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VNGRAGWLAGAAGVAAVGSAAGMSVARSLRRRVTDDDPHRDEDFELLDADRGCVVSTPDGVPLTVREVGP VDAPLTVVFAHGFSLRMGSFYFQRARLTEQWGDQVRMVFYDQRGHGQSGDAPPETYTVEQLGQDLESVLA VMAPRGPIVLVGHSMGGMTVLSHARQYPQRYPTRIVGAALISSAAEGVARSPVGEILKNPALEAVRFSAR YAPKLVHRSRGAARSVIGPILRAASYGDEKVSPSVVAFSERMMHDTSVATLVEFLHALEVHDETAGLKTL NKVETLVACGDRDLLTPVEYSREMADALAKSELVIAGGAGHLVQLERPEVINDALVRLVERATPSKLVAL TRRVKERVRSHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1485 | - | - | 100% (362) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_1865 | - | 1e-21 | 31.31% (297) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 6e-12 | 26.96% (293) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3196c | hpx | 5e-21 | 30.41% (319) | non-Heme haloperoxidase Hpx |
| M. gilvum PYR-GCK | Mflv_4933 | - | 0.0 | 88.61% (360) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3171c | hpx | 1e-21 | 30.72% (319) | non-Heme haloperoxidase Hpx |
| M. leprae Br4923 | MLBr_00376 | - | 1e-84 | 49.45% (362) | hypothetical protein MLBr_00376 |
| M. abscessus ATCC 19977 | MAB_3738c | - | 1e-116 | 57.66% (359) | putative hydrolase alpha/beta fold |
| M. marinum M | MMAR_1120 | - | 1e-141 | 71.19% (354) | hydrolase |
| M. avium 104 | MAV_4371 | - | 1e-129 | 65.90% (349) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1576 | - | 1e-161 | 80.06% (351) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_1693 | - | 1e-145 | 72.52% (353) | alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_0880 | - | 1e-139 | 70.62% (354) | hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1485|M.vanbaalenii_PYR-1 ----------------------------------------------MNGR
Mflv_4933|M.gilvum_PYR-GCK ----------------------------------------------MSRG
MSMEG_1576|M.smegmatis_MC2_155 --------------------------------------------------
TH_1693|M.thermoresistible__bu VTGSSGEAAPRPRRRRSWDEQIVRRATRSATRVADASDAEDTSKPRVVKY
MMAR_1120|M.marinum_M --------------------------------------MSAEETRRRQ--
MUL_0880|M.ulcerans_Agy99 --------------------------------------MSAEETRRRQ--
MAV_4371|M.avium_104 --------------------------------------------------
MLBr_00376|M.leprae_Br4923 --------------------------------------MTDDEIRRRRNG
MAB_3738c|M.abscessus_ATCC_199 ---------------------------------------------MSNKS
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1485|M.vanbaalenii_PYR-1 AGWLAGAAGVAAVGSAAGMSVARS-LRRRVTDDDPHRDEDFELLDADRGC
Mflv_4933|M.gilvum_PYR-GCK AGWLAGAAGVAAVGSAAGVSMARS-LRRRVTDEDPHRDEDFELLDADRSC
MSMEG_1576|M.smegmatis_MC2_155 ------MAGLAAVGTVAGVSIARS-LTLRVSKEDPYAGEDFELLDADRSS
TH_1693|M.thermoresistible__bu PKLTAGVAGLTAVGTVAGVSAARS-LRRRR-RIDPYEGEDFALLEADRAV
MMAR_1120|M.marinum_M RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MUL_0880|M.ulcerans_Agy99 RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MAV_4371|M.avium_104 ---------MTAVATIVGASARRSMTQR-ATIEDPYADEDFNTFDGDRAL
MLBr_00376|M.leprae_Br4923 RPWLAGGTGLVPVATIVGALSLRSIFERDNACRDPYVDRDFEKLGDERRC
MAB_3738c|M.abscessus_ATCC_199 NAWLAGVAGLGAVVAVAGVGTARSIGRR--RFDDPYRGENFDLLQTDRGS
Mb3196c|M.bovis_AF2122/97 -------------------------------------------------M
Rv3171c|M.tuberculosis_H37Rv -------------------------------------------------M
Mvan_1485|M.vanbaalenii_PYR-1 VVSTPDGVPLTVREVGPVDAPLTVVFAHGFSLRMGSFYFQRARLTEQWGD
Mflv_4933|M.gilvum_PYR-GCK VVTTSDGVPLAVREVGPEDAPLTVVFAHGFCLRMGSFHFQRVRLTEHWGA
MSMEG_1576|M.smegmatis_MC2_155 VITTDDGVPLAVREVGPKDAKLTVVFAHGFCLRMSAFHFQRARLAEQWGD
TH_1693|M.thermoresistible__bu VVTTPDGVPLVVREVGPITAPVTVVFAHGWCLRMGAFHFQRARLEQEWGD
MMAR_1120|M.marinum_M VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFQRMRLGEQWGS
MUL_0880|M.ulcerans_Agy99 VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFERMRLGEQWGS
MAV_4371|M.avium_104 VVTTPDGVPLAVREAGPPDAPLTMVFVHGFCLQMGAFHFQRTRLPEQLGP
MLBr_00376|M.leprae_Br4923 WVTISGGMALVVREEGAVKAPVAMVFAYGFYLRMDSFHFQRKRFGKRWGP
MAB_3738c|M.abscessus_ATCC_199 IVTTDDGVPLAVREVGPSNAPLTVVFVHGFCLQMASFHFQRRELASRWGD
Mb3196c|M.bovis_AF2122/97 TVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAGDY--
Rv3171c|M.tuberculosis_H37Rv TVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAGDY--
: .* .* .: *. . .:*:.:*: : :: :: :
Mvan_1485|M.vanbaalenii_PYR-1 QVRMVFYDQRGHGQSGDAPPETYTVEQLGQDLESVLAV-MAPRGPIVLVG
Mflv_4933|M.gilvum_PYR-GCK QVRMVFFDQRGHGQSGDAPPETYTVEQLGRDLEAVLAV-MAPKGPVVLVG
MSMEG_1576|M.smegmatis_MC2_155 QVRMVFYDQRGHGRSGEAPPDTYTVEQLGRDLESVLAV-TAPRGPVVLVG
TH_1693|M.thermoresistible__bu QVRMVFYDQRGHGQSGEAHTETYTVPQLGQDLETVLRV-VVPRGPIVLVG
MMAR_1120|M.marinum_M RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQA-TAPRGPIVLVG
MUL_0880|M.ulcerans_Agy99 RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQA-TAPRGPIVLVG
MAV_4371|M.avium_104 DVRMVFYDQRGHGRSGEAAPESYTLTQLGRDLQTVLQV-VAPRGLVVLVG
MLBr_00376|M.leprae_Br4923 QVRMVFYDHCGHVQSSEVALDTYTLTQLGQDLRTVLQT-VTPHGMIVLVG
MAB_3738c|M.abscessus_ATCC_199 NVRMVFYDQRGHGRSGLPAPASCTVGQLGDDLESVLRV-LVPRGNAVLVG
Mb3196c|M.bovis_AF2122/97 --RVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAG
Rv3171c|M.tuberculosis_H37Rv --RVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAG
*:: :*: ** :*. : :: :*. ** :** . .*: *:.*
Mvan_1485|M.vanbaalenii_PYR-1 HSMGGMTVLSHARQYPQRYPTRIVGAALISSAAEGVARSPVGEILKNPAL
Mflv_4933|M.gilvum_PYR-GCK HSMGGMAVLSHARQYPQRYPTRVVGAALISSAAEGVARSPVGEILKNPAL
MSMEG_1576|M.smegmatis_MC2_155 HSMGGMTVLSHARQFPQRYPARIVGAALISSAAEGVDRSPLGEILRNPAL
TH_1693|M.thermoresistible__bu HSMGGMTVLSHARQFPRRYGRRIVGAAVISSAAEGLPRSPLGEILQNPAL
MMAR_1120|M.marinum_M HSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPAL
MUL_0880|M.ulcerans_Agy99 HSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPAL
MAV_4371|M.avium_104 HSMGGMTVLSHARQFPEQYGRRIVGAALISSAAEGVSRSPLGEILKNPAL
MLBr_00376|M.leprae_Br4923 HSMEG--------------------------------------ILKSPAL
MAB_3738c|M.abscessus_ATCC_199 HSMGGMTVLAHARRHPEQYGRRIVGVGLIASAAEGLSHTAIGEGLRNPAL
Mb3196c|M.bovis_AF2122/97 HSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELS
Rv3171c|M.tuberculosis_H37Rv HSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELS
*** * :
Mvan_1485|M.vanbaalenii_PYR-1 EAVRFSARYAPKLVHRS--RGAARSVIGPILRAASYGDEKVSPSVVAFSE
Mflv_4933|M.gilvum_PYR-GCK EAVRFTARYAPKLVHRG--RGAARSVIGPILRAASYGDEKISPSVVAFSE
MSMEG_1576|M.smegmatis_MC2_155 EAVRFSARYAPKLVHRT--RGAARSLIAPILQAGSFGDEQVSPSVAAFAA
TH_1693|M.thermoresistible__bu EAFRFAARYAPGLVHRT--RGAAWTVLRPILRAASFGSDRVSPSVMAFSE
MMAR_1120|M.marinum_M EAVRFTARSAPKLMHRG--RTASRSLIGPILRAASYSDLEVSRSLDAFSQ
MUL_0880|M.ulcerans_Agy99 EAVRFTARSAPKLMHRG--RTASRSLIGPILRAASYSDLEVSRSLDAFSQ
MAV_4371|M.avium_104 EAVRVAARSAPKLMHRG--RNVSRSLIGPVLRAASFSDLQVSRSLDAFSQ
MLBr_00376|M.leprae_Br4923 EAVRLTSRSASKLMHRG--SIASQSLIGPILRAASYSDLRVSRGLDAFSQ
MAB_3738c|M.abscessus_ATCC_199 RVLRTAVHYAPGPAHHG--RGAIKSLVGPVLQAASYGGHRVSPTLVKFSE
Mb3196c|M.bovis_AF2122/97 PVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAAD-ADPSATRLVY
Rv3171c|M.tuberculosis_H37Rv PVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAAD-ADPSATRLVY
. : : . :: :: : : . . :
Mvan_1485|M.vanbaalenii_PYR-1 RMMHDTSVATLVEFLHALEVHDETAGLKTL-NKVETLVACGDRDLLTPVE
Mflv_4933|M.gilvum_PYR-GCK RMMHDTPIATLVEFLHALEVHDETAGLETL-RRVPTLVACGDRDLLTPKE
MSMEG_1576|M.smegmatis_MC2_155 DMMHGTPIPTLVEFLHALEVHDETAALDVL-AGVPTLIACGDRDLLTPVE
TH_1693|M.thermoresistible__bu SMIQNTPIATLVEFMHALEVHDETAALPVL-ARIPTLIACGSDDVLTPAV
MMAR_1120|M.marinum_M QMMNDTPIATLVGFLHALEVHDETAGLWTL-LRIPTLIACGDHDLMTPDE
MUL_0880|M.ulcerans_Agy99 QMMNDTPIATLGGFLHALEVHDETAGLWTL-LRIPTLIACGDHDLMTPDE
MAV_4371|M.avium_104 RMMNSTPIPTMVGFLDALEHHDETAGLWTL-LRVPTLIACGDHDLLTPDE
MLBr_00376|M.leprae_Br4923 RIMNDTLIAILVSFLHALELHEETAGLWPL-LRVPALIACGDHDLLTSDE
MAB_3738c|M.abscessus_ATCC_199 RMIHQTPVTTIVDFLRALEQHDETAALPTI-APLPSLVICGDTDMLTPHT
Mb3196c|M.bovis_AF2122/97 ELFTQMSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPIS
Rv3171c|M.tuberculosis_H37Rv ELFTQTSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPIS
:: . * . :* * : :*: * * :*.
Mvan_1485|M.vanbaalenii_PYR-1 YSREMADALAKS---ELVIAGGAGHLVQLERPEVINDALVRLVERATPSK
Mflv_4933|M.gilvum_PYR-GCK YSQEMADVLAKS---ELVIVPGAGHLVQLECPEVINDALVRLVERATPSK
MSMEG_1576|M.smegmatis_MC2_155 YSREMAERLPKS---ELVVVGGAGHLVQLEEPEVINDALIRLVERATPSK
TH_1693|M.thermoresistible__bu HSKRMAAALPDS---ELLIVEGAGHLVQLEAPEVINDALVRLVQRATPST
MMAR_1120|M.marinum_M YSRKMAASLPQS---ELVIVGGASHLALLDKPDAINEGLVRLVDRALPGK
MUL_0880|M.ulcerans_Agy99 YSRKMAASLPQS---ELVIVGGASHLALLDEPDAINGGLVRLVDRALPGK
MAV_4371|M.avium_104 YSRKMAASLPQS---ELVIVAGASHLALLDKPEAINGGLVRLVRRATPSR
MLBr_00376|M.leprae_Br4923 RSRGMAAVLPLL---ALVIVSGASRLALLDKPGAINDGLVRLVNRAVPGK
MAB_3738c|M.abscessus_ATCC_199 QSESMAARLAASGHNELILVRESGHLVQLEHPEIVNDGIDRLVRRSTPPL
Mb3196c|M.bovis_AF2122/97 QSRRIARTAPNVVG--LVELPG-GHCSMLERHQEVNSHLRALAESVTR--
Rv3171c|M.tuberculosis_H37Rv QSRRIARTAPNVVG--LVELPG-GHCSMLERHQEVNSHLRALAESVTR--
*. :* . *: .: *: :* : *.
Mvan_1485|M.vanbaalenii_PYR-1 LVALTRRVKERV----RSHG
Mflv_4933|M.gilvum_PYR-GCK LTALTRRVTQRV----RSDD
MSMEG_1576|M.smegmatis_MC2_155 LVALARRVRNRV----RPHG
TH_1693|M.thermoresistible__bu LVALTRRIRDKV----RPHD
MMAR_1120|M.marinum_M LTLRYRRVGERLRDRWRRHG
MUL_0880|M.ulcerans_Agy99 LTLRYRRVGERLRDRWRRHG
MAV_4371|M.avium_104 AALALRRIGERL---WRRG-
MLBr_00376|M.leprae_Br4923 AALRYRRFKERL----QRHG
MAB_3738c|M.abscessus_ATCC_199 FAAIKQRLRDRTGL------
Mb3196c|M.bovis_AF2122/97 -HVRDRRISS----------
Rv3171c|M.tuberculosis_H37Rv -HVRDRRISS----------
:*. .