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GSTTQGVDSPNRLGEHAVVLGAGIAGLLAARVLSEFYDSVSVVERDKLPDYPCHRRGIPQGRHVHNFYSR GLQVLEELFPGLLDDLARAGAVVVDDGDLSRFYVRFGRYEMKNSGAFADPDALALHMTTRPFMEFHLRRR VKALPNVTFLDGHDVCDLLNTADIVNGVRITRRYNGFLMALDADLVVDAMGRSARTPAFLESLGYQRPTE ERAVARYGYASQQLSMPEGSIAQRLVMFNPGGGRPAGLLLANEHDTFILAIGVPADTGEPPTDFAAMLAM AEPSLPPAIVEGLRRAYPIGEAVTYHHTAAFWRRYDQLADFPSGLLVMGDALCSLDPTYGQGMTIAALEA LTLRECLRAGDALLAQRFFRATTQYIGATWAINQARDRTTSGVYHGMRQRLQGWISRATLNASTQDVVLT ERCFRVFNFIDPPSRLRDPALLPRIVWGNLRARFVAKRHRSETAPVGPASPPGNRIAVRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2316 | - | - | 100% (481) | hypothetical protein MAV_2316 |
| M. avium 104 | MAV_0575 | - | 4e-91 | 44.00% (450) | hypothetical protein MAV_0575 |
| M. avium 104 | MAV_4218 | - | 7e-67 | 37.03% (451) | hypothetical protein MAV_4218 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3282 | - | 1e-60 | 34.53% (472) | hypothetical protein Mb3282 |
| M. gilvum PYR-GCK | Mflv_4723 | - | 9e-63 | 34.42% (462) | hypothetical protein Mflv_4723 |
| M. tuberculosis H37Rv | Rv3254 | - | 1e-60 | 34.53% (472) | hypothetical protein Rv3254 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1628c | - | 1e-108 | 46.64% (461) | hypothetical protein MAB_1628c |
| M. marinum M | MMAR_1288 | - | 6e-66 | 35.96% (470) | hypothetical protein MMAR_1288 |
| M. smegmatis MC2 155 | MSMEG_3511 | - | 2e-95 | 43.17% (461) | hydroxylase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2599 | - | 3e-65 | 35.53% (470) | hypothetical protein MUL_2599 |
| M. vanbaalenii PYR-1 | Mvan_5929 | - | 1e-101 | 43.98% (457) | hypothetical protein Mvan_5929 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2316|M.avium_104 MGSTTQGVDSPNRLGEHAVVLGAGIAGLLAARVLSEFYDSVSVVERDKLP
MAB_1628c|M.abscessus_ATCC_199 ---MTPHVRDHR---DHAVVLGAGMAGLLAARVLSESYASVTVVERDELH
MSMEG_3511|M.smegmatis_MC2_155 -------------MAGQAVVLGASMSGLLAARVLADHFDTVAVVERDVLP
Mvan_5929|M.vanbaalenii_PYR-1 --MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDVLP
Mb3282|M.bovis_AF2122/97 ------------------MVIGASIAGLCAARVLSDFYSTVTVFERDELP
Rv3254|M.tuberculosis_H37Rv ------------------MVIGASIAGLCAARVLSDFYSTVTVFERDELP
MMAR_1288|M.marinum_M ------MRGTLSTSNNHALVIGASIAGLCAARVLSDFFHRVTLIERDELP
MUL_2599|M.ulcerans_Agy99 ----------MSTSNNHALVIGASIAGLCAARVLSDFFHRVTLIERDELP
Mflv_4723|M.gilvum_PYR-GCK ------------MGRKHAIVIGASLGGLCAARVLSSAFDDVTVFERDPLP
:*:**.:.** *****:. : *::.*** *
MAV_2316|M.avium_104 DYPCHRRGIPQGRHVHNFYSRGLQVLEELFPGLLDDLARAGAVVVDDGDL
MAB_1628c|M.abscessus_ATCC_199 KVAAARSGVPQGHHIHMFMAAGTQGLEQLFPGILDDLRTDGATVCDEGDL
MSMEG_3511|M.smegmatis_MC2_155 DGTDQRRGVPQGRHVHGLLCAGASALDALFPGFLDELAADGATRLDERGA
Mvan_5929|M.vanbaalenii_PYR-1 NDPVNRRGVPQGRHVHALLARGSRILEELFPGLLDEVVAGGAPVLDGTDP
Mb3282|M.bovis_AF2122/97 EAPANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-P
Rv3254|M.tuberculosis_H37Rv EAPANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-P
MMAR_1288|M.marinum_M SAPHGRATVPQDRHLHMLMARGANEFENLFPGLLTDMVAAGVPMLENR-P
MUL_2599|M.ulcerans_Agy99 SVPHGRATVPQDRHLHMLMARGANEFENLFPGLLTDMVAAG-PMLENR-P
Mflv_4723|M.gilvum_PYR-GCK EGPANRPAVPQGRHVHLLMARGAAEFETLFPGLLDDMVACGVPILENR-P
. . * :**.:*:* : . * :: ****:* :: * :
MAV_2316|M.avium_104 SRFYVRFGRYEMKN-SGAFADPDALALHMTTRPFMEFHLRRRVKALPNVT
MAB_1628c|M.abscessus_ATCC_199 SRIRMLLGTHEMFNRTKKFSDPETFKLYLTTRPFLEFHVRQRVQRLGNVK
MSMEG_3511|M.smegmatis_MC2_155 HRLSMMFGGHPLHF-PMSFTRP--LVSYLCSRPFLETHVRQRVRSAGNIQ
Mvan_5929|M.vanbaalenii_PYR-1 SEGYFRFGGHLLPR-DGRPKDP--ITLLLPSRPMLEYLVRQKVRGIPNIA
Mb3282|M.bovis_AF2122/97 DCIYLGAAGHVLGT---GHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQ
Rv3254|M.tuberculosis_H37Rv DCIYLGAAGHVLGT---GHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQ
MMAR_1288|M.marinum_M DCIYFAAAGHALGT---GHTLRKEFTAYVPSRPHLEWQLRRRVLELDNIE
MUL_2599|M.ulcerans_Agy99 DCIYFAAAGHALGT---GHTLRKEFTAYVPSRPHLEWQLRRRVLELDNIE
Mflv_4723|M.gilvum_PYR-GCK DCIHFGAAGHLLGT---THRLQDEFTAYVPSRPHLEWQIRRRVLALDNVR
. . : : : : :** :* :*::* *:
MAV_2316|M.avium_104 FLDGHDVCDLLNTAD--IVNGVRITRRYN----GFLMALDADLVVDAMGR
MAB_1628c|M.abscessus_ATCC_199 FLDGHDVIEPMTAEH--RITGVRVARRST----GLVTTLICDLVVDATGR
MSMEG_3511|M.smegmatis_MC2_155 ILDGHDVADMTMSGDGRRVSGVRIADRAG----GAEQTLDADLVVDATGR
Mvan_5929|M.vanbaalenii_PYR-1 MLEAHDVVDLTSASQQDRVTGARVRARDN----GAERVLNAELVVDATGR
Mb3282|M.bovis_AF2122/97 IVR-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGR
Rv3254|M.tuberculosis_H37Rv IVR-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGR
MMAR_1288|M.marinum_M IVR-GLVIEPRFEPTTQTVSGVLVAPPDD-DDGAEPQFLAADLVVDAAGR
MUL_2599|M.ulcerans_Agy99 IVR-GLVIEHRFEPTTQTVSGVLVAPPDD-DDGAEPQFLAADLVVDAAGR
Mflv_4723|M.gilvum_PYR-GCK LID-CGVDEPVYDG--HRVTGVRTADGAT---------VDADFVVDATGR
:: * : : *. : .::**** **
MAV_2316|M.avium_104 SARTPAFLESLGYQRPTEERAVARYGYASQQLSMPEGSIAQRLVMFNPGG
MAB_1628c|M.abscessus_ATCC_199 TPRTQTFLDRLGFARPAETRVASPVTYASQLLHVSEDTDLDKLTFLNAAP
MSMEG_3511|M.smegmatis_MC2_155 SARTPAFLERHGYPRPVEERIAIQVAYSSQLLRIPRDAVEQILFLIAPAP
Mvan_5929|M.vanbaalenii_PYR-1 GSRTPAFLDHLGYNRPAQDHIDVRLTYSSQLLRLPPGAVKERIVIVGPIP
Mb3282|M.bovis_AF2122/97 GTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASH
Rv3254|M.tuberculosis_H37Rv GTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASH
MMAR_1288|M.marinum_M GTRLPVWLSKWGYQRPAEQSMDIGINYASQQLRIPDGLIQEKVVVAGVAH
MUL_2599|M.ulcerans_Agy99 GTRLPVWLSKWGYQHPAEQSMDIGINYASQQLRIPDGLIQEKVVVAGVAH
Mflv_4723|M.gilvum_PYR-GCK GTRLPTWLSQWGFERPREDTVDVGISYATHQLRIPDGLIDEKVIVVGASR
.* .:* *: :* : *::: : :. . : : .
MAV_2316|M.avium_104 GRPAG-LLLANEHDTFILAIGVPADTGEPPTDFAAMLAMAEPSLPPAIVE
MAB_1628c|M.abscessus_ATCC_199 GRPFGGAIARCENDTVMMTLG-QFNLDEPPTTFAEMITLAEQFVPHAVVE
MSMEG_3511|M.smegmatis_MC2_155 ELAAAAVLFAYENDTWMFTAVGLTGN-DPPTDPGGMKAFVAPFAPQALRA
Mvan_5929|M.vanbaalenii_PYR-1 GRPTGMALFGYENATWIFTAIGMAGR-ESPAELTEMLTFVDDFTPPHVAA
Mb3282|M.bovis_AF2122/97 DQSLGLGMLCYEDGTWVLTTFGVADA-KPPPTFDEMRALADKLLPARFTA
Rv3254|M.tuberculosis_H37Rv DQSLGLGMLCYEDGTWVLTTFGVADA-KPPPTFDEMRALADKLLPARFTA
MMAR_1288|M.marinum_M DRSLGLGMLCYEDGTWVMTTFGVAGA-KPPPTFGEMRALAERLLPARFNA
MUL_2599|M.ulcerans_Agy99 DRSLGLGMLCYEDGTWVMTTFGVAGA-KPPPTFGEMRALAERLLPARFNA
Mflv_4723|M.gilvum_PYR-GCK TQPRGLGMLYYEDGTWGLTTFGVGKV-PAPTDFNEMRELAEELLPAHIGA
. . : *. * :: .*. * :. * .
MAV_2316|M.avium_104 GLRRAYPIGEAVTYHHTAAFWRRYDQLADFPSGLLVMGDALCSLDPTYGQ
MAB_1628c|M.abscessus_ATCC_199 TLRSAEPVGAVHNFWYRDAVWRRYDEMDGFPEGLLVIGDAVCSLDPIRGQ
MSMEG_3511|M.smegmatis_MC2_155 ALDAAQPLSQVSSYRYPASVRRRYDRIRRFPLGLLVTGDAICSFNPAYGQ
Mvan_5929|M.vanbaalenii_PYR-1 ALREAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYGQ
Mb3282|M.bovis_AF2122/97 ALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQ
Rv3254|M.tuberculosis_H37Rv ALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQ
MMAR_1288|M.marinum_M ALAQSEPIGAPMFHAFPASKWRRYDKLDRFPAGIVPFGDAVASFNPTFGQ
MUL_2599|M.ulcerans_Agy99 ALAQSEPIGAPMFHAFPASKWRRYDKLDRFPAGIVPFGDAVASFNPTFGQ
Mflv_4723|M.gilvum_PYR-GCK ALYQTHPLGDVALHKYPTSRWRRFDELDRYPRGILPFGDAVASFNPTFGQ
* : *:. . : **:*.: :* *:: ***:.*::* **
MAV_2316|M.avium_104 GMTIAALEALTLRECLRAG----DALLAQRFFRATTQYIGATWAIN----
MAB_1628c|M.abscessus_ATCC_199 GMTMALLEAAALRDCLFEG----DADLARRYFQTVGKRISTAWEHNRMTA
MSMEG_3511|M.smegmatis_MC2_155 GMSVAALEALILRDCLESG----TRDLHRRFQHSAAKLLDRVWQMAAG--
Mvan_5929|M.vanbaalenii_PYR-1 GMTVAALQAEALRKCLQHG----AAGLARRYFRATAKPISVAWRLAAG--
Mb3282|M.bovis_AF2122/97 GMTMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIG-
Rv3254|M.tuberculosis_H37Rv GMTMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIG-
MMAR_1288|M.marinum_M GMTMTSLQAGHLRRALQSP----HGDLATQLNRATAKTTYPVWTMNAIG-
MUL_2599|M.ulcerans_Agy99 GMTMTSLQAGHLRRALQSP----HGDLATQLNRATAKTTYPVWTMNAIG-
Mflv_4723|M.gilvum_PYR-GCK GMTMTSLQAGHLQRALQEP------EPEATFLAATAKSTWPVWTMNAIG-
**::: *:* *: .* :. : .*
MAV_2316|M.avium_104 --QARDRTTSGVYHGMRQRLQGWISRATLNASTQDVVLTERCFRVFNFID
MAB_1628c|M.abscessus_ATCC_199 PLHSSAPDSATFGQRVKWNLMAWWSAKMLMAARNDIAITETILRVNNMQD
MSMEG_3511|M.smegmatis_MC2_155 --ADLTFPQVEGPRPVSIRLNNWYTDRVLTAAESDTTVSEAFFRVMNLVD
Mvan_5929|M.vanbaalenii_PYR-1 --ADLNLHEVEGRRPPSVRIANRYVDRLQRAAESDNVVAEQFVKVTGLID
Mb3282|M.bovis_AF2122/97 --DISFHHATAEPLPRWWRPAGSLFDQFLGAAETDPVLAEWFLRRFSLLD
Rv3254|M.tuberculosis_H37Rv --DISFHHATAEPLPRWWRPAGSLFDQFLGAAETDPVLAEWFLRRFSLLD
MMAR_1288|M.marinum_M --DISFHHGLTQSPPAWWRPAGALFDQFLGAAETDPVLAEWFLRRFSLLD
MUL_2599|M.ulcerans_Agy99 --DISFHHGLTQSPPAWWRPAGALFDQFLGAAETDPVLAEWFLRRFSLLD
Mflv_4723|M.gilvum_PYR-GCK --DLTMHGADG-PAPWWYRPVGALFDQFLGAAESDPVLAEWFLRRFSLLD
. *: * .::* .: .: *
MAV_2316|M.avium_104 PPSRLRDPALLPRIVWGNLRARFVAKRHRSETAPVGPASPPGNRIAVRS
MAB_1628c|M.abscessus_ATCC_199 APRSMRRPTFVLRVLR------HCWRRHETSTAPAPQRQLTLSGV----
MSMEG_3511|M.smegmatis_MC2_155 PPTRLLRPSVLARSIAARS-----HRAPATATGQLSAAPGVTSDR----
Mvan_5929|M.vanbaalenii_PYR-1 PPARLLHPKILLR-VAFTS-----WRRRGRHR-----------------
Mb3282|M.bovis_AF2122/97 SLYMVPSVPIIGRAIAHNLR---LWLKEQRE----RRQPVTTRRSP---
Rv3254|M.tuberculosis_H37Rv SLYMVPSVPIIGRAIAHNLR---LWLKEQRE----RRQPVTTRRSP---
MMAR_1288|M.marinum_M SLYIVPPPRLIGRTIAHNVG---LWLRERRQSASSRGRTLTAPRSP---
MUL_2599|M.ulcerans_Agy99 SLYIVPPPRLIGRTIAHNVG---LWLRERRQSASSRGRTLTAPRSP---
Mflv_4723|M.gilvum_PYR-GCK SLYMVPSARLIGRTVRHNMT---LWARSRRS----PGTASSAPAR----
. : .: * :