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MAADVDIEASGLLDGLEGTARQDRAELIAWLLERGFSFEHIQASAAAPVMLPAYRVLGDDGTLVSAREIC AATGIELDVLQRLQRAVSLPRIDDPDEAVLPRADAEAVRHAKVFLDIGYDLEDAVAVMRVLVESLGHAAA MMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRLELRHSVETEAVNAAERAAGTLPGAR PVTVAFADMAGFTRLGEVMPAEDLERVAARLADLAHDAATMPVRFVKSIGDAVMLVCPEPAPLLRAALDL AAAAANNLPPLRIGVASGAAVTRAGDWFGSPVNLASRVTSIAYPGTVVVAESTRDAVGNAGDFEWFSIGA QRIRGMRAEVKLFRVEPARPAGRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4940 | cyaA | - | 100% (374) | adenylate cyclase, CyaA |
| M. ulcerans Agy99 | MUL_4470 | - | e-100 | 52.50% (360) | adenylate cyclase |
| M. ulcerans Agy99 | MUL_2743 | - | 4e-13 | 31.61% (155) | LuxR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 1e-104 | 53.83% (366) | adenylyl cyclase |
| M. gilvum PYR-GCK | Mflv_2243 | - | 1e-107 | 54.02% (361) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 1e-105 | 54.10% (366) | adenylyl cyclase |
| M. leprae Br4923 | MLBr_01399 | - | 1e-10 | 25.30% (249) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 2e-21 | 25.76% (295) | putative adenylate cyclase |
| M. marinum M | MMAR_0157 | cyaA | 0.0 | 99.20% (374) | adenylate cyclase, CyaA |
| M. avium 104 | MAV_1415 | - | 1e-105 | 55.07% (365) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 1e-109 | 56.79% (368) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 1e-108 | 54.18% (371) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 1e-105 | 52.86% (367) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4940|M.ulcerans_Agy99 --------------MAADVDIEASGLLDGLEGTARQDRAELIAWLLERGF
MMAR_0157|M.marinum_M --------------MAADVDIEASGLLDGLEGTARQDRAELIAWLLERGF
Mflv_2243|M.gilvum_PYR-GCK --------------------METSGLLDGLEGAARAERAELIGWLLDRGV
Mvan_4452|M.vanbaalenii_PYR-1 --------------MAEDLDLETSELLDGLEGDARGERAELIRWLVGRGV
TH_1842|M.thermoresistible__bu --------------MADDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
MSMEG_5018|M.smegmatis_MC2_155 -------------MVSQQVQPDIQPLLEGLDGAARSQREELINWLLSRGI
Mb1295|M.bovis_AF2122/97 MT----------DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
Rv1264|M.tuberculosis_H37Rv MT----------DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
MAB_4771|M.abscessus_ATCC_1997 ---------------------------------------------MPESD
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
MUL_4940|M.ulcerans_Agy99 SFEHIQASAAAPVMLPAYRVLGDDGTLVSAREICAATGIELDVLQRLQRA
MMAR_0157|M.marinum_M SLEHIQASAAAPVMLPAYRVLGDDGTLVSAREICAATGIELDVLQRLQRA
Mflv_2243|M.gilvum_PYR-GCK AVDEIRG-NPAPMLLASRRVIGDDGEYVSARQAADRAGVELELFERIQRA
Mvan_4452|M.vanbaalenii_PYR-1 GIDQIRG-NPAPMLLASRRVIGDDGLYVSARQAAANAGVDLELFERIQRA
TH_1842|M.thermoresistible__bu SIEEIRE-SVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRMLRA
MSMEG_5018|M.smegmatis_MC2_155 SVDQIGQ-AITPMLLASRRVAGDDGTYVSAREISEQTGLDLDLLQRLQRA
Mb1295|M.bovis_AF2122/97 TPDEIRA-TNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRA
Rv1264|M.tuberculosis_H37Rv TPDEIRA-TNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRA
MAV_1415|M.avium_104 TAEEIRT-TNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQRA
MAB_4771|M.abscessus_ATCC_1997 ELNAVVDAAVEQVLLGGPRRY-------TRSQVSQLSGVPVERARTLWVA
MLBr_01399|M.leprae_Br4923 ---------MPPSAKS---------TYPGQVEGAPHDGTPSAPQEPDEDT
: . * . :
MUL_4940|M.ulcerans_Agy99 VSLPRIDDPDEAVLPRADAEAVRHAKVFLDIGYDLED-AVAVMRVLVESL
MMAR_0157|M.marinum_M VGLPRIDDPDEAVLPRADAEAVRHAKVFLDIGYDLED-AVAVMRVLVESL
Mflv_2243|M.gilvum_PYR-GCK MGLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDE-LVQITRLLGDGL
Mvan_4452|M.vanbaalenii_PYR-1 MGLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDE-LVQITRLLGDGL
TH_1842|M.thermoresistible__bu LGLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQ-MVQIAAVLSEGL
MSMEG_5018|M.smegmatis_MC2_155 MGLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQ-VVLITRVLAEGL
Mb1295|M.bovis_AF2122/97 VGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ-VVLVVRVLAEGL
Rv1264|M.tuberculosis_H37Rv VGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ-VVLVVRVLAEGL
MAV_1415|M.avium_104 IGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQ-VVLVAQVLAEGL
MAB_4771|M.abscessus_ATCC_1997 LGFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQIAAARTLGQAM
MLBr_01399|M.leprae_Br4923 VTVP------APALIRRSSVSMPNAAQWLHTTNRSPR-LVAMVRRARRLL
: . . . : : :
MUL_4940|M.ulcerans_Agy99 GHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRL
MMAR_0157|M.marinum_M GHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRL
Mflv_2243|M.gilvum_PYR-GCK ARAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEVLLL
Mvan_4452|M.vanbaalenii_PYR-1 SRAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVLLL
TH_1842|M.thermoresistible__bu AKAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLLLL
MSMEG_5018|M.smegmatis_MC2_155 SRAAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFV
Mb1295|M.bovis_AF2122/97 SHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM
Rv1264|M.tuberculosis_H37Rv SHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM
MAV_1415|M.avium_104 SRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFM
MAB_4771|M.abscessus_ATCC_1997 ARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIAT-------LT
MLBr_01399|M.leprae_Br4923 PGDPDFGDPLSTAGEGGPR----AAARAADRLLGDRG-----------AA
. * .
MUL_4940|M.ulcerans_Agy99 ELRHSVETEAVNAAERAAGT-LPGARPVTVAFADMAGFTRLGEVMPAEDL
MMAR_0157|M.marinum_M ELRHSVETEAVNAAERAAGT-LPGARPVTVAFADMAGFTRLGEVMPAEDL
Mflv_2243|M.gilvum_PYR-GCK QLRHAIETEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPPEDL
Mvan_4452|M.vanbaalenii_PYR-1 QLRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPPEDL
TH_1842|M.thermoresistible__bu QLRHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPEEL
MSMEG_5018|M.smegmatis_MC2_155 QLRHAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQL
Mb1295|M.bovis_AF2122/97 QLRHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL
Rv1264|M.tuberculosis_H37Rv QLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL
MAV_1415|M.avium_104 QLRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEEL
MAB_4771|M.abscessus_ATCC_1997 ALQNYAWQRHLAAALHRANETGSTTRQLLVGFADMVGYTRLSRHLDPDEL
MLBr_01399|M.leprae_Br4923 SREVSLSVLQVWQALTEAIARRPVNPEVTLVFTDLVGFSGWSLQAGDEAT
. : . : : *:*:.*:: . :
MUL_4940|M.ulcerans_Agy99 ERVAARLADLAHDAATMP-VRFVKSIGDAVMLVCPEPAP----LLRAALD
MMAR_0157|M.marinum_M ERVAARLADLAHDAATMP-VRFVKSIGDAVMLVCPEPAP----LLRAALD
Mflv_2243|M.gilvum_PYR-GCK ERLAQRLADLTREIAVAP-VRFIKTIGDEVMLVSPEPAP----LLETMLR
Mvan_4452|M.vanbaalenii_PYR-1 EQLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPEPAP----LLDTLLR
TH_1842|M.thermoresistible__bu EQLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAAMLE
MSMEG_5018|M.smegmatis_MC2_155 EQLANSLAEATRDVVRPP-VRLIKTIGDAVMLVSPEPAA----LLDAVLN
Mb1295|M.bovis_AF2122/97 GHLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLK
Rv1264|M.tuberculosis_H37Rv GHLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLK
MAV_1415|M.avium_104 GQLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDVVLK
MAB_4771|M.abscessus_ATCC_1997 ASLLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMNTA
MLBr_01399|M.leprae_Br4923 LALLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQ-AVLAATE
: . . .:* :** :* . .. :
MUL_4940|M.ulcerans_Agy99 LAAAAAN--NLPPLRIGVASGAAVTRAGDWFGSPVNLASRVTSIAYPGTV
MMAR_0157|M.marinum_M LAAAAAN--NLPPLRIGVASGAAVTRAGDWFGSPVNLASRVTSIAYPGTV
Mflv_2243|M.gilvum_PYR-GCK LVEETEGDDDFPRLRAGVATGMAVSRAGDWFGSPVNLAARMTGAARPGTV
Mvan_4452|M.vanbaalenii_PYR-1 LVDETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARPGSV
TH_1842|M.thermoresistible__bu LIDGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPGSV
MSMEG_5018|M.smegmatis_MC2_155 LVAATEADPEFPGLRVGLATGMAVSRAGDWFGSPVNLASRVTGVARPGTV
Mb1295|M.bovis_AF2122/97 LVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAV
Rv1264|M.tuberculosis_H37Rv LVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAV
MAV_1415|M.avium_104 LVEAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPGTV
MAB_4771|M.abscessus_ATCC_1997 ITEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPGTI
MLBr_01399|M.leprae_Br4923 AMKSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATKGGI
. * :* *: * .* * **:*:*: * * :
MUL_4940|M.ulcerans_Agy99 VVAESTRDAVGN--------AGDFEWFSIGAQRIRGMR-AEVKLFRVEPA
MMAR_0157|M.marinum_M VVAESTRDAVGN--------AGDFEWFSIGAQRIRGMR-AEVKLFRVEPA
Mflv_2243|M.gilvum_PYR-GCK LVAEAAREAIGE--------DDRFAWSFAGAKHLKGIK-SDVKSFRARWA
Mvan_4452|M.vanbaalenii_PYR-1 LVAEATREAIGE--------DERFTWSFAGGKHLKGFK-SDVKTFRARRT
TH_1842|M.thermoresistible__bu LVAEATREAIGD--------DERFRWSFAGSRRLKGIK-GEVKLYRARRA
MSMEG_5018|M.smegmatis_MC2_155 LVAESTRQAIAAA-------DDRFRWSFAGARRLKGIK-GDVKMFRARMR
Mb1295|M.bovis_AF2122/97 LVADSVREALGDA-----PEADGFQWSFAGPRRLRGIR-GDVRLFRVRRG
Rv1264|M.tuberculosis_H37Rv LVADSVREALGDA-----PEADGFQWSFAGPRRLRGIR-GDVRLFRVRRG
MAV_1415|M.avium_104 LVADSVWDVIGDN-----GEFSG---SFAGARRLKGIK-NEVKLFRVRRG
MAB_4771|M.abscessus_ATCC_1997 LLDDGAAAALGD--------DGEFSLRHLRGVRVKGFSRLGSHVLRARKR
MLBr_01399|M.leprae_Br4923 MISGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIP-PDMVIYRIKAR
:: . : :. *: * .
MUL_4940|M.ulcerans_Agy99 RPAGRG--------------
MMAR_0157|M.marinum_M RPAARG--------------
Mflv_2243|M.gilvum_PYR-GCK PADSH---------------
Mvan_4452|M.vanbaalenii_PYR-1 TNL-----------------
TH_1842|M.thermoresistible__bu E-------------------
MSMEG_5018|M.smegmatis_MC2_155 DQ------------------
Mb1295|M.bovis_AF2122/97 ATRTGSGGAAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv ATRTGSGGAAQDDDLAGSSP
MAV_1415|M.avium_104 G-------------------
MAB_4771|M.abscessus_ATCC_1997 --------------------
MLBr_01399|M.leprae_Br4923 RELTASDETAQTNSLT----