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MTSHVTLRVDGQVARVTLSRPEKLNGLTIDMLNGLTAAARHIASDNSIRVVVLSGEGDTFSTGLDFAAAG KDPARVVANFIPLPWLGTNGFQEACWAWRRLRIPVIALIHGRCYGGGLQLALAADFRFTTPDAEFSILEA KWGLIPDMSGSVTLSQLIGIDTAKRLTMTGEMFDGFYAKEIGLVTQVSADPEADAQELIDQILSRSPDSV AATKTLFDKAWSMVPRRAFGLERRLQLRLMRGANFAIARKAGIDKTEPQFKARSI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4431 | - | - | 100% (265) | enoyl-CoA hydratase/isomerase family protein |
| M. abscessus ATCC 19977 | MAB_3350 | - | 2e-22 | 30.37% (270) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1069c | - | 1e-21 | 33.33% (216) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3545 | echA19 | 1e-21 | 28.09% (267) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4495 | - | 1e-24 | 31.93% (238) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv3516 | echA19 | 1e-21 | 29.02% (255) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 1e-21 | 31.34% (268) | enoyl-CoA hydratase |
| M. marinum M | MMAR_2974 | - | 3e-24 | 30.60% (268) | enoyl-CoA hydratase |
| M. avium 104 | MAV_4717 | - | 6e-29 | 34.44% (270) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_1739 | - | 3e-25 | 35.96% (203) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_1663 | echA21 | 2e-25 | 33.92% (227) | POSSIBLE ENOYL-CoA HYDRATASE ECHA21 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_4410 | - | 7e-24 | 32.29% (223) | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE |
| M. vanbaalenii PYR-1 | Mvan_3400 | - | 1e-25 | 33.08% (263) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3545|M.bovis_AF2122/97 -MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPD
Rv3516|M.tuberculosis_H37Rv -MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPD
MLBr_02402|M.leprae_Br4923 -MKYDT-ILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKELDIDPD
TH_1663|M.thermoresistible__bu MADTYESVTVDVDGHVARVTLIGPGKGNAMGPAFWRELPEVFTRLDEDQN
MUL_4410|M.ulcerans_Agy99 MGETYESVTVEIKDQVAQATLIGPGKGNAMGPAFWSELPEVFAALDADRD
MMAR_2974|M.marinum_M ----MTDLTVSVTDGIAILTLNRPQRRNAYTAEMGLSLSSAYRQCDDDDA
Mvan_3400|M.vanbaalenii_PYR-1 ----MTDLTVTVGDGVAVLTLDRPDRRNAYTARMGELLSAAYRDCDEDDG
MAV_4717|M.avium_104 ---MTADLTVEIDSGVAVLTLNRPERLNAYTAAMGELLSRAYRECDEDDD
MAB_4431|M.abscessus_ATCC_1997 ---MTSHVTLRVDGQVARVTLSRPEKLNGLTIDMLNGLTAAARHIASDNS
Mflv_4495|M.gilvum_PYR-GCK --MTEDLVLTADHDGVRVITLNRPAARNALSRDLIRATYTALTSADDDDA
MSMEG_1739|M.smegmatis_MC2_155 MSLAQPLDVTRPRPDIAVLTLNRPDKLNALSYELVEALHAALDDIAADND
*: * *. : . *
Mb3545|M.bovis_AF2122/97 IRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYDP---------SRI
Rv3516|M.tuberculosis_H37Rv IRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYGP---------SRI
MLBr_02402|M.leprae_Br4923 VGAILITGSPKVFAAGADIKEMASLTFTDAFDADFFS-------------
TH_1663|M.thermoresistible__bu VRAIVLTGSGKNFSYGLDLPAMGDSLAGVMGPDASARSRAEFHATVQRMQ
MUL_4410|M.ulcerans_Agy99 VRAIVITGSGKNFSYGLDVPAMGGTFAPLMAEGALARPRTDFHAEVLRMQ
MMAR_2974|M.marinum_M VRAIVVTGAGDAFCAGADFSGDTNPFDAPDGGGGFTAA------------
Mvan_3400|M.vanbaalenii_PYR-1 VRAIVLTGAGDAFCVGADFGAQEDPFASTT--AAFTAS------------
MAV_4717|M.avium_104 VRVIVLTGAGRAFCAGADFSGGASPFDAPAGDGAFTAS------------
MAB_4431|M.abscessus_ATCC_1997 IRVVVLSGEGDTFSTGLDFAAAGKDPARVVANFIPLPWLG-----TNGFQ
Mflv_4495|M.gilvum_PYR-GCK VRAVVLTGADPAFCAGVDLKEAARDGLSYFAEFRTQSC------------
MSMEG_1739|M.smegmatis_MC2_155 CRVVVLTGAGRGFCSGLDLSAPNPPEAAGGTEFPRSGMR-----WQERIA
:::* *. * *.
Mb3545|M.bovis_AF2122/97 DALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKW
Rv3516|M.tuberculosis_H37Rv DALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKW
MLBr_02402|M.leprae_Br4923 -AWGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKL
TH_1663|M.thermoresistible__bu AAINAVADCRTPTIASVHGWCIGGGVDLISAVDIRYASADARFSVREVKL
MUL_4410|M.ulcerans_Agy99 KATNAVADCRTPTIASVHGWCIGGGVDLISAVDMRYASADAKFSIREVKL
MMAR_2974|M.marinum_M PIDPAAFELRTPVIAAVNGHAIGIGLTIALQADIRIMAEFAKYAVAQVRR
Mvan_3400|M.vanbaalenii_PYR-1 PVDPAAFELRTPVIAAVNGHAIGIGLTLALQSDIRIMAADAKYAVAQARR
MAV_4717|M.avium_104 PITPAAFELRKPVIAAVNGHAVGIGLTIALQADIRIVAADAKYGVVQVRR
MAB_4431|M.abscessus_ATCC_1997 EACWAWRRLRIPVIALIHGRCYGGGLQLALAADFRFTTPDAEFSILEAKW
Mflv_4495|M.gilvum_PYR-GCK --IAAVAAMRTPVVGAINGATFTGGLEMALGCDFMIASERAVFADTHARV
MSMEG_1739|M.smegmatis_MC2_155 NLTAKLHRLRQPVIAAVNGPAYGGGFALAAASDIRLAAESARFCTQFIKL
* :. : * * : *: * : :
Mb3545|M.bovis_AF2122/97 SLYP-MGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVP-D
Rv3516|M.tuberculosis_H37Rv SLYP-MGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVP-D
MLBr_02402|M.leprae_Br4923 GVLP-GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVL-A
TH_1663|M.thermoresistible__bu AIVA-DVGSLARLPLILNDGHLRELALTGKDIDAGRAEKIGLVNDVFADA
MUL_4410|M.ulcerans_Agy99 AIVA-DMGSLARLPMILNDGHLRELALTGRDIDAARAEKIGLVNQVFEDA
MMAR_2974|M.marinum_M GVIA-DCMSHWTLPHLVGSAAAADIHLTGRTFDGAEALAMGIATRTLP-G
Mvan_3400|M.vanbaalenii_PYR-1 GVIG-DCMSHWTLPHLVGGAVAADLLLTGRTFDGAEAAAMGVASRCVP-A
MAV_4717|M.avium_104 GVLP-DCMAHWTLPQLTNLGVAAELLLTGRMFGGAEAAALGVANRALP-A
MAB_4431|M.abscessus_ATCC_1997 GLIP-DMSGSVTLSQLIGIDTAKRLTMTGEMFDGFYAKEIGLVTQVSA--
Mflv_4495|M.gilvum_PYR-GCK GILP-GGGMTARLPQLVGAAMARRLSMTGEVVDAARAERIGLVTEVVA-H
MSMEG_1739|M.smegmatis_MC2_155 GIGGCDIGVSYTLPRIIGAGPAFDLILTARAVDATEALRLGLVSRVCA--
.: * : :*.. . . * *:
Mb3545|M.bovis_AF2122/97 GQALTKALELADAISANGPLAVQAILRSIRETECMP---ENEAFKIDTQI
Rv3516|M.tuberculosis_H37Rv GQALTKALELADAISANGPLAVQAILRSIRETECMP---ENEAFKIDTQI
MLBr_02402|M.leprae_Br4923 DDLLPEAKAVATTISQMSRSATRMAKEAVNRSFEST---LAEGLLHERRL
TH_1663|M.thermoresistible__bu EASLEAAHRTAAEIAANPPLTVRGIKDVLDQQRIDR---VSASLRYVAAW
MUL_4410|M.ulcerans_Agy99 DATLAAAHATATEIAANPPLAVYGVKDVLDQQRASA---VAENLRYVAAW
MMAR_2974|M.marinum_M PHVLGHAMAVARDIAANTAPMSVALSKRLLWDTLINGYTPRQVAELETQL
Mvan_3400|M.vanbaalenii_PYR-1 ARVLDEAMVIARDIATNVAPMSAALSKRLLWDTMARGYGPRQVATLETAA
MAV_4717|M.avium_104 DRVLDEAMALARDIAVNVAPMSAALCKRLLWDSAINRYPPRQVAALETLL
MAB_4431|M.abscessus_ATCC_1997 -DPEADAQELIDQILSRSPDSVAATKTLFDKAWSMVP---RRAFGLERRL
Mflv_4495|M.gilvum_PYR-GCK QHLLQRAIDLAHQIAEVPRPTMRGLKEIYTAGASAVVDPALAAEERIAFA
MSMEG_1739|M.smegmatis_MC2_155 -DVTAEAMDIAETLCGYGKFGVESTKQVLWANLDAG------CLEAALHV
* :
Mb3545|M.bovis_AF2122/97 GIKVFLSDDAKEGPRAFAEKRAPNFQNR----------------------
Rv3516|M.tuberculosis_H37Rv GIKVFLSDDAKEGPRAFAEKRAPNFQNR----------------------
MLBr_02402|M.leprae_Br4923 FHSTFVTDDQSEGMAAFIEKRAPQFTHR----------------------
TH_1663|M.thermoresistible__bu NAAFLPSKDLTEGIAATFEKRAPNFTGE----------------------
MUL_4410|M.ulcerans_Agy99 NAAFLPSKDLTEGISATFAKRPPQFTGEQAAASTYPRGVASMTEDGRIRV
MMAR_2974|M.marinum_M HRRVMGSADAREGVEAFLQHRAPRWSASVSSAWKPLPAPDHREQP-----
Mvan_3400|M.vanbaalenii_PYR-1 HHRVMGGADAREGVAAFLERRTPRWSSSVSKEWEPL-----REI------
MAV_4717|M.avium_104 HERVMGGADAAEGVAAFREHRAPRFTARLSSEWEPLP-----EP------
MAB_4431|M.abscessus_ATCC_1997 QLRLMRGANFAIARKAGIDKTEPQFKARSI--------------------
Mflv_4495|M.gilvum_PYR-GCK QHRDLEG--LGDRFSAVSQRNRDQIGGA----------------------
MSMEG_1739|M.smegmatis_MC2_155 ENRSQILASTEGGVRAFSEEFRRRPR------------------------
* . .
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 PADLDAVTALGAEDHSEIDSAAIERIWQATRYWYQAGMHPAIQLCIRHNG
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 RVVLNRAIGHGWGNAPSDAPDAEKIPVSTDTPFCTYSSAKAITATVVHML
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 AERGHFSLDDRVCEYIPSYTSHGKDHTTIRHVLTHSAGVPFPTGPRPDVT
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 RADDHDYAARKLGELRPLYPPGLVHIYHALTWGPLMREIIWATTRKEIRD
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 ILATEILDPLGFRWTNFGVAEEDLPLVAPSHATGRPLPPVIAAAFRKAIG
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 GTVHEVIPYTNKPLFLRTIIPSSNTVSTANELSRFMEILRRGGELDGVRI
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 MAPETVRSAVTECRRLRPDSATGLAPLRWGTGFMLGSNRFGPFGRNAPAA
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 --------------------------------------------------
Rv3516|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
TH_1663|M.thermoresistible__bu --------------------------------------------------
MUL_4410|M.ulcerans_Agy99 FGHLGLVNIATWADPDRGLSVGLINSGKPGRDPDAKRYVALKNAITAEIP
MMAR_2974|M.marinum_M --------------------------------------------------
Mvan_3400|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4717|M.avium_104 --------------------------------------------------
MAB_4431|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1739|M.smegmatis_MC2_155 --------------------------------------------------
Mb3545|M.bovis_AF2122/97 -----
Rv3516|M.tuberculosis_H37Rv -----
MLBr_02402|M.leprae_Br4923 -----
TH_1663|M.thermoresistible__bu -----
MUL_4410|M.ulcerans_Agy99 PKTVE
MMAR_2974|M.marinum_M -----
Mvan_3400|M.vanbaalenii_PYR-1 -----
MAV_4717|M.avium_104 -----
MAB_4431|M.abscessus_ATCC_1997 -----
Mflv_4495|M.gilvum_PYR-GCK -----
MSMEG_1739|M.smegmatis_MC2_155 -----