWSTLGPLVERLGVT
TKGVTTWPVQETAELAQKFGVLDSGPAAGQPAITTAERMADVILALSGTSNGRLAVEGFRELERRTGRPL
AHLAEGSEERRITYADTQARPVPVITSPEWSGSETGGRRYAPFTVNIEALKPFHTLTGRMHFYLDHDWLE
ELGEQLPVYRPPLDMARLFGEPAIGARGELGLTVRYLTPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSPA
DAAKIQVRDNDWVEAVNRNGVLVCRAIVSHRMPEGVVYVYHAQERTIDVPLTETTGRRGGIHNSLTRLLV
KPSHLAGGYAQTAFAFNYLGPTGNQRDEVTIVRRRSQEVVYQ*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4546--100% (1233)nitrate reductase, alpha subunit
M. vanbaalenii PYR-1Mvan_2438-9e-0827.36% (201) molybdopterin guanine dinucleotide-containing S/N-oxide
M. vanbaalenii PYR-1Mvan_4442-6e-0535.21% (71) molydopterin dinucleotide-binding region

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1193narG0.080.16% (1235) respiratory nitrate reductase subunit alpha NarG
M. gilvum PYR-GCKMflv_2156-0.091.73% (1234) nitrate reductase, alpha subunit
M. tuberculosis H37RvRv1161narG0.080.24% (1235) respiratory nitrate reductase subunit alpha NarG
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3041-4e-0727.87% (183) putative biotin sulfoxide reductase BisC
M. marinum MMMAR_5195-2e-0630.33% (122) formate dehydrogenase, beta subunit, selenocysteine-containing
M. avium 104MAV_1303-0.080.86% (1233) nitrate reductase, alpha subunit
M. smegmatis MC2 155MSMEG_5140-0.085.52% (1229) nitrate reductase, alpha subunit
M. thermoresistible (build 8)TH_1885narX0.086.93% (1232) PROBABLE NITRATE REDUCTASE NARX
M. ulcerans Agy99MUL_3154-1e-0525.00% (188) dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1193|M.bovis_AF2122/97            MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRW
Rv1161|M.tuberculosis_H37Rv         MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRW
MAV_1303|M.avium_104                MTATPHVGGVLEELLERSGRFFTPGEFSADLRTVTRQGGREADVFYRDRW
Mvan_4546|M.vanbaalenii_PYR-1       MTSPPRTGGVVEELLQRSGRFFTPGDFSEDLRTVTRRGGRDGDVFYRDRW
Mflv_2156|M.gilvum_PYR-GCK          MSTPPRTGGVVEDLLARSGRFFTPGEFSDDLRTVTRRGGRDGDIFYRDRW
TH_1885|M.thermoresistible__bu      VTSPPRVGGPIEDLLQRSGRFFTPGDVSDDGRIVHRRGGREGDVFYRDRW
MSMEG_5140|M.smegmatis_MC2_155      ----------MEELLQRSGRFFTPGTFSSDLRTVSRQGGREGDVFYRDRW
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               --------------------------------------------------
                                                                                      

Mb1193|M.bovis_AF2122/97            SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEP
Rv1161|M.tuberculosis_H37Rv         SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEP
MAV_1303|M.avium_104                SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEP
Mvan_4546|M.vanbaalenii_PYR-1       SHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQETDYPSVGPDRPEYEP
Mflv_2156|M.gilvum_PYR-GCK          SHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQETDYPSVGPDRPEYEP
TH_1885|M.thermoresistible__bu      SHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQETDYPSVGPDRPEYEP
MSMEG_5140|M.smegmatis_MC2_155      SHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQETDYPSVGPDRPEYEP
MAB_3041|M.abscessus_ATCC_1997      ----MIRPAFSAVQVSGSARLSHTHWGAFTPEVRDGEVIGVTPIETDLDP
MUL_3154|M.ulcerans_Agy99           ----------------MCGLEIRVADGLSGGRVVS---------------
MMAR_5195|M.marinum_M               -----MGSNMAEAHPVGFQWVIEAKTRGAQVIHIDPRFTRTSAVADRHVP
                                                           .          .               

Mb1193|M.bovis_AF2122/97            RGCPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWADIQ
Rv1161|M.tuberculosis_H37Rv         RGCPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWADIQ
MAV_1303|M.avium_104                RGCPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKARLGDPVLAWADIQ
Mvan_4546|M.vanbaalenii_PYR-1       RGCPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARLGDPVLAWADIQ
Mflv_2156|M.gilvum_PYR-GCK          RGCPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARIGDPVLAWADIQ
TH_1885|M.thermoresistible__bu      RGCPRGAAFSWYTYSPTRVRYPYARGVLVEMYREAKARLTDPVLAWADIQ
MSMEG_5140|M.smegmatis_MC2_155      RGCPRGAAFSWYTYSPTRVRYPYARGVLVEMYREARARLGDPVLAWADIQ
MAB_3041|M.abscessus_ATCC_1997      S--------------------PLLQNIPGSIRHQARVTAPAVRSGWLREG
MUL_3154|M.ulcerans_Agy99           -----------------------IRGNRDDVWSRGHICPKGASLGALHDD
MMAR_5195|M.marinum_M               ----------------------LRAGSDIAFLGGVINYILSNDLDFREYV
                                                             .    .                   

Mb1193|M.bovis_AF2122/97            ADPERRRRYQQARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAGFS
Rv1161|M.tuberculosis_H37Rv         ADPERRRRYQQARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAGFS
MAV_1303|M.avium_104                ADPERRRRYQRARGKGGLVRITWAEATELIAAAHVHTIKTYGPDRVAGFS
Mvan_4546|M.vanbaalenii_PYR-1       ADPQRRRRYQQARGKGGLVRVTWAEATEMIAAAHVHTIKTYGPDRVAGFS
Mflv_2156|M.gilvum_PYR-GCK          ADPQRRRRYQQARGKGGLVRVTWAEATEMIAAAHVHTVKTYGPDRVAGFS
TH_1885|M.thermoresistible__bu      ADPQRRRRYQQARGKGGLVRISWAEATEMIAAAHVHTIKTHGPDRVAGFS
MSMEG_5140|M.smegmatis_MC2_155      ADPERRRRYQSARGKGGLVRVSWAEATEMIAAAHVHTIKTYGPDRIAGFS
MAB_3041|M.abscessus_ATCC_1997      PGPSDKR------GADEYVEVSWDELTELLADELRRVVDTHGNEAIYGGS
MUL_3154|M.ulcerans_Agy99           PD---RIRHPMIRIDGQWHEVSWDAAFRRCTELLAPVIDTYGIGAVTAYT
MMAR_5195|M.marinum_M               TAYTNAPFLVGEDYCDAEDLDGLFSGYDHASASYDPTTWRYQPGDHADPT
                                    .              .              :     .   :        :

Mb1193|M.bovis_AF2122/97            PIPAMSMVSHAAG---SRFVELIGGVMTSFYDWYADLP-VASPQVFGDQT
Rv1161|M.tuberculosis_H37Rv         PIPAMSMVSHAAG---SRFVELIGGVMTSFYDWYADLP-VASPQVFGDQT
MAV_1303|M.avium_104                PIPAMSMVSYTAG---SRFFELIGAPMTSFYDWYADLP-VASPQVFGDQT
Mvan_4546|M.vanbaalenii_PYR-1       PIPAMSMVSHAAG---SRFVELVGGAMTSFYDWYADLP-VASPQVFGDQT
Mflv_2156|M.gilvum_PYR-GCK          PIPAMSMVSHAAG---ARFVSLIGGAMTSFYDWYADLP-VASPQVFGDQT
TH_1885|M.thermoresistible__bu      PIPAMSMVSFAAG---SRFIELLGGVMTSFYDWYADLP-VASPQVFGDQT
MSMEG_5140|M.smegmatis_MC2_155      PIPAMSMVSHAAG---SRFVELIGGVMTSFYDWYADLP-VASPQVFGDQT
MAB_3041|M.abscessus_ATCC_1997      YGWASAGRFHHAQSQVHRFLKLLGGYTFSRHSYSLGATGVIMPHVIGTHD
MUL_3154|M.ulcerans_Agy99           GNPLAHSFSLARY----------AGVLLGMSGMPVTYSPGTVDQWPKNLS
MMAR_5195|M.marinum_M               LQHPRCVYQILKRHYARYTPEMVERVCGVPAQSFLQVARAWTENSGRERT
                                                                         .     :      

Mb1193|M.bovis_AF2122/97            DVPESGDWWDASYLVMWGSNVPITRTPDAHWMAEARYRGAKVVVVSPDYA
Rv1161|M.tuberculosis_H37Rv         DVPESGDWWDASYLVMWGSNVPITRTPDAHWMAEARYRGAKVVVVSPDYA
MAV_1303|M.avium_104                DVPESGDWWDAAYLMMWGSNVPITRTPDAHWMAEARYRGTKVVTVSPDYA
Mvan_4546|M.vanbaalenii_PYR-1       DVPESGDWWDASYLMMWGSNVPVTRTPDAHWMAEVRYRGTKVVSVSPDYA
Mflv_2156|M.gilvum_PYR-GCK          DVPESGDWWDATYLMMWGSNVPVTRTPDAHWMAEVRYRGTKVVSVSPDYA
TH_1885|M.thermoresistible__bu      DVPESGDWWDAAYLMMWGSNVPVTRTPDAHWMAEVRYRGTKVVAVSPDYA
MSMEG_5140|M.smegmatis_MC2_155      DVPESGDWWDAAYLMMWGSNVPVTRTPDAHWMAEVRYRGTKVVSVSPDYA
MAB_3041|M.abscessus_ATCC_1997      GLFKRSTSWD----------------------------------------
MUL_3154|M.ulcerans_Agy99           SHLMYGGWWT----------------------------------------
MMAR_5195|M.marinum_M               TALVYSVGWTQHS-------------------------------------
                                         .  *                                         

Mb1193|M.bovis_AF2122/97            DNTKFADEWVRCAAGTDTALAMAMGHVILSECYVRNQVPFFVDYVRRYTD
Rv1161|M.tuberculosis_H37Rv         DNTKFADEWVRCAAGTDTALAMAMGHVILSECYVRNQVPFFVDYVRRYTD
MAV_1303|M.avium_104                DNTKFADEWMPCAAGTDGALAMAMGHVILSECYVQKQVPFFTDYARRYTD
Mvan_4546|M.vanbaalenii_PYR-1       DNTKFADEWMPCAAGTDGALAMAMGHVILTENFVRRRVPFFVDYVRTYTD
Mflv_2156|M.gilvum_PYR-GCK          DNTKFADEWMPCAAGTDGALAMAMGHVILTENYVRQRVPFFDEYVRTYTD
TH_1885|M.thermoresistible__bu      DNTKFADEWMPCAAGTDGAMAMAMGHVILSEFFVRKQVPFFTDYVRRYTD
MSMEG_5140|M.smegmatis_MC2_155      DNTKFADEWMPCAAGTDGALAMAMGHVILSECFVQNEVPYFTDFARRFTD
MAB_3041|M.abscessus_ATCC_1997      ------------VIVENTDLLIAFGGIALKNTGVNHGG------TTAHPA
MUL_3154|M.ulcerans_Agy99           ---------FPEPDIERTGLLVIMDANPAASQGS---------LLAAPDV
MMAR_5195|M.marinum_M               ---------MGAQFIRAGSIIQLLLGNIGRPGGGIFALRGHASIQGSTDV
                                                       :   :                          

Mb1193|M.bovis_AF2122/97            LPFLIKLEKRGDLLVPGKFLTAADIG---EESENAAFKPALLDELTNTVV
Rv1161|M.tuberculosis_H37Rv         LPFLIKLEKRGDLLVPGKFLTAADIG---EESENAAFKPALLDELTNTVV
MAV_1303|M.avium_104                LPFLIKLEERGDMLVPGKNLTAADLG---EAVENAALKPALLDETTNSVA
Mvan_4546|M.vanbaalenii_PYR-1       LPFLVKLEERDGVLVPGKMLTAADLGPGYDGQENAAFKPVLLDGATDSVV
Mflv_2156|M.gilvum_PYR-GCK          LPFLVKLEERGGVTVPGKMLTAADLGPAYGG-ENAEFKPALLNLATDSVT
TH_1885|M.thermoresistible__bu      LPFLVKLEERDGALVPGKMLTVADLGEVFGQHENAAFKPMLLDEATDTVT
MSMEG_5140|M.smegmatis_MC2_155      LPFLAKLEERDGALVPGKNLTAADLTPDVAAQENAAFKPALLDSASDSIA
MAB_3041|M.abscessus_ATCC_1997      RDALNRFRDRGGRIVSFS--------------------------------
MUL_3154|M.ulcerans_Agy99           MGLIDAIRQRGKVIVIDPVR------------------------------
MMAR_5195|M.marinum_M               PTLFNLLPGYLDMPHAGQATLSDYLDN-----------------------
                                       :  :                                           

Mb1193|M.bovis_AF2122/97            VPQGSLGFRFGEDGVGKWNLDLGSVVPALSVEMDKAVNGDRSAELVTLPS
Rv1161|M.tuberculosis_H37Rv         VPQGSLGFRFGEDGVGKWNLDLGSVVPALSVEMDKAVNGDRSAELVTLPS
MAV_1303|M.avium_104                VPHGSLGFRYGESGVGKWNLDLGDLVPALSVRAAPTEDGE--TALVHLPS
Mvan_4546|M.vanbaalenii_PYR-1       VPPGSLGFRYGDEGVGKWNLDLGDVVPALTVAPPDG--QSGETTSISLTR
Mflv_2156|M.gilvum_PYR-GCK          VPPGSLGFRYGDEGVGRWNLDLGDVVPALTVATGDV--HDGGSAAVTLSR
TH_1885|M.thermoresistible__bu      VPHGSLGFRYGTDGAGKWNLDLGPVVPALTVRTGD-----GPVTEVRLPC
MSMEG_5140|M.smegmatis_MC2_155      IPQGSLGFRFGESGLGNWNLDLENLAPALTVAADT-----GETAEVTLPR
MAB_3041|M.abscessus_ATCC_1997      ------PLHDDIDGECEWHAPIPGTDVAVMLALAHV--------------
MUL_3154|M.ulcerans_Agy99           --------TVTAARADEWLPIVPGTDAALLLAVAHT--------------
MMAR_5195|M.marinum_M               --------IKSRNQKGFWHNADAYMVSLLKEYWGEH--------------
                                                     *          :                     

Mb1193|M.bovis_AF2122/97            FDTIDGHGETVSRGLPVRRAGKHLVCTVFDLMLAHYGVARAGLPGEWPTG
Rv1161|M.tuberculosis_H37Rv         FDTIDGHGETVSRGVPVRRAGKHLVCTVFDLMLAHYGVARAGLPGEWPTG
MAV_1303|M.avium_104                FDTVDGEGTTVARGVPVRRVGKHLVCTVFDLMLAQYGVARPGLPGEWPTG
Mvan_4546|M.vanbaalenii_PYR-1       FDTVDGRGATLQRGVPVRRVGEHRVCTVFDLMLAQYGVARPGLPGDWPAG
Mflv_2156|M.gilvum_PYR-GCK          FDTVDGHGATMLRGVPVRQVGAHRVCTVFDLMLAQYGVARPGLPGDWPTG
TH_1885|M.thermoresistible__bu      FDSVDGHGTTVTRGVPVRHVGDHRVCTVFDLMLAQYGVSRPGLPGDWPTG
MSMEG_5140|M.smegmatis_MC2_155      FDTLDGHGDTMVRGVPVRRVGEHLVCTVFDLMLAQYGVARPGLPGDWPTG
MAB_3041|M.abscessus_ATCC_1997      --------------LAVEKLADLTFLSSYCTGYERFERYLLGVDDGVPK-
MUL_3154|M.ulcerans_Agy99           ---------------------------LFDEDLVNPGQHVDGVD------
MMAR_5195|M.marinum_M               -----------------ATADNDYCFDYLPRINGDHSTYRTVMDMIDGKV
                                                                              :       

Mb1193|M.bovis_AF2122/97            YHDRTQQNTPAWQESITGVPAAQAIRFAKEFARNATESGGRSMIIMGGGI
Rv1161|M.tuberculosis_H37Rv         YHDRTQQNTPAWQESITGVPAAQAIRFAKEFARNATESGGRSMIIMGGGI
MAV_1303|M.avium_104                YDDATQQNTPAWQEAITGVSAAQATRVAREFARSAEESGGRSMIIMGGGI
Mvan_4546|M.vanbaalenii_PYR-1       YDDPDQPYTPAWQESITGVSASQAIRVAREFARNAEESGGRSMIIMGAGI
Mflv_2156|M.gilvum_PYR-GCK          YDDPRSPYTPAWQEPITGVSAGQAIRVAREFARNAEESGGRSMIIMGAGI
TH_1885|M.thermoresistible__bu      YDDATRPYTPAWQEPITGVSAAQVIRIATEFARNAEESGGRSMIIMGAGI
MSMEG_5140|M.smegmatis_MC2_155      FDDATRPYTPAWQEPITGVAAAQAIRVAREFARNAEETRGRSMIIMGAGI
MAB_3041|M.abscessus_ATCC_1997      --------SPEWAAPISGLDAAELRTLARRMAA------GRTLVTVSWSL
MUL_3154|M.ulcerans_Agy99           --------------------------TMRRVAGSSRDKTARKVFSLGR--
MMAR_5195|M.marinum_M               FGYFLLGQNPAVGSAHGRMQRLGMANLDWLVVRDLVMIESATFWKEAPEV
                                                                  ..       . ..   .   

Mb1193|M.bovis_AF2122/97            CHWFHSDVMYRSVLALLMLTGSMGRNGGGWAHYVGQEKVRPLTGWQTMAM
Rv1161|M.tuberculosis_H37Rv         CHWFHSDVMYRSVLALLMLTGSMGRNGGGWAHYVGQEKVRPLTGWQTMAM
MAV_1303|M.avium_104                CHWFHSDAIYRAVLALLMLTGSMGRNGGGWAHYVGQEKVRPLTGFQTMAM
Mvan_4546|M.vanbaalenii_PYR-1       CQWFHGDTTYRAVLAMLLLTGSMGRNGGGWAHYVGQEKCRPVTGWATMAM
Mflv_2156|M.gilvum_PYR-GCK          CQWFHGDTTYRAVLAMLLLTGSMGRNGGGWAHYVGQEKCRPVTGWATMGS
TH_1885|M.thermoresistible__bu      CQWFHGDATYRAVLALLLLTGSMGRNGGGWAHYVGQEKCRPVTGWATMAM
MSMEG_5140|M.smegmatis_MC2_155      CQWFHGDATYRAVLALLLLTGSMGRNGGGWAHYVGQEKCRPVTGWATMAM
MAB_3041|M.abscessus_ATCC_1997      QRVRHGEQAPWMGLTLAAMLGQIGLPGGGFGHGYG--------------S
MUL_3154|M.ulcerans_Agy99           ----RNRTPNWANTSSEAVAAHVAKPA-----------------------
MMAR_5195|M.marinum_M               ETGEISPQTCRTEVFFFPAASHVEKAG--------------------TFT
                                         .              . :   .                       

Mb1193|M.bovis_AF2122/97            ATDWSRPPRQVPGASYWYAHTDQWRYDGYGADKLASPVGRGRFAGKHTMD
Rv1161|M.tuberculosis_H37Rv         ATDWSRPPRQVPGASYWYAHTDQWRYDGYGADKLASPVGRGRFAGKHTMD
MAV_1303|M.avium_104                ATDWVRPPRQVPGASYWYAHTDQWRYDGYGADKLASPVGRGRFAGRHTMD
Mvan_4546|M.vanbaalenii_PYR-1       ATDWTRPPRQMPGTSYWYAHTGQWRYDGYRADALASPTARGRFAGKHTMD
Mflv_2156|M.gilvum_PYR-GCK          ALDWSRPPRQMPGTSYWYAHTDQWRYDGYRADTLASPTARGRFTGKHTMD
TH_1885|M.thermoresistible__bu      ATDWSRPPRQMPGTSYWYVHTDQWNYDGYRADALASPIGRGRFRGKHTMD
MSMEG_5140|M.smegmatis_MC2_155      ATDWSRPPRQMAGTSYWYAHTDQWRYDGYQADALSSPVGRGRFRGRHTMD
MAB_3041|M.abscessus_ATCC_1997      MNEPGLAPVSCPLPTFP--------------------------QGPNPVE
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               QTQRMLQWREKAVDPPGDARSELWFFYHLGRKLREKLSGSTDERDRPLLQ
                                                                                      

Mb1193|M.bovis_AF2122/97            LLTSATAMGWSPFYPQFDRSSLDVADEARAAGRDVGDYVAEQLAQHKLKL
Rv1161|M.tuberculosis_H37Rv         LLTSATAMGWSPFYPQFDRSSLDVADEARAAGRDVGDYVAEQLAQHKLKL
MAV_1303|M.avium_104                LLASAVAMGWSPYYPQFDRSSLDVADEARAAGRDVADYVAEQLGRRNLKL
Mvan_4546|M.vanbaalenii_PYR-1       VVAAAAAMGWMPFYPQFDRNSLDVADEARAAGQDIGKYVCEKLASGELKM
Mflv_2156|M.gilvum_PYR-GCK          VVAAAAAMGWMPFYPQFDRNSLDIADEALAAGRDIPQYLCEKLASGELKM
TH_1885|M.thermoresistible__bu      VLASATAMGWSPFYPQFDRSSLDIADEARAAGKEIGAYVCEQLASGGLKL
MSMEG_5140|M.smegmatis_MC2_155      VLASAAAMGWSPFFPQFDRSSLDVADEARAADQEIPAYVTAKLADGSLKL
MAB_3041|M.abscessus_ATCC_1997      TFIPVAAISELLLRPGQ-----------------TLAYNGQTLTLPDIRC
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               LAWDYATEGDEPSGEDVLRHMNGIDLGTGRTIDGYPSLKADGSTACGCWI
                                                                                      

Mb1193|M.bovis_AF2122/97            SITDPDNPVNWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNVQSDPPT
Rv1161|M.tuberculosis_H37Rv         SITDPDNPVNWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNVQSDPPT
MAV_1303|M.avium_104                AVTDPDNPVNWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNASAVPPE
Mvan_4546|M.vanbaalenii_PYR-1       AVTDPDNPANWPRVLNVWRANLLGSSSKGNEYFLRHLLGADSNLQATPTE
Mflv_2156|M.gilvum_PYR-GCK          AVTDPDNPANWPRVLNVWRANLLGSSSKGNEYFLRHLLGTDSNLQASPTP
TH_1885|M.thermoresistible__bu      AVTDPDDPRNWPRVLSVWRSNLLGSSSKGNEYFLRHLLGTDSNLRATRTP
MSMEG_5140|M.smegmatis_MC2_155      AVTDPDNPANWPRVLDVWRANLLGSSSKGNEYFLRHLLGTTSNLQAAPN-
MAB_3041|M.abscessus_ATCC_1997      VYWAGGNPFHHHQNLPRLRRALS---------------------------
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               YSGVYADEVNQAARRKPR--------------------------------
                                                                                      

Mb1193|M.bovis_AF2122/97            DGVHPRDVVWDSDIPEGKLDLIMSIDFRMTSTTLVSDVVLPAATWYEKSD
Rv1161|M.tuberculosis_H37Rv         DGVHPRDVVWDSDIPEGKLDLIMSIDFRMTSTTLVSDVVLPAATWYEKSD
MAV_1303|M.avium_104                DGVRPVDVTCGADIPEGKLDLMMSIDFRMTSTTLVSDVVLPAATWYEKAD
Mvan_4546|M.vanbaalenii_PYR-1       EALRPKDVTWPDDIPEGKLDLLMSVDFRMTSTTLLSDVVLPAATWYEKAD
Mflv_2156|M.gilvum_PYR-GCK          EALRPADVVWPDDIPEGKLDLLMSIDFRMTSTTLLSDVVLPAATWYEKAD
TH_1885|M.thermoresistible__bu      EALRPNDVRSPDEIPEGKLDLLMSIDFRMTSTTLLSDIVLPAATWYEKHD
MSMEG_5140|M.smegmatis_MC2_155      -GVRPSSVTCTDDIPEGKLDLLMSIDFRMTSTTLLSDVVLPAATWYEKAD
MAB_3041|M.abscessus_ATCC_1997      -----------------RVDTVVVHDPVWTAMAKHADIVVPSTTSLERDD
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               -------------------DEQRPYENEWGWTWPLNRRVLYNRASADPQG
                                                                                      

Mb1193|M.bovis_AF2122/97            LSSTDMHPYVHSFSPAIDPPWETRSDFGAFAAIARAFSALAKRHLGTRTD
Rv1161|M.tuberculosis_H37Rv         LSSTDMHPYVHSFSPAIDPPWETRSDFDAFAAIARAFSALAKRHLGTRTD
MAV_1303|M.avium_104                ISSTDMHPYVHAFSAATDPPWETRSDFDAFGAIARAFSTMAKEHLGTRTD
Mvan_4546|M.vanbaalenii_PYR-1       LSSTDMHPYVHAFSPAIDPPWETRSDFEAFGAIARTFSTLARSHLGTRTD
Mflv_2156|M.gilvum_PYR-GCK          LSSTDMHPYVHAFSPAIDPPWETRSDFDAFGAVASAFSALARTHLGTRTD
TH_1885|M.thermoresistible__bu      LSSTDMHPYVHAFSPAIDPPWETRSDYDAFGAIARAFSALARKHLGTRTD
MSMEG_5140|M.smegmatis_MC2_155      LSSTDMHPYVHAFSPAVDPPWETRSDFEAFGAIARAFSTLAARHLGVRTD
MAB_3041|M.abscessus_ATCC_1997      FSGSRNDPLLVAMKAVAPPYANSRDDYTTFSALADRLGFGEQFSEGRTAA
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               RPWSERKKLVWWDAELGEWTGHDVPDFEKHKAPDYRPPAGAVGVEALRGD
                                                                                      

Mb1193|M.bovis_AF2122/97            VVLTALQHDTPDEMAYPDGTERDWLATGEVPVPGRTMSKLTVVERDYTAI
Rv1161|M.tuberculosis_H37Rv         VVLTALQHDTPDEMAYPDGTERDWLATGEVPVPGRTMSKLTVVERDYTAI
MAV_1303|M.avium_104                VVLTALQHDTPDAMAYPDGAEHDWLRSGATPVPGRTMGKLTVVERDYAAV
Mvan_4546|M.vanbaalenii_PYR-1       VVLGALQHDTPGAMAYPAGTQRDWRETGETPVPGKTIGPITVVERDYAAI
Mflv_2156|M.gilvum_PYR-GCK          VVLGALQHDTPGAMAYPAGTQRDWRETGEVPVPGATIGPIAVVERDYTAI
TH_1885|M.thermoresistible__bu      VVLGALQHDTPGAMAYAGGTERDWRVTGEVPVPGKTIGPLAVVERDYTAI
MSMEG_5140|M.smegmatis_MC2_155      VVLGTLQHDTLGAMAYPSGTEHDWRVTGETPVPGRTMGPLAVVERDYGAI
MAB_3041|M.abscessus_ATCC_1997      QWLRHIYTEWAGALNFSVPSFDEFWDRGYLELP-----------------
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               DAF-VMQADGKGWLFAPSGLADGPLPTHYEPHESPVRNALYAQ-------
                                                                                      

Mb1193|M.bovis_AF2122/97            YDKWLTLGPLIDQFGMTTKGYTVHPFREVSELAANFGVMNSGVAVGRPAI
Rv1161|M.tuberculosis_H37Rv         YDKWLTLGPLIDQFGMTTKGYTVHPFREVSELAANFGVMNSGVAVGRPAI
MAV_1303|M.avium_104                YDKWRTLGPLVDKFGLTTKGVTVHPFREVEELAARFGVLKSGVAAGRPAI
Mvan_4546|M.vanbaalenii_PYR-1       ADKWSTLGPLVERLGVTTKGVTTWPVQETAELAQKFGVLDSGPAAGQPAI
Mflv_2156|M.gilvum_PYR-GCK          ADKWSTLGPLVEKLGLTTKGVTTHPDREADELARKFGVFDSGPAAGRPAI
TH_1885|M.thermoresistible__bu      ADKWAALGPLVEELGVTTKGVTTWPVQEVAELAKAFGVMDSGPAAGRPAI
MSMEG_5140|M.smegmatis_MC2_155      AQKWAALGPLVEGLGVTTKGLTTHPTREVAELGAKFGVMDSGAAQGRPAI
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               --------------------------------------------------
                                                                                      

Mb1193|M.bovis_AF2122/97            TTAKRMADVILALSGTCNGRLAVEGFLELEKRTGQRLAHLAEGSEERRIT
Rv1161|M.tuberculosis_H37Rv         TTAKRMADVILALSGTCNGRLAVEGFLELEKRTGQRLAHLAEGSEERRIT
MAV_1303|M.avium_104                TTAARMADVLLLLSGTTNGRLAVEGFHELEKRTGQRLVHLAEGSEDKRIS
Mvan_4546|M.vanbaalenii_PYR-1       TTAERMADVILALSGTSNGRLAVEGFRELERRTGRPLAHLAEGSEERRIT
Mflv_2156|M.gilvum_PYR-GCK          TTAERMADVILALSGTSNGRLAVEGFRELQRRTGTPLAHLAEGSEERRIT
TH_1885|M.thermoresistible__bu      TTAARMAEVILALSGTSNGRLAVEGFRELEKRTGQRLAQLAEGSEERRIT
MSMEG_5140|M.smegmatis_MC2_155      TTGERMADVILALSGTSNGRLAVEGFAELERRTGRKLVHLALGSEERRIT
MAB_3041|M.abscessus_ATCC_1997      ---------------TDAGLTLLSDFRE----------------------
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               ---------------QGNPTRIVFGRKD----------------------
                                                                                      

Mb1193|M.bovis_AF2122/97            YADTQARPVPVITSPEWSGSESGGRRYAPFTINIEHLKPFHTLTGRMHFY
Rv1161|M.tuberculosis_H37Rv         YADTQARPVPVITSPEWSGSESGGRRYAPFTINIEHLKPFHTLTGRMHFY
MAV_1303|M.avium_104                YADTQARPVPVVTSPEWSGSETGGRRYAPFTINIENLKPFHTLTGRMHFY
Mvan_4546|M.vanbaalenii_PYR-1       YADTQARPVPVITSPEWSGSETGGRRYAPFTVNIEALKPFHTLTGRMHFY
Mflv_2156|M.gilvum_PYR-GCK          YADTQARPVPVITSPEWSGSETGGRRYAPFTVNIEQLKPFHTLTGRMHFY
TH_1885|M.thermoresistible__bu      FADTQARPVPVITSPEWSGSETAGRRYAPFTVNIEHLKPFHTLTGRMHFY
MSMEG_5140|M.smegmatis_MC2_155      YADAQARPVPVITSPEWSGSETGGRRYAPFTVNIEELKPFHTLTGRMHFY
MAB_3041|M.abscessus_ATCC_1997      -------------NPAAHPLHTPSGRIEIFSETIDGFG-YSDCGGHPQWY
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               -------------NPSNPSPPEAHGEVFPFVFTAARLTEHHTAGG-----
                                                                                      

Mb1193|M.bovis_AF2122/97            LAHDWVEELGEQLPVYRPPLDMARLFNQPELG-----PTDDGLGLTVRYL
Rv1161|M.tuberculosis_H37Rv         LAHDWVEELGEQLPVYRPPLDMARLFNQPELG-----PTDDGLGLTVRYL
MAV_1303|M.avium_104                LAHDWVEELGEHLPVFRPPLDMARLFGQPRLG-----ACEDGIGLTVRYL
Mvan_4546|M.vanbaalenii_PYR-1       LDHDWLEELGEQLPVYRPPLDMARLFGEPAIG----ARG--ELGLTVRYL
Mflv_2156|M.gilvum_PYR-GCK          LDHDWLEELGEQLPVYRPPLDLGRLFGEPAIG----APGATGVGLTVRYL
TH_1885|M.thermoresistible__bu      LDHDWLEELGEQLPVYRPPLDMARLFGAQQIG----HSD--GVGLTVRYL
MSMEG_5140|M.smegmatis_MC2_155      VDHDWLEELGEQLPVYRPPLDMARLFGESRLGAGPGADGAGGVGLTVRYL
MAB_3041|M.abscessus_ATCC_1997      EPTEWLGGERAQR------FPLHLIANQPRTR------------------
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               --------MSRQLPYLTELQPALFMEVSPELAR-----------------
                                                                                      

Mb1193|M.bovis_AF2122/97            TPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKINVRDNDWVEAVN
Rv1161|M.tuberculosis_H37Rv         TPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKINVRDNDWVEAVN
MAV_1303|M.avium_104                TPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKIQVRDNDWVEAVN
Mvan_4546|M.vanbaalenii_PYR-1       TPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSPADAAKIQVRDNDWVEAVN
Mflv_2156|M.gilvum_PYR-GCK          TPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSPADAEKIEVRDNDWVEAVN
TH_1885|M.thermoresistible__bu      TPHSKWSIHSEYQDNLLMLSLSRGGPTMWMSPADAAKIGVADNDWVEAVN
MSMEG_5140|M.smegmatis_MC2_155      TPHSKWSIHSEYQDNLFMLSLSRGGPTMWMSPGDADKIAVRDNDWVEAVN
MAB_3041|M.abscessus_ATCC_1997      -LHSQLDFGGTSQG-----SKVRGREPLRIHPQDAATRGIADGDVVRVFN
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               -------MRGLTHMDWAHVITSRTAVDARVFVTDRMRPLRIEDHVVQQVW
                                                                                      

Mb1193|M.bovis_AF2122/97            ANGIYVCRAIVSHRMPEGVVFVYHVQERTVDTPRTETNGKRGGNHNALTR
Rv1161|M.tuberculosis_H37Rv         ANGIYVCRAIVSHRMPEGVVFVYHVQERTVDTPRTETNGKRGGNHNALTR
MAV_1303|M.avium_104                ANGIYVCRAIVSHRMPDGVVYVYHVQERTVDTPRTETNDKRGGNHNALTR
Mvan_4546|M.vanbaalenii_PYR-1       RNGVLVCRAIVSHRMPEGVVYVYHAQERTIDVPLTETTGRRGGIHNSLTR
Mflv_2156|M.gilvum_PYR-GCK          RNGVLVCRAIVSHRMPEGVVYVYHAQERTIDVPLTETTGRRGGIHNSLTR
TH_1885|M.thermoresistible__bu      PNGVLVCRAIVSHRMPEGVVYVYHVQERTIDVPIAETTGKRGGIHNSLTR
MSMEG_5140|M.smegmatis_MC2_155      RNGVLVCRAIVSHRMPDGVVYVYHAQERTIDVPLTETTGTRGGIHNSLTR
MAB_3041|M.abscessus_ATCC_1997      DRGACLAGAVLDEGLRRQVVQLSTGAWFDPIEPADPNSACAHGNPNVLTD
MUL_3154|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5195|M.marinum_M               MPYHWGYTGLVEGDVVNDLLGVVLDPNVFIQESKVATCDVQPGRRPRGPA
                                                                                      

Mb1193|M.bovis_AF2122/97            VRIKPSHLAGGYGQHAFAFNYLGPTGNQRDEVTVVRRRSQEVRY-
Rv1161|M.tuberculosis_H37Rv         VRIKPSHLAGGYGQHAFAFNYLGPTGNQRDEVTVVRRRSQEVRY-
MAV_1303|M.avium_104                VRIKPSHLAGGYAQHAFAFNYLGPTGNQRDEVTIVRRRSQEVVY-
Mvan_4546|M.vanbaalenii_PYR-1       LLVKPSHLAGGYAQTAFAFNYLGPTGNQRDEVTIVRRRSQEVVYQ
Mflv_2156|M.gilvum_PYR-GCK          LLVKPSHLAGGYAQTAFAFNYLGPTGNQRDEVTVVRRRSQEVVY-
TH_1885|M.thermoresistible__bu      LLIKPSHLAGGYAQNAFAFNYLGPTGNQRDEVTVVRRRSQRVVF-
MSMEG_5140|M.smegmatis_MC2_155      LLIKPSHLAGGYAQHSYAFNYLGPTGNQRDEVTVVRRRSQEVTYR
MAB_3041|M.abscessus_ATCC_1997      DSGTSSLAQGCTGQHVLVQIERFEGTPPPVRAHTPPRFVARD---
MUL_3154|M.ulcerans_Agy99           ---------------------------------------------
MMAR_5195|M.marinum_M               LLDYIAEYRRRAGITTETGTHLDTTRDDGIAHPDPEESP------