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TETADIDSMPRAGFGAPVWDRKLQTDRLEYLDRDDVPAKKRSVVESLDLLGEKKGLHRWNAEQAAGFLVG IDSPRVLELGAAHGGLSRELLKLRPDASITVTDIEPSSVAGIAASGMGSDPRVSVRVMDATAIDAPDGAF DLVVFALSFHHLPPSLAAKVFVEGTRVGRTLLIIDLLRLPAPLLAPAYLFAAAVGWVRPVAHDGAISQLR AYGPRALRSLAEHADPSIIIELRARLQLPMPLQIVVARRGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3985c | - | - | 100% (252) | hypothetical protein MAB_3985c |
| M. abscessus ATCC 19977 | MAB_4700c | - | 3e-65 | 53.25% (246) | hypothetical protein MAB_4700c |
| M. abscessus ATCC 19977 | MAB_3381c | - | 3e-05 | 35.44% (79) | hypothetical protein MAB_3381c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2000 | - | 9e-55 | 46.96% (247) | hypothetical protein Mb2000 |
| M. gilvum PYR-GCK | Mflv_1326 | - | 6e-60 | 54.66% (247) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1978 | - | 1e-55 | 47.37% (247) | hypothetical protein Rv1978 |
| M. leprae Br4923 | MLBr_01723 | - | 4e-05 | 33.77% (77) | hypothetical protein MLBr_01723 |
| M. marinum M | MMAR_1415 | - | 6e-10 | 37.86% (103) | hypothetical protein MMAR_1415 |
| M. avium 104 | MAV_0081 | - | 8e-56 | 49.59% (244) | hypothetical protein MAV_0081 |
| M. smegmatis MC2 155 | MSMEG_6231 | - | 8e-63 | 54.00% (250) | hypothetical protein MSMEG_6231 |
| M. thermoresistible (build 8) | TH_2189 | - | 9e-05 | 35.06% (77) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1900 | - | 2e-05 | 34.18% (79) | hypothetical protein MUL_1900 |
| M. vanbaalenii PYR-1 | Mvan_5469 | - | 2e-64 | 56.05% (248) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3985c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3985c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3985c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3985c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 ------------------------------------------MAYMATST
MAB_3985c|M.abscessus_ATCC_199 ----------------------------------------------MTET
Mb2000|M.bovis_AF2122/97 ------------------------------------------MGEANIRE
Rv1978|M.tuberculosis_H37Rv ------------------------------------------MGEANIRE
MAV_0081|M.avium_104 ------------------------------------------MSEALTVD
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MUL_1900|M.ulcerans_Agy99 ------------------------------------------MTRSSE--
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTE--
MMAR_1415|M.marinum_M --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK ----------MPRGGPRASCLDRLLETDRQEYLDRASELPADVAR-KRSV
Mvan_5469|M.vanbaalenii_PYR-1 ----------MPRGGPDASCLDRLLQTDRQEYLDRDSAGDAGLEQTKRSV
MSMEG_6231|M.smegmatis_MC2_155 ADIA-----AMPRGGPRASCLDRLLQTDRLEYLDRDDVD----QRVKRSV
MAB_3985c|M.abscessus_ATCC_199 ADID-----SMPRAGFGAPVWDRKLQTDRLEYLDRDDVP-----AKKRSV
Mb2000|M.bovis_AF2122/97 QAIA-----TMPRGGPDASWLDRRFQTDALEYLDRDDVP----DEVKQKI
Rv1978|M.tuberculosis_H37Rv QAIA-----TMPRGGPDASWLDRRFQTDALEYLDRDDVP----DEVKQKI
MAV_0081|M.avium_104 PAIA-----SMPRGGPDASWLDRRLQTEKLEYTDRYDIP----DEVKQTV
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHDWEA---ESYDDKW
MUL_1900|M.ulcerans_Agy99 IPAD-----AAPNPHATAEEVEAARHDSKLAQVLYHDWEA---ENYDEKW
MLBr_01723|M.leprae_Br4923 ISAN-----AVPNPHATAEQVAAARKDSKLAQVLYHDWEA---ENYDEKW
MMAR_1415|M.marinum_M --------------------------------------------MPAMSR
.
Mflv_1326|M.gilvum_PYR-GCK IRALEWTGETFGHHVRFAEIVLDQISDVPDPKILELGAGHGALSRKLLDW
Mvan_5469|M.vanbaalenii_PYR-1 IRALDWTGEVFGNHEKFAKIALDEVADVADPRILELGAGHGGLSRKLLEW
MSMEG_6231|M.smegmatis_MC2_155 VRALEWTGDMFGNHEKFAAISLDLLAEVPDPRILELGAGHGSVSRRLLAN
MAB_3985c|M.abscessus_ATCC_199 VESLDLLGEKKGLHRWNAEQAAGFLVGIDSPRVLELGAAHGGLSRELLKL
Mb2000|M.bovis_AF2122/97 IGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILEL
Rv1978|M.tuberculosis_H37Rv IGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILEL
MAV_0081|M.avium_104 VAALDRMGTRAGYHERNARTALDIVADIANPRILELGAGHGKLSAEILTS
TH_2189|M.thermoresistible__bu SISYDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLNLIQS
MUL_1900|M.ulcerans_Agy99 SISYDQRCVEYARGRFDAIVPAQVHADLPYERALELGCGTGFFLLNLIQA
MLBr_01723|M.leprae_Br4923 SISYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQS
MMAR_1415|M.marinum_M IESVFCRSAPWRAATRRLVLPWALQGIEPVGEVLEIGAGSGAMAAEMLAA
**:*.. * . .::
Mflv_1326|M.gilvum_PYR-GCK HPTARLTVTDIEPASVAAIADSDVGAHPRATVRQMDATALDAADGEFDLA
Mvan_5469|M.vanbaalenii_PYR-1 HPSARLTVTDVEPASVAAIAAGDLGSHPRATVRQMDATALDAADGEFDLA
MSMEG_6231|M.smegmatis_MC2_155 HPTAHVTVTDVDPAAVAAMADGELGDHPRAVVRAMDATDIDADDGSFDLA
MAB_3985c|M.abscessus_ATCC_199 RPDASITVTDIEPSSVAGIAASGMGSDPRVSVRVMDATAIDAPDGAFDLV
Mb2000|M.bovis_AF2122/97 HPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHGHSYDLA
Rv1978|M.tuberculosis_H37Rv HPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLA
MAV_0081|M.avium_104 HPTATVTVSDLDPTSVANIAAGPLGADPRARTQVVDATAIDAPDDSYDLV
TH_2189|M.thermoresistible__bu GVARRGSVTDLSPGMVRVATRNGRSLGLDVDGRVADAEGIPYDDNTFDLV
MUL_1900|M.ulcerans_Agy99 GVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYDDDTFDLV
MLBr_01723|M.leprae_Br4923 GVARRGSVTDLSPGMVKIATRNGQSLGLDINGRVADAEGIPYDDNTFDLV
MMAR_1415|M.marinum_M QPDTRITVTDYDDAMVAAAAQRLAPFQTRATARQADATALPFGDNTFDTV
:::* . * : : ** : . :* .
Mflv_1326|M.gilvum_PYR-GCK VFALSFHHLP-PAAAARVIAEGTRAADTLLIIDLPRP--------PAPLH
Mvan_5469|M.vanbaalenii_PYR-1 VFALSFHHLP-PQLAARAIAEGARVADKLLIIDLPRP--------PAPLH
MSMEG_6231|M.smegmatis_MC2_155 LFALSFHHLS-PAQAAAVFAEGTRVARTLLIIDLPRP--------PAPLH
MAB_3985c|M.abscessus_ATCC_199 VFALSFHHLP-PSLAAKVFVEGTRVGRTLLIIDLLRL--------PAPLL
Mb2000|M.bovis_AF2122/97 VFALAFHHLP-PTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLL
Rv1978|M.tuberculosis_H37Rv VFALAFHHLP-PTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLL
MAV_0081|M.avium_104 VFAQAFHHLP-PATAVRAIAEATRVGKRFLVIDLPRPRSVQLLLTPLILA
TH_2189|M.thermoresistible__bu VGHAVLHHIPDVELSLREVVRVLRPGGRFVFAGEPTTVGNSYARALSTLT
MUL_1900|M.ulcerans_Agy99 VGHAVLHHIPDVELSLREVMRVLKPGGRFVFAGEPTTVGNEYARTLSTLT
MLBr_01723|M.leprae_Br4923 VGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLT
MMAR_1415|M.marinum_M LTFIMLHHTVRWEQTLAEAVRVLAPHGTLIGYDLLSS-------------
: :** : . :: .
Mflv_1326|M.gilvum_PYR-GCK LVRLATMLPWAPLVPFVHDG-------------VISSLRAYSPAALRALA
Mvan_5469|M.vanbaalenii_PYR-1 VLRLAAMLPWAPLVPFLHDG-------------VISSLRAYSPSALRALA
MSMEG_6231|M.smegmatis_MC2_155 LLRLATMLPLAPLVPFVHDG-------------VISSLRCYSPSALRALA
MAB_3985c|M.abscessus_ATCC_199 APAYLFAAAVGWVRPVAHDG-------------AISQLRAYGPRALRSLA
Mb2000|M.bovis_AF2122/97 PLH-LLLLPWSSMRSSMHDG-------------FISALRAYSPSALQTLA
Rv1978|M.tuberculosis_H37Rv PLH-LLLLPWSSMRSSMHDG-------------FISALRAYSPSALQTLA
MAV_0081|M.avium_104 PFAAALALVRPSLKHVMHDA-------------YISALRAYSRSAFIALG
TH_2189|M.thermoresistible__bu WHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFEPSDLERMA
MUL_1900|M.ulcerans_Agy99 WRIATNVTKLPGLGGWRRPQEELDESSRAAALEAIVDLHTFAPEDLERMA
MLBr_01723|M.leprae_Br4923 WKVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMA
MMAR_1415|M.marinum_M ---------WPTRTLHRLEG---------------APHRLIERGELQPVL
: : :
Mflv_1326|M.gilvum_PYR-GCK AHAGEDIDIELRG---GLFSP---QVAVAARR------------------
Mvan_5469|M.vanbaalenii_PYR-1 THADPAVDIELRG---GLLSP---QVAVATRR------------------
MSMEG_6231|M.smegmatis_MC2_155 AHAG--VALELRG---GLTTP---QIAIARRA------------------
MAB_3985c|M.abscessus_ATCC_199 EHADPSIIIELRA---RLQLPMPLQIVVARRGL-----------------
Mb2000|M.bovis_AF2122/97 RAADPGMQVEILP-APTRLFPPSLAVVFSRSSSAPTESSECSADRQPGE-
Rv1978|M.tuberculosis_H37Rv RAADPGMQVEILP-APTRLFPPSLAVVFSRSSSAPTESSECSADRQPGE-
MAV_0081|M.avium_104 KAADPRMGVEFLPLSACRLRPGHVGIVFTRPRAS----------------
TH_2189|M.thermoresistible__bu RNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFGSWTA
MUL_1900|M.ulcerans_Agy99 KNAGAIRVETASEEFSAAMFGWPVRTFESSVPPGRLGWNWARFAFNGWKA
MLBr_01723|M.leprae_Br4923 TNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKT
MMAR_1415|M.marinum_M RQLPLSASRVRQN----RLLVRFTAMKQASPS------------------
:
Mflv_1326|M.gilvum_PYR-GCK -----------------------------
Mvan_5469|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_6231|M.smegmatis_MC2_155 -----------------------------
MAB_3985c|M.abscessus_ATCC_199 -----------------------------
Mb2000|M.bovis_AF2122/97 -----------------------------
Rv1978|M.tuberculosis_H37Rv -----------------------------
MAV_0081|M.avium_104 -----------------------------
TH_2189|M.thermoresistible__bu LSWVDANVWRRVMPKGWFYNVMVTGVKPS
MUL_1900|M.ulcerans_Agy99 LGWMDANVWRHVAPKGWFYNVMVTGVKPS
MLBr_01723|M.leprae_Br4923 LSWVDANVWRRVIPKSWFYNIIITGVKPS
MMAR_1415|M.marinum_M -----------------------------