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LTDDEIRRRRNGRPWLAGGTGLVPVATIVGALSLRSIFERDNACRDPYVDRDFEKLGDERRCWVTISGGM ALVVREEGAVKAPVAMVFAYGFYLRMDSFHFQRKRFGKRWGPQVRMVFYDHCGHVQSSEVALDTYTLTQL GQDLRTVLQTVTPHGMIVLVGHSMEGILKSPALEAVRLTSRSASKLMHRGSIASQSLIGPILRAASYSDL RVSRGLDAFSQRIMNDTLIAILVSFLHALELHEETAGLWPLLRVPALIACGDHDLLTSDERSRGMAAVLP LLALVIVSGASRLALLDKPGAINDGLVRLVNRAVPGKAALRYRRFKERLQRHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00376 | - | - | 100% (333) | hypothetical protein MLBr_00376 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4933 | - | 5e-84 | 49.58% (357) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3738c | - | 1e-58 | 38.87% (355) | putative hydrolase alpha/beta fold |
| M. marinum M | MMAR_1120 | - | 1e-115 | 60.80% (375) | hydrolase |
| M. avium 104 | MAV_4371 | - | 7e-98 | 57.35% (347) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1576 | - | 5e-75 | 46.15% (351) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_1693 | - | 2e-74 | 45.76% (354) | alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_0880 | - | 1e-114 | 60.00% (375) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_1485 | - | 4e-84 | 49.45% (362) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4933|M.gilvum_PYR-GCK ----------------------------------------------MSRG
Mvan_1485|M.vanbaalenii_PYR-1 ----------------------------------------------MNGR
MSMEG_1576|M.smegmatis_MC2_155 --------------------------------------------------
TH_1693|M.thermoresistible__bu VTGSSGEAAPRPRRRRSWDEQIVRRATRSATRVADASDAEDTSKPRVVKY
MAB_3738c|M.abscessus_ATCC_199 ---------------------------------------------MSNKS
MAV_4371|M.avium_104 --------------------------------------------------
MMAR_1120|M.marinum_M ----------------------------------------MSAEETRRRQ
MUL_0880|M.ulcerans_Agy99 ----------------------------------------MSAEETRRRQ
MLBr_00376|M.leprae_Br4923 --------------------------------------MTDDEIRRRRNG
Mflv_4933|M.gilvum_PYR-GCK AGWLAGAAGVAAVGSAAGVSMARSLR-RRVTDEDPHRDEDFELLDADRSC
Mvan_1485|M.vanbaalenii_PYR-1 AGWLAGAAGVAAVGSAAGMSVARSLR-RRVTDDDPHRDEDFELLDADRGC
MSMEG_1576|M.smegmatis_MC2_155 ------MAGLAAVGTVAGVSIARSLT-LRVSKEDPYAGEDFELLDADRSS
TH_1693|M.thermoresistible__bu PKLTAGVAGLTAVGTVAGVSAARSLR-RRR-RIDPYEGEDFALLEADRAV
MAB_3738c|M.abscessus_ATCC_199 NAWLAGVAGLGAVVAVAGVGTARSIG-RRR-FDDPYRGENFDLLQTDRGS
MAV_4371|M.avium_104 ---------MTAVATIVGASARRSMT-QRATIEDPYADEDFNTFDGDRAL
MMAR_1120|M.marinum_M RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MUL_0880|M.ulcerans_Agy99 RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MLBr_00376|M.leprae_Br4923 RPWLAGGTGLVPVATIVGALSLRSIFERDNACRDPYVDRDFEKLGDERRC
: .* : .* **: **: ..:* : :*
Mflv_4933|M.gilvum_PYR-GCK VVTTSDGVPLAVREVGPEDAPLTVVFAHGFCLRMGSFHFQRVRLTEHWGA
Mvan_1485|M.vanbaalenii_PYR-1 VVSTPDGVPLTVREVGPVDAPLTVVFAHGFSLRMGSFYFQRARLTEQWGD
MSMEG_1576|M.smegmatis_MC2_155 VITTDDGVPLAVREVGPKDAKLTVVFAHGFCLRMSAFHFQRARLAEQWGD
TH_1693|M.thermoresistible__bu VVTTPDGVPLVVREVGPITAPVTVVFAHGWCLRMGAFHFQRARLEQEWGD
MAB_3738c|M.abscessus_ATCC_199 IVTTDDGVPLAVREVGPSNAPLTVVFVHGFCLQMASFHFQRRELASRWGD
MAV_4371|M.avium_104 VVTTPDGVPLAVREAGPPDAPLTMVFVHGFCLQMGAFHFQRTRLPEQLGP
MMAR_1120|M.marinum_M VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFQRMRLGEQWGS
MUL_0880|M.ulcerans_Agy99 VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFERMRLGEQWGS
MLBr_00376|M.leprae_Br4923 WVTISGGMALVVREEGAVKAPVAMVFAYGFYLRMDSFHFQRKRFGKRWGP
:: .*:.*.*** *. * :::**.:*: *:* :*:*:* .: .. *
Mflv_4933|M.gilvum_PYR-GCK QVRMVFFDQRGHGQSGDAPPETYTVEQLGRDLEAVLAVMAPKGPVVLVGH
Mvan_1485|M.vanbaalenii_PYR-1 QVRMVFYDQRGHGQSGDAPPETYTVEQLGQDLESVLAVMAPRGPIVLVGH
MSMEG_1576|M.smegmatis_MC2_155 QVRMVFYDQRGHGRSGEAPPDTYTVEQLGRDLESVLAVTAPRGPVVLVGH
TH_1693|M.thermoresistible__bu QVRMVFYDQRGHGQSGEAHTETYTVPQLGQDLETVLRVVVPRGPIVLVGH
MAB_3738c|M.abscessus_ATCC_199 NVRMVFYDQRGHGRSGLPAPASCTVGQLGDDLESVLRVLVPRGNAVLVGH
MAV_4371|M.avium_104 DVRMVFYDQRGHGRSGEAAPESYTLTQLGRDLQTVLQVVAPRGLVVLVGH
MMAR_1120|M.marinum_M RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQATAPRGPIVLVGH
MUL_0880|M.ulcerans_Agy99 RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQATAPRGPIVLVGH
MLBr_00376|M.leprae_Br4923 QVRMVFYDHCGHVQSSEVALDTYTLTQLGQDLRTVLQTVTPHGMIVLVGH
*****:*: ** :*. : *: *** **.:** . .*:* *****
Mflv_4933|M.gilvum_PYR-GCK SMGGMAVLSHARQYPQRYPTRVVGAALISSAAEGVARSPVGEILKNPALE
Mvan_1485|M.vanbaalenii_PYR-1 SMGGMTVLSHARQYPQRYPTRIVGAALISSAAEGVARSPVGEILKNPALE
MSMEG_1576|M.smegmatis_MC2_155 SMGGMTVLSHARQFPQRYPARIVGAALISSAAEGVDRSPLGEILRNPALE
TH_1693|M.thermoresistible__bu SMGGMTVLSHARQFPRRYGRRIVGAAVISSAAEGLPRSPLGEILQNPALE
MAB_3738c|M.abscessus_ATCC_199 SMGGMTVLAHARRHPEQYGRRIVGVGLIASAAEGLSHTAIGEGLRNPALR
MAV_4371|M.avium_104 SMGGMTVLSHARQFPEQYGRRIVGAALISSAAEGVSRSPLGEILKNPALE
MMAR_1120|M.marinum_M SMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPALE
MUL_0880|M.ulcerans_Agy99 SMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPALE
MLBr_00376|M.leprae_Br4923 SMEG--------------------------------------ILKSPALE
** * *:.***.
Mflv_4933|M.gilvum_PYR-GCK AVRFTARYAPKLVHRGRGAARSVIGPILRAASYGDEKISPSVVAFSERMM
Mvan_1485|M.vanbaalenii_PYR-1 AVRFSARYAPKLVHRSRGAARSVIGPILRAASYGDEKVSPSVVAFSERMM
MSMEG_1576|M.smegmatis_MC2_155 AVRFSARYAPKLVHRTRGAARSLIAPILQAGSFGDEQVSPSVAAFAADMM
TH_1693|M.thermoresistible__bu AFRFAARYAPGLVHRTRGAAWTVLRPILRAASFGSDRVSPSVMAFSESMI
MAB_3738c|M.abscessus_ATCC_199 VLRTAVHYAPGPAHHGRGAIKSLVGPVLQAASYGGHRVSPTLVKFSERMI
MAV_4371|M.avium_104 AVRVAARSAPKLMHRGRNVSRSLIGPVLRAASFSDLQVSRSLDAFSQRMM
MMAR_1120|M.marinum_M AVRFTARSAPKLMHRGRTASRSLIGPILRAASYSDLEVSRSLDAFSQQMM
MUL_0880|M.ulcerans_Agy99 AVRFTARSAPKLMHRGRTASRSLIGPILRAASYSDLEVSRSLDAFSQQMM
MLBr_00376|M.leprae_Br4923 AVRLTSRSASKLMHRGSIASQSLIGPILRAASYSDLRVSRGLDAFSQRIM
..* : : *. *: . ::: *:*:*.*:.. .:* : *: ::
Mflv_4933|M.gilvum_PYR-GCK HDTPIATLVEFLHALEVHDETAGLETLRRVPTLVACGDRDLLTPKEYSQE
Mvan_1485|M.vanbaalenii_PYR-1 HDTSVATLVEFLHALEVHDETAGLKTLNKVETLVACGDRDLLTPVEYSRE
MSMEG_1576|M.smegmatis_MC2_155 HGTPIPTLVEFLHALEVHDETAALDVLAGVPTLIACGDRDLLTPVEYSRE
TH_1693|M.thermoresistible__bu QNTPIATLVEFMHALEVHDETAALPVLARIPTLIACGSDDVLTPAVHSKR
MAB_3738c|M.abscessus_ATCC_199 HQTPVTTIVDFLRALEQHDETAALPTIAPLPSLVICGDTDMLTPHTQSES
MAV_4371|M.avium_104 NSTPIPTMVGFLDALEHHDETAGLWTLLRVPTLIACGDHDLLTPDEYSRK
MMAR_1120|M.marinum_M NDTPIATLVGFLHALEVHDETAGLWTLLRIPTLIACGDHDLMTPDEYSRK
MUL_0880|M.ulcerans_Agy99 NDTPIATLGGFLHALEVHDETAGLWTLLRIPTLIACGDHDLMTPDEYSRK
MLBr_00376|M.leprae_Br4923 NDTLIAILVSFLHALELHEETAGLWPLLRVPALIACGDHDLLTSDERSRG
: * :. : *: *** *:***.* : : :*: **. *::*. *.
Mflv_4933|M.gilvum_PYR-GCK MADVLAKS---ELVIVPGAGHLVQLECPEVINDALVRLVERATPSKLTAL
Mvan_1485|M.vanbaalenii_PYR-1 MADALAKS---ELVIAGGAGHLVQLERPEVINDALVRLVERATPSKLVAL
MSMEG_1576|M.smegmatis_MC2_155 MAERLPKS---ELVVVGGAGHLVQLEEPEVINDALIRLVERATPSKLVAL
TH_1693|M.thermoresistible__bu MAAALPDS---ELLIVEGAGHLVQLEAPEVINDALVRLVQRATPSTLVAL
MAB_3738c|M.abscessus_ATCC_199 MAARLAASGHNELILVRESGHLVQLEHPEIVNDGIDRLVRRSTPPLFAAI
MAV_4371|M.avium_104 MAASLPQS---ELVIVAGASHLALLDKPEAINGGLVRLVRRATPSRAALA
MMAR_1120|M.marinum_M MAASLPQS---ELVIVGGASHLALLDKPDAINEGLVRLVDRALPGKLTLR
MUL_0880|M.ulcerans_Agy99 MAASLPQS---ELVIVGGASHLALLDEPDAINGGLVRLVDRALPGKLTLR
MLBr_00376|M.leprae_Br4923 MAAVLPLL---ALVIVSGASRLALLDKPGAINDGLVRLVNRAVPGKAALR
** *. *::. :.:*. *: * :* .: *** *: * .
Mflv_4933|M.gilvum_PYR-GCK TR----RVTQRVRSDD
Mvan_1485|M.vanbaalenii_PYR-1 TR----RVKERVRSHG
MSMEG_1576|M.smegmatis_MC2_155 AR----RVRNRVRPHG
TH_1693|M.thermoresistible__bu TR----RIRDKVRPHD
MAB_3738c|M.abscessus_ATCC_199 KQ----RLRDRTGL--
MAV_4371|M.avium_104 LR----RIGERLWRRG
MMAR_1120|M.marinum_M YRRVGERLRDRWRRHG
MUL_0880|M.ulcerans_Agy99 YRRVGERLRDRWRRHG
MLBr_00376|M.leprae_Br4923 YR----RFKERLQRHG
: *. ::