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MKLLRNKVAAALLAAVVLGAVVLAVGGAYVKQQMGAITVTAQFDSAAGLYEGNVVAVLGMPVGEVKKIRN RNGYVEVEFTVDKGVNIPADVQAATISNSILTDRQIELTPPYRGGPTLQNNATIGLNRTRTPVEFARVLD VLDKLAGSLRGDGKGNGPIADVLGAGASIVDGNGQQMKDALGELSNALRLSSDRGQVTKDQLTTIVRNLS ALSQAAADNDAMMREFGSSVRALSQIVADEDLGSGTTGKKINEVLTHTGQVLETHRDAIKDLVANGDVVL NTVAVDHERDVKELLDIAPMTLDNLYNVADKKNGALRVKVVTDKLLFDNQLIKEVCNMMGLRQLGCSTGT LQDFGPDFGLSSMLDGLAAMGQK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1146 | - | - | 100% (373) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_5897 | - | 4e-42 | 33.33% (306) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 6e-36 | 31.68% (303) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 3e-41 | 33.77% (305) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0007 | - | 1e-151 | 71.35% (370) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 3e-41 | 33.77% (305) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 4e-28 | 28.04% (321) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_2945c | - | 1e-126 | 61.05% (362) | putative Mce family protein |
| M. marinum M | MMAR_3867 | mce5D | 1e-129 | 62.10% (372) | MCE-family protein Mce5D |
| M. avium 104 | MAV_2385 | - | 1e-130 | 62.19% (365) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3076 | - | 1e-162 | 76.41% (373) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4916 | mce6D | 1e-123 | 60.55% (365) | MCE-family protein Mce6D |
| M. vanbaalenii PYR-1 | Mvan_0962 | - | 1e-152 | 71.89% (370) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1146|M.smegmatis_MC2_155 ----------MKLLRNKVAAALLAAVVLGAVVLAVGGAYVKQQMGAITVT
TH_3076|M.thermoresistible__bu ---------MMRDVRTRVIALIAAGLVAVAAVAVVAVKVARDQLDTITVT
Mflv_0007|M.gilvum_PYR-GCK -----------MSGRAKVTALVVAGLVAVVAVAAIGWSFLSDRLDAITVT
Mvan_0962|M.vanbaalenii_PYR-1 -----------MGTRSKLVSLAVAAVAVVVVVAAVGWSYLGDRMDTISVT
MAB_2945c|M.abscessus_ATCC_199 ------------------MVRVVPVLAMVAVICGVGALWPTQHRRYITVT
MMAR_3867|M.marinum_M -----------MTTSKVKILAVVAAVLAVVALAGAGWWRMGADDDPMTVT
MAV_2385|M.avium_104 -----------MTRLGTKALAVVAGVAVVAAAVGIGWWLLRPDDDTITVT
MUL_4916|M.ulcerans_Agy99 -----------MTHR-HNLIRVGVGLVVVAALACAGWYGLARDRGPIVVT
Mb3526c|M.bovis_AF2122/97 -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSSTGNKRTIV
Rv3496c|M.tuberculosis_H37Rv -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSSTGNKRTIV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
. :.
MSMEG_1146|M.smegmatis_MC2_155 AQFDSAAGLYEGNVVAVLGMPVGEVKKIRNRNGYVEVEFTVDKGVNIPAD
TH_3076|M.thermoresistible__bu AQFDSAAGLYVGNVVAVLGMPVGKVTEITPKTNYVEVTFTVDKDVKVPAD
Mflv_0007|M.gilvum_PYR-GCK AQFDSAAGLYEGNTVAVLGMPVGKVVRIEPKGGYVEVEFTVDGDVAVPAD
Mvan_0962|M.vanbaalenii_PYR-1 AQFDSAAGLYEGNTVAVLGMPVGEVTKIVTKGGYVEVEFTVDGDVRVPAD
MAB_2945c|M.abscessus_ATCC_199 AQFDSAAGLYPGSTVAVLGMRVGSVEKITPEGGYVEVEFTVDRQVALPAD
MMAR_3867|M.marinum_M AQFDSASGLYEGNVVAVLGMPVGQVTKIRPKGGYVEVEFTIDRKVKIPAD
MAV_2385|M.avium_104 AQFDSASGLYEGNVVAVLGMPVGKITKINPRGGYVEVEFTVDRGVKVPAN
MUL_4916|M.ulcerans_Agy99 AQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSGYAEVEFTVDRAVQVPAD
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
* :* .** *. * ::*: ** : * . :: : . :*.:
MSMEG_1146|M.smegmatis_MC2_155 VQAATISNSILTDRQIELTPPYRG-GPTLQNNATIGLNRTRTPVEFARVL
TH_3076|M.thermoresistible__bu VQAVTLSNSILTDRQIELTPPYRG-GPTLQDHDTIGLNRTRTPVEFARVL
Mflv_0007|M.gilvum_PYR-GCK VQAVTISNSILTDRQIELTPPYRGDGPTLRDHDTIGLNRTRTPVEFARVL
Mvan_0962|M.vanbaalenii_PYR-1 AMAVTISNSILTDRQIELTPPYRGDGPMLQNHDTIGLNRTRTPVEFARVL
MAB_2945c|M.abscessus_ATCC_199 VQAVTISTSILTDRQIELTPPYRG-GAVMHDNETIGLNRTKTPVEFSRVV
MMAR_3867|M.marinum_M AQAVTVSTSILTDRQIELTPPYRG-GPVLQSHDTIGLTRTKTPVEFSRVL
MAV_2385|M.avium_104 AQAVTVSTSILTDRQIELTPPYRG-GPVLGNHDTIGLPRTKTPVEFSSVL
MUL_4916|M.ulcerans_Agy99 VQAVTISTSILTDRQIELTPAYRG-GPTLRNHDTIGLTRTRAPVEFDRVL
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEVK
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEVK
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKG-GPALGDNAVIPLERTQVPVEWDELR
. *. :. .::: * *:* * * * *. : .: * * ** .***: :
MSMEG_1146|M.smegmatis_MC2_155 DVLDKLAGSLR-GDGKGNGPIADVLGAGASIVDGNGQQMKDALGELSNAL
TH_3076|M.thermoresistible__bu DVLDKLALSLR-GDGKGGGPIADVVDAGAAIVDGQGRQMKDALGELSNAL
Mflv_0007|M.gilvum_PYR-GCK DVLDKLSTSLR-GDGRGGGPVADVVNASAAIADGNGQQMKDALGELSTAL
Mvan_0962|M.vanbaalenii_PYR-1 DVLDKLSTSLR-GDGKGNGPVRDVVDASAAIADGNGQAMKDALGELSNAL
MAB_2945c|M.abscessus_ATCC_199 AVLDKLSISLR-GDGEGGGPVADIVNTGADAVDGNGQKIKGALDELSRAL
MMAR_3867|M.marinum_M SVLDKVTKSLQ-GDGHGGGPVADVLSGGTEIVDGNGAKIKGALDALSRAL
MAV_2385|M.avium_104 NVLDKVTKSLE-GDGHGGGPIADVLGGGAEVVNGNGEKIKAALGELSKAL
MUL_4916|M.ulcerans_Agy99 GMLDRLASSLQ-VDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELSKAL
Mb3526c|M.bovis_AF2122/97 EGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVA
Rv3496c|M.tuberculosis_H37Rv EGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVA
MLBr_02592|M.leprae_Br4923 DSITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRAL
: :: .* . **. : *:* :: :: *: .
MSMEG_1146|M.smegmatis_MC2_155 RLSSDRGQVTKDQLTTIVRNLSALSQAAADNDAMMREFGSSVRALSQIVA
TH_3076|M.thermoresistible__bu RLSADRGELTRDQLTTIVRNVSSLAEAAARNDELLREFGSSVRAMSQILA
Mflv_0007|M.gilvum_PYR-GCK RLSADHGQVTRDQLTTIIRNVSTLSQAAADNDATLREFGSSVRQLSQVLA
Mvan_0962|M.vanbaalenii_PYR-1 RLSSDRGEVTRDQLTTIIRNVSTLFEAAANNDATLREFGSTIRALSQILA
MAB_2945c|M.abscessus_ATCC_199 RLGADGGRVTAEQLATVIKNVGTLMDAAARNDSKLREFTSTIHQLSQIVD
MMAR_3867|M.marinum_M RLSSDGGAQTREQITTIIRNVSSLFDAAAANDAKLREFASTIHQVSQILA
MAV_2385|M.avium_104 RLSSDGGAATREQITTIVKNLSTLFDAVASNDTKLREFASTIHQVSQIMA
MUL_4916|M.ulcerans_Agy99 RLSADRGVHTREQMTAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQIMA
Mb3526c|M.bovis_AF2122/97 GRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLA
Rv3496c|M.tuberculosis_H37Rv GRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLA
MLBr_02592|M.leprae_Br4923 TALNEG----RGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLA
: :: :..: : :* .* : : : .: :
MSMEG_1146|M.smegmatis_MC2_155 DEDLGSGTTGKKINEVLTHTGQVLETHRDAIKDLVANGDVVLNTVAVDHE
TH_3076|M.thermoresistible__bu DEKLGSGTTGRKINEVLTHAGEVLQTHRETIRDLIANGDVVLN-AAVDHE
Mflv_0007|M.gilvum_PYR-GCK DENFGTGTTGKKLNEVIVQFGEVLDTHREAIRQIVTNGNTAVT-TTVDHQ
Mvan_0962|M.vanbaalenii_PYR-1 DENFGSGSTGRKLNDVINQLGEVLHTHRDAIRQIVSNGDTALT-TTVEHQ
MAB_2945c|M.abscessus_ATCC_199 DESLGTGSVGRKLNDVLKQAAEVLETNRDHIKQSVLNGDGAFK-TLVDQQ
MMAR_3867|M.marinum_M DEDIGGGNTGKRLDQLVQRAGDLLDANREAIRQTVLNGNTTLQ-TVSDQQ
MAV_2385|M.avium_104 DEDLGSGNTGHKLDQLIQRAGDLLDANRDNIKHAVLSGNDTLK-TVTDQR
MUL_4916|M.ulcerans_Agy99 NEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQ-SVVDRQ
Mb3526c|M.bovis_AF2122/97 DSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQS
Rv3496c|M.tuberculosis_H37Rv DSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQS
MLBr_02592|M.leprae_Br4923 HSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNN-TVVQPE
.. . . :: : .* :.. : : . :
MSMEG_1146|M.smegmatis_MC2_155 --RDVKELLDIAPMTLDNLYNVADKKNGALRVKVVTDKLLFDNQLIKEVC
TH_3076|M.thermoresistible__bu --RDLKELLDVTPMTLDNLYNVADQRNGALRIKVVTDKVLFDNQLVKEVC
Mflv_0007|M.gilvum_PYR-GCK --RDLAEFLDVTPMTLDNIYNAIDRTNGAVRVHVLTDKVLFDTQTVKEMC
Mvan_0962|M.vanbaalenii_PYR-1 --RDLAEFLDLAPLTLDNIYNAIDNKNGAVRVHVLTDKVLFDTQTVKEMC
MAB_2945c|M.abscessus_ATCC_199 --RELTELVDVLPLALDNLYNIIDQDNGAVRTRAMVDHILFDSQHIKEIC
MMAR_3867|M.marinum_M --RDLAEILDLAPLVADNGYNAIDRANGAVRAHFLTDRMIFDSQLTKEVC
MAV_2385|M.avium_104 --RDLAELLDLAPLVADNAYNMIDRANGSVRARFLTDRLLFDSQYTKEIC
MUL_4916|M.ulcerans_Agy99 --REVTEFFDVLPLMADNLYNAVDRRNGSIRAHQLTDRMIFDSQFGKEVC
Mb3526c|M.bovis_AF2122/97 --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGS
Rv3496c|M.tuberculosis_H37Rv --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGS
MLBr_02592|M.leprae_Br4923 PLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS--
. : ...: * : . :*:: .. *
MSMEG_1146|M.smegmatis_MC2_155 N---------------MMGLRQLGCSTGTLQDFGPDFGLSSMLDGLAAMG
TH_3076|M.thermoresistible__bu N---------------MMGLRQLGCSTGTLQDFGPDFGLTYMLEGLAAMG
Mflv_0007|M.gilvum_PYR-GCK N---------------MMGLRQLGCSTGTLQDFGPDFGLSYVLDGLTAMG
Mvan_0962|M.vanbaalenii_PYR-1 N---------------MMGLRQLGCSSGTLQDFGPDFGLSYVLDGLAAMG
MAB_2945c|M.abscessus_ATCC_199 N---------------LMGLRQLGCSTGTMKDFGPDFGLTYILDGLAAMG
MMAR_3867|M.marinum_M N---------------MMGLRQLGCSTGTLQDFGPDFGLTFVLDGMAAMG
MAV_2385|M.avium_104 N---------------LMGLRQLGCSTGTIQDFGPDFGLTYVLDGLAAMG
MUL_4916|M.ulcerans_Agy99 N---------------LMGLRQLGCSTGTLQDYGPDFGLTYLLDGLAAMG
Mb3526c|M.bovis_AF2122/97 FDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKG
Rv3496c|M.tuberculosis_H37Rv FDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKG
MLBr_02592|M.leprae_Br4923 --AIQAGSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPK
: . *. : : : . .
MSMEG_1146|M.smegmatis_MC2_155 QK------------------------------------------------
TH_3076|M.thermoresistible__bu QR------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK QK------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 QK------------------------------------------------
MAB_2945c|M.abscessus_ATCC_199 QK------------------------------------------------
MMAR_3867|M.marinum_M QK------------------------------------------------
MAV_2385|M.avium_104 QK------------------------------------------------
MUL_4916|M.ulcerans_Agy99 QK------------------------------------------------
Mb3526c|M.bovis_AF2122/97 QIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG-----
Rv3496c|M.tuberculosis_H37Rv QIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG-----
MLBr_02592|M.leprae_Br4923 EVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQV
:
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2945c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3867|M.marinum_M --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 ------------------------------APVGNPADLQSLLVPP----
Rv3496c|M.tuberculosis_H37Rv ------------------------------APVGNPADLQSLLVPP----
MLBr_02592|M.leprae_Br4923 GPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGL
MSMEG_1146|M.smegmatis_MC2_155 -----------------------------------------
TH_3076|M.thermoresistible__bu -----------------------------------------
Mflv_0007|M.gilvum_PYR-GCK -----------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 -----------------------------------------
MAB_2945c|M.abscessus_ATCC_199 -----------------------------------------
MMAR_3867|M.marinum_M -----------------------------------------
MAV_2385|M.avium_104 -----------------------------------------
MUL_4916|M.ulcerans_Agy99 -----------------------------------------
Mb3526c|M.bovis_AF2122/97 -------------APGPAPAPPAPGAGPG------EHGGGG
Rv3496c|M.tuberculosis_H37Rv -------------APGPAPAPPAPGAGPG------EHGGGG
MLBr_02592|M.leprae_Br4923 QASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ