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MSKTVLILGAGVGGLTTADTLRQLLPPEDRIILVDRSFDGTLGLSLLWVLRGWRRPDDVRVRPTAASLPG VEMVTATVAHIDIAAQVVHTDNSVIGYDALVIALGAALNTDAVPGLSDALDADVAGQFYTLDGAAELRAK VEALEHGRIAVAIAGVPFKCPAAPFEAAFLIAAQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSM LKDHGVGFHPRKALARVDEAARTMHFGDGTSEPFDLLAVVPPHVPSAAARSAGLSESGWIPVDPRTLSTS ADNVWAIGDATVLTLPNGKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYVETGDHQAAKG DGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0338 | - | - | 100% (388) | dehydrogenase/reductase |
| M. bovis AF2122 / 97 | Mb0707 | - | 1e-08 | 25.71% (315) | putative ferredoxin reductase |
| M. bovis AF2122 / 97 | Mb1900c | - | 6e-07 | 24.41% (340) | reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0986 | - | 7e-20 | 23.87% (377) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0331 | - | 0.0 | 100.00% (388) | dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02061 | - | 1e-06 | 22.38% (353) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4743c | - | 1e-83 | 40.87% (389) | putative dehydrogenase/reductase |
| M. marinum M | MMAR_1017 | - | 3e-08 | 25.65% (308) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 1e-08 | 24.74% (291) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 2e-10 | 27.36% (318) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_2797 | - | 1e-27 | 29.13% (381) | PUTATIVE FAD-dependent pyridine nucleotide-disulphide |
| M. ulcerans Agy99 | MUL_0769 | - | 6e-09 | 26.40% (303) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1831 | - | 6e-21 | 25.46% (381) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0338|M.bovis_AF2122/97 -------------------MSKTVLILGAGVGGLTTADTLRQLLPPED--
Rv0331|M.tuberculosis_H37Rv -------------------MSKTVLILGAGVGGLTTADTLRQLLPPED--
MAB_4743c|M.abscessus_ATCC_199 --------------------MKKIVILGAGIGGLSVINEIRQSDVPLDGV
Mflv_0986|M.gilvum_PYR-GCK ----------------MIKDKHQIVIVGGGTAGISVAARLLR----NGYS
Mvan_1831|M.vanbaalenii_PYR-1 ----------------MTTGKHKILIVGGGTAGISVAARLLR----KGHT
TH_2797|M.thermoresistible__bu ----------VTMMSTRTTARHRILIIGGGTAGITVAARLLR----RGHT
MMAR_1017|M.marinum_M MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAG-YEGQL
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAG-YEGQL
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNN-FDGRI
MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDND-FDGQV
MLBr_02061|M.leprae_Br4923 -------MNAQPAATAAQDRRHQVVIIGSGFGGLNAAKKLKRAN-----V
.:*:*.* .. . :
Mb0338|M.bovis_AF2122/97 RIILVDRSFDGTLGLSLLWVLRGWRRPDDVRVRPTAASLPG--VEMVTAT
Rv0331|M.tuberculosis_H37Rv RIILVDRSFDGTLGLSLLWVLRGWRRPDDVRVRPTAASLPG--VEMVTAT
MAB_4743c|M.abscessus_ATCC_199 DITVVDEDFSHFLGFTLPWVMRGWREVESVPIRPNAESLSG--VTAITGS
Mflv_0986|M.gilvum_PYR-GCK DVAVIEPSSVHYYQPLWTLVGGGQAKAATTARPESSVMPAG--ATWIKNA
Mvan_1831|M.vanbaalenii_PYR-1 DVAVIEPSEVHYYQPLWTLVGGGQAKASTTARAEASVMPKG--ATWIKNA
TH_2797|M.thermoresistible__bu DVAVIEPSETHYYQAMWTLVGGGQAQAVRTARPQAAVMPKG--ATWIKKS
MMAR_1017|M.marinum_M TIVSDEVHLPYDRPPLSKEVLR--SEVDDVSLKPREWYDEKDIALRLGSA
MUL_0769|M.ulcerans_Agy99 TIVSDEVHLPYDRPPLSKEVLR--SEVDDVSLKPREWYDEKGITLRLGSA
MAV_2849|M.avium_104 IVFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSDWYRDNDVDLRLNTR
MSMEG_3594|M.smegmatis_MC2_155 LLFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPAWYRDHDVTLRLGTE
MLBr_02061|M.leprae_Br4923 DIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNIQVLLGN
: :
Mb0338|M.bovis_AF2122/97 VAHIDIA---AQVVHT-DNSVIGYDALVIALGAALNTDAVPGLSDALDAD
Rv0331|M.tuberculosis_H37Rv VAHIDIA---AQVVHT-DNSVIGYDALVIALGAALNTDAVPGLSDALDAD
MAB_4743c|M.abscessus_ATCC_199 VTAIDPN---AHTVTLSDSSTLSFDALVIATGARNALDKVRGLAESAARG
Mflv_0986|M.gilvum_PYR-GCK AAAVDPD---NNTVTCADGAVYEYDVLVVAPGIQLDWNRTEGLADALGKD
Mvan_1831|M.vanbaalenii_PYR-1 AAQVDPD---NNRVICVDGADYGYDVLVVCPGIQLDWNRTEGLADAVGKD
TH_2797|M.thermoresistible__bu AATVDPA---AGTVGCTDGSSYGYDVLVMSPGIQLDWDRTDGLVDALGHD
MMAR_1017|M.marinum_M ATGLDTA---AQTVTLADGTVLGYDELVIATGLVPR--------------
MUL_0769|M.ulcerans_Agy99 ATGLDTA---AQTVTLADGTVLGYDELVIATGLVPR--------------
MAV_2849|M.avium_104 VCALDAA---GHTVGLPDGTTVAYDKLLLATGSAAR--------------
MSMEG_3594|M.smegmatis_MC2_155 VAAINPA---DHTVTLPDGSAVGYDKLLLATGSASR--------------
MLBr_02061|M.leprae_Br4923 VTHIDLANQCVVSELLGHTYETLYDSLIVAAGAGQSYFGNDQFAEFAPG-
. :: . :* *::. *
Mb0338|M.bovis_AF2122/97 VAGQFYTLDGAAELRAKVEALEHGR--------IAVAIAGVPFKCPAAPF
Rv0331|M.tuberculosis_H37Rv VAGQFYTLDGAAELRAKVEALEHGR--------IAVAIAGVPFKCPAAPF
MAB_4743c|M.abscessus_ATCC_199 DAVHYYSVAGAGDARRALADFSAGK--------LVFLVTSQPFRCPVAPY
Mflv_0986|M.gilvum_PYR-GCK GVSSNYRFDLAPRTWEFIRDLRSGT--------AVFAMPSGPIKCAGAPQ
Mvan_1831|M.vanbaalenii_PYR-1 GVSSNYRFDLAPRTWEFIRTLRSGS--------AVFAMPSGPIKCAGAPQ
TH_2797|M.thermoresistible__bu GVSSNYRYDLAPRTWEFIRTTRSGT--------AVFAMPSGPIKCAGAPQ
MMAR_1017|M.marinum_M ------RIPAFP-ELEGIRVLRSFD--------ECMALRSHASAAKRAVV
MUL_0769|M.ulcerans_Agy99 ------RIPAFP-ELEGIRVLRSFD--------ECMALRSHASAAKRAVV
MAV_2849|M.avium_104 ------RPPIPGSDCAGVHYLRTYE--------VAVALNSFLGEGKSLAV
MSMEG_3594|M.smegmatis_MC2_155 ------RLPIPGADASGVHYLRTVD--------DAAALDAVLTEGASLAV
MLBr_02061|M.leprae_Br4923 MKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGAGPTGVEMAG
. : .
Mb0338|M.bovis_AF2122/97 EAAFLIAAQLGDRYA---TGTVQIDTFTPDPLPMPVAG-PEVGEALVSML
Rv0331|M.tuberculosis_H37Rv EAAFLIAAQLGDRYA---TGTVQIDTFTPDPLPMPVAG-PEVGEALVSML
MAB_4743c|M.abscessus_ATCC_199 EGALLASDLLNEKNV---RSAVEISMYTPEVHPMPSAG-PYAGPQLVQLL
Mflv_0986|M.gilvum_PYR-GCK KIAYLASDYWRSQGV---LDNIDVHLVVPTPRLFGIP---AIADTLDTIA
Mvan_1831|M.vanbaalenii_PYR-1 KIAYLAADYWRSQGV---LQDIDVHLVVPTPRLFGIP---AIADNLDKVA
TH_2797|M.thermoresistible__bu KIAYLACDHWRREGV---LSHIDVHLVLPTPRAFGIP---EIADSLEEII
MMAR_1017|M.marinum_M IGAGFIGCEVAASLR---GLGVEVVLVEPQPTPLAAVLGEQIGELVARLH
MUL_0769|M.ulcerans_Agy99 IGAGFIGCEVAASLR---GLGVEVVLVEPQPTPLAAVLGEQIGELVARLH
MAV_2849|M.avium_104 VGAGWIGLEVAAAAR---QRGVEVTVVEAARQPLTAALGETVGEVFATLH
MSMEG_3594|M.smegmatis_MC2_155 VGAGWIGLEVAASAR---TRGVNVTVVEAARLPLLGALGAEVAEVFAQLH
MLBr_02061|M.leprae_Br4923 QIAELADHTLKGAFRRIDSTKARVVLLDAAPAVLPPMG-EKLGQRAAARL
* : . : .
Mb0338|M.bovis_AF2122/97 KDHGVGFHPRKALARVDEAARTMHF-------GDGTSEPFDLLAVVPPHV
Rv0331|M.tuberculosis_H37Rv KDHGVGFHPRKALARVDEAARTMHF-------GDGTSEPFDLLAVVPPHV
MAB_4743c|M.abscessus_ATCC_199 KDNGITFHGERTTECIDPERKVVVF-------GDGTTASFDLLVFVPPHE
Mflv_0986|M.gilvum_PYR-GCK AGYGITVHTDAEVTSIDAAAHKVGVTPAG--GGADTVLAYDVLHAVPRQS
Mvan_1831|M.vanbaalenii_PYR-1 AGYGITVHTSAEVTAIDAAAHKVALTPVGEAGGSETVLPYDVLHAVPRQS
TH_2797|M.thermoresistible__bu AGYGIHLHTNTEVTAVDGGARKVALTSLGD-GGTDTTLPYDLLHIAPRQS
MMAR_1017|M.marinum_M RSEGVDVRTGVGVAEVR-GDGHVDTVVLA---DGTQLDADLVVVGIGSHP
MUL_0769|M.ulcerans_Agy99 RSEGVDVRTGVGVAEVR-GDGHVDTVVLA---DGTQLDADLVVVGIGSHP
MAV_2849|M.avium_104 REHGVDLRLETQVREITRADGSATGLRTT---DGSAIPADAVLVAVGARP
MSMEG_3594|M.smegmatis_MC2_155 REHGVDLRLEQTVEEITTADGRATGLRLG---DGSTIAADAVLVAVGAAP
MLBr_02061|M.leprae_Br4923 QKMGVEIQLSAMVTDVDRNGITVQDSDGT--VRRIESACKVWSAGVSASR
*: .: :
Mb0338|M.bovis_AF2122/97 PSAAARSAGLSE---SGWIPVDPRTLSTS-ADNVWAIGDATVLTL--PNG
Rv0331|M.tuberculosis_H37Rv PSAAARSAGLSE---SGWIPVDPRTLSTS-ADNVWAIGDATVLTL--PNG
MAB_4743c|M.abscessus_ATCC_199 PSVTIDGQ--------GWIAVDAETMQTQ-YDGIWAIGDTAAVTS--PSG
Mflv_0986|M.gilvum_PYR-GCK APDWIKSGPLSTGDANGYVEIDKHTMQHVRYPNVFSLGDAGSS-------
Mvan_1831|M.vanbaalenii_PYR-1 APDWIKASPLSTGDANGYVEIDKHTLQHVRHRNVFSLGDAGSS-------
TH_2797|M.thermoresistible__bu APDWIKASPLSTGDAGGYVDVDKHTLQHVRYPNVFSLGDAAST-------
MMAR_1017|M.marinum_M ATGWLDGSGIAV--DNG-VVCDAAGRTSA--PNVWALGDVASWRD-QMGH
MUL_0769|M.ulcerans_Agy99 ATGWLDGSGIAV--DNG-VVCDAAGRTSA--PNVWAFGDVASWRD-QMGH
MAV_2849|M.avium_104 NIELAEAAGLSL--ADGGVLVDASLRTSD--PDIYAVGDIAAAEHPLLRT
MSMEG_3594|M.smegmatis_MC2_155 NIGLAERAGLAT--ADGGVLVDASLRTSD--PDIYAVGDIAAAQHPLFGV
MLBr_02061|M.leprae_Br4923 LGRDLAEQSLVELDWAGRVKVLPDLSIPG-YRNVFVVGDMAAIDGVPGVA
* : .:: .**
Mb0338|M.bovis_AF2122/97 KPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYVETGDHQAA
Rv0331|M.tuberculosis_H37Rv KPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYVETGDHQAA
MAB_4743c|M.abscessus_ATCC_199 KPLPKAAIFAKNGAKAAAQNVLHYLGRSDRKAVLSGLGYCYLDTGQHRAA
Mflv_0986|M.gilvum_PYR-GCK -PNSKTGAAIRKQAPVVVENIDALLTGRPLTASYNGYGSCPIVTSSHEML
Mvan_1831|M.vanbaalenii_PYR-1 -PNSKTGAAIRKQAPVVVENIDAYLAGRPLTASYNGYGSCPLVTSSHDML
TH_2797|M.thermoresistible__bu -PNSKTGAAIRKQAPVVVDNVDAFLAGRPITAHYDGYASCPIVTSARSVL
MMAR_1017|M.marinum_M QVRVEHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYDVKIQCLG-E
MUL_0769|M.ulcerans_Agy99 QVRVEHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYDVKIQCLG-E
MAV_2849|M.avium_104 RIRTEHWANALKQPAIAVAGMLGRPGE-YDELPYFFTDQYDLGMEYVGHA
MSMEG_3594|M.smegmatis_MC2_155 RIRTEHWANALKQPAVAVAGMLGRPAE-YAELPYFFTDQYDLGMEYAGHA
MLBr_02061|M.leprae_Br4923 QGAIQGAKYVANNIKAELGEANPAEREPFQYFDKGSMATVSRFSAVAKIG
:
Mb0338|M.bovis_AF2122/97 KGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT----------
Rv0331|M.tuberculosis_H37Rv KGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT----------
MAB_4743c|M.abscessus_ATCC_199 QGKGDFFTLPHPAITLTEPSVGQHHDKRDEEAQWRDMWESRSGA------
Mflv_0986|M.gilvum_PYR-GCK LAEFDYDLNMTPSFPLLDPTKPHRGYWYLKKYGLPFMYWNLMLKGLA---
Mvan_1831|M.vanbaalenii_PYR-1 LAEFDYDLNLEPSFPLLDPTKPHRAYWYLKKYGLPFMYWNLMLKGLA---
TH_2797|M.thermoresistible__bu LAEFDYSFAMKPTFPLLDPARPHRAYWYLKKYGLPFMYWNLMLKGLV---
MMAR_1017|M.marinum_M PHSTDVVHLVEDDGRKFLAYYER--DGVLVGVVGGGVPGKVMKVRAKIAA
MUL_0769|M.ulcerans_Agy99 PHSTDVVHLVEDDGRKLLAYYQR--DGVLVGVVGGGVPGKVMKVRAKIAA
MAV_2849|M.avium_104 PRFERVVFRGDVAAREFVAFWLDADDRVLAGMNVN-IWDVLDDVKALIRS
MSMEG_3594|M.smegmatis_MC2_155 PSYERVVFRGDVPGREFVSFWLDGDNRVLAGMNVN-IWDVLDDVKALIRS
MLBr_02061|M.leprae_Br4923 PLEFSGFIAWLMWLVLHLMYLIGFKTKITTLLSWTVTFLSTRRGQLTITE
Mb0338|M.bovis_AF2122/97 --------------------------------------------------
Rv0331|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4743c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0986|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1831|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2797|M.thermoresistible__bu --------------------------------------------------
MMAR_1017|M.marinum_M AVPISEMLDESQG-------------------------------------
MUL_0769|M.ulcerans_Agy99 AVPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRAEKATAS
MAV_2849|M.avium_104 RAPIDADRLGDPGAPLGELLG-----------------------------
MSMEG_3594|M.smegmatis_MC2_155 REPVDPDLLADPGRPLNAPG------------------------------
MLBr_02061|M.leprae_Br4923 QQAFARTRLEQLAELTAESQSTAAANRATMRAS-----------------
Mb0338|M.bovis_AF2122/97 ---------------------------
Rv0331|M.tuberculosis_H37Rv ---------------------------
MAB_4743c|M.abscessus_ATCC_199 ---------------------------
Mflv_0986|M.gilvum_PYR-GCK ---------------------------
Mvan_1831|M.vanbaalenii_PYR-1 ---------------------------
TH_2797|M.thermoresistible__bu ---------------------------
MMAR_1017|M.marinum_M ---------------------------
MUL_0769|M.ulcerans_Agy99 SPVARVDGIGLEPGPRRTASWPDVPGT
MAV_2849|M.avium_104 ---------------------------
MSMEG_3594|M.smegmatis_MC2_155 ---------------------------
MLBr_02061|M.leprae_Br4923 ---------------------------