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KKIVILGAGIGGLSVINEIRQSDVPLDGVDITVVDEDFSHFLGFTLPWVMRGWREVESVPIRPNAESLSG VTAITGSVTAIDPNAHTVTLSDSSTLSFDALVIATGARNALDKVRGLAESAARGDAVHYYSVAGAGDARR ALADFSAGKLVFLVTSQPFRCPVAPYEGALLASDLLNEKNVRSAVEISMYTPEVHPMPSAGPYAGPQLVQ LLKDNGITFHGERTTECIDPERKVVVFGDGTTASFDLLVFVPPHEPSVTIDGQGWIAVDAETMQTQYDGI WAIGDTAAVTSPSGKPLPKAAIFAKNGAKAAAQNVLHYLGRSDRKAVLSGLGYCYLDTGQHRAAQGKGDF FTLPHPAITLTEPSVGQHHDKRDEEAQWRDMWESRSGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4743c | - | - | 100% (389) | putative dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_3838c | - | 9e-12 | 25.00% (312) | putative ferredoxin reductase |
| M. abscessus ATCC 19977 | MAB_3522c | - | 1e-08 | 25.73% (307) | nitrite reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0338 | - | 1e-83 | 40.87% (389) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0986 | - | 1e-25 | 26.39% (379) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0331 | - | 1e-83 | 40.87% (389) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0689 | ndh_1 | 2e-07 | 34.51% (113) | NADH dehydrogenase Ndh_1 |
| M. avium 104 | MAV_4103 | - | 8e-11 | 26.55% (354) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 8e-10 | 25.65% (347) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_2797 | - | 2e-23 | 25.00% (380) | PUTATIVE FAD-dependent pyridine nucleotide-disulphide |
| M. ulcerans Agy99 | MUL_0769 | - | 2e-09 | 27.21% (305) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1831 | - | 1e-21 | 24.41% (381) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0338|M.bovis_AF2122/97 -------------------MSKTVLILGAGVGGLTTADTLRQLLPPED--
Rv0331|M.tuberculosis_H37Rv -------------------MSKTVLILGAGVGGLTTADTLRQLLPPED--
MAB_4743c|M.abscessus_ATCC_199 --------------------MKKIVILGAGIGGLSVINEIRQSDVPLDGV
Mflv_0986|M.gilvum_PYR-GCK ----------------MIKDKHQIVIVGGGTAGISVAARLLR----NGYS
Mvan_1831|M.vanbaalenii_PYR-1 ----------------MTTGKHKILIVGGGTAGISVAARLLR----KGHT
TH_2797|M.thermoresistible__bu ----------VTMMSTRTTARHRILIIGGGTAGITVAARLLR----RGHT
MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDND-FDGQV
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAG-YEGQL
MAV_4103|M.avium_104 ------------------------MIVGSGFTGFTCARRLAKTLR-RAPV
MMAR_0689|M.marinum_M -------MTPPSSESSAAGRRHHVVIIGSGFGGLSAARALKR-----ADV
:*:*.* . :
Mb0338|M.bovis_AF2122/97 RIILVDRSFDGTLGLSLLWVLRGWRRPDDVRVRPTAASLPG--VEMVTAT
Rv0331|M.tuberculosis_H37Rv RIILVDRSFDGTLGLSLLWVLRGWRRPDDVRVRPTAASLPG--VEMVTAT
MAB_4743c|M.abscessus_ATCC_199 DITVVDEDFSHFLGFTLPWVMRGWREVESVPIRPNAESLSG--VTAITGS
Mflv_0986|M.gilvum_PYR-GCK DVAVIEPSSVHYYQPLWTLVGGGQAKAATTARPESSVMPAG--ATWIKNA
Mvan_1831|M.vanbaalenii_PYR-1 DVAVIEPSEVHYYQPLWTLVGGGQAKASTTARAEASVMPKG--ATWIKNA
TH_2797|M.thermoresistible__bu DVAVIEPSETHYYQAMWTLVGGGQAQAVRTARPQAAVMPKG--ATWIKKS
MSMEG_3594|M.smegmatis_MC2_155 LLFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPAWYRDHDVTLRLGTE
MUL_0769|M.ulcerans_Agy99 TIVSDEVHLPYDRPPLSKEVLR--SEVDDVSLKPREWYDEKGITLRLGSA
MAV_4103|M.avium_104 DITMISPVDYMLYTPLLPDVAGGVVDARFVAVP-LANSLRG--MHAVRGR
MMAR_0689|M.marinum_M DITLISKTTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGE
: . :
Mb0338|M.bovis_AF2122/97 VAHIDIAAQVVHT-DNSV----IGYDALVIALGAALNTDAVPGLS-----
Rv0331|M.tuberculosis_H37Rv VAHIDIAAQVVHT-DNSV----IGYDALVIALGAALNTDAVPGLS-----
MAB_4743c|M.abscessus_ATCC_199 VTAIDPNAHTVTLSDSST----LSFDALVIATGARNALDKVRGLA-----
Mflv_0986|M.gilvum_PYR-GCK AAAVDPDNNTVTCADGAV----YEYDVLVVAPGIQLDWNRTEGLA-----
Mvan_1831|M.vanbaalenii_PYR-1 AAQVDPDNNRVICVDGAD----YGYDVLVVCPGIQLDWNRTEGLA-----
TH_2797|M.thermoresistible__bu AATVDPAAGTVGCTDGSS----YGYDVLVMSPGIQLDWDRTDGLV-----
MSMEG_3594|M.smegmatis_MC2_155 VAAINPADHTVTLPDGSA----VGYDKLLLATGSAS--------------
MUL_0769|M.ulcerans_Agy99 ATGLDTAAQTVTLADGTV----LGYDELVIATGLVP--------------
MAV_4103|M.avium_104 VDAVDFTGRTLTYRDPEERSHSMSWDRLVLTPGSVTKLFDVPGLARHARG
MMAR_0689|M.marinum_M VMGIDLNAQTVTSKLMDMTT-VSPYDSLIVAAGAQQSYFGNDDFAIFAPG
. :: : :* *:: *
Mb0338|M.bovis_AF2122/97 --DALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKCPAAPF
Rv0331|M.tuberculosis_H37Rv --DALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKCPAAPF
MAB_4743c|M.abscessus_ATCC_199 --ESAARGDAVHYYSVAGAGDARRALADFSAGKLVFLVTSQPFRCPVAPY
Mflv_0986|M.gilvum_PYR-GCK --DALGKDGVSSNYRFDLAPRTWEFIRDLRSGTAVFAMPSGPIKCAGAPQ
Mvan_1831|M.vanbaalenii_PYR-1 --DAVGKDGVSSNYRFDLAPRTWEFIRTLRSGSAVFAMPSGPIKCAGAPQ
TH_2797|M.thermoresistible__bu --DALGHDGVSSNYRYDLAPRTWEFIRTTRSGTAVFAMPSGPIKCAGAPQ
MSMEG_3594|M.smegmatis_MC2_155 -------------RRLPIPGADASGVHYLRTVDDAAALDAVLTEGASLAV
MUL_0769|M.ulcerans_Agy99 -------------RRIPAF-PELEGIRVLRSFDECMALRSHASAAKRAVV
MAV_4103|M.avium_104 LKTTAEALYLRDHFVEQLELANIEDDPRVAAARRTVVVVGASYSGTELVA
MMAR_0689|M.marinum_M MKTIDDALELRGRILGAFEAAEVATDHDERERRLTFVVVGAGPTGVELAG
: .
Mb0338|M.bovis_AF2122/97 EAAFLIAAQLG--DRYATGTVQIDTFTPDPLPMPVAG-PEVGEALVSMLK
Rv0331|M.tuberculosis_H37Rv EAAFLIAAQLG--DRYATGTVQIDTFTPDPLPMPVAG-PEVGEALVSMLK
MAB_4743c|M.abscessus_ATCC_199 EGALLASDLLN--EKNVRSAVEISMYTPEVHPMPSAG-PYAGPQLVQLLK
Mflv_0986|M.gilvum_PYR-GCK KIAYLASDYWR--SQGVLDNIDVHLVVPTPRLFGIP---AIADTLDTIAA
Mvan_1831|M.vanbaalenii_PYR-1 KIAYLAADYWR--SQGVLQDIDVHLVVPTPRLFGIP---AIADNLDKVAA
TH_2797|M.thermoresistible__bu KIAYLACDHWR--REGVLSHIDVHLVLPTPRAFGIP---EIADSLEEIIA
MSMEG_3594|M.smegmatis_MC2_155 VGAGWIGLEVA--ASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQLHR
MUL_0769|M.ulcerans_Agy99 IGAGFIGCEVA--ASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHR
MAV_4103|M.avium_104 QLRALADAAAR--QMGFDPGAVRFLLLDLAEQVMPEVGKKLGDAALKVLR
MMAR_0689|M.marinum_M EIVQLAERTLAGAFRTITPSECRVILLDAAPAVLPPMGPKLGLKAQKKLE
. .
Mb0338|M.bovis_AF2122/97 DHGVGFHPRKALARVDEAARTMHF-------GDGTSEPFDLLAVVPPHVP
Rv0331|M.tuberculosis_H37Rv DHGVGFHPRKALARVDEAARTMHF-------GDGTSEPFDLLAVVPPHVP
MAB_4743c|M.abscessus_ATCC_199 DNGITFHGERTTECIDPERKVVVF-------GDGTTASFDLLVFVPPHEP
Mflv_0986|M.gilvum_PYR-GCK GYGITVHTDAEVTSIDAAAHKVGVTPAG--GGADTVLAYDVLHAVPRQSA
Mvan_1831|M.vanbaalenii_PYR-1 GYGITVHTSAEVTAIDAAAHKVALTPVGEAGGSETVLPYDVLHAVPRQSA
TH_2797|M.thermoresistible__bu GYGIHLHTNTEVTAVDGGARKVALTSLGD-GGTDTTLPYDLLHIAPRQSA
MSMEG_3594|M.smegmatis_MC2_155 EHGVDLRLEQTVEEITTADGRATGLRLG---DGSTIAADAVLVAVGAAPN
MUL_0769|M.ulcerans_Agy99 SEGVDVRTGVGVAEVR-GDGHVDTVVLA---DGTQLDADLVVVGIGSHPA
MAV_4103|M.avium_104 RRGIDVRLGTTLKEAHADHVVLSD---------GSRIDTHTIAWVTGVTG
MMAR_0689|M.marinum_M KMDVEIQLNAMVTAVDYKGITVKDKD-----GTERRIDCACKVWAAGVQA
.: .:
Mb0338|M.bovis_AF2122/97 SAA----ARSAGLSE---SGWIPVDPRTLSTS-ADNVWAIGDATVLTLPN
Rv0331|M.tuberculosis_H37Rv SAA----ARSAGLSE---SGWIPVDPRTLSTS-ADNVWAIGDATVLTLPN
MAB_4743c|M.abscessus_ATCC_199 SVT----IDGQ--------GWIAVDAETMQTQ-YDGIWAIGDTAAVTSPS
Mflv_0986|M.gilvum_PYR-GCK PDW----IKSGPLSTGDANGYVEIDKHTMQHVRYPNVFSLGDAGSS----
Mvan_1831|M.vanbaalenii_PYR-1 PDW----IKASPLSTGDANGYVEIDKHTLQHVRHRNVFSLGDAGSS----
TH_2797|M.thermoresistible__bu PDW----IKASPLSTGDAGGYVDVDKHTLQHVRYPNVFSLGDAAST----
MSMEG_3594|M.smegmatis_MC2_155 IGL----AERAGLAT--ADGGVLVDASLRTSD--PDIYAVGDIAAAQHP-
MUL_0769|M.ulcerans_Agy99 TGW----LDGSGIAV--DNG-VVCDAAGRTSA--PNVWAFGDVASWRD--
MAV_4103|M.avium_104 APL----IQDLGLPTE--KGRLKVQPDLQVPG-HPGVFAAGDAAAVPDLT
MMAR_0689|M.marinum_M SPLGKMIAEQSDGTETDRAGRVIVEPDLTVKG-HPHVFVIGDLMSVPGVP
* : : :: **
Mb0338|M.bovis_AF2122/97 --GKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYVETGDH
Rv0331|M.tuberculosis_H37Rv --GKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYVETGDH
MAB_4743c|M.abscessus_ATCC_199 --GKPLPKAAIFAKNGAKAAAQNVLHYLGRSDRKAVLSGLGYCYLDTGQH
Mflv_0986|M.gilvum_PYR-GCK ----PNSKTGAAIRKQAPVVVENIDALLTGRPLTASYNGYGSCPIVTSSH
Mvan_1831|M.vanbaalenii_PYR-1 ----PNSKTGAAIRKQAPVVVENIDAYLAGRPLTASYNGYGSCPLVTSSH
TH_2797|M.thermoresistible__bu ----PNSKTGAAIRKQAPVVVDNVDAFLAGRPITAHYDGYASCPIVTSAR
MSMEG_3594|M.smegmatis_MC2_155 -----LFGVRIRTEHWANALKQPAVAVAGMLGRPAEY-AELPYFFTDQYD
MUL_0769|M.ulcerans_Agy99 -----QMGHQVRVEHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYD
MAV_4103|M.avium_104 QPGKITPPTAQHATRQGKVLARNVAASLGHGSAKEYKHRNLGLVVDLGPR
MMAR_0689|M.marinum_M G---MAQGAIQGAHYATKTIKQAVKGHDDPANRKPFQYFNKGSMALISHY
.
Mb0338|M.bovis_AF2122/97 QAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQ-----------------
Rv0331|M.tuberculosis_H37Rv QAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQ-----------------
MAB_4743c|M.abscessus_ATCC_199 RAAQGKGDFFTLPHPAITLTEPSVGQHHDKRDE-----------------
Mflv_0986|M.gilvum_PYR-GCK EMLLAEFDYDLNMTPSFPLLDPTKPHRGYWYLK-----------------
Mvan_1831|M.vanbaalenii_PYR-1 DMLLAEFDYDLNLEPSFPLLDPTKPHRAYWYLK-----------------
TH_2797|M.thermoresistible__bu SVLLAEFDYSFAMKPTFPLLDPARPHRAYWYLK-----------------
MSMEG_3594|M.smegmatis_MC2_155 LGMEYAGHAPSYERVVFRGDVPGREFVSFWLDG----------------D
MUL_0769|M.ulcerans_Agy99 VKIQCLGEPHSTDVVHLVEDD-GRKLLAYYQRDGVLVGVVGGGVPGKVMK
MAV_4103|M.avium_104 YAVANPLNIHLSGLPAKAVTRGYHLYAIPRGVN-----------------
MMAR_0689|M.marinum_M SAVAKVGKVEFAGFIAWLAWLFLHLLYLVGHRNRVAAAFSWG----LAFL
.
Mb0338|M.bovis_AF2122/97 ---ELAWLTRWKT-------------------------------------
Rv0331|M.tuberculosis_H37Rv ---ELAWLTRWKT-------------------------------------
MAB_4743c|M.abscessus_ATCC_199 ---EAQWRDMWESRSGA---------------------------------
Mflv_0986|M.gilvum_PYR-GCK ---KYGLPFMYWNLMLKGLA------------------------------
Mvan_1831|M.vanbaalenii_PYR-1 ---KYGLPFMYWNLMLKGLA------------------------------
TH_2797|M.thermoresistible__bu ---KYGLPFMYWNLMLKGLV------------------------------
MSMEG_3594|M.smegmatis_MC2_155 NRVLAGMNVNIWDVLDDVKALIRSREPVD-----------PDLLAD----
MUL_0769|M.ulcerans_Agy99 VRAKIAAAVPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWR
MAV_4103|M.avium_104 -RWAVSLAYLTDALFARSVVSIGLSSEDDAQFTASEGIPMPKTG------
MMAR_0689|M.marinum_M GRTRGQMAITSQMVYARLAMRYLQARAEEDALSAAEHAEQAEQRATG---
Mb0338|M.bovis_AF2122/97 ----------------------------------
Rv0331|M.tuberculosis_H37Rv ----------------------------------
MAB_4743c|M.abscessus_ATCC_199 ----------------------------------
Mflv_0986|M.gilvum_PYR-GCK ----------------------------------
Mvan_1831|M.vanbaalenii_PYR-1 ----------------------------------
TH_2797|M.thermoresistible__bu ----------------------------------
MSMEG_3594|M.smegmatis_MC2_155 ---------------------PGRPLNAPG----
MUL_0769|M.ulcerans_Agy99 AEKATASSPVARVDGIGLEPGPRRTASWPDVPGT
MAV_4103|M.avium_104 ----------------------------------
MMAR_0689|M.marinum_M ----------------------------------