For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTTGKHKILIVGGGTAGISVAARLLRKGHTDVAVIEPSEVHYYQPLWTLVGGGQAKASTTARAEASVMPK GATWIKNAAAQVDPDNNRVICVDGADYGYDVLVVCPGIQLDWNRTEGLADAVGKDGVSSNYRFDLAPRTW EFIRTLRSGSAVFAMPSGPIKCAGAPQKIAYLAADYWRSQGVLQDIDVHLVVPTPRLFGIPAIADNLDKV AAGYGITVHTSAEVTAIDAAAHKVALTPVGEAGGSETVLPYDVLHAVPRQSAPDWIKASPLSTGDANGYV EIDKHTLQHVRHRNVFSLGDAGSSPNSKTGAAIRKQAPVVVENIDAYLAGRPLTASYNGYGSCPLVTSSH DMLLAEFDYDLNLEPSFPLLDPTKPHRAYWYLKKYGLPFMYWNLMLKGLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1831 | - | - | 100% (400) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4022 | - | 0.0 | 99.50% (400) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0338 | - | 4e-21 | 25.46% (381) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0986 | - | 0.0 | 87.25% (400) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0331 | - | 4e-21 | 25.46% (381) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4743c | - | 1e-21 | 24.41% (381) | putative dehydrogenase/reductase |
| M. marinum M | MMAR_4486 | - | 3e-06 | 24.30% (107) | dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3621 | ndh | 8e-06 | 26.91% (249) | NADH dehydrogenase |
| M. thermoresistible (build 8) | TH_2797 | - | 0.0 | 76.13% (398) | PUTATIVE FAD-dependent pyridine nucleotide-disulphide |
| M. ulcerans Agy99 | MUL_4658 | - | 2e-07 | 25.23% (107) | dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1831|M.vanbaalenii_PYR-1 ------MTTGKHKILIVGGGTAGISVAARLLR----KGHTDVAVIEPSEV
Mflv_0986|M.gilvum_PYR-GCK ------MIKDKHQIVIVGGGTAGISVAARLLR----NGYSDVAVIEPSSV
TH_2797|M.thermoresistible__bu VTMMSTRTTARHRILIIGGGTAGITVAARLLR----RGHTDVAVIEPSET
Mb0338|M.bovis_AF2122/97 ---------MSKTVLILGAGVGGLTTADTLRQLLPPED--RIILVDRSFD
Rv0331|M.tuberculosis_H37Rv ---------MSKTVLILGAGVGGLTTADTLRQLLPPED--RIILVDRSFD
MAB_4743c|M.abscessus_ATCC_199 ----------MKKIVILGAGIGGLSVINEIRQSDVPLDGVDITVVDEDFS
MMAR_4486|M.marinum_M ---MSEMTEDRNHVVVIGGGYAGIMAANHLRS----RADLEITVVNPRPV
MUL_4658|M.ulcerans_Agy99 ---MSEMTEDRNHVVVIGGGYAGIMAANHLRS----RADLEITVVNPRPV
MSMEG_3621|M.smegmatis_MC2_155 MSHPGATASDRHKVVIIGSGFGGLTAAKTLKR-----ADVDVKLIARTTH
: ::::*.* .*: . : : ::
Mvan_1831|M.vanbaalenii_PYR-1 HYYQPLWTLVGGGQAKASTTARAEASVMPKG--ATWIKNAAAQVDPD---
Mflv_0986|M.gilvum_PYR-GCK HYYQPLWTLVGGGQAKAATTARPESSVMPAG--ATWIKNAAAAVDPD---
TH_2797|M.thermoresistible__bu HYYQAMWTLVGGGQAQAVRTARPQAAVMPKG--ATWIKKSAATVDPA---
Mb0338|M.bovis_AF2122/97 GTLGLSLLWVLRGWRRPDDVRVRPTAASLPG--VEMVTATVAHIDIA---
Rv0331|M.tuberculosis_H37Rv GTLGLSLLWVLRGWRRPDDVRVRPTAASLPG--VEMVTATVAHIDIA---
MAB_4743c|M.abscessus_ATCC_199 HFLGFTLPWVMRGWREVESVPIRPNAESLSG--VTAITGSVTAIDPN---
MMAR_4486|M.marinum_M FVERIRLHQLAAG---SGTATVDYDSMLGDG--IHLVVDAVDRIDAD---
MUL_4658|M.ulcerans_Agy99 FVERIRLHQLAAG---SGTATVDYDSMLGDG--IHLVVDAVDRIDAD---
MSMEG_3621|M.smegmatis_MC2_155 HLFQPLLYQVATGIISEGEIAPATRVILRKQKNAQVLLGDVTHIDLENKT
: * : . :*
Mvan_1831|M.vanbaalenii_PYR-1 NNRVICVDGADYGYDVLVVCPGIQLDWNRTEGLADAVGKDGVSSNYRFDL
Mflv_0986|M.gilvum_PYR-GCK NNTVTCADGAVYEYDVLVVAPGIQLDWNRTEGLADALGKDGVSSNYRFDL
TH_2797|M.thermoresistible__bu AGTVGCTDGSSYGYDVLVMSPGIQLDWDRTDGLVDALGHDGVSSNYRYDL
Mb0338|M.bovis_AF2122/97 AQVVHT-DNSVIGYDALVIALGAALNTDAVPGLSDALDADVAGQFYTLDG
Rv0331|M.tuberculosis_H37Rv AQVVHT-DNSVIGYDALVIALGAALNTDAVPGLSDALDADVAGQFYTLDG
MAB_4743c|M.abscessus_ATCC_199 AHTVTLSDSSTLSFDALVIATGARNALDKVRGLAESAARGDAVHYYSVAG
MMAR_4486|M.marinum_M EHRLLLTSGSELRYDYLIYAVGSTAAMPAVAGAAEFAFS-----VADLDG
MUL_4658|M.ulcerans_Agy99 EHRLLLTSGSELGYDYLIYAVGSTAAMPAVAGAAEFAFS-----VADLDG
MSMEG_3621|M.smegmatis_MC2_155 VDSVLLGHTYSTPYDSLIIAAGAGQSYFGNDHFAEFAPG-MKSIDDALEL
: :* *: . * :
Mvan_1831|M.vanbaalenii_PYR-1 APRTWEFIRTLRSGS---------AVFAMPS--GPIKCAGAPQKIAYLAA
Mflv_0986|M.gilvum_PYR-GCK APRTWEFIRDLRSGT---------AVFAMPS--GPIKCAGAPQKIAYLAS
TH_2797|M.thermoresistible__bu APRTWEFIRTTRSGT---------AVFAMPS--GPIKCAGAPQKIAYLAC
Mb0338|M.bovis_AF2122/97 AAELRAKVEALEHGR---------IAVAIAG--VPFKCPAAPFEAAFLIA
Rv0331|M.tuberculosis_H37Rv AAELRAKVEALEHGR---------IAVAIAG--VPFKCPAAPFEAAFLIA
MAB_4743c|M.abscessus_ATCC_199 AGDARRALADFSAGK---------LVFLVTS--QPFRCPVAPYEGALLAS
MMAR_4486|M.marinum_M ATRLRHAMADLPADA---------AITVVGGGLTGIEAAAELAERGRRVT
MUL_4658|M.ulcerans_Agy99 ATRLRHAMADLPADA---------AITVVGGGLTGIEAAAELAERGRRVT
MSMEG_3621|M.smegmatis_MC2_155 RGRILGAFEQAERSSDPVRRAKLLTFTVVGAGPTGVEMAGQIAELADQTL
. . : . .. . : .
Mvan_1831|M.vanbaalenii_PYR-1 DYWRSQGVLQDIDVHLVVPT--PRLFGIPAIADNLDKVAAGYGITVHTSA
Mflv_0986|M.gilvum_PYR-GCK DYWRSQGVLDNIDVHLVVPT--PRLFGIPAIADTLDTIAAGYGITVHTDA
TH_2797|M.thermoresistible__bu DHWRREGVLSHIDVHLVLPT--PRAFGIPEIADSLEEIIAGYGIHLHTNT
Mb0338|M.bovis_AF2122/97 AQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGFHPRK
Rv0331|M.tuberculosis_H37Rv AQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGFHPRK
MAB_4743c|M.abscessus_ATCC_199 DLLNEKNVRSAVEISMYTPEVHPMPSAGPYAGPQLVQLLKDNGITFHGER
MMAR_4486|M.marinum_M LVCGGRLGPSLSNRGRRSVARQLGKLGVNVLESAAVSEVRWNAVVLADDT
MUL_4658|M.ulcerans_Agy99 LVCGGRLGPSLSNRGRRSVARQLGKLGVNVLESAAVSEVRWNAVVLADDT
MSMEG_3621|M.smegmatis_MC2_155 RGSFRHIDPTEARVILLDAAPAVLPPMGEKLGKKARARLEKMGVEVQLGA
. .: .
Mvan_1831|M.vanbaalenii_PYR-1 EVTAIDAAAHKVALTPVGEAGGSETVLPYDVLHAVPRQSAPDWIKASPLS
Mflv_0986|M.gilvum_PYR-GCK EVTSIDAAAHKVGVTPAG--GGADTVLAYDVLHAVPRQSAPDWIKSGPLS
TH_2797|M.thermoresistible__bu EVTAVDGGARKVALTSLGD-GGTDTTLPYDLLHIAPRQSAPDWIKASPLS
Mb0338|M.bovis_AF2122/97 ALARVDEAARTMHF-------GDGTSEPFDLLAVVPPHVPSAAARSAGLS
Rv0331|M.tuberculosis_H37Rv ALARVDEAARTMHF-------GDGTSEPFDLLAVVPPHVPSAAARSAGLS
MAB_4743c|M.abscessus_ATCC_199 TTECIDPERKVVVF-------GDGTTASFDLLVFVPPHEPSVTIDGQ---
MMAR_4486|M.marinum_M VLASAATVWTAGFG--VPDLAARSGLRTDDLGRLLTDETLTSVSDDRIVA
MUL_4658|M.ulcerans_Agy99 VLASAATVWTAGFG--VPDLAARSGLRTDDLGRLLTDETLTSVSDDRIVA
MSMEG_3621|M.smegmatis_MC2_155 MVTDVDRNGITVKDSDGTIRRIESACKVWSAGVSASPLGKDLAEQSGVEL
. .
Mvan_1831|M.vanbaalenii_PYR-1 TGDANGYVEIDKHTLQHVRHRNVFSLGDAGSS------------------
Mflv_0986|M.gilvum_PYR-GCK TGDANGYVEIDKHTMQHVRYPNVFSLGDAGSS------------------
TH_2797|M.thermoresistible__bu TGDAGGYVDVDKHTLQHVRYPNVFSLGDAAST------------------
Mb0338|M.bovis_AF2122/97 E---SGWIPVDPRTLSTS-ADNVWAIGDATVLTLPN--------------
Rv0331|M.tuberculosis_H37Rv E---SGWIPVDPRTLSTS-ADNVWAIGDATVLTLPN--------------
MAB_4743c|M.abscessus_ATCC_199 -----GWIAVDAETMQTQ-YDGIWAIGDTAAVTSPS--------------
MMAR_4486|M.marinum_M AG---DAVAPSGQPLRMS-CQAAGPLGAQAAN------------------
MUL_4658|M.ulcerans_Agy99 AG---DAVAPSGQPLRMS-CQAAGPLGAQAAN------------------
MSMEG_3621|M.smegmatis_MC2_155 DR--AGRVKVQP-DLTLPGHPNVFVVGDMAAVEGVPGVAQGAIQGGRYAA
. : . : :*
Mvan_1831|M.vanbaalenii_PYR-1 -----PNSKTGAAIRKQAPVVVENIDAYLA-----GRPLTASYNGYGSCP
Mflv_0986|M.gilvum_PYR-GCK -----PNSKTGAAIRKQAPVVVENIDALLT-----GRPLTASYNGYGSCP
TH_2797|M.thermoresistible__bu -----PNSKTGAAIRKQAPVVVDNVDAFLA-----GRPITAHYDGYASCP
Mb0338|M.bovis_AF2122/97 ---GKPLPKAAVFAEAQAAVVAHGVARHLG-----YDVAERHFTGTGACY
Rv0331|M.tuberculosis_H37Rv ---GKPLPKAAVFAEAQAAVVAHGVARHLG-----YDVAERHFTGTGACY
MAB_4743c|M.abscessus_ATCC_199 ---GKPLPKAAIFAKNGAKAAAQNVLHYLG-----RSDRKAVLSGLGYCY
MMAR_4486|M.marinum_M ----TVLSRIAGDQPVALNQAFVGQCISVG-----RSYGTIQLARTDDTP
MUL_4658|M.ulcerans_Agy99 ----TVLSRIAGDQPVALNQAFVGQCISVG-----RSYGTIQLAHTDDTP
MSMEG_3621|M.smegmatis_MC2_155 KIIKREVSGTSPKIRTPFEYFDKGSMATVSRFSAVAKVGPVEFAGFFAWL
. . . :
Mvan_1831|M.vanbaalenii_PYR-1 LVTSSHDMLLAEFDYDLNLEPSFPLLDPTKPHRAYWYLKKYGLPFMYWNL
Mflv_0986|M.gilvum_PYR-GCK IVTSSHEMLLAEFDYDLNMTPSFPLLDPTKPHRGYWYLKKYGLPFMYWNL
TH_2797|M.thermoresistible__bu IVTSARSVLLAEFDYSFAMKPTFPLLDPARPHRAYWYLKKYGLPFMYWNL
Mb0338|M.bovis_AF2122/97 VETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT-
Rv0331|M.tuberculosis_H37Rv VETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT-
MAB_4743c|M.abscessus_ATCC_199 LDTGQHRAAQGKGDFFTLPHPAITLTEPSVGQHHDKRDEEAQWRDMWESR
MMAR_4486|M.marinum_M VNVIIGGRAGAAVKETICKGTLWALRREAAKPGSYFWLKGGSRPVQPSAE
MUL_4658|M.ulcerans_Agy99 VNVIIGGRAGAAVKEAICKGTLWALRREAAKPGSYFWLKGGSRPVQPSAE
MSMEG_3621|M.smegmatis_MC2_155 CWLVLHLVYLVGFKTKIVTLLSWGVTFLSTKRGQLTITEQQAYARTRIEE
. : : :
Mvan_1831|M.vanbaalenii_PYR-1 MLKGLA----------
Mflv_0986|M.gilvum_PYR-GCK MLKGLA----------
TH_2797|M.thermoresistible__bu MLKGLV----------
Mb0338|M.bovis_AF2122/97 ----------------
Rv0331|M.tuberculosis_H37Rv ----------------
MAB_4743c|M.abscessus_ATCC_199 SGA-------------
MMAR_4486|M.marinum_M QPVVLS----------
MUL_4658|M.ulcerans_Agy99 QPVVLP----------
MSMEG_3621|M.smegmatis_MC2_155 LEEIAAAVQDTEKAAS