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VTVSWLRGSGLVGAVLVAATAVAKTAGAAPPPALPAPPPSPGIGVDHENGRCTAGFAAQGSDGSYYLMTS GHCDAHDGAEWTYGNDAPLGRISASEHEGDKRDAAIIRLEPSVGMPVGDVGGRYQVRDVLSRPQIQVGMP FCKIGAVTGETCGAIKGVDGDVVEASVFSLDGDSGSPGFVMNPDGSVSAVGLLMSSPDGDDYTTYFMLVN PLLDRWGLRILP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0678 | - | - | 100% (222) | hypothetical protein MAV_0678 |
| M. avium 104 | MAV_3280 | - | 3e-17 | 30.49% (246) | hypothetical protein MAV_3280 |
| M. avium 104 | MAV_0279 | - | 2e-10 | 29.00% (200) | trypsin domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1845 | - | 7e-08 | 26.94% (193) | hypothetical protein Mb1845 |
| M. gilvum PYR-GCK | Mflv_0488 | - | 3e-17 | 31.51% (219) | hypothetical protein Mflv_0488 |
| M. tuberculosis H37Rv | Rv1815 | - | 7e-08 | 26.80% (194) | hypothetical protein Rv1815 |
| M. leprae Br4923 | MLBr_02242 | - | 6e-65 | 55.66% (221) | hypothetical protein MLBr_02242 |
| M. abscessus ATCC 19977 | MAB_3347 | - | 4e-10 | 26.87% (201) | hypothetical protein MAB_3347 |
| M. marinum M | MMAR_2300 | - | 2e-14 | 27.04% (233) | hypothetical protein MMAR_2300 |
| M. smegmatis MC2 155 | MSMEG_6359 | - | 9e-23 | 35.42% (192) | trypsin domain-containing protein |
| M. thermoresistible (build 8) | TH_2227 | - | 1e-13 | 29.53% (193) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1503 | - | 3e-15 | 27.90% (233) | hypothetical protein MUL_1503 |
| M. vanbaalenii PYR-1 | Mvan_3169 | - | 1e-14 | 30.73% (192) | hypothetical protein Mvan_3169 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0678|M.avium_104 --------------------------------------------------
MLBr_02242|M.leprae_Br4923 --------------------------------------------------
MMAR_2300|M.marinum_M MVGVSAHALANLDSPSSLARTALLLAGALLCLSVAAWPVLSQRRRQHPET
MUL_1503|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0488|M.gilvum_PYR-GCK --------------------------------------------------
Mb1845|M.bovis_AF2122/97 --------------------------------------------------
Rv1815|M.tuberculosis_H37Rv --------------------------------------------------
TH_2227|M.thermoresistible__bu --------------------------------------------------
Mvan_3169|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3347|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6359|M.smegmatis_MC2_155 -------------------------------------------------M
MAV_0678|M.avium_104 --------------------------MTVSWLRGSGLVGAVLVAATAVAK
MLBr_02242|M.leprae_Br4923 -------------------------MRSIYWFTGETCATVRWLRGLGLAS
MMAR_2300|M.marinum_M QEQLFAGTNVPYAAPPQRRQSDGGRLTIAALICAAGFVAAIWLPSKSTMP
MUL_1503|M.ulcerans_Agy99 ---MFAGTNVPYAAPPQRRQSDGGRLTIAALICAAGFVAAVWLPSKSTMP
Mflv_0488|M.gilvum_PYR-GCK --------------------------MMRNLLKTVGGTAAAALAALTFTQ
Mb1845|M.bovis_AF2122/97 ------------------------------------MVRLVPRAFAATVA
Rv1815|M.tuberculosis_H37Rv ------------------------------------MVRLVPRAFAATVA
TH_2227|M.thermoresistible__bu ---------------------------------------------MVLAP
Mvan_3169|M.vanbaalenii_PYR-1 -------------------------------MSGRSSSRVLHLLFAVLAP
MAB_3347|M.abscessus_ATCC_1997 ------------------------------MFGIAGRFPLAAAPAAVLVA
MSMEG_6359|M.smegmatis_MC2_155 TGGVYAPVPPGVPAPTPTPVKPRRRILRRLLITSLGLATVLAVAFVAFVF
MAV_0678|M.avium_104 TAGAAP----PPALPAPPPSP-----------GIGVDHEN-----GRCTA
MLBr_02242|M.leprae_Br4923 AAVIAPKVFASMVLAEYAPSP-----------GLRLCDES-----SICTA
MMAR_2300|M.marinum_M ARPLVALPGASAIAPGTGIAV-----------TYADGSGG-----MGCTA
MUL_1503|M.ulcerans_Agy99 ARPLVALPGASAIAPGTGIAV-----------TYADGSGG-----MGCTA
Mflv_0488|M.gilvum_PYR-GCK APVAHAFGEYPVASPGAHLVS-----------TTLAGNGLP----YQCTA
Mb1845|M.bovis_AF2122/97 LLAAGFSPATASADP-VLVFP-----------GMEIRQDN-----HVCTL
Rv1815|M.tuberculosis_H37Rv LLAAGFSPATASADP-VLVFP-----------GMEIRQDN-----HVCTL
TH_2227|M.thermoresistible__bu LAALTLASAPAHSSPGVVVHP-----------GMEIHQDT-----NSCTL
Mvan_3169|M.vanbaalenii_PYR-1 VLALALQTVPAQAQPGVLVFP-----------GMEIHQDT-----VLCTL
MAB_3347|M.abscessus_ATCC_1997 AALIWTVPTAIAHADAPLVYP-----------GMRINQGT-----QSCTL
MSMEG_6359|M.smegmatis_MC2_155 WPNPTVPADQPNMTQVMTGTDNDWLSFDDFVPGTAIAADGSDNDEYECTL
**
MAV_0678|M.avium_104 GFAAQGSDGSYYLMTSGHCDAHDGAEWTYGNDAPLGR-------ISASEH
MLBr_02242|M.leprae_Br4923 ACVARGNDGSSYLLTIGHCDAYDGSVWPYGPDVPLGK-------RTVSEN
MMAR_2300|M.marinum_M GFLVRTNAGRTGILTAGHCNK-EGEASKVSINYSAGG-------GYVNIG
MUL_1503|M.ulcerans_Agy99 GFLVRTNAGRTGILTAGHCNK-EGEASKVSINYSTGG-------GYVNIG
Mflv_0488|M.gilvum_PYR-GCK GFTVRTPGGSPGMLTAGHCDR-DPLNDTVLQRTPTGD-------RVVGRY
Mb1845|M.bovis_AF2122/97 GYVDP---ALKIAFTAGHCRGG--GAVTSRDYKVIGH-------LRAFRD
Rv1815|M.tuberculosis_H37Rv GYVDP---ALKIAFTAGHCRGG--GAVTSRDYKVIGH-------LRAIRD
TH_2227|M.thermoresistible__bu GFIDA---VRRIAYTAGHCRGS--GTVTDRAGRFIGT-------QLMFRD
Mvan_3169|M.vanbaalenii_PYR-1 GYVDP---QTRIGYTAGHCRAS--GTVSDKFGTMIGT-------QGTFRD
MAB_3347|M.abscessus_ATCC_1997 GFVDP---GARIGLTAGHCALDSDGPVYDDSGNRVGT-------ADIAHF
MSMEG_6359|M.smegmatis_MC2_155 GFLGRDSSGTPIGFTAGHCDRPGDDSPHFTRKADEDTPVELGRFTTVQTA
. * *** .
MAV_0678|M.avium_104 EGDK----------RDAAIIRLEPSVGMPVGDVGGRYQVRDV----LSRP
MLBr_02242|M.leprae_Br4923 EGDR----------KDAAIILLDLSQGYSSGDVYS-QLLRNV----LSEN
MMAR_2300|M.marinum_M TFSQSVSEGLNGEAHDIGLITLDSGKIPQSPAIKAAVPVTGI----ATD-
MUL_1503|M.ulcerans_Agy99 TFSQSVSEGLNGEAHDIGLITLDSGKIPQSPAIKAAVPVTGI----ATD-
Mflv_0488|M.gilvum_PYR-GCK VRWEVLPG-----VRDVGLVDLAGSSVPLVDQVDGMRVSRVM----SGDD
Mb1845|M.bovis_AF2122/97 NTPSGSTVATHELIADYEAIVLADDVTAS--NILPSGRALES----RPGV
Rv1815|M.tuberculosis_H37Rv NTPSGSTVATHELIADYEAIVLADDVTAS--NILPSGRALES----RPGV
TH_2227|M.thermoresistible__bu NTPNGSTVATDHQIADWQTIQLAGDVVMN--NVLPTGRVLVE----DPTV
Mvan_3169|M.vanbaalenii_PYR-1 NTPDGMTVDTNHQIIDWEVIHLAPHVAVN--NVLPGGKVLVT----DPAV
MAB_3347|M.abscessus_ATCC_1997 EPTPQDKSFAEQPPIDYEGIAFYEGIPIN--NVLPNGLVLES----NPKI
MSMEG_6359|M.smegmatis_MC2_155 DMPDKVVKTGPDGWSDFAVIEIDPSLTDSAEDNARIAGVYRVTKVLDYEY
* : :
MAV_0678|M.avium_104 QIQVGMPFCKIGAVTG-ETCGAIKGVDG--DVVEASVFSLDGDSGSPGFV
MLBr_02242|M.leprae_Br4923 EIQLGMLFCKVGAITG-ETCGTIKSMDG--DVVEASVYSLSAGSGSPGFV
MMAR_2300|M.marinum_M -LKVGQLLCKFGMKTGRAECGQVTDISA--SKVAFLAASECGDSGGPVYR
MUL_1503|M.ulcerans_Agy99 -LKVGQLLCKFGMKTGRAECGQVTDISA--SKVAFLAASECGDSGGPVYR
Mflv_0488|M.gilvum_PYR-GCK VRREQPELCKSGARTG-LSCGPVTSVTD--NQVSFRAWDDLGDSGAPVYA
Mb1845|M.bovis_AF2122/97 VLHPGQAVCHFGVSTG-ETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYL
Rv1815|M.tuberculosis_H37Rv VLHPGQAVCHFGVSTG-ETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYL
TH_2227|M.thermoresistible__bu VPQPGQPVCHFGVVTG-ESCGRIAAVNNGWFTMGDGVVSQKGDSGGPVYT
Mvan_3169|M.vanbaalenii_PYR-1 LPVRGMPVCHFGVVTG-ESCGTIESVNNGWFTMANGVVSRKGDSGGPVYT
MAB_3347|M.abscessus_ATCC_1997 VPAIGMPVCRSGVTTG-EACGVILETTDSLLVIDG-LPADHGDSGSPVYA
MSMEG_6359|M.smegmatis_MC2_155 LLNNNVTLCKFGFVSG-ETCGKVIGHDN--LTVEAELYSASGDSGSPAYV
.*: * :* ** : : ..**.* :
MAV_0678|M.avium_104 MNPDGSVSAVGLLMSSPDGDDYTT---------YFMLVNPLLDRWGLRIL
MLBr_02242|M.leprae_Br4923 KNVDGIVSAVGILMSSPEGDDHTT---------YFVPMPPLLEKRGLQSF
MMAR_2300|M.marinum_M LDDDGTAVAVGILIRAGHANDPHPGCSTPATFSIAELVRPWLDRWSLTAI
MUL_1503|M.ulcerans_Agy99 LDDDGTAVAVGILIRAGHANDPHPGCSTPATFSIAELVRPWLDRWSLTAI
Mflv_0488|M.gilvum_PYR-GCK RQPDGTVAAVGILF--AHSDDAFG------RIVHASLVAPVMSLWGLSTW
Mb1845|M.bovis_AF2122/97 APDGGPAQIVGIFNSVWG------------GFPAAVSWRSTSEQVHADLG
Rv1815|M.tuberculosis_H37Rv APDGGPAQIVGIFNSVWG------------GFPAAVSWRSTSEQVHADLG
TH_2227|M.thermoresistible__bu VNEAGQAVIIGMFNSTWG------------QFPAAVSWQSTTAQINDEII
Mvan_3169|M.vanbaalenii_PYR-1 PTPDGRTVLVGLFNSTWG------------TLPAAISWQVASQMAEADTI
MAB_3347|M.abscessus_ATCC_1997 ITEPGRAAIVGITTEVLTSKSTGQ------RATMAISWRAIWRQIKSDID
MSMEG_6359|M.smegmatis_MC2_155 KFGNDEVAAVGILRGSPEGED---------NITEFSLLAPILEATSSSLF
. . :*:
MAV_0678|M.avium_104 P------------------------------
MLBr_02242|M.leprae_Br4923 PEVLKRLSPRLVGWGSGS-------------
MMAR_2300|M.marinum_M TEPGSP-------------------------
MUL_1503|M.ulcerans_Agy99 TEPGSP-------------------------
Mflv_0488|M.gilvum_PYR-GCK G------------------------------
Mb1845|M.bovis_AF2122/97 VTPLA--------------------------
Rv1815|M.tuberculosis_H37Rv VTPLA--------------------------
TH_2227|M.thermoresistible__bu KATAGTPAAAA--------------------
Mvan_3169|M.vanbaalenii_PYR-1 SAASAVVAPQP--------------------
MAB_3347|M.abscessus_ATCC_1997 RVGHADMPPDPPRNAREPAGDVPAEPPTSDV
MSMEG_6359|M.smegmatis_MC2_155 CDDPTCRGNGS--------------------