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TAPVQSGGLLESVSRGLLAVGDVFRRSWKWLSVVGLVAILVICVGYVMFGTLKVNPIESEYQVKVQLHES GGLLPNQEVTLRGVPIGRVESVNLDKGGVVAIAAINGSVKLPVDSEVRVSGLSPAGEQYLDFRPTTNNGP FLGNNSVVALGKATTPITLAQVLADSDGLLAQLDTQKLSTLRKELGVSAQGPEKLANILDGGTFLITTLD GVLPETVTLLKSSKVTFSTLVDLNSGLDATGQQLGSTFAGLKKMDGGFRTLLERAPQTLHGVDNLFTDNS DTMVQLLGNLATVAQLNYVRVPALNALFPGPEVRGSMLESAASIFHDGAVWALADLLYPRPTCDYVTPRK PVSDASFYEPALYSTYCANPDPAMLVRGARNAPRPADDDTAGPPPNADLAKVSDPTPRGKWSVPTPYGGP QWPLPIPGDAPLPPEAPAPPPGFGNTPPTGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4594c | - | - | 100% (452) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1005c | - | e-133 | 54.89% (419) | putative MCE family protein |
| M. abscessus ATCC 19977 | MAB_4563c | - | e-128 | 55.28% (398) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 3e-25 | 26.90% (435) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0005 | - | 1e-128 | 53.22% (419) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 7e-25 | 26.90% (435) | MCE-family protein MCE1F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 8e-26 | 24.77% (436) | putative secreted protein |
| M. marinum M | MMAR_3869 | mce5F | 1e-129 | 53.46% (419) | Mce family protein Mce5F |
| M. avium 104 | MAV_0107 | - | 1e-128 | 53.22% (419) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1148 | - | 1e-127 | 54.70% (404) | mce related protein |
| M. thermoresistible (build 8) | TH_2636 | - | 1e-90 | 51.08% (323) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_4914 | mce6F | 1e-128 | 55.53% (398) | MCE-family protein Mce6F |
| M. vanbaalenii PYR-1 | Mvan_0964 | - | 1e-124 | 51.79% (419) | hypothetical protein Mvan_0964 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0005|M.gilvum_PYR-GCK ---------MINALADSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFV
Mvan_0964|M.vanbaalenii_PYR-1 ---------MIGSVADAVVGVARFGYRRRAWLSTAALIMTLVVASAYLFF
MSMEG_1148|M.smegmatis_MC2_155 ---------MINAVADRIVGLVRFGYRKRSWLSALGLVMTLVVATAYLFF
TH_2636|M.thermoresistible__bu ---------MIGAVADRIVALVRFGHRRRATLSTIGLILTLVVATAYLLF
MMAR_3869|M.marinum_M ---------MITPIANAVVRVVRAGHRQQTWLSVAGLVLTLVVAAAYLLV
MAV_0107|M.avium_104 ---------MIDTLGRLVVGVVKAGHRQRTWLSGLALLVTLVVGGAYLAL
MUL_4914|M.ulcerans_Agy99 -------------MTDVAPSLTNMRGGRHTWLSCVGLLLTLVVSVAYLLI
MAB_4594c|M.abscessus_ATCC_199 MTAPVQSGGLLESVSRGLLAVGDVFRRSWKWLSVVGLVAILVICVGYVMF
Mb0180|M.bovis_AF2122/97 -------------------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRI
Rv0174|M.tuberculosis_H37Rv -------------------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRI
MLBr_02594|M.leprae_Br4923 -------------------MLTPLIRRQLVLFAILTVISLTVLGVYYLQI
: :: :: *: *: .
Mflv_0005|M.gilvum_PYR-GCK GALQVNPLAKSYRVTVQLPESAGLLPNQNVTLRGVPIGRVERLDITPAGV
Mvan_0964|M.vanbaalenii_PYR-1 GALQVNPLASSYRVTVELPESAGLLPNQNVTMRGVPIGRVERLDITPAGV
MSMEG_1148|M.smegmatis_MC2_155 GALQVNPLDSDYGLTVQLPESAGLLPDQDVTLRGVPIGRVERLDITPSGV
TH_2636|M.thermoresistible__bu GALQVNPFASSYQVTVALPESGGLLPNQAVTLRGVPVGRVERLDITPEGV
MMAR_3869|M.marinum_M GALRLTPFASSYRVTVSLPESGGLLPNQDVALRGVRIGRIESLHITESGV
MAV_0107|M.avium_104 GALRVNPLESTYQVTIRLPESGGLLANQDVSVRGIRVGRITSLRPIPSGV
MUL_4914|M.ulcerans_Agy99 GVLHVRPLASNYALTVELGQSGGLLPNQDVALHGVQIGKVESLEISRTGV
MAB_4594c|M.abscessus_ATCC_199 GTLKVNPIESEYQVKVQLHESGGLLPNQEVTLRGVPIGRVESVNLDKGGV
Mb0180|M.bovis_AF2122/97 PSLVG---IGQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGA
Rv0174|M.tuberculosis_H37Rv PSLVG---IGQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGA
MLBr_02594|M.leprae_Br4923 PSLVG---IGRYSLKAELSATGGLYPTANVTYRGIAIGKVTDVEPTATGA
* * :. * :.** . *: :*: :*:: : *.
Mflv_0005|M.gilvum_PYR-GCK DAVVSMDSSVAVPMSSAVRVSGLSPAGEQYIDFV--ADSDAGPYLENGSV
Mvan_0964|M.vanbaalenii_PYR-1 NAVVSVDSSAAVPVASSVRVSGLSPAGEQYIDFV--ADSGDGPYLADGAV
MSMEG_1148|M.smegmatis_MC2_155 NAIVKVKSTVRIPEASDVRVSGLSPAGEQYIDFIDVPAEDSSRFLADGAV
TH_2636|M.thermoresistible__bu NAVVDIDSAVKIPDSSAVRVSGLSPAGEQYIDFI--PEEDTGRYLADGAH
MMAR_3869|M.marinum_M DAIASITSQVKIPASSAVHVSALSPAGEQFLDFE--PESDTGPYLGEGAV
MAV_0107|M.avium_104 EVVANINAHTKIPASSPVRVSGLSPAGEQYIDFE--PTSNTGPFLSNGSV
MUL_4914|M.ulcerans_Agy99 TAILRINAGVRIPVASTVRVSALSPAGEQYVDFN--ATSGEGPFLKNGDA
MAB_4594c|M.abscessus_ATCC_199 VAIAAINGSVKLPVDSEVRVSGLSPAGEQYLDFR--PTTNNGPFLGNNSV
Mb0180|M.bovis_AF2122/97 RVTMSIASNYKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQT
Rv0174|M.tuberculosis_H37Rv RVTMSIASNYKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQT
MLBr_02594|M.leprae_Br4923 EATMSIDSRYKIPIDSAANVHSVSAVGEQYLDLVS--SGNPGKYLAPGQT
. : . :* : ..* .:*..***::*: . :: .
Mflv_0005|M.gilvum_PYR-GCK IAQDNTTVPVSLADLLANADGALSQVDPGKLEVIKHELSMTEAGP-QKLA
Mvan_0964|M.vanbaalenii_PYR-1 VSQDNTVVPVSLADLLANADGALAQADPAKLELIKRELSMSEAGP-QKLA
MSMEG_1148|M.smegmatis_MC2_155 IRQGQATVPVSLADLLADADGALGQVDTAKIELIKRELSLTDAGP-QKLA
TH_2636|M.thermoresistible__bu IGQGTATVPVPLAELLADADGALAQADVEKLEIIRRELSLSPAGP-QKLK
MMAR_3869|M.marinum_M IGVDQARVPVSLAQLLGDANGLLAQIDPHQVELIKKELSLSQAGP-KKLA
MAV_0107|M.avium_104 IGPQHTTTPIPLSQVLADADGLIAQTDPKKLEIVKRELSLSNQGP-QKLT
MUL_4914|M.ulcerans_Agy99 ISQDRTTTPVTPAELLQHADGVLAQIDPAKLAGIRRELNLSKAAP-EKLT
MAB_4594c|M.abscessus_ATCC_199 VALGKATTPITLAQVLADSDGLLAQLDTQKLSTLRKELGVSAQGP-EKLA
Mb0180|M.bovis_AF2122/97 ITKG--TVPSEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQ
Rv0174|M.tuberculosis_H37Rv ITKG--TVPSEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQ
MLBr_02594|M.leprae_Br4923 ITKS--KIPIEIGPALDSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQ
: * . * : :. :: : * : . *
Mflv_0005|M.gilvum_PYR-GCK DIIDGGTFLLTTLDSVLPETSSMLRTSRVVFTLAADKNAGIEVASDNLAQ
Mvan_0964|M.vanbaalenii_PYR-1 DIIDGGTFLLTTLDSVLPETSSMLRTSRVVLTLAADKNAGIEVASQNLDQ
MSMEG_1148|M.smegmatis_MC2_155 DIVDGGTFLLSTLDSVLPETSSLLRTSRVVFTLMADKNPGISVASDNLTE
TH_2636|M.thermoresistible__bu DIVDGGTFLLSTLDSVLPETSSLLRTSRVVFTLIDDKNAGIDVAADNLAD
MMAR_3869|M.marinum_M AIVDGGTFLLSTLDSVLPETTSIIRTGRVVLNLVADKNAGLAATAVALDR
MAV_0107|M.avium_104 DIIDGSTFLLSTMDPVLPQTVSMLKTSRVVLMTLSDKNAGLSVAARNVGD
MUL_4914|M.ulcerans_Agy99 AIVDGGVFLISTLDSVLPQTVSLLRNSRVVLSAAIDVNDGIDATARNVHQ
MAB_4594c|M.abscessus_ATCC_199 NILDGGTFLITTLDGVLPETVTLLKSSKVTFSTLVDLNSGLDATGQQLGS
Mb0180|M.bovis_AF2122/97 RLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNN
Rv0174|M.tuberculosis_H37Rv RLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNN
MLBr_02594|M.leprae_Br4923 RLVSSTQAIVDAFKTNITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNV
::.. :: :. : :. ::... : . . : :
Mflv_0005|M.gilvum_PYR-GCK TFDGVNRMRDGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLGNLTTTSQL
Mvan_0964|M.vanbaalenii_PYR-1 VFDGVNRMRQGFRTLTEQTPETLAEVDNLFADNSETMVQLLGSLTSTSQL
MSMEG_1148|M.smegmatis_MC2_155 TFTGMDKMREGYRRLTNQTPETLAAVDNLFVDNSDTMVQLLGNLTTASRL
TH_2636|M.thermoresistible__bu TFDGVNRMREGYRRLTDQTPEVLAHVDNLFADNSDTMVQLLGNLTTTSRL
MMAR_3869|M.marinum_M TLAGVARMQGGYRSLTERTPHTLAAIDHLFADNSDTMVQLLGSMATAAQL
MAV_0107|M.avium_104 LMAGVNKMDRGYRRLVDQTPHALSTVDNLFDDNSDTMVGLLANLVTTARV
MUL_4914|M.ulcerans_Agy99 LLTGVSSMDDGYRRMVDQTPGVLEAADNLFSDNSDTMVQLLGNLTTVAKL
MAB_4594c|M.abscessus_ATCC_199 TFAGLKKMDGGFRTLLERAPQTLHGVDNLFTDNSDTMVQLLGNLATVAQL
Mb0180|M.bovis_AF2122/97 LAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDM
Rv0174|M.tuberculosis_H37Rv LAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDM
MLBr_02594|M.leprae_Br4923 LAAQSARQDQHLKSILSQAAPTADEVNTVFSDVRDSLPQTLANFEILIDM
: : .::. . : :* . ::: *..: :
Mflv_0005|M.gilvum_PYR-GCK LYLRVPALHALFP--DYRTSVLDAIGSAMHDNGLWATGEIY----PRYTC
Mvan_0964|M.vanbaalenii_PYR-1 LYLRVPALNALFP--AHRTSVLDAIGSIMHDNGLWATGDIY----PRYSC
MSMEG_1148|M.smegmatis_MC2_155 LYLRVPALNALFP--SYRTSVLDALGTAIHDGGLWGTAEPY----PRYTC
TH_2636|M.thermoresistible__bu LYLRVPALNALFP--SHRTSVLDALGAAMHDGGLWGXXXP-----PTICC
MMAR_3869|M.marinum_M LYLRVPALNALFP--DYRGSVLDALASAFHDHGVWATAELY----PRYTC
MAV_0107|M.avium_104 VYLRVPALNAVFP--NYRGSTLEALMTTMHEHGLWATADIY----PRYTC
MUL_4914|M.ulcerans_Agy99 SYLRVPALKALFP--DYRGSALEAFMSTMHDGGLWATADLY----PRYTC
MAB_4594c|M.abscessus_ATCC_199 NYVRVPALNALFPGPEVRGSMLESAASIFHDGAVWALADLLY---PRPTC
Mb0180|M.bovis_AF2122/97 LKRYHAGVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTG
Rv0174|M.tuberculosis_H37Rv LKRYHAGVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTG
MLBr_02594|M.leprae_Br4923 LKRYHHGVEQMLVFLPQGASIAQTASATFPNMAALDLALSINQPPPCLTG
.:. :: : :: : . *
Mflv_0005|M.gilvum_PYR-GCK DYGTPRRPPSSADFPEPFMY-NYCRD--DHPGVLVRGAKNAP--------
Mvan_0964|M.vanbaalenii_PYR-1 DYGTPRLPPSSADYPEAFMY-TYCRD--DHPGVLVRGAKNAP--------
MSMEG_1148|M.smegmatis_MC2_155 DYGTPKLPPSSADFPEPFMY-TYCRD--VHPGVLVRGAKNAP--------
TH_2636|M.thermoresistible__bu NARRTRPPPI----------------------------------------
MMAR_3869|M.marinum_M DYGTPSYLPSAADYPEPFMY-TYCRD--DDPAVSIRGAKNAP--------
MAV_0107|M.avium_104 DYGTPRRPSSSADYPEPFLY-TYCRD--DDPQVLVRGAKNAP--------
MUL_4914|M.ulcerans_Agy99 DYGTPSHPPSAADYPEPFLY-TYCRD--DDPAVLIRGARNAP--------
MAB_4594c|M.abscessus_ATCC_199 DYVTPRKPVSDASFYEPALYSTYCAN--PDPAMLVRGARNAP--------
Mb0180|M.bovis_AF2122/97 FLPASEWRSPADTSPRPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVPGKR
Rv0174|M.tuberculosis_H37Rv FLPASEWRSPADTSPRPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVLGKR
MLBr_02594|M.leprae_Br4923 FIPAAEWRSPADTSLQPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKR
.
Mflv_0005|M.gilvum_PYR-GCK ---------------------------------------RPAGDDTAGPP
Mvan_0964|M.vanbaalenii_PYR-1 ---------------------------------------RPAGDDTAGPP
MSMEG_1148|M.smegmatis_MC2_155 ---------------------------------------RPADDDTAGPP
TH_2636|M.thermoresistible__bu --------------------------------------------------
MMAR_3869|M.marinum_M ---------------------------------------RPGGDDTAGPP
MAV_0107|M.avium_104 ---------------------------------------RPGGDDTAGPP
MUL_4914|M.ulcerans_Agy99 ---------------------------------------RPPGDDTAGPP
MAB_4594c|M.abscessus_ATCC_199 ---------------------------------------RPADDDTAGPP
Mb0180|M.bovis_AF2122/97 AATPKECRSKDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPA
Rv0174|M.tuberculosis_H37Rv AATPKECRSKDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPA
MLBr_02594|M.leprae_Br4923 AASPRECRDSKPYVPLGTNPWFGDPNQLLTCPAPGARCDQPVKPGLVIPA
Mflv_0005|M.gilvum_PYR-GCK PGADLGRQTDPTPRGRYTIP--------------------------TPYG
Mvan_0964|M.vanbaalenii_PYR-1 AGADLGRTTDPTPKGRYTIP--------------------------TPYG
MSMEG_1148|M.smegmatis_MC2_155 PGADLGRQTDPTPRGRYTIP--------------------------TPYG
TH_2636|M.thermoresistible__bu --------------------------------------------------
MMAR_3869|M.marinum_M PGADLGRRTDPTPRGRFTIP--------------------------TPYG
MAV_0107|M.avium_104 PGADLGQTTDPTPKGRFTIP--------------------------TPYG
MUL_4914|M.ulcerans_Agy99 PGADLGATTGPTPQGRFTIP--------------------------TPYG
MAB_4594c|M.abscessus_ATCC_199 PNADLAKVSDPTPRGKWSVP--------------------------TPYG
Mb0180|M.bovis_AF2122/97 PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
Rv0174|M.tuberculosis_H37Rv PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
MLBr_02594|M.leprae_Br4923 PTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSG
Mflv_0005|M.gilvum_PYR-GCK GPTLPIEPPR--------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 GPTLPIEPPR--------------------------------
MSMEG_1148|M.smegmatis_MC2_155 GPTLPIEPPR--------------------------------
TH_2636|M.thermoresistible__bu ------------------------------------------
MMAR_3869|M.marinum_M GPVLPIEPPH--------------------------------
MAV_0107|M.avium_104 GPVLPIEPPH--------------------------------
MUL_4914|M.ulcerans_Agy99 GPRLPIEPPH--------------------------------
MAB_4594c|M.abscessus_ATCC_199 GPQWPLPIPGDAPLPPEAPAPPPGFGNTPPTGR---------
Mb0180|M.bovis_AF2122/97 GPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
Rv0174|M.tuberculosis_H37Rv GPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
MLBr_02594|M.leprae_Br4923 PPSAVYSPQSGELVGPDGVAYAVENSTKTGDDGWKEMLAPAG