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GESPSITGVAVKFPPNRYTQSEAIRALTDIAGPEFRRFAHSSGVEFRNTALRLPRYRELSGFSEANDAYL EVALDLGEQALVAALDRAKVKPSEVDIVFSTTVTGLAVPTLEARLATRVGLRPDVKRVPLFGLGCVAGAA GVARMHDYLRAFPDQTAALLAVELCSLTIQRHDTSIANLVATSLFGDGAAAVITEGARRAGAEHTGPRIL ATRSRIYPDTEEVMGWKIGGDGFRIVLSADVANIAEKYLGEDVRDFLADHGLAPRDVTTWVCHPGGPRVI EAVESVLDLPADALDHTRNSLRENGNLSSVSVLDVLAANLADPPAPGSIGLMIAMGPAFCSELVLLAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1280 | - | - | 100% (349) | transferase |
| M. avium 104 | MAV_3110 | - | 7e-93 | 52.71% (351) | Pks10 protein |
| M. avium 104 | MAV_3105 | - | 4e-91 | 49.86% (353) | Pks11 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1688 | pks10 | 3e-96 | 53.28% (351) | chalcone synthase |
| M. gilvum PYR-GCK | Mflv_5140 | - | 5e-97 | 52.15% (349) | chalcone/stilbene synthase domain-containing protein |
| M. tuberculosis H37Rv | Rv1660 | pks10 | 3e-96 | 53.28% (351) | chalcone synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1141c | - | 2e-06 | 24.40% (291) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. marinum M | MMAR_4313 | - | 1e-157 | 80.52% (349) | chalcone synthase |
| M. smegmatis MC2 155 | MSMEG_0808 | - | 5e-97 | 54.02% (348) | chalcone synthase Pks10 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1656 | pks11 | 2e-94 | 50.14% (347) | chalcone synthase, Pks11 |
| M. vanbaalenii PYR-1 | Mvan_1196 | - | 6e-96 | 52.99% (351) | chalcone/stilbene synthase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1280|M.avium_104 -------MGESPSITGVAVKFPPNRYTQSEAIRALTDIAG-----PEFRR
MMAR_4313|M.marinum_M -------------MAGVAVKFPPNRYQQAEAIGALTEFAG-----PEFRR
Mb1688|M.bovis_AF2122/97 ----------MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQ
Rv1660|M.tuberculosis_H37Rv ----------MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQ
MUL_1656|M.ulcerans_Agy99 ----------MSVIAGVFGALPPHRYSQSEITESFLEFPGLQEHEEIVRR
Mflv_5140|M.gilvum_PYR-GCK ---MTDVHTPVSVIAGVQGALPPHRYSQAEVTDAFLAAPAFAEVGDLLRS
Mvan_1196|M.vanbaalenii_PYR-1 ------MNDRISVIAGVQGALPPYRYSQAEITERFVAVPAFAELEDVVRG
MSMEG_0808|M.smegmatis_MC2_155 MENTAFTPSGTCTIAGVHGVLPPHRYTQAEVTEALLDLPGYADFEGIVRS
MAB_1141c|M.abscessus_ATCC_199 ----------MTDIAEITGINKIGLLSLGAYRP-----------ERVVTN
:: : .
MAV_1280|M.avium_104 FAHSSGVEFRNTALRLPRYRELSGFSEANDAYLEVALDLGEQALVAALDR
MMAR_4313|M.marinum_M FALSSGVEARHTALPLERYAELSGFTEANDAFVDVALDLGEQALRAALDE
Mb1688|M.bovis_AF2122/97 LHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDE
Rv1660|M.tuberculosis_H37Rv LHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDE
MUL_1656|M.ulcerans_Agy99 MHAAAKVNSRQFVLPIEQYPALTDFGDTNEIFIEKAVDLGIEALMGALDE
Mflv_5140|M.gilvum_PYR-GCK LHTNAKVDARHLVLPLEQYPDLLDFGDANDLYIHHAVELGCQALTAALDE
Mvan_1196|M.vanbaalenii_PYR-1 LHKHAKVDARHFVLPMDRYPTLVDFGETNDLYLEHSLDLACEALTAALDE
MSMEG_0808|M.smegmatis_MC2_155 LHKSAKVNSRYLTLPLEEYAALDDFGETNGLFIEHATELGCAALTGALDE
MAB_1141c|M.abscessus_ATCC_199 DEICERIESSDEWIYTRTGIKTRRFAADEETAQTLAIEAGRKAIANALLT
:: : * : : : . *: **
MAV_1280|M.avium_104 AKVKPSEVDIVFSTTVTGLAVPTLEARLATRVGLRPDVKRVPLFGL--GC
MMAR_4313|M.marinum_M AKVRPSEVDVIFSTTVTGLAVPTLEARLAHRVGLREDVKRIPLFGL--GC
Mb1688|M.bovis_AF2122/97 SGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGL--GC
Rv1660|M.tuberculosis_H37Rv SGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGL--GC
MUL_1656|M.ulcerans_Agy99 AGLTPQDIDLIITTTVTGVAVPSLDARIAGRLGLRPDVRRMPLFGL--GC
Mflv_5140|M.gilvum_PYR-GCK AGLAPSDLDVIMSTTVTGIAVPSLDARIAAKLGLRPDVRRVPLFGL--GC
Mvan_1196|M.vanbaalenii_PYR-1 AGLGPRDLDMIMTTTVTGIAVPSLDARIADRLGLRPDVRRVPLFGL--GC
MSMEG_0808|M.smegmatis_MC2_155 AGLRPEDVDLIITTTVTGAVVPSLDARIAGRVGLRPDVRRVPIFGL--GC
MAB_1141c|M.abscessus_ATCC_199 G---AEIDAVIVATSTHYLQTPASAPAVATALGAQG----VPAFDLSAGC
. . ::.:::. .*: . :* :* : :* *.* **
MAV_1280|M.avium_104 VAGAAGVARMHDYLRAFPDQTAALLAVELCSLTIQRHDTSIANLVATSLF
MMAR_4313|M.marinum_M VAGAAGVARMHDYLRGFPDQVGALLAVELCSLTIQRHDNSVANLVASSLF
Mb1688|M.bovis_AF2122/97 VAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALF
Rv1660|M.tuberculosis_H37Rv VAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALF
MUL_1656|M.ulcerans_Agy99 VAGAAGVARLHDYLRGAPDGVAVLIAVELCSLTYPAVKPTVSGIVGTALF
Mflv_5140|M.gilvum_PYR-GCK VAGAAGIARMHDYLRGAPGHVAALISVELCSLTRPALAPTIGSLVGSALF
Mvan_1196|M.vanbaalenii_PYR-1 VAGAAGIARMHDYLRGAPDHIAALVSVELCSLTYPAVEPTMASLVGSALF
MSMEG_0808|M.smegmatis_MC2_155 VAGAAGVARLNDYLRGAPDKVAVLVSVELCSLTH-KHTPSMPTLVAGALF
MAB_1141c|M.abscessus_ATCC_199 AGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTDRGN-----CFIF
.. . .:. * :*. . ::. * * : :*
MAV_1280|M.avium_104 GDGAAAVITEGARR---AGAEHT---GPRILATRSRIYPDTEEVMGWKIG
MMAR_4313|M.marinum_M GDAAAAVVTKGAHRVRGAGAASNGYAGPRVLATRSRIYPNTENVMGWKIG
Mb1688|M.bovis_AF2122/97 ADGAAAVVAAGVKR-----AQDIGADGPDILDSRSHLYPDSLRTMGYDVG
Rv1660|M.tuberculosis_H37Rv ADGAAAVVAAGVKR-----AQDIGADGPDILDSRSHLYPDSLRTMGYDVG
MUL_1656|M.ulcerans_Agy99 GDGAAAVVAVGDRR-----AEQIRAGGPDILDSRSRLYPESLDIMGWDVG
Mflv_5140|M.gilvum_PYR-GCK GDGAAAVVAVGEER-----AGHIRASGPDVLDSRSRMYPDSLDIMGWSVN
Mvan_1196|M.vanbaalenii_PYR-1 GDGAAAVIAVGAER-----AETIGATGPEVLDTRSRMYPDSLDTMGWRVG
MSMEG_0808|M.smegmatis_MC2_155 GDGASAVVAVGAGR-----AEQLDPIGPDVLDSRSHLYPDSLHAMGWDIG
MAB_1141c|M.abscessus_ATCC_199 GDGAGAVVVGETAEQG-IGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEG
.*.*.**:. . . *. *. : .
MAV_1280|M.avium_104 GDGFRIVLSADVANIAEKYLGEDVRDFLADHGLAPRDVTTWVCHPGGPRV
MMAR_4313|M.marinum_M TSGFQIVLSVDVATVTEKYLGEDVRSFLADHGLTPEDVTTWVCHPGGPRV
Mb1688|M.bovis_AF2122/97 SAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKI
Rv1660|M.tuberculosis_H37Rv SAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKI
MUL_1656|M.ulcerans_Agy99 SHGLQLRLAPELTNLIEEYLPDDVDAFLAMHDLTKNDIGAWVSHPGGPKV
Mflv_5140|M.gilvum_PYR-GCK HNGFQLVLSPELPALIERYLPDDMASFLGEHDLGIGDIATWVSHPGGPKV
Mvan_1196|M.vanbaalenii_PYR-1 ASGFQLILSPNLPELIERYLADDMAGFLGAHDLQIGDIAAWVSHPGGPKV
MSMEG_0808|M.smegmatis_MC2_155 TKGFEIVLSAEVPGFVGRYLGDDVTEFLGEHGVATDDVSAWVSHPGGPKV
MAB_1141c|M.abscessus_ATCC_199 PRPYLRIEGTSVFRWAAFEMGKVGQRAMEAAKVGPEQIDVFVPHQANTRI
. .: : . : : :: .:* * ...::
MAV_1280|M.avium_104 IEAVESVLDLPADALDHTRNSLRENGNLSSVSVLDVLAANLAD-PPAPGS
MMAR_4313|M.marinum_M IEAVETVLGLPEDALAHTRNSLRNNGNLSSVSILDVLRANLAD-PPPAGS
Mb1688|M.bovis_AF2122/97 INAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAK-PPPSGS
Rv1660|M.tuberculosis_H37Rv INAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAK-PPPSGS
MUL_1656|M.ulcerans_Agy99 LDAIANSLGLPSDALELTWRSLGEIGNLSSASVLRILRDTIAK-VPPSGS
Mflv_5140|M.gilvum_PYR-GCK LEAIASALDLPDDALELSWRSLAEIGNLSSSSVLHILRDTIAK-KPPAAT
Mvan_1196|M.vanbaalenii_PYR-1 MEAISETLGLPDDALDLAWRSLAEVGNLSSSSVLHVLRDTRAK-KPPAGT
MSMEG_0808|M.smegmatis_MC2_155 IEAIIETLDLPSDALDLTWQSLAEVGNLSSSSVLHVLRDTIRK-RPPAGT
MAB_1141c|M.abscessus_ATCC_199 NELLAKNLHLRADAVIAN--DIEHTGNTSAASVPLAMETLLSTGAAKPGD
: : * * :*: .: . ** *: *: : . ..
MAV_1280|M.avium_104 IGLMIAMGPAFCSELVLLAF------
MMAR_4313|M.marinum_M IGLMIAMGPAFCSELVLLTW------
Mb1688|M.bovis_AF2122/97 PGLMIAMGPGFCSELVLLRWH-----
Rv1660|M.tuberculosis_H37Rv PGLMIAMGPGFCSELVLLRWH-----
MUL_1656|M.ulcerans_Agy99 PGLMLAMGPGFCAELVLLRWH-----
Mflv_5140|M.gilvum_PYR-GCK PGLLMAMGPGFCSELVLLRWH-----
Mvan_1196|M.vanbaalenii_PYR-1 PGLLMAMGPGFCSELVLLRWR-----
MSMEG_0808|M.smegmatis_MC2_155 PGVLMAMGPGFCSELVLLRWR-----
MAB_1141c|M.abscessus_ATCC_199 LALLIGYGAGLSYAAQVVRMPPVPFE
.:::. *..:. ::