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TETIQALLQQRMSDSSIAVKYHDLQWTWREYLAEAAARAAGLIAAADPDRPLHIGSLLGNTPEMLAQMAA AGLGGYVLCGLNTTRRGEALAADIRRAECQIIVTDAENRSLLDGLDLADVEIFDTSTPRWAELVGGAGSL VPHRKVEMMDPFMMIFTSGTSGNPKAVQVSHLMPTFAGRSLTERFGLSAHDTCYVSMPLFHSNAVVAGWA PAVVSGAAIAPAKFSATGFLDDIRRYQATYMNYVGKPLAYILATPERDDDDENPLRVAFGNEANEKDIEE FSRRFAVQVEDGFGSTENAVIVIREPGTPPGSIGKGVDGVAVYNSDSVTECAVARFDEHGALANADEAVG ELVNTMGSGFFTGYYNDPGANAERMRHGMYWSGDLAYRDSQGWIYLAGRTADWMRVDGENLAAAPIERIL LRDNSVNRVAVYAVPDARVGDQVMAAVVPHRDQRFTPESLEAFLRAQPDLSAKAWPRYVRIAADLPSTAT HKVLKRQLVAEGTAIGPDEALWVREQRGTRYRIASDESR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2625 | fadD1 | - | 100% (530) | fatty-acid-CoA ligase FadD1 |
| M. marinum M | MMAR_4994 | fadD17 | e-133 | 48.94% (517) | fatty-acid-CoA synthetase FadD17 |
| M. marinum M | MMAR_4232 | fadD6 | 1e-35 | 27.60% (529) | fatty-acid-CoA ligase FadD6 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1779c | fadD1 | 0.0 | 81.32% (530) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2305 | - | 0.0 | 64.20% (528) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1750c | fadD1 | 0.0 | 81.32% (530) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 1e-22 | 26.72% (479) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2609 | - | 0.0 | 62.84% (522) | acyl-CoA synthetase |
| M. avium 104 | MAV_5257 | - | 0.0 | 78.82% (524) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4952 | - | 0.0 | 65.52% (522) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4470 | - | 0.0 | 64.96% (528) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4069 | fadD17 | 1e-132 | 48.74% (517) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4341 | - | 0.0 | 65.78% (526) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1779c|M.bovis_AF2122/97 -----------MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAAR
Rv1750c|M.tuberculosis_H37Rv -----------MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAAR
MMAR_2625|M.marinum_M -----------MTETIQALLQQRMSDSSIAVKYHDLQWTWREYLAEAAAR
MAV_5257|M.avium_104 ----------MAEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAAR
Mflv_2305|M.gilvum_PYR-GCK -----------MAETVQQLLRERVTDDGIAMKHEDRTWTWREHLGEAAAQ
Mvan_4341|M.vanbaalenii_PYR-1 -----------MAETVQQLLRERLDSDGIALKYEGSTWTWREHLGEAAMQ
MSMEG_4952|M.smegmatis_MC2_155 -----------MADTLQQLLRSRAEQDTVAVKYGDRTWTWREHIAEAAAQ
TH_4470|M.thermoresistible__bu -----------MADTLQQLLRERAAQDTIAIKYDDRRITWREHVADAARQ
MAB_2609|M.abscessus_ATCC_1997 -----------MAETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARH
MUL_4069|M.ulcerans_Agy99 ---------MSADPTVPQLLVPLAEIGDRGIYFEDSFTSWADHIGHGAAI
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
: : . .
Mb1779c|M.bovis_AF2122/97 AAALITIADPQRPT----------------HIGSLLGNTPEMLAQLAAAG
Rv1750c|M.tuberculosis_H37Rv AAALITIADPQRPT----------------HIGSLLGNTPEMLAQLAAAG
MMAR_2625|M.marinum_M AAGLIAAADPDRPL----------------HIGSLLGNTPEMLAQMAAAG
MAV_5257|M.avium_104 AAALLGAADPGRPM----------------HVGTLLGNTPEMLSQMAAAG
Mflv_2305|M.gilvum_PYR-GCK ASALIGLADPSRPL----------------HVGVLLGNTPDMLTAMAAAG
Mvan_4341|M.vanbaalenii_PYR-1 AAALIGAADPERPL----------------HVGVLLGNNPDMLTAMAAAG
MSMEG_4952|M.smegmatis_MC2_155 ARFLISRADHGRPL----------------HVGVLLGNTPQMLTALAAAA
TH_4470|M.thermoresistible__bu AAALLAAADPNRPP----------------HIAVLLGNTPDMLTALAGAA
MAB_2609|M.abscessus_ATCC_1997 AAALIGIADPTRPL----------------HVGTLLGNTPAMTTAMAAAA
MUL_4069|M.ulcerans_Agy99 AAALRERLDPTRPP----------------HVGVLLRNTPFFSAMLTAAG
MLBr_02661|M.leprae_Br4923 NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLAAS
: * * ::. .. : : .*.
Mb1779c|M.bovis_AF2122/97 LGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAGARI
Rv1750c|M.tuberculosis_H37Rv LGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAGARI
MMAR_2625|M.marinum_M LGGYVLCGLNTTRRGEALAADIRRAECQIIVTDAENRSLLDGLDLADVEI
MAV_5257|M.avium_104 LGGYVLCGLNTTRRGKALAADVRRADCQFVVTDAEHRPLLDGLDLAGTQI
Mflv_2305|M.gilvum_PYR-GCK LGGYVLCGINTTRRGSALGRDVLRGDCQILITDDAHRGLLDGVDLPGVRV
Mvan_4341|M.vanbaalenii_PYR-1 LGGYVLCGINNTRRGDALARDIRRADCQFLITDDAHRHLLDGLDLSGVRV
MSMEG_4952|M.smegmatis_MC2_155 LGGYVLCGINTTRRGEGLARDIARVDCQLLITDAEHRGLIDGLELPGVTV
TH_4470|M.thermoresistible__bu LGGYVLCGINTTRRGAALARDVERVDAQILITDAEHRHLLDGLELPGVTV
MAB_2609|M.abscessus_ATCC_1997 QGGYILCAINNTRRGEGLLRDIRKSDVQVLLVDAEHRPLLDAVDLPDVTV
MUL_4069|M.ulcerans_Agy99 MSGIIPVGLNPVRRGAALARDIEHADCQMVLADTASASTLDGIEH-----
MLBr_02661|M.leprae_Br4923 RAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATMRY
.* : :: . :. :.* :.
Mb1779c|M.bovis_AF2122/97 LDTSTPRWAELVAGDG-AFVPYREVDTM------------DPFMMIFTSG
Rv1750c|M.tuberculosis_H37Rv LDTSTPRWAELVAGDG-AFVPYREVDTM------------DPFMMIFTSG
MMAR_2625|M.marinum_M FDTSTPRWAELVGGAG-SLVPHRKVEMM------------DPFMMIFTSG
MAV_5257|M.avium_104 LDTSTPDWAGFVDAAG-ELTPHREVAAM------------DPFMMIFTSG
Mflv_2305|M.gilvum_PYR-GCK LVVGTPEWSELIGRAG-ELTPHREVTVT------------DTYMLIFTSG
Mvan_4341|M.vanbaalenii_PYR-1 LVVGTPEWKELTGRAG-TLTPHREVTAT------------DTYMLIFTSG
MSMEG_4952|M.smegmatis_MC2_155 LDAS-----DICPEAG-ELTPYREAGPD------------DTFMMIFTSG
TH_4470|M.thermoresistible__bu FDTSTTEWARLLAAAP-ELTPHREVTPD------------DTFMMIFTSG
MAB_2609|M.abscessus_ATCC_1997 IDVDSAEWIERMKTPG-ELHPYRTAAPL------------DPFMMIFTSG
MUL_4069|M.ulcerans_Agy99 VNVDSAEWAEVIDAHRNSEISFQNAAPA------------DLFMLIYTSG
MLBr_02661|M.leprae_Br4923 WPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDAMIMFTGG
. * *:::*.*
Mb1779c|M.bovis_AF2122/97 TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGW
Rv1750c|M.tuberculosis_H37Rv TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGW
MMAR_2625|M.marinum_M TSGNPKAVQVSHLMPTFAGRSLTERFGLSAHDTCYVSMPLFHSNAVVAGW
MAV_5257|M.avium_104 TSGNPKAVQVSHLMAVFAGSNLVQRFGLTEHDTCYVSMPLFHSNAVVAGW
Mflv_2305|M.gilvum_PYR-GCK TSGDPKAVKMMHAMVLLAGAALAGRYELTPRDVCYLSMPLFHSNAVLAGW
Mvan_4341|M.vanbaalenii_PYR-1 TSGDPKAVKMMHAMVLLAGAALMGRYELTSDDVCYLSMPLFHSNAVLAGW
MSMEG_4952|M.smegmatis_MC2_155 TSGDPKAVEVPHAMVLFAGSALVERYGLTCEDVCYLAMPLFHSNAVYAGW
TH_4470|M.thermoresistible__bu TSGEPKAVQVPHSTVLFSGTALVDRYQLGSADTCYLAMPLFHSNAVYAGW
MAB_2609|M.abscessus_ATCC_1997 TSGDPKAVLVTHATVLVAAESLVERFSLSAADVCYVSMPLFHSNAVLAGW
MUL_4069|M.ulcerans_Agy99 TSGDPKAVKCGHSKVAIAGVTMTQRFGLGRDDVCYVSMPLFHSNAVLVGW
MLBr_02661|M.leprae_Br4923 TTGLPKMVPWTDGNIAGSVHAIITAYQLGPQDATVVVMPLYHGHGLIAAL
*:* ** * . : : : * *. : ***:*.:.: ..
Mb1779c|M.bovis_AF2122/97 APAVVSG--AAIAP-ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPE
Rv1750c|M.tuberculosis_H37Rv APAVVSG--AAIAP-ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPE
MMAR_2625|M.marinum_M APAVVSG--AAIAP-AKFSATGFLDDIRRYQATYMNYVGKPLAYILATPE
MAV_5257|M.avium_104 APAVCSG--AAIVP-AKFSARNFLDDIRRYGATYMNYVGKPLAYVLATPE
Mflv_2305|M.gilvum_PYR-GCK SVALNAG--AAMAP-AHFSASGFLGDIRRYGATYMNYVGKPLAYILASPE
Mvan_4341|M.vanbaalenii_PYR-1 SVAVNSG--AAMAP-AQFSASRFVDDIRRYGATYMNYVGKPLAYILAGPE
MSMEG_4952|M.smegmatis_MC2_155 SVAVGAG--AAMAP-ATFSASGFLPDIRRYGATYMNYVGKPLAYILATPE
TH_4470|M.thermoresistible__bu SVAVGAG--AAMAP-ATFSASRFLHDIRRYGATYMNYVGKPLAYILATPE
MAB_2609|M.abscessus_ATCC_1997 AVAVAAG--AALAP-AKFSASRFLADIREVGATYMNYVGKPLAYVLATAE
MUL_4069|M.ulcerans_Agy99 AVAVACQ--GSMALRRKFSASQFLSDVRRYGATYANYVGKPLSYVLATPE
MLBr_02661|M.leprae_Br4923 LSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHRILLELAS
:: . : *** * *: **: . . :* ..
Mb1779c|M.bovis_AF2122/97 RDDDADNPLRVAFGNEA----NDKDIEEFSRRFGVQVEDGFGSTENAVIV
Rv1750c|M.tuberculosis_H37Rv RDDDADNPLRVAFGNEA----NDKDIEEFSRRFGVQVEDGFGSTENAVIV
MMAR_2625|M.marinum_M RDDDDENPLRVAFGNEA----NEKDIEEFSRRFAVQVEDGFGSTENAVIV
MAV_5257|M.avium_104 RADDADNPLRVAFGNEA----NDKDIEEFGRRFGVQVEDGFGSTENAVIV
Mflv_2305|M.gilvum_PYR-GCK KPDDIDNPLRVAFGNEA----GDRDIAEFSRRFGCEVWDGFGSTENAVTI
Mvan_4341|M.vanbaalenii_PYR-1 RPDDADNPLRVAFGNEA----SDRDIAEFARRFGCQVWDGFGSTENAVTV
MSMEG_4952|M.smegmatis_MC2_155 KPDDHDNPLRIAFGNEA----ADRDIAAFSRRFGCTVWDGFGSTETAVII
TH_4470|M.thermoresistible__bu KPDDHDNPLRIAFGNEA----TDRDIEAFSRRFGCTVWDGFGSTEIAVII
MAB_2609|M.abscessus_ATCC_1997 HADDAANPLRVAFGNEA----SESDIAEFARRFDVTVYDGFGSTENAVII
MUL_4069|M.ulcerans_Agy99 RPDDADNPLRAVYGNEG----VPGDIERFGCRFGCVVQDGFGSTEGGVAI
MLBr_02661|M.leprae_Br4923 TQSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTEATHQV
. : : : .. : .* * .** ** :
Mb1779c|M.bovis_AF2122/97 IREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGEL
Rv1750c|M.tuberculosis_H37Rv IREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGEL
MMAR_2625|M.marinum_M IREPGTPPGSIGKGVDGVAVYNSDSVTECAVARFDEHGALANADEAVGEL
MAV_5257|M.avium_104 IREPGTPRGSIGRGIDGVAIYNSDTVTECPVARFDADGALINADEAVGEL
Mflv_2305|M.gilvum_PYR-GCK TREDGCPPGSIGKGFPGVAIYDPDTLTECAVAEFDAHGALVNGDDAIGEL
Mvan_4341|M.vanbaalenii_PYR-1 TREDGCPPGSIGKGFPGVAIYDAETLTECAVAEFDEHGALANADDAIGEL
MSMEG_4952|M.smegmatis_MC2_155 TRPDDCPPGSIGKGFPGVAIYDPQTVTECAVAEFDATGALANPDAAIGEL
TH_4470|M.thermoresistible__bu TRPDDCPPGSVGKGFPGVAIYNPETLQECSVARFDANGALINPDEAIGEL
MAB_2609|M.abscessus_ATCC_1997 TREEGTPTGSIGKGFPGIAVYNPDTLRECAVARFDAHGILANPADAVGEL
MUL_4069|M.ulcerans_Agy99 ARTPDTPAGSLGPLPENIEIVDPETGQQCPVG-------------AVGEL
MLBr_02661|M.leprae_Br4923 TTTN---IKWFGQGENPTVTNGLVGQSTGVQIRIVGSDGQPLPPDTVGEV
.* . ::**:
Mb1779c|M.bovis_AF2122/97 VNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTAD
Rv1750c|M.tuberculosis_H37Rv VNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTAD
MMAR_2625|M.marinum_M VNTMGSGFFTGYYNDPGANAERMRHGMYWSGDLAYRDSQGWIYLAGRTAD
MAV_5257|M.avium_104 VNTAGSGFFTGYYNDPDANAERMRHGMYWSGDLAYRDADGWIYLAGRTAD
Mflv_2305|M.gilvum_PYR-GCK VNTQGAGMFAGYYNDQDATDDRMRHGMFWSGDLAYRDADGWIYLAGRTAD
Mvan_4341|M.vanbaalenii_PYR-1 VNTQGAGMFAGYYNDQGATDERMRHGMFWSGDLAYRDADGWIYLAGRTAD
MSMEG_4952|M.smegmatis_MC2_155 VNTAGGGLFRGYYNDQGATDQRMRHGMYWSGDLAYRDADGWIYLAGRTAD
TH_4470|M.thermoresistible__bu VNTAGAGLFRGYYNDPQATDERMRHGMYWSGDLAYRDADGWIYLAGRTAD
MAB_2609|M.abscessus_ATCC_1997 VNTQGAGFFSGYYNDDDATGERMRHGMYWSGDLAYRDADGWIYLAGRTPD
MUL_4069|M.ulcerans_Agy99 VNTAGPGRFEGYYNDEAASAQRMSGGVYHSGDLAYRDAAGYAYFAGRLGD
MLBr_02661|M.leprae_Br4923 W-LRGSTVVRGYLGDPAITAANFTHGWLRTGDLGSLSVTGDLRIRGRIKE
* . ** .* . .: * :***. . * : ** :
Mb1779c|M.bovis_AF2122/97 WMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAG
Rv1750c|M.tuberculosis_H37Rv WMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAG
MMAR_2625|M.marinum_M WMRVDGENLAAAPIERILLRDNSVNRVAVYAVPDARVGDQVMAAVVPHRD
MAV_5257|M.avium_104 WMRVDGENLAAAPIERILLRHTAINRVAVYAVPDGHVGDQVMAAVVLNDG
Mflv_2305|M.gilvum_PYR-GCK WMRVDGENMTAAPIERILIRLPAISMAAVYPVPDEFVGDQVMAAIVVQDE
Mvan_4341|M.vanbaalenii_PYR-1 WMRVDGENMTSAPIERILIRLPAISMAAVYPVPDEFVGDQVMAALVLQDE
MSMEG_4952|M.smegmatis_MC2_155 WMRVDGENLTAAPIERILLRLDAVNRVAVYPVPDEYVGDQVMAAIVLQDG
TH_4470|M.thermoresistible__bu WMRVDGENLTAAPIERILLRLPAINRAAVYPVPDELVGDQVMAAVVLQD-
MAB_2609|M.abscessus_ATCC_1997 WMRINGENLAAAPIERVLQRHPAISQAAVYAVRDEHGGDAVMAALVLRAP
MUL_4069|M.ulcerans_Agy99 WMRVDGENLGTAPIERVLLRYPDAIEVAVYAIPDPVVGDQVMAAMVLTPG
MLBr_02661|M.leprae_Br4923 LINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVIVPREV
:. .**:: . :* :* .**: * *: * *.:*
Mb1779c|M.bovis_AF2122/97 DTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDEG
Rv1750c|M.tuberculosis_H37Rv DTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDEG
MMAR_2625|M.marinum_M QRFTPESLEAFLRAQPDLSAKAWPRYVRIAADLPSTATHKVLKRQLVAEG
MAV_5257|M.avium_104 ETLTPAAFEVFLDAQPDLSPKARPRYVRIAADLPSTATHKVLKRQLISQG
Mflv_2305|M.gilvum_PYR-GCK ATLTPQEFGTFLSEQPDLSPKAWPRYVWIADELPSTATNKVLKRELVAMG
Mvan_4341|M.vanbaalenii_PYR-1 ATLTPDEFARFLAAQPDLSPKAWPRHVWIADALPSTATNKVLKRELVAMG
MSMEG_4952|M.smegmatis_MC2_155 ATLTPGEFEEFLAAQRDLSPKAWPRYVWIAEDLPTTATNKILKRELVATG
TH_4470|M.thermoresistible__bu -ELTPRQFADFLAAQTDLSPKAWPRYVWVADDLPVTATNKVLKRELIARG
MAB_2609|M.abscessus_ATCC_1997 --LTYLGLAEFLSAQQDLPRIGWPRYIRLSENLPTTATNKILKRVLISEG
MUL_4069|M.ulcerans_Agy99 AKFDVDKFRAFLAGQSDLGPKQWPSYVRICSALPRTETFKVLKRQLAADG
MLBr_02661|M.leprae_Br4923 IAPTPSELAVFCRDR--LAAFEVPTRFQEASALPHTAKGSLDRRAVAEQF
: * : * * . . ** * . .: :* :
Mb1779c|M.bovis_AF2122/97 TAVGKADTLWVREPRGSAYHHASGPAKAI---------------------
Rv1750c|M.tuberculosis_H37Rv TAVGKADTLWVREPRGSAYHHASGPAKAI---------------------
MMAR_2625|M.marinum_M TAIGPDEALWVREQRGTRYRIASDESR-----------------------
MAV_5257|M.avium_104 TAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAPSTVAPV--------
Mflv_2305|M.gilvum_PYR-GCK TTPA-GRTLWTRD--GSGYRTVAEE-------------------------
Mvan_4341|M.vanbaalenii_PYR-1 VEPA-GRTLWRRD--GGTYRTVSAQE------------------------
MSMEG_4952|M.smegmatis_MC2_155 TDPA-GRVLWHRD--GTRFTDLSAASAPGAAPGISPA-------------
TH_4470|M.thermoresistible__bu TAPD-GRVLWRRD--GAQYHVYAESDE-----------------------
MAB_2609|M.abscessus_ATCC_1997 LDIA-DETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIGAAAPPSEPTR
MUL_4069|M.ulcerans_Agy99 VDCG--DPVWPIRDQS----------------------------------
MLBr_02661|M.leprae_Br4923 AHRG----------------------------------------------