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LSAEETRRRQRAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRARVVTTPDGVPL AVREAGPVDAPLTMVFAHGFCLRMGAFHFERMRLGEQWGSRVRMVFYDQRGHGQSGEADPQTYTLTQLGQ DLETVLQATAPRGPIVLVGHSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPALE AVRFTARSAPKLMHRGRTASRSLIGPILRAASYSDLEVSRSLDAFSQQMMNDTPIATLGGFLHALEVHDE TAGLWTLLRIPTLIACGDHDLMTPDEYSRKMAASLPQSELVIVGGASHLALLDEPDAINGGLVRLVDRAL PGKLTLRYRRVGERLRDRWRRHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0880 | - | - | 100% (373) | hydrolase |
| M. ulcerans Agy99 | MUL_2488 | hpx | 2e-19 | 27.01% (311) | non-heme haloperoxidase Hpx |
| M. ulcerans Agy99 | MUL_4891 | - | 3e-09 | 26.72% (262) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3196c | hpx | 2e-19 | 29.17% (312) | non-Heme haloperoxidase Hpx |
| M. gilvum PYR-GCK | Mflv_4933 | - | 1e-140 | 69.55% (358) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3171c | hpx | 3e-20 | 29.49% (312) | non-Heme haloperoxidase Hpx |
| M. leprae Br4923 | MLBr_00376 | - | 1e-114 | 60.00% (375) | hypothetical protein MLBr_00376 |
| M. abscessus ATCC 19977 | MAB_3738c | - | 1e-104 | 52.62% (363) | putative hydrolase alpha/beta fold |
| M. marinum M | MMAR_1120 | - | 0.0 | 98.93% (373) | hydrolase |
| M. avium 104 | MAV_4371 | - | 1e-160 | 80.11% (352) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1576 | - | 1e-137 | 70.22% (356) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_1693 | - | 1e-132 | 67.33% (352) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_1485 | - | 1e-139 | 70.62% (354) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0880|M.ulcerans_Agy99 --------------------------------------MSAEETRRRQ--
MMAR_1120|M.marinum_M --------------------------------------MSAEETRRRQ--
MAV_4371|M.avium_104 --------------------------------------------------
MLBr_00376|M.leprae_Br4923 --------------------------------------MTDDEIRRRRNG
Mflv_4933|M.gilvum_PYR-GCK ----------------------------------------------MSRG
Mvan_1485|M.vanbaalenii_PYR-1 ----------------------------------------------MNGR
MSMEG_1576|M.smegmatis_MC2_155 --------------------------------------------------
TH_1693|M.thermoresistible__bu VTGSSGEAAPRPRRRRSWDEQIVRRATRSATRVADASDAEDTSKPRVVKY
MAB_3738c|M.abscessus_ATCC_199 ---------------------------------------------MSNKS
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0880|M.ulcerans_Agy99 RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MMAR_1120|M.marinum_M RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MAV_4371|M.avium_104 ---------MTAVATIVGASARRSMTQR-ATIEDPYADEDFNTFDGDRAL
MLBr_00376|M.leprae_Br4923 RPWLAGGTGLVPVATIVGALSLRSIFERDNACRDPYVDRDFEKLGDERRC
Mflv_4933|M.gilvum_PYR-GCK AGWLAGAAGVAAVGSAAGVSMARSLRRR-VTDEDPHRDEDFELLDADRSC
Mvan_1485|M.vanbaalenii_PYR-1 AGWLAGAAGVAAVGSAAGMSVARSLRRR-VTDDDPHRDEDFELLDADRGC
MSMEG_1576|M.smegmatis_MC2_155 ------MAGLAAVGTVAGVSIARSLTLR-VSKEDPYAGEDFELLDADRSS
TH_1693|M.thermoresistible__bu PKLTAGVAGLTAVGTVAGVSAARSLRRR-R-RIDPYEGEDFALLEADRAV
MAB_3738c|M.abscessus_ATCC_199 NAWLAGVAGLGAVVAVAGVGTARSIGRR--RFDDPYRGENFDLLQTDRGS
Mb3196c|M.bovis_AF2122/97 -------------------------------------------------M
Rv3171c|M.tuberculosis_H37Rv -------------------------------------------------M
MUL_0880|M.ulcerans_Agy99 VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFERMRLGEQWGS
MMAR_1120|M.marinum_M VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFQRMRLGEQWGS
MAV_4371|M.avium_104 VVTTPDGVPLAVREAGPPDAPLTMVFVHGFCLQMGAFHFQRTRLPEQLGP
MLBr_00376|M.leprae_Br4923 WVTISGGMALVVREEGAVKAPVAMVFAYGFYLRMDSFHFQRKRFGKRWGP
Mflv_4933|M.gilvum_PYR-GCK VVTTSDGVPLAVREVGPEDAPLTVVFAHGFCLRMGSFHFQRVRLTEHWGA
Mvan_1485|M.vanbaalenii_PYR-1 VVSTPDGVPLTVREVGPVDAPLTVVFAHGFSLRMGSFYFQRARLTEQWGD
MSMEG_1576|M.smegmatis_MC2_155 VITTDDGVPLAVREVGPKDAKLTVVFAHGFCLRMSAFHFQRARLAEQWGD
TH_1693|M.thermoresistible__bu VVTTPDGVPLVVREVGPITAPVTVVFAHGWCLRMGAFHFQRARLEQEWGD
MAB_3738c|M.abscessus_ATCC_199 IVTTDDGVPLAVREVGPSNAPLTVVFVHGFCLQMASFHFQRRELASRWGD
Mb3196c|M.bovis_AF2122/97 TVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAGDY--
Rv3171c|M.tuberculosis_H37Rv TVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAGDY--
: .* .* .: *. . .:*:.:*: : :: :: :
MUL_0880|M.ulcerans_Agy99 RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQA-TAPRGPIVLVG
MMAR_1120|M.marinum_M RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQA-TAPRGPIVLVG
MAV_4371|M.avium_104 DVRMVFYDQRGHGRSGEAAPESYTLTQLGRDLQTVLQV-VAPRGLVVLVG
MLBr_00376|M.leprae_Br4923 QVRMVFYDHCGHVQSSEVALDTYTLTQLGQDLRTVLQT-VTPHGMIVLVG
Mflv_4933|M.gilvum_PYR-GCK QVRMVFFDQRGHGQSGDAPPETYTVEQLGRDLEAVLAV-MAPKGPVVLVG
Mvan_1485|M.vanbaalenii_PYR-1 QVRMVFYDQRGHGQSGDAPPETYTVEQLGQDLESVLAV-MAPRGPIVLVG
MSMEG_1576|M.smegmatis_MC2_155 QVRMVFYDQRGHGRSGEAPPDTYTVEQLGRDLESVLAV-TAPRGPVVLVG
TH_1693|M.thermoresistible__bu QVRMVFYDQRGHGQSGEAHTETYTVPQLGQDLETVLRV-VVPRGPIVLVG
MAB_3738c|M.abscessus_ATCC_199 NVRMVFYDQRGHGRSGLPAPASCTVGQLGDDLESVLRV-LVPRGNAVLVG
Mb3196c|M.bovis_AF2122/97 --RVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAG
Rv3171c|M.tuberculosis_H37Rv --RVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAG
*:: :*: ** :*. : :: :*. ** :** . .*: *:.*
MUL_0880|M.ulcerans_Agy99 HSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPAL
MMAR_1120|M.marinum_M HSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPAL
MAV_4371|M.avium_104 HSMGGMTVLSHARQFPEQYGRRIVGAALISSAAEGVSRSPLGEILKNPAL
MLBr_00376|M.leprae_Br4923 HSMEG--------------------------------------ILKSPAL
Mflv_4933|M.gilvum_PYR-GCK HSMGGMAVLSHARQYPQRYPTRVVGAALISSAAEGVARSPVGEILKNPAL
Mvan_1485|M.vanbaalenii_PYR-1 HSMGGMTVLSHARQYPQRYPTRIVGAALISSAAEGVARSPVGEILKNPAL
MSMEG_1576|M.smegmatis_MC2_155 HSMGGMTVLSHARQFPQRYPARIVGAALISSAAEGVDRSPLGEILRNPAL
TH_1693|M.thermoresistible__bu HSMGGMTVLSHARQFPRRYGRRIVGAAVISSAAEGLPRSPLGEILQNPAL
MAB_3738c|M.abscessus_ATCC_199 HSMGGMTVLAHARRHPEQYGRRIVGVGLIASAAEGLSHTAIGEGLRNPAL
Mb3196c|M.bovis_AF2122/97 HSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELS
Rv3171c|M.tuberculosis_H37Rv HSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELS
*** * :
MUL_0880|M.ulcerans_Agy99 EAVRFTARSAPKLMHRG--RTASRSLIGPILRAASYSDLEVSRSLDAFSQ
MMAR_1120|M.marinum_M EAVRFTARSAPKLMHRG--RTASRSLIGPILRAASYSDLEVSRSLDAFSQ
MAV_4371|M.avium_104 EAVRVAARSAPKLMHRG--RNVSRSLIGPVLRAASFSDLQVSRSLDAFSQ
MLBr_00376|M.leprae_Br4923 EAVRLTSRSASKLMHRG--SIASQSLIGPILRAASYSDLRVSRGLDAFSQ
Mflv_4933|M.gilvum_PYR-GCK EAVRFTARYAPKLVHRG--RGAARSVIGPILRAASYGDEKISPSVVAFSE
Mvan_1485|M.vanbaalenii_PYR-1 EAVRFSARYAPKLVHRS--RGAARSVIGPILRAASYGDEKVSPSVVAFSE
MSMEG_1576|M.smegmatis_MC2_155 EAVRFSARYAPKLVHRT--RGAARSLIAPILQAGSFGDEQVSPSVAAFAA
TH_1693|M.thermoresistible__bu EAFRFAARYAPGLVHRT--RGAAWTVLRPILRAASFGSDRVSPSVMAFSE
MAB_3738c|M.abscessus_ATCC_199 RVLRTAVHYAPGPAHHG--RGAIKSLVGPVLQAASYGGHRVSPTLVKFSE
Mb3196c|M.bovis_AF2122/97 PVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAAD-ADPSATRLVY
Rv3171c|M.tuberculosis_H37Rv PVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAAD-ADPSATRLVY
. : : . :: :: : : . . :
MUL_0880|M.ulcerans_Agy99 QMMNDTPIATLGGFLHALEVHDETAGLWTL-LRIPTLIACGDHDLMTPDE
MMAR_1120|M.marinum_M QMMNDTPIATLVGFLHALEVHDETAGLWTL-LRIPTLIACGDHDLMTPDE
MAV_4371|M.avium_104 RMMNSTPIPTMVGFLDALEHHDETAGLWTL-LRVPTLIACGDHDLLTPDE
MLBr_00376|M.leprae_Br4923 RIMNDTLIAILVSFLHALELHEETAGLWPL-LRVPALIACGDHDLLTSDE
Mflv_4933|M.gilvum_PYR-GCK RMMHDTPIATLVEFLHALEVHDETAGLETL-RRVPTLVACGDRDLLTPKE
Mvan_1485|M.vanbaalenii_PYR-1 RMMHDTSVATLVEFLHALEVHDETAGLKTL-NKVETLVACGDRDLLTPVE
MSMEG_1576|M.smegmatis_MC2_155 DMMHGTPIPTLVEFLHALEVHDETAALDVL-AGVPTLIACGDRDLLTPVE
TH_1693|M.thermoresistible__bu SMIQNTPIATLVEFMHALEVHDETAALPVL-ARIPTLIACGSDDVLTPAV
MAB_3738c|M.abscessus_ATCC_199 RMIHQTPVTTIVDFLRALEQHDETAALPTI-APLPSLVICGDTDMLTPHT
Mb3196c|M.bovis_AF2122/97 ELFTQMSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPIS
Rv3171c|M.tuberculosis_H37Rv ELFTQTSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPIS
:: . * . :* * : :*: * * :*.
MUL_0880|M.ulcerans_Agy99 YSRKMAASLPQS---ELVIVGGASHLALLDEPDAINGGLVRLVDRALPGK
MMAR_1120|M.marinum_M YSRKMAASLPQS---ELVIVGGASHLALLDKPDAINEGLVRLVDRALPGK
MAV_4371|M.avium_104 YSRKMAASLPQS---ELVIVAGASHLALLDKPEAINGGLVRLVRRATPSR
MLBr_00376|M.leprae_Br4923 RSRGMAAVLPLL---ALVIVSGASRLALLDKPGAINDGLVRLVNRAVPGK
Mflv_4933|M.gilvum_PYR-GCK YSQEMADVLAKS---ELVIVPGAGHLVQLECPEVINDALVRLVERATPSK
Mvan_1485|M.vanbaalenii_PYR-1 YSREMADALAKS---ELVIAGGAGHLVQLERPEVINDALVRLVERATPSK
MSMEG_1576|M.smegmatis_MC2_155 YSREMAERLPKS---ELVVVGGAGHLVQLEEPEVINDALIRLVERATPSK
TH_1693|M.thermoresistible__bu HSKRMAAALPDS---ELLIVEGAGHLVQLEAPEVINDALVRLVQRATPST
MAB_3738c|M.abscessus_ATCC_199 QSESMAARLAASGHNELILVRESGHLVQLEHPEIVNDGIDRLVRRSTPPL
Mb3196c|M.bovis_AF2122/97 QSRRIARTAPNVVG--LVELPG-GHCSMLERHQEVNSHLRALAESVTR--
Rv3171c|M.tuberculosis_H37Rv QSRRIARTAPNVVG--LVELPG-GHCSMLERHQEVNSHLRALAESVTR--
*. :* . *: .: *: :* : *.
MUL_0880|M.ulcerans_Agy99 LTLRYRRVGERLRDRWRRHG
MMAR_1120|M.marinum_M LTLRYRRVGERLRDRWRRHG
MAV_4371|M.avium_104 AALALRRIGERL---WRRG-
MLBr_00376|M.leprae_Br4923 AALRYRRFKERL----QRHG
Mflv_4933|M.gilvum_PYR-GCK LTALTRRVTQRV----RSDD
Mvan_1485|M.vanbaalenii_PYR-1 LVALTRRVKERV----RSHG
MSMEG_1576|M.smegmatis_MC2_155 LVALARRVRNRV----RPHG
TH_1693|M.thermoresistible__bu LVALTRRIRDKV----RPHD
MAB_3738c|M.abscessus_ATCC_199 FAAIKQRLRDRTGL------
Mb3196c|M.bovis_AF2122/97 -HVRDRRISS----------
Rv3171c|M.tuberculosis_H37Rv -HVRDRRISS----------
:*. .