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SASLSTGTRRTLWIAGALAIVIAVVAGAFGWTYLRDRSHRLTITAQFESVSGLYPDNKVSVLGMPIGKVT KITSRGTYMEVEFTIDSTVKVPADAKAVTVSTSILTDRHIELTPVYRGGPTLKNGDIIGLDRTKTPVEFD RVLAMIDRLSKAMKGDGKGAGPLADLINNSTNALSGNGELMTSSLDELSKALRLSADGGAMTRDQLTKIV TRLSSLFEASARNDQNIREFSSTVRQLSQVLDQEQLGSGTTGKQLNNILLQAGSLLEQNRDAIKQSVGNS SQIAQAVYDNRRELSEGFDLLPLMADNVYNIIDPVNNVVRAHVPADRLLFDTQAAKEICNLMGLRQLGCS TGTLQDYGPDFGLTYVLDGLAAMGQK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4565c | - | - | 100% (377) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1698 | - | e-131 | 62.26% (371) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4513c | - | e-129 | 61.96% (368) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 2e-39 | 32.34% (303) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0007 | - | 1e-121 | 57.65% (366) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 2e-39 | 32.34% (303) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 7e-33 | 28.73% (275) | putative secreted protein |
| M. marinum M | MMAR_3867 | mce5D | 1e-123 | 59.07% (364) | MCE-family protein Mce5D |
| M. avium 104 | MAV_2385 | - | 1e-124 | 61.26% (364) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1146 | - | 1e-113 | 54.92% (366) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3076 | - | 1e-115 | 55.28% (369) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4916 | mce6D | 1e-121 | 56.79% (368) | MCE-family protein Mce6D |
| M. vanbaalenii PYR-1 | Mvan_0962 | - | 1e-123 | 57.68% (371) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3867|M.marinum_M ----------MTTSKVKILAVVAAVLAVVALAG--AGWWRMGADDDPMTV
MAV_2385|M.avium_104 ----------MTRLGTKALAVVAGVAVVAAAVG--IGWWLLRPDDDTITV
MUL_4916|M.ulcerans_Agy99 ----------MTHR-HNLIRVGVGLVVVAALAC--AGWYGLARDRGPIVV
Mflv_0007|M.gilvum_PYR-GCK ----------MSGRAKVTALVVAGLVAVVAVAA--IGWSFLSDRLDAITV
Mvan_0962|M.vanbaalenii_PYR-1 ----------MGTRSKLVSLAVAAVAVVVVVAA--VGWSYLGDRMDTISV
MSMEG_1146|M.smegmatis_MC2_155 ---------MKLLRNKVAAALLAAVVLGAVVLA--VGGAYVKQQMGAITV
TH_3076|M.thermoresistible__bu --------MMRDVRTRVIALIAAGLVAVAAVAV--VAVKVARDQLDTITV
MAB_4565c|M.abscessus_ATCC_199 ------MSASLSTGTRRTLWIAGALAIVIAVVAGAFGWTYLRDRSHRLTI
Mb3526c|M.bovis_AF2122/97 -----MMGRVAMLTGSRGLRYATVIALVAALVG-GVY--VLSSTGNKRTI
Rv3496c|M.tuberculosis_H37Rv -----MMGRVAMLTGSRGLRYATVIALVAALVG-GVY--VLSSTGNKRTI
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVV-GFVGWRLYQKLTNNTV
: . :
MMAR_3867|M.marinum_M TAQFDSASGLYEGNVVAVLGMPVGQVTKIRPKGGYVEVEFTIDRKVKIPA
MAV_2385|M.avium_104 TAQFDSASGLYEGNVVAVLGMPVGKITKINPRGGYVEVEFTVDRGVKVPA
MUL_4916|M.ulcerans_Agy99 TAQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSGYAEVEFTVDRAVQVPA
Mflv_0007|M.gilvum_PYR-GCK TAQFDSAAGLYEGNTVAVLGMPVGKVVRIEPKGGYVEVEFTVDGDVAVPA
Mvan_0962|M.vanbaalenii_PYR-1 TAQFDSAAGLYEGNTVAVLGMPVGEVTKIVTKGGYVEVEFTVDGDVRVPA
MSMEG_1146|M.smegmatis_MC2_155 TAQFDSAAGLYEGNVVAVLGMPVGEVKKIRNRNGYVEVEFTVDKGVNIPA
TH_3076|M.thermoresistible__bu TAQFDSAAGLYVGNVVAVLGMPVGKVTEITPKTNYVEVTFTVDKDVKVPA
MAB_4565c|M.abscessus_ATCC_199 TAQFESVSGLYPDNKVSVLGMPIGKVTKITSRGTYMEVEFTIDSTVKVPA
Mb3526c|M.bovis_AF2122/97 VGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPV
Rv3496c|M.tuberculosis_H37Rv VGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPV
MLBr_02592|M.leprae_Br4923 VVYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPA
. * :. .** .: * ::*: :* : * :: : . :*.
MMAR_3867|M.marinum_M DAQAVTVSTSILTDRQIELTPPYRG-GPVLQSHDTIGLTRTKTPVEFSRV
MAV_2385|M.avium_104 NAQAVTVSTSILTDRQIELTPPYRG-GPVLGNHDTIGLPRTKTPVEFSSV
MUL_4916|M.ulcerans_Agy99 DVQAVTISTSILTDRQIELTPAYRG-GPTLRNHDTIGLTRTRAPVEFDRV
Mflv_0007|M.gilvum_PYR-GCK DVQAVTISNSILTDRQIELTPPYRGDGPTLRDHDTIGLNRTRTPVEFARV
Mvan_0962|M.vanbaalenii_PYR-1 DAMAVTISNSILTDRQIELTPPYRGDGPMLQNHDTIGLNRTRTPVEFARV
MSMEG_1146|M.smegmatis_MC2_155 DVQAATISNSILTDRQIELTPPYRG-GPTLQNNATIGLNRTRTPVEFARV
TH_3076|M.thermoresistible__bu DVQAVTLSNSILTDRQIELTPPYRG-GPTLQDHDTIGLNRTRTPVEFARV
MAB_4565c|M.abscessus_ATCC_199 DAKAVTVSTSILTDRHIELTPVYRG-GPTLKNGDIIGLDRTKTPVEFDRV
Mb3526c|M.bovis_AF2122/97 DVQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEV
Rv3496c|M.tuberculosis_H37Rv DVQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEV
MLBr_02592|M.leprae_Br4923 NASAVILNPTLVASRSIQLEPPYKG-GPALGDNAVIPLERTQVPVEWDEL
:. *. :. .::: * *:* * * * *. * . * * ** .***: :
MMAR_3867|M.marinum_M LSVLDKVTKSLQ-GDGHGGGPVADVLSGGTEIVDGNGAKIKGALDALSRA
MAV_2385|M.avium_104 LNVLDKVTKSLE-GDGHGGGPIADVLGGGAEVVNGNGEKIKAALGELSKA
MUL_4916|M.ulcerans_Agy99 LGMLDRLASSLQ-VDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELSKA
Mflv_0007|M.gilvum_PYR-GCK LDVLDKLSTSLR-GDGRGGGPVADVVNASAAIADGNGQQMKDALGELSTA
Mvan_0962|M.vanbaalenii_PYR-1 LDVLDKLSTSLR-GDGKGNGPVRDVVDASAAIADGNGQAMKDALGELSNA
MSMEG_1146|M.smegmatis_MC2_155 LDVLDKLAGSLR-GDGKGNGPIADVLGAGASIVDGNGQQMKDALGELSNA
TH_3076|M.thermoresistible__bu LDVLDKLALSLR-GDGKGGGPIADVVDAGAAIVDGQGRQMKDALGELSNA
MAB_4565c|M.abscessus_ATCC_199 LAMIDRLSKAMK-GDGKGAGPLADLINNSTNALSGNGELMTSSLDELSKA
Mb3526c|M.bovis_AF2122/97 KEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQV
Rv3496c|M.tuberculosis_H37Rv KEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQV
MLBr_02592|M.leprae_Br4923 RDSITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRA
: :: : . **. : *:* : :: *: .
MMAR_3867|M.marinum_M LRLSSDGGAQTREQITTIIRNVSSLFDAAAANDAKLREFASTIHQVSQIL
MAV_2385|M.avium_104 LRLSSDGGAATREQITTIVKNLSTLFDAVASNDTKLREFASTIHQVSQIM
MUL_4916|M.ulcerans_Agy99 LRLSADRGVHTREQMTAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQIM
Mflv_0007|M.gilvum_PYR-GCK LRLSADHGQVTRDQLTTIIRNVSTLSQAAADNDATLREFGSSVRQLSQVL
Mvan_0962|M.vanbaalenii_PYR-1 LRLSSDRGEVTRDQLTTIIRNVSTLFEAAANNDATLREFGSTIRALSQIL
MSMEG_1146|M.smegmatis_MC2_155 LRLSSDRGQVTKDQLTTIVRNLSALSQAAADNDAMMREFGSSVRALSQIV
TH_3076|M.thermoresistible__bu LRLSADRGELTRDQLTTIVRNVSSLAEAAARNDELLREFGSSVRAMSQIL
MAB_4565c|M.abscessus_ATCC_199 LRLSADGGAMTRDQLTKIVTRLSSLFEASARNDQNIREFSSTVRQLSQVL
Mb3526c|M.bovis_AF2122/97 AGRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVL
Rv3496c|M.tuberculosis_H37Rv AGRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVL
MLBr_02592|M.leprae_Br4923 LTALNEG----RGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRL
: : :: : : : :* .* : : : .: :
MMAR_3867|M.marinum_M ADEDIGGGNTGKRLDQLVQRAGDLLDANREAIRQTVLNGNTTLQ-TVSDQ
MAV_2385|M.avium_104 ADEDLGSGNTGHKLDQLIQRAGDLLDANRDNIKHAVLSGNDTLK-TVTDQ
MUL_4916|M.ulcerans_Agy99 ANEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQ-SVVDR
Mflv_0007|M.gilvum_PYR-GCK ADENFGTGTTGKKLNEVIVQFGEVLDTHREAIRQIVTNGNTAVT-TTVDH
Mvan_0962|M.vanbaalenii_PYR-1 ADENFGSGSTGRKLNDVINQLGEVLHTHRDAIRQIVSNGDTALT-TTVEH
MSMEG_1146|M.smegmatis_MC2_155 ADEDLGSGTTGKKINEVLTHTGQVLETHRDAIKDLVANGDVVLNTVAVDH
TH_3076|M.thermoresistible__bu ADEKLGSGTTGRKINEVLTHAGEVLQTHRETIRDLIANGDVVLN-AAVDH
MAB_4565c|M.abscessus_ATCC_199 DQEQLGSGTTGKQLNNILLQAGSLLEQNRDAIKQSVGNSSQIAQ-AVYDN
Mb3526c|M.bovis_AF2122/97 ADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQ
Rv3496c|M.tuberculosis_H37Rv ADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQ
MLBr_02592|M.leprae_Br4923 AHSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNN-TVVQP
.. . . : :: : .* :.. : : . :
MMAR_3867|M.marinum_M Q--RDLAEILDLAPLVADNGYNAIDRANGAVR----AHFLTDRMIFDSQ-
MAV_2385|M.avium_104 R--RDLAELLDLAPLVADNAYNMIDRANGSVR----ARFLTDRLLFDSQ-
MUL_4916|M.ulcerans_Agy99 Q--REVTEFFDVLPLMADNLYNAVDRRNGSIR----AHQLTDRMIFDSQ-
Mflv_0007|M.gilvum_PYR-GCK Q--RDLAEFLDVTPMTLDNIYNAIDRTNGAVR----VHVLTDKVLFDTQ-
Mvan_0962|M.vanbaalenii_PYR-1 Q--RDLAEFLDLAPLTLDNIYNAIDNKNGAVR----VHVLTDKVLFDTQ-
MSMEG_1146|M.smegmatis_MC2_155 E--RDVKELLDIAPMTLDNLYNVADKKNGALR----VKVVTDKLLFDNQ-
TH_3076|M.thermoresistible__bu E--RDLKELLDVTPMTLDNLYNVADQRNGALR----IKVVTDKVLFDNQ-
MAB_4565c|M.abscessus_ATCC_199 R--RELSEGFDLLPLMADNVYNIIDPVNNVVR----AHVPADRLLFDTQ-
Mb3526c|M.bovis_AF2122/97 S--ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGG
Rv3496c|M.tuberculosis_H37Rv S--ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGG
MLBr_02592|M.leprae_Br4923 EPLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-
. : :.: * : . :. : :: : *
MMAR_3867|M.marinum_M ---LTKEVCNMMGLRQLGCSTGTLQDFGPDFGLTFVLDGMAAMGQK----
MAV_2385|M.avium_104 ---YTKEICNLMGLRQLGCSTGTIQDFGPDFGLTYVLDGLAAMGQK----
MUL_4916|M.ulcerans_Agy99 ---FGKEVCNLMGLRQLGCSTGTLQDYGPDFGLTYLLDGLAAMGQK----
Mflv_0007|M.gilvum_PYR-GCK ---TVKEMCNMMGLRQLGCSTGTLQDFGPDFGLSYVLDGLTAMGQK----
Mvan_0962|M.vanbaalenii_PYR-1 ---TVKEMCNMMGLRQLGCSSGTLQDFGPDFGLSYVLDGLAAMGQK----
MSMEG_1146|M.smegmatis_MC2_155 ---LIKEVCNMMGLRQLGCSTGTLQDFGPDFGLSSMLDGLAAMGQK----
TH_3076|M.thermoresistible__bu ---LVKEVCNMMGLRQLGCSTGTLQDFGPDFGLTYMLEGLAAMGQR----
MAB_4565c|M.abscessus_ATCC_199 ---AAKEICNLMGLRQLGCSTGTLQDYGPDFGLTYVLDGLAAMGQK----
Mb3526c|M.bovis_AF2122/97 SFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYK
Rv3496c|M.tuberculosis_H37Rv SFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYK
MLBr_02592|M.leprae_Br4923 ---AIQAGSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLP
. . . : : .. : :.
MMAR_3867|M.marinum_M --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAB_4565c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 GQIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG----
Rv3496c|M.tuberculosis_H37Rv GQIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG----
MLBr_02592|M.leprae_Br4923 KEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQ
MMAR_3867|M.marinum_M --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAB_4565c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 -------------------------------APVGNPADLQSLLVPP---
Rv3496c|M.tuberculosis_H37Rv -------------------------------APVGNPADLQSLLVPP---
MLBr_02592|M.leprae_Br4923 VGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIG
MMAR_3867|M.marinum_M ------------------------------------------
MAV_2385|M.avium_104 ------------------------------------------
MUL_4916|M.ulcerans_Agy99 ------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK ------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 ------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 ------------------------------------------
TH_3076|M.thermoresistible__bu ------------------------------------------
MAB_4565c|M.abscessus_ATCC_199 ------------------------------------------
Mb3526c|M.bovis_AF2122/97 --------------APGPAPAPPAPGAGPG------EHGGGG
Rv3496c|M.tuberculosis_H37Rv --------------APGPAPAPPAPGAGPG------EHGGGG
MLBr_02592|M.leprae_Br4923 LQASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ