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RLGRIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPNFTGRSWPLADVRLLAPILASKVVCVGKNYA DHIAEMGEATGPVPADPVIFLKPNTAIIGPNVPIRLPANASPVHFEGELAVVIGRPCKDVSAAQAAENIL GYTIGNDVSARDQQRSDGQWTRAKGHDTFCPVGPWIVTDLNPLDPGDLELRTEVNGEVKQRSRTSLLIHD IGSIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSITIEGIGTLTNPVVRKGKS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3844 | - | - | 100% (268) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. avium 104 | MAV_1057 | - | 1e-22 | 33.73% (249) | fumarylacetoacetate hydrolase family protein, putative |
| M. avium 104 | MAV_1803 | - | 3e-22 | 35.11% (225) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 1e-125 | 90.04% (241) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 1e-126 | 80.97% (268) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 1e-125 | 90.04% (241) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 1e-122 | 85.54% (242) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3299c | - | 1e-123 | 80.15% (267) | hypothetical protein MAB_3299c |
| M. marinum M | MMAR_1718 | - | 1e-142 | 91.04% (268) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. smegmatis MC2 155 | MSMEG_2382 | - | 1e-125 | 82.77% (267) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. thermoresistible (build 8) | TH_2040 | - | 1e-122 | 80.15% (267) | POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD |
| M. ulcerans Agy99 | MUL_1956 | - | 1e-125 | 89.26% (242) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 1e-126 | 81.72% (268) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4230|M.gilvum_PYR-GCK MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPTFTGRQWPLA
Mvan_2132|M.vanbaalenii_PYR-1 MRLGRIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPTFTGRQWPLA
MMAR_1718|M.marinum_M MRLGRIASPDGVAFASIEGELDNPGAMTAREIAEHPFGTPNFTGRSWPLA
MUL_1956|M.ulcerans_Agy99 --------------------------MTAREIAEDPFGTPNFTGRSWPLA
Mb3017c|M.bovis_AF2122/97 --------------------------MTAREIAEHPFGTPTFTGRSWPLA
Rv2993c|M.tuberculosis_H37Rv --------------------------MTAREIAEHPFGTPTFTGRSWPLA
MLBr_01689|M.leprae_Br4923 --------------------------MFARELAEYPFGELTFTGRSWPLA
MAV_3844|M.avium_104 MRLGRIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPNFTGRSWPLA
MAB_3299c|M.abscessus_ATCC_199 MRLGRIASPDGVAFVSIEGEDGREESAIAREIAEHPFGTPTFTGRQWPLA
MSMEG_2382|M.smegmatis_MC2_155 MRLGRIASPDGVAFVSIEG-DGPD--AVCKEIAEHPFGNPNFTGRSWPLA
TH_2040|M.thermoresistible__bu MRLGRIASPDGVAFVSIEG-PPDEPTAVAREIAEHPFGTPEFTGRQWSLA
.:*:** *** ****.*.**
Mflv_4230|M.gilvum_PYR-GCK DVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FEDPIIFLKPNTAIIG
Mvan_2132|M.vanbaalenii_PYR-1 DVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FEDPIIFLKPNTAIIG
MMAR_1718|M.marinum_M DVRLLAPILASKVVCVGKNYTDHIAEMGGQTGPTPADPVIFLKPNTAIVG
MUL_1956|M.ulcerans_Agy99 DVRLLAPILASKVVCVGKNYTGHIAEMGGQTGPTPADPVIFLKSNTAIVG
Mb3017c|M.bovis_AF2122/97 DVRLLAPILASKVVCVGKNYADHIAEMGGRP---PADPVIFLKPNTAIIG
Rv2993c|M.tuberculosis_H37Rv DVRLLAPILASKVVCVGKNYADHIAEMGGRP---PADPVIFLKPNTAIIG
MLBr_01689|M.leprae_Br4923 DVRLLAPMLASKVVCIGKNYADHIVEMGGQTGLASADPVIFLKPNTAIIG
MAV_3844|M.avium_104 DVRLLAPILASKVVCVGKNYADHIAEMGEATGPVPADPVIFLKPNTAIIG
MAB_3299c|M.abscessus_ATCC_199 DVRLLAPILASKVVAMGKNYAAHAAEMGGDP---PESPVIFIKPNTSIIG
MSMEG_2382|M.smegmatis_MC2_155 DVRLLAPILASKVIAVGKNYAAHAEEMGGVA---PEDPVIFLKPNTAIIG
TH_2040|M.thermoresistible__bu DVRLLAPILASKVVCMGKNYAAHVDEMGGET---VPHPVIFIKPNTSIIG
*******:*****:.:****: * *** . *:**:*.**:*:*
Mflv_4230|M.gilvum_PYR-GCK PYTPIQLPADADPVHFEGELAAVIGRPCKDVPASRAAENILGYTIANDVS
Mvan_2132|M.vanbaalenii_PYR-1 PNTPIQLPADANPVHFEGELAAVIGRPCKDVPASRAAENILGYTIANDVS
MMAR_1718|M.marinum_M PNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNILGYTIGNDVS
MUL_1956|M.ulcerans_Agy99 PNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNILGYTIGNDVS
Mb3017c|M.bovis_AF2122/97 PNTPIRLPANASPVHFEGELAIVIGRACKDVPAAQAVDNILGYTIGNDVS
Rv2993c|M.tuberculosis_H37Rv PNTPIRLPANASPVHFEGELAIVIGRACKDVPAAQAVDNILGYTIGNDVS
MLBr_01689|M.leprae_Br4923 PNVPIRLPANASPVHFEGELALVVGRSCKDVPAVQAVDCILGYTIGNDMS
MAV_3844|M.avium_104 PNVPIRLPANASPVHFEGELAVVIGRPCKDVSAAQAAENILGYTIGNDVS
MAB_3299c|M.abscessus_ATCC_199 PGLPIQLPPSATEVHHEGELAIVIGRPCKDVPAARAAENILGYTIGNDVS
MSMEG_2382|M.smegmatis_MC2_155 PNVPIQLPADADPVHHEGELAIVIGRPCKDVPAARAAEFILGYTIGNDVS
TH_2040|M.thermoresistible__bu PNVPIQLPVDADPVHHEGELAVVIGRPCKDVPAARAADVILGYTVANDVT
* **:** .* **.***** *:**.****.* :*.: *****:.**::
Mflv_4230|M.gilvum_PYR-GCK ARDQQKKDGQWMRAKGHDTFCPVGPWIVTDI---DPSDLEIRTEVNGELK
Mvan_2132|M.vanbaalenii_PYR-1 ARDQQQKDGQWMRAKGHDTFCPVGPWIVTDL---DPSDLEIRTEVNGDVK
MMAR_1718|M.marinum_M ARDQQKSDGQWTRAKGHDTFCPVGPWIVTDV---DPADLELRTEVNGAVK
MUL_1956|M.ulcerans_Agy99 ARDQQKSDGQWTRAKGHDTFCPVGPWIVTDV---DPAGLELRTEVNGAVK
Mb3017c|M.bovis_AF2122/97 ARDQQQSDGQWTRAKGHDTFCPVGPWIVTDLAPFDPADLELRTVVNGDVK
Rv2993c|M.tuberculosis_H37Rv ARDQQQSDGQWTRAKGHDTFCPVGPWIVTDLAPFDPADLELRTVVNGDVK
MLBr_01689|M.leprae_Br4923 ARDQQRADGQWTRAKGHDTFCPVGPWIVTDLGPLDPADLELRTAVNGEVK
MAV_3844|M.avium_104 ARDQQRSDGQWTRAKGHDTFCPVGPWIVTDLNPLDPGDLELRTEVNGEVK
MAB_3299c|M.abscessus_ATCC_199 ARDHQRADGQWTRAKGHDTFCPLGPWIVTDL---DPADLEIRTEVNGQVR
MSMEG_2382|M.smegmatis_MC2_155 ARDQQRKDGQWMRAKGHDTFCPLGPWIVTDL---DPSDVELRTEVNGQVR
TH_2040|M.thermoresistible__bu ARNQQRADGQWTRAKGHDTFCPVGPWIVTDV---DPTDLELRTEVNGEVR
**::*: **** **********:*******: ** .:*:** *** ::
Mflv_4230|M.gilvum_PYR-GCK QHSRTSLMIHDIGAIIEWISSVMTLLPGDLILTGTPEGVGPLEHGDTVSI
Mvan_2132|M.vanbaalenii_PYR-1 QRSRTSLMIHDIGAIIEWISAVMTLLPGDLILTGTPEGVGPLEHGDSVSI
MMAR_1718|M.marinum_M QHARTSLMIHDVGAIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSI
MUL_1956|M.ulcerans_Agy99 QHARTSLMIHDVGAIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSI
Mb3017c|M.bovis_AF2122/97 QHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPAGVGPIEDGDTVSI
Rv2993c|M.tuberculosis_H37Rv QHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPAGVGPIEDGDTVSI
MLBr_01689|M.leprae_Br4923 QHSRTSLMIHGIGAIMEWISAVMTLLPGDLILTGTPAGVGPVEDGDIVSI
MAV_3844|M.avium_104 QRSRTSLLIHDIGSIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSI
MAB_3299c|M.abscessus_ATCC_199 QRSRTSLLLHDVGAIVEWVSAVMTLLPGDVILTGTPEGVGPIVDGDTVSV
MSMEG_2382|M.smegmatis_MC2_155 QRSRTSLLLHDIGRLVEWTSAVMTLLPGDVILTGTPEGVGPIEDGDTVSI
TH_2040|M.thermoresistible__bu QRSRTSLMIHDIGAIIEWVSRVMTLLPGDLILTGTPEGVGPIEHGDTVAV
*::****::*.:* ::** * :*******:****** ****: .** *::
Mflv_4230|M.gilvum_PYR-GCK TVEGIGTLSNPVVRKGKS
Mvan_2132|M.vanbaalenii_PYR-1 TVEGIGTLTNPVVRKGRS
MMAR_1718|M.marinum_M TIEGIGTLTNPVVRKGKS
MUL_1956|M.ulcerans_Agy99 TIEGIDTLTNPVVRKGKS
Mb3017c|M.bovis_AF2122/97 TIEGIGTLTNPVVRKGKP
Rv2993c|M.tuberculosis_H37Rv TIEGIGTLTNPVVRKGKP
MLBr_01689|M.leprae_Br4923 TVEGIGTLTNPVVRKGKS
MAV_3844|M.avium_104 TIEGIGTLTNPVVRKGKS
MAB_3299c|M.abscessus_ATCC_199 TIEGIGTLSNPVVRKAK-
MSMEG_2382|M.smegmatis_MC2_155 TVEGIGTLTNPVVRKGKK
TH_2040|M.thermoresistible__bu TIENIGTLTNPVVRKGKK
*:*.*.**:******.: